Effective targeting of Aβ to macrophages by sonochemically prepared surface-modified protein microspheres.

abstract：:The importance of the stabilization of the quaternary structure of multimeric enzymes has been illustrated using a model reaction with great industrial relevance: the enzymatic synthesis of ampicillin from 6-amino penicillanic acid (6APA) and phenylglycine methyl ester (PGM) catalyzed by the tetrameric enzyme alpha-am...

journal_title：Biomacromolecules

authors： Fernández-Lafuente R,Hernández-Jústiz O,Mateo C,Terreni M,Fernández-Lorente G,Moreno MA,Alonso J,García-López JL,Guisan JM

更新日期：2001-04-01 00:00:00

abstract：:Hybrid dendritic-linear block copolymers based on a 4-arm poly(ethylene glycol) (PEG) core were synthesized using an accelerated AB2/CD2 dendritic growth approach through orthogonal amine/epoxy and thiol-yne chemistries. The biological activity of these 4-arm and the corresponding 2-arm hybrid dendrimers revealed an e...

journal_title：Biomacromolecules

authors： Albertazzi L,Mickler FM,Pavan GM,Salomone F,Bardi G,Panniello M,Amir E,Kang T,Killops KL,Bräuchle C,Amir RJ,Hawker CJ

更新日期：2012-12-10 00:00:00

abstract：:Chimeric DNA containing parallel (ps) and antiparallel (aps) duplex elements as well as poly-dC tracts were designed and synthesized. Oligonucleotide duplexes with ps chain orientation containing reverse Watson-Crick dA-dT base pairs and short d(C)2 tails are stabilized under slightly acidic conditions by hemiprotonat...

journal_title：Biomacromolecules

authors： Mei H,Budow S,Seela F

更新日期：2012-12-10 00:00:00

abstract：:Nowadays, active targeting of nanotherapeutics is a challenging issue. Here, we propose a rational design of a ternary nanoassembly (SAP) composed of nonionic amphiphilic β-cyclodextrins (amphiphilic CD) incorporating pheophorbide (Pheo) as a phototherapeutic and an adamantanyl-folic acid conjugate (Ada-FA) to target ...

journal_title：Biomacromolecules

authors： Zagami R,Rapozzi V,Piperno A,Scala A,Triolo C,Trapani M,Xodo LE,Monsù Scolaro L,Mazzaglia A

更新日期：2019-07-08 00:00:00

abstract：:Selectively spooling single plasmid DNA (pDNA), as a giant polyelectrolyte, into a nanosized toroidal structure or folding it into a rod-like structure has been accomplished by polyion complexation with block catiomers to form polymeric micelles in varying NaCl concentrations. The interactive potency between the pDNA ...

journal_title：Biomacromolecules

authors： Li Y,Osada K,Chen Q,Tockary TA,Dirisala A,Takeda KM,Uchida S,Nagata K,Itaka K,Kataoka K

更新日期：2015-09-14 00:00:00

abstract：:Owing to their diverse functions and tunable physicochemical properties, peptides are promising alternatives to the conventional gene delivery tools that are available for plant systems. However, peptide-mediated gene delivery is limited by low transfection efficiency in plants because of the insufficient cytosolic tr...

journal_title：Biomacromolecules

authors： Miyamoto T,Tsuchiya K,Numata K

更新日期：2020-07-13 00:00:00

abstract：:Cellular uptake and intracellular targeting to specific organelles are key events in the cellular processing of nanomaterials. Herein, we perform a detailed structure-property relationship study on carboxylic acid-side-chain-bearing polyacrylates to provide design criteria for the manipulation of their cellular intera...

journal_title：Biomacromolecules

authors： Mahmoud AM,Morrow JP,Pizzi D,Azizah AM,Davis TP,Tabor RF,Kempe K

更新日期：2020-08-10 00:00:00

abstract：:Cancer cells have a large amount of ROS (reactive oxygen species) because of disturbed ROS homeostasis. Cancer cells therefore undertake redox adaptation to drive proliferation in tumor environments and even survive during anticancer treatment by upregulating endogenous antioxidants. As one of antioxidant defense syst...

journal_title：Biomacromolecules

authors： Noh J,Jung E,Lee J,Hyun H,Hong S,Lee D

更新日期：2019-02-11 00:00:00

abstract：:Experimental and theoretical investigations of the swelling and mechanical properties of hydrogels formed from chitosan, bovine serum albumin (BSA), and chitosan/BSA mixtures cross-linked with genipin were performed. The properties of cross-linked chitosan hydrogels were explained in terms of its polyelectrolyte behav...

