Abstract:
:Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could be achieved while retaining mechanical properties close to the widely used poly(HEMA) hydrogels. All hydrogels showed an unprecedentedly low fouling from blood plasma. Remarkably, by copolymerization with 10 mol % of carboxybetaine acrylamide, hydrogels fully resistant to blood plasma were prepared.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Kostina NY,Rodriguez-Emmenegger C,Houska M,Brynda E,Michálek Jdoi
10.1021/bm301441xsubject
Has Abstractpub_date
2012-12-10 00:00:00pages
4164-70issue
12eissn
1525-7797issn
1526-4602journal_volume
13pub_type
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