Cross-Linking Chemistry of Tyramine-Modified Hyaluronan Hydrogels Alters Mesenchymal Stem Cell Early Attachment and Behavior.

abstract：:It was aim of the study to investigate the in vivo potential of a novel insulin-thiomer complex nanoparticulate delivery system. Insulin loaded nanoparticles were obtained by the formation of hydrogen bonds between poly(vinyl pyrrolidone) (PVP) and poly(acrylic acid)-cysteine (PAA-Cys) or poly(acrylic acid) (PAA), res...

journal_title：Biomacromolecules

authors： Deutel B,Greindl M,Thaurer M,Bernkop-Schnürch A

更新日期：2008-01-01 00:00:00

abstract：:Water-soluble T-antigen containing glycopolymers [Gal beta(1,3)-GalNAc alpha) having a high degree of lipophilicity were synthesized from poly[N-(acryloxy)succinimide] (6-10) by amidation with an amine-ending T-antigen derivative (3) and various amines of increasing alkyl chain length (ammonia and methyl-, ethyl-, and...

journal_title：Biomacromolecules

authors： Baek MG,Roy R

更新日期：2000-01-01 00:00:00

abstract：:Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization o...

journal_title：Biomacromolecules

authors： Brandl F,Hammer N,Blunk T,Tessmar J,Goepferich A

更新日期：2010-02-08 00:00:00

abstract：:The synergistic interaction between xanthan and glucomannan in solution and in the gel phase has been studied by circular dichroism spectroscopy and differential scanning calorimetry. The study in solution of the polysaccharidic mixture indicates a preferred stoichiometry of the interaction corresponding to a weight f...

journal_title：Biomacromolecules

authors： Paradossi G,Chiessi E,Barbiroli A,Fessas D

更新日期：2002-05-01 00:00:00

abstract：:High molecular weight trimethylene carbonate (TMC) and epsilon-caprolactone (CL) (co)polymers were synthesized. Melt pressed (co)polymer films were cross-linked by gamma irradiation (25 kGy or 50 kGy) in vacuum, yielding gel fractions of up to 70%. The effects of copolymer composition and irradiation dose on the cytot...

journal_title：Biomacromolecules

authors： Bat E,Plantinga JA,Harmsen MC,van Luyn MJ,Zhang Z,Grijpma DW,Feijen J

更新日期：2008-11-01 00:00:00

abstract：:In this work, biodegradable branched polycationic polymers were synthesized by Michael addition polymerization from different amine monomers and the triacrylate monomer trimethylolpropane triacrylate. The polymers varied in the number of amines that dissociate in different pH ranges, which are considered to be benefic...

journal_title：Biomacromolecules

authors： Chew SA,Hacker MC,Saraf A,Raphael RM,Kasper FK,Mikos AG

更新日期：2010-03-08 00:00:00

abstract：:Amino acid-based poly(ester urea) (PEU) copolymers functionalized with pendant catechol groups that address the need for strongly adhesive yet degradable biomaterials have been developed. Lap-shear tests with aluminum adherends demonstrated that these polymers have lap-shear adhesion strengths near 1 MPa. An increase ...

journal_title：Biomacromolecules

authors： Zhou J,Defante AP,Lin F,Xu Y,Yu J,Gao Y,Childers E,Dhinojwala A,Becker ML

更新日期：2015-01-12 00:00:00

abstract：:The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26-44% yield demonstrating the u...

journal_title：Biomacromolecules

authors： Eniade A,Ben RN

更新日期：2001-07-01 00:00:00

abstract：:The conformation of a single elastin-like peptide GVG(VPGVG)3 in liquid water is studied by computer simulations in the temperature interval between 280 and 440 K. Two main conformational states of the peptide can be distinguished: a rigid conformational state, dominating at low temperatures, and a flexible conformati...

journal_title：Biomacromolecules

authors： Krukau A,Brovchenko I,Geiger A

更新日期：2007-07-01 00:00:00

abstract：:In marine mussels (Mytilus), byssal threads are made in minutes from prefabricated smectic polymer liquid crystals by a process resembling reaction injection molding. The mesogens in these arrays are known to be natural block copolymers with rodlike collagen cores. Using atomic force microscopy, it was shown that thes...

journal_title：Biomacromolecules

authors： Hassenkam T,Gutsmann T,Hansma P,Sagert J,Waite JH

更新日期：2004-07-01 00:00:00

abstract：:A new mathematical model is presented for the analysis of the substituent distribution in the polymer chain of polysaccharide derivatives. For the first time, the influence of substitution on the reactivity of neighbored monomer units is taken into account. The model was applied to various cellulose and amylose ethers...