journal_title：Biomacromolecules

authors： Butler MF,Clark AH,Adams S

更新日期：2006-11-01 00:00:00

abstract：:Low tolerability and tumor selectivity restricts many potent anticancer drugs including mertansine from wide clinical use. Here, glutathione-activatable hyaluronic acid-SS-mertansine prodrug (HA-SS-DM1) was designed and developed to achieve enhanced tolerability and targeted therapy of CD44+ human breast tumor xenogra...

journal_title：Biomacromolecules

authors： Zhong P,Zhang J,Deng C,Cheng R,Meng F,Zhong Z

更新日期：2016-11-14 00:00:00

abstract：:The mechanical rigidity and degradation rate of hydrogels utilized as cell transplantation vehicles have been regarded as critical factors in new tissue formation. However, conventional approaches to accelerate the degradation rate of gels deteriorate their function as a mechanical support in parallel. We hypothesized...

journal_title：Biomacromolecules

authors： Kong HJ,Kaigler D,Kim K,Mooney DJ

更新日期：2004-09-01 00:00:00

abstract：:Cartilage tissue engineering highly relies on the ability to store and transport chondrocytes in order to be clinically successful. Cryopreservation is a most reliable technology for chondrocyte storage, but it suffers from the intrinsic toxicity of current state-of-the-art cryoprotectant, dimethyl sulfoxide (DMSO). I...

journal_title：Biomacromolecules

authors： Liu M,Zhang X,Guo H,Zhu Y,Wen C,Sui X,Yang J,Zhang L

更新日期：2019-10-14 00:00:00

abstract：:A combination of chemo-photodynamic therapy has been manifested as a promising strategy for efficient cancer treatment due to the enhanced therapeutic efficacy. Here, we designed doxorubicin (DOX)-loaded photoresponsive micelles (DPRMs) based on a combination of chlorin e6 (Ce6) and lipoic acid (LA) conjugated methoxy...

journal_title：Biomacromolecules

authors： Kim DH,Hwang HS,Na K

更新日期：2018-08-13 00:00:00

abstract：:To continue expanding the use of Single Electron Transfer-Living Radical Polymerization (SET-LRP) in applications at the interface between macromolecular science, biomacromolecules, biology and medicine, it is essential to develop novel initiators that do not compromise the structural stability of synthesized polymers...

journal_title：Biomacromolecules

authors： Lligadas G,Enayati M,Grama S,Smail R,Sherman SE,Percec V

更新日期：2017-08-14 00:00:00

abstract：:Adhesive hydrogels were prepared by copolymerizing dopamine methacrylamide with either acrylic acid (AAc) or N-(3-aminopropyl)methacrylamide hydrochloride (APMH). The effect of incorporating the anionic and cationic side chains on the oxidation state of catechol was characterized using the FOX assay to track the produ...

journal_title：Biomacromolecules

authors： Narkar AR,Kelley JD,Pinnaratip R,Lee BP

更新日期：2018-05-14 00:00:00

abstract：:Peak force infrared (PFIR) microscopy is a recently developed approach to acquire multiple chemical and physical material properties simultaneously and with nanometer resolution: topographical features, infrared (IR)-sensitive maps, adhesion, stiffness, and locally resolved IR spectra. This multifunctional mapping is ...

journal_title：Biomacromolecules

authors： Gusenbauer C,Jakob DS,Xu XG,Vezenov DV,Cabane É,Konnerth J

更新日期：2020-10-12 00:00:00

abstract：:Chitosan hydrogel microspheres were obtained by cross-linking chitosan in its inverse emulsion using genipin as cross-linker. The genipin-cross-linked chitosan microspheres (ChGp) swell significantly in water at pH values below 6.5 and shrink to a smaller extent at pH values above 6.5. ChGp microspheres bind heparin i...

journal_title：Biomacromolecules

authors： Kamiński K,Zazakowny K,Szczubiałka K,Nowakowska M

更新日期：2008-11-01 00:00:00

abstract：:Electrospinning for the formation of nanoscale diameter fibers has been explored for high-performance filters and biomaterial scaffolds for vascular grafts or wound dressings. Fibers with nanoscale diameters provide benefits due to high surface area. In the present study we explore electrospinning for protein-based bi...

journal_title：Biomacromolecules

authors： Jin HJ,Fridrikh SV,Rutledge GC,Kaplan DL

更新日期：2002-11-01 00:00:00

abstract：:The mechanical and melt flow properties of two thermoplastic potato starch materials with different amylose contents were evaluated. The materials were prepared by mixing starch, glycerol, and water, mainly in the weight proportions of 10:3:4.5. Compression molding was used to produce sheets/films with a thickness in ...

journal_title：Biomacromolecules

authors： Thunwall M,Boldizar A,Rigdahl M

更新日期：2006-03-01 00:00:00

abstract：:Dual-cross-linked network (DCN) hydrogels with multiresponsive and self-healing properties are attracting intensive interests due to their enhanced mechanical strength for a wide range of applications. Herein, we developed a DCN hydrogel that combines a dynamic imine and a benzoxaboronic ester with a neutral pKa value...

