Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides.

Abstract:

:Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could be achieved while retaining mechanical properties close to the widely used poly(HEMA) hydrogels. All hydrogels showed an unprecedentedly low fouling from blood plasma. Remarkably, by copolymerization with 10 mol % of carboxybetaine acrylamide, hydrogels fully resistant to blood plasma were prepared.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Kostina NY,Rodriguez-Emmenegger C,Houska M,Brynda E,Michálek J

doi

10.1021/bm301441x

subject

Has Abstract

pub_date

2012-12-10 00:00:00

pages

4164-70

issue

12

eissn

1525-7797

issn

1526-4602

journal_volume

13

pub_type

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