journal_title：Biomacromolecules

authors： Mischnick P,Hennig C

更新日期：2001-04-01 00:00:00

abstract：:Although research on nanopaper structures from cellulose nanofibrils (CNFs) is well established, the mechanical behavior is not well understood, especially not when CNF is combined with hard nanoparticles. Cationic CNF (Q-CNF) was prepared and successfully decorated by anionic nanodiamond (ND) nanoparticles in hydroco...

journal_title：Biomacromolecules

authors： Morimune-Moriya S,Salajkova M,Zhou Q,Nishino T,Berglund LA

更新日期：2018-07-09 00:00:00

abstract：:The proteinaceous material present in beta-lactoglobulin fibrils formed after heating (20 h at 85 degrees C) at pH 2 was identified during this study. Fibrils were separated from the nonaggregated material, and the fibrils were dissociated using 8 M guanidine chloride and 0.1 M 1,4-dithiothreitol (pH 8). Characterizat...

journal_title：Biomacromolecules

authors： Akkermans C,Venema P,van der Goot AJ,Gruppen H,Bakx EJ,Boom RM,van der Linden E

更新日期：2008-05-01 00:00:00

abstract：:One of the major drawbacks found in most bone tissue engineering approaches developed so far consists in the lack of strategies to promote vascularisation. Some studies have addressed different issues that may enhance vascularisation in tissue engineered constructs, most of them involving the use of growth factors (GF...

journal_title：Biomacromolecules

authors： Santo VE,Frias AM,Carida M,Cancedda R,Gomes ME,Mano JF,Reis RL

更新日期：2009-06-08 00:00:00

abstract：:The formation of a suitable extracellular matrix (ECM) that promotes cell adhesion, organization, and proliferation is essential within biomaterial scaffolds for tissue engineering applications. In this work, short elastin mimetic peptide sequences, EM-19 and EM-23, were engineered to mimic the active motifs of human ...

journal_title：Biomacromolecules

authors： Patel D,Menon R,Taite LJ

更新日期：2011-02-14 00:00:00

abstract：:A surface force balance was used to measure the normal and shear forces between two mica surfaces each bearing an adsorbed layer of porcine gastric mucin ("Orthana" mucin), genetically similar to human MUC6. This mucin is a highly purified, 546 kDa, weakly negative, polyampholytic molecule with a "dumbbell" structure....

journal_title：Biomacromolecules

authors： Harvey NM,Yakubov GE,Stokes JR,Klein J

更新日期：2011-04-11 00:00:00

abstract：:Although the field of cancer immunotherapy is intensively investigated, there is still a need for generic strategies that allow easy, mild and efficient formulation of vaccine antigens. Here we report on a generic polymer-protein ligation strategy to formulate protein antigens into reversible polymeric conjugates for ...

journal_title：Biomacromolecules

authors： Lybaert L,Vanparijs N,Fierens K,Schuijs M,Nuhn L,Lambrecht BN,De Geest BG

更新日期：2016-03-14 00:00:00

abstract：:We have developed herein an engineered polymer-based nanoplatform showing the convergence of two-photon fluorescence imaging and bimodal phototherapeutic activity in a single nanostructure. It was achieved through the appropriate choice of three different components: a β-cyclodextrin-based polymer acting as a suitable...

journal_title：Biomacromolecules

authors： Kandoth N,Kirejev V,Monti S,Gref R,Ericson MB,Sortino S

更新日期：2014-05-12 00:00:00

abstract：:A challenge in the development of multifunctional drug delivery systems is to establish a reasonable and effective synthetic route for multifunctional polymer preparation. Herein, we propose a unique protocol to prepare multifunctional micelles by a cross-assembly process using three different functional polyurethanes...

journal_title：Biomacromolecules

authors： Pan Z,Ren Y,Song N,Song Y,Li J,He X,Luo F,Tan H,Fu Q

更新日期：2016-06-13 00:00:00

abstract：:Aggregation phenomena in aqueous solutions of purified human tracheobronchial mucin have been studied by rheological methods, steady-state fluorescence, quasielastic light scattering, and spin probe techniques. At temperatures below 30 degrees C and concentrations above 15 mg/mL and in the absence of chaotropic agents...

journal_title：Biomacromolecules

authors： Bromberg LE,Barr DP

更新日期：2000-10-01 00:00:00

abstract：:Multiblock copolymers (MBCs) are fascinating in the field of biology-polymer chemistry interfaces. Synthesizing libraries of MBCs with tailor-made functionality is challenging as it involves multiple steps. Herein, a simple synthesis, analogous to polyurethane/Michael addition reactions, has been introduced to obtain ...