journal_title：Biomacromolecules

authors： Zhao J,Diaz-Dussan D,Wu M,Peng YY,Wang J,Zeng H,Duan W,Kong L,Hao X,Narain R

更新日期：2020-12-15 00:00:00

abstract：:In this work, cell-responsive polysaccharide hydrogels were prepared by a simple procedure based on the sequential bioconjugation and cross-linking of the polysaccharide backbone with bioactive peptides and poly(ethylene glycol)-bis(thiol) (PEG-(SH)2), respectively. Using thiol-ene reactions, we successfully functiona...

journal_title：Biomacromolecules

authors： Jing J,Fournier A,Szarpak-Jankowska A,Block MR,Auzély-Velty R

更新日期：2015-03-09 00:00:00

abstract：:Inorganic polyphosphates, linear polymers of orthophosphate, occur naturally throughout biology and have many industrial applications. Their biodegradable nature makes them attractive for a multitude of uses, and it would be important to understand how polyphosphates are turned over enzymatically. Studies of inorganic...

journal_title：Biomacromolecules

authors： Hebbard CF,Wang Y,Baker CJ,Morrissey JH

更新日期：2014-08-11 00:00:00

abstract：:Recently, we have developed a photopolymerizable poly(L-lysine) (PLL) that can be covalently incorporated into poly(ethylene glycol) diacrylate (PEGDA) hydrogels to improve their bioactivity by providing positive charges. To explore the potential of these PLL-grafted PEGDA hydrogels as a cell delivery vehicle and lumi...

journal_title：Biomacromolecules

authors： Cai L,Lu J,Sheen V,Wang S

更新日期：2012-05-14 00:00:00

abstract：:Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could b...

journal_title：Biomacromolecules

authors： Kostina NY,Rodriguez-Emmenegger C,Houska M,Brynda E,Michálek J

更新日期：2012-12-10 00:00:00

abstract：:A dual-targeted siRNA nanocarrier has been synthesized and validated that is selectively activated in environments where there is colocalization of two breast cancer hallmarks, elevated matrix metalloproteinase (MMP) activity and folate receptor overexpression. This siRNA nanocarrier is self-assembled from two polymer...

journal_title：Biomacromolecules

authors： Li H,Miteva M,Kirkbride KC,Cheng MJ,Nelson CE,Simpson EM,Gupta MK,Duvall CL,Giorgio TD

更新日期：2015-01-12 00:00:00

abstract：:Placing a physical barrier between the injured site and the adjacent tissues is a very common and highly effective approach to prevent abdominal adhesions in these days. A biodegradable trilayered barrier was fabricated to prevent formation of abdominal adhesions, in which a poly(lactide-co-glycolide)/poly(lactide)-b-...

journal_title：Biomacromolecules

authors： Xia Q,Liu Z,Wang C,Zhang Z,Xu S,Han CC

更新日期：2015-09-14 00:00:00

abstract：:Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated, mechanically stable, and well-integrated hydrogel scaffolds supporting chondrocytes and chondrogenesis. We designed and synthesize...

journal_title：Biomacromolecules

authors： Söntjens SH,Nettles DL,Carnahan MA,Setton LA,Grinstaff MW

更新日期：2006-01-01 00:00:00

abstract：:RNA interference (RNAi) requires the intracellular delivery of RNA molecules to initiate the neutralization of targeted mRNA molecules, inhibiting the expression or translation of the targeted gene. Current polymers and lipids that are used to deliver RNA molecules are generally required to be positively charged, to a...

journal_title：Biomacromolecules

authors： Jiang Z,Cui W,Prasad P,Touve MA,Gianneschi NC,Mager J,Thayumanavan S

更新日期：2019-01-14 00:00:00

abstract：:Multifunctional cellulose nanocrystals have been synthesized and applied as a new type of glyconanomaterial in lectin binding and bacterial imaging. The cellulose nanocrystals were prepared by TEMPO-mediated oxidation and acidic hydrolysis, followed by functionalization with a quinolone fluorophore and carbohydrate li...

journal_title：Biomacromolecules

authors： Zhou J,Butchosa N,Jayawardena HS,Park J,Zhou Q,Yan M,Ramström O

更新日期：2015-04-13 00:00:00

abstract：:Hydrogel scaffolds are used in biomedicine to study cell differentiation and tissue evolution, where it is critical to control the delivery of chemical cues both spatially and temporally. While large molecules can be physically entrapped in a hydrogel, moderate molecular weight therapeutics must be tethered to the hyd...

journal_title：Biomacromolecules

authors： Griffin DR,Schlosser JL,Lam SF,Nguyen TH,Maynard HD,Kasko AM

更新日期：2013-04-08 00:00:00