Abstract:
:Safe delivery systems that can not only encapsulate hydrophobic drug molecules, but also release them in response to specific triggers are important in several therapeutic and biomedical applications. In this paper, we have designed a nanogel based on molecules that are generally recognized as safe (GRAS). We have shown that the resultant polymeric nanogels exhibit responsive molecular release and also show high in vitro cellular viability on HEK 293T, HeLa, MCF 7, and A549 cell lines. The toxicity of these nanogels was further evaluated with a highly sensitive assay using mouse preimplantation embryo development, where blastocysts were formed after 4 days of in vitro culture, and live pups were born when morulae/early blastocysts were transferred to the uteri of surrogate recipients. Our results indicate that these nanogels are nontoxic during mammalian development and do not alter normal growth or early embryo success rate.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Prasad P,Molla MR,Cui W,Canakci M,Osborne B,Mager J,Thayumanavan Sdoi
10.1021/acs.biomac.5b00900subject
Has Abstractpub_date
2015-11-09 00:00:00pages
3491-8issue
11eissn
1525-7797issn
1526-4602journal_volume
16pub_type
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journal_title:Biomacromolecules
pub_type: 杂志文章
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2012-10-08 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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journal_title:Biomacromolecules
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更新日期:2012-03-12 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm020074y
更新日期:2002-11-01 00:00:00
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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更新日期:2019-03-11 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2020-09-14 00:00:00
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pub_type: 杂志文章
doi:10.1021/bm900589r
更新日期:2009-10-12 00:00:00
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journal_title:Biomacromolecules
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更新日期:2014-07-14 00:00:00
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2015-12-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500641f
更新日期:2014-08-11 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025535u
更新日期:2002-09-01 00:00:00
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2020-09-14 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm3007242
更新日期:2012-09-10 00:00:00
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journal_title:Biomacromolecules
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更新日期:2008-03-01 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2013-03-11 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章,评审
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更新日期:2016-03-14 00:00:00
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更新日期:2009-07-13 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
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更新日期:2017-04-10 00:00:00
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journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm050086u
更新日期:2005-07-01 00:00:00