Abstract：
:One of the major drawbacks found in most bone tissue engineering approaches developed so far consists in the lack of strategies to promote vascularisation. Some studies have addressed different issues that may enhance vascularisation in tissue engineered constructs, most of them involving the use of growth factors (GFs) that are involved in the restitution of the vascularity in a damaged zone. The use of sustained delivery systems might also play an important role in the re-establishment of angiogenesis. In this study, kappa-carrageenan, a naturally occurring polymer, was used to develop hydrogel beads with the ability to incorporate GFs with the purpose of establishing an effective angiogenesis mechanism. Some processing parameters were studied and their influence on the final bead properties was evaluated. Platelet derived growth factor (PDGF-BB) was selected as the angiogenic factor to incorporate in the developed beads, and the results demonstrate the achievement of an efficient encapsulation and controlled release profile matching those usually required for the development of a fully functional vascular network. In general, the obtained results demonstrate the potential of these systems for bone tissue engineering applications.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Santo VE,Frias AM,Carida M,Cancedda R,Gomes ME,Mano JF,Reis RLdoi
10.1021/bm8014973subject
Has Abstractpub_date
2009-06-08 00:00:00pages
1392-401issue
6eissn
1525-7797issn
1526-4602journal_volume
10pub_type
杂志文章abstract：:We report the rational design of a chitosan-based drug delivery system. The chitosan derivative N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride (HTCC) was ionically cross-linked by sodium tripolyphosphate (TPP) to form sub-200-nm microgels that are responsive to pH changes. When these microgels were loaded ...
journal_title：Biomacromolecules
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更新日期：2004-11-01 00:00:00
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journal_title：Biomacromolecules
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更新日期：2003-09-01 00:00:00
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