journal_title：Biomacromolecules

authors： Nutan B,Kumar A,Jewrajka SK

更新日期：2020-12-14 00:00:00

abstract：:The outcome for glioblastoma patients remains dismal for its invariably recrudesces within 2 cm of the resection cavity. Local immunotherapy has the potential to eradicate the residual infiltrative component of these tumors. Here, we report the development of a biodegradable hydrogel containing therapeutic T lymphocyt...

journal_title：Biomacromolecules

authors： Tsao CT,Kievit FM,Ravanpay A,Erickson AE,Jensen MC,Ellenbogen RG,Zhang M

更新日期：2014-07-14 00:00:00

abstract：:We have designed, synthesized, and characterized peptides containing four repeats of the sequences VAALEKE (peptide E) or VAALKEK (peptide K). While the peptides alone adopt in aqueous solutions a random coil conformation, their equimolar mixture forms heterodimeric coiled coils as confirmed by CD spectroscopy. 5-Azid...

journal_title：Biomacromolecules

authors： Pechar M,Pola R,Laga R,Ulbrich K,Bednárová L,Maloň P,Sieglová I,Král V,Fábry M,Vaněk O

更新日期：2011-10-10 00:00:00

abstract：:Biodegradable multilayered capsules encapsulating basic fibroblast growth factor (bFGF) were developed as a cytokine release carrier for drug delivery systems. The multilayered hollow capsules were fabricated via the layer-by-layer (LbL) assembly of chitosan (CT) and dextran sulfate (Dex). The bFGF was encapsulated in...

journal_title：Biomacromolecules

authors： Itoh Y,Matsusaki M,Kida T,Akashi M

更新日期：2008-08-01 00:00:00

abstract：:Poloxamer thermoresponsive gels are widely explored in controlled drug delivery. Nevertheless, these gels possess inadequate mechanical properties, poor bioadhesiveness, and high permeability to water. To overcome these issues, we blended mucoadhesive hyaluronic acid (HA) with poloxamer analogs. This study aimed to in...

journal_title：Biomacromolecules

authors： Mayol L,Biondi M,Quaglia F,Fusco S,Borzacchiello A,Ambrosio L,La Rotonda MI

更新日期：2011-01-10 00:00:00

abstract：:The use of polyelectrolyte surface-modified Cowpea mosaic virus (CPMV) for the templated synthesis of narrowly dispersed gold nanoparticles is described. The cationic polyelectrolyte, poly(allylamine) hydrochloride (PAH), is electrostatically bound to the external surface of the virus capsid; the polyelectrolyte promo...

journal_title：Biomacromolecules

authors： Aljabali AA,Lomonossoff GP,Evans DJ

更新日期：2011-07-11 00:00:00

abstract：:In this work, we have analyzed the structural, topographical, and surface dilatational characteristics of pure beta-lactoglobulin adsorbed films and the effect of the self-assembly of monoglycerides (monopalmitin or monoolein) in beta-lactoglobulin films at the air-water interface. Measurements were performed in a sin...

journal_title：Biomacromolecules

authors： Rodríguez Patino JM,Fernandez MC,Rodríguez Niño MR,Sanchez CC

更新日期：2006-09-01 00:00:00

abstract：:We demonstrate the fabrication of protein·gold nanoparticle (AuNP) nanocomposites in situ, leading to distinct assemblies dependent upon protein secondary structure. In the presence of pentameric coiled-coil proteins C and Q, which contain histidine tags and have helicities of 54 and 65%, respectively, templation of A...

journal_title：Biomacromolecules

authors： Hume J,Chen R,Jacquet R,Yang M,Montclare JK

更新日期：2015-06-08 00:00:00

abstract：:Herein we present a unique method of using dynamic cross-links, which are dynamic covalent bonding and ionic interaction, for the construction of injectable double-network (DN) hydrogels, with the objective of cell delivery for cartilage repair. Glycol chitosan and dibenzaldhyde capped poly(ethylene oxide) formed the ...

journal_title：Biomacromolecules

authors： Yan Y,Li M,Yang D,Wang Q,Liang F,Qu X,Qiu D,Yang Z

更新日期：2017-07-10 00:00:00

abstract：:Escherichia coli serogroup O5 comprises two different subgroups (O5ab and O5ac), which are indiscernible from the point of view of standard immunological serotyping. The structural similarities between the O-antigen polysaccharides (PSs) of these two strains are remarkable, with the only difference being the glycosidi...

journal_title：Biomacromolecules

authors： Sarkar A,Fontana C,Imberty A,Pérez S,Widmalm G

更新日期：2013-07-08 00:00:00