Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles.

abstract：:Laminin is a heterotrimeric glycoprotein with a key role in the formation and maintenance of the basement membrane architecture and properties, as well as on the modulation of several biological functions, including cell adhesion, migration, differentiation and matrix-mediated signaling. In the central nervous system ...

journal_title：Biomacromolecules

authors： Barros D,Amaral IF,Pêgo AP

更新日期：2020-02-10 00:00:00

abstract：:The currently used hemostatic agents are highly effective in stopping hemorrhages but have a limited role in the modulation of the wound-healing environment. Herein, we propose an intrinsically bioactive hemostatic cryogel based on platelet lysate (PL) and aldehyde-functionalized cellulose nanocrystals (a-CNCs). PL ha...

journal_title：Biomacromolecules

authors： Mendes BB,Gómez-Florit M,Araújo AC,Prada J,Babo PS,Domingues RMA,Reis RL,Gomes ME

更新日期：2020-09-14 00:00:00

abstract：:We report a simple and novel top-down method based on a drop-casting process for the controlled synthesis of all-bone-minerals biomimetic multicomponent bionanocomposites. Integration of micro- and nanoscale binary features into nanofibrous biocompatible polymer scaffold structures is successfully demonstrated. Compos...

journal_title：Biomacromolecules

authors： Biswas A,Bayer IS,Zhao H,Wang T,Watanabe F,Biris AS

更新日期：2010-10-11 00:00:00

abstract：:As a biomaterial, silk presents unique features with a combination of excellent mechanical properties, biocompatibility, and biodegradability. The biodegradability aspects of silk biomaterials, especially with options to control the rate from short (days) to long (years) time frames in vivo, make this protein-based bi...

journal_title：Biomacromolecules

authors： Guo C,Li C,Kaplan DL

更新日期：2020-05-11 00:00:00

abstract：:Biomaterials conceived for vectorization of bioactives are currently considered for biomedical, biological, and environmental applications. We have produced a pH-sensitive biomaterial composed of natural source alginate and chitosan polysaccharides for application as a drug delivery system via oral administration. The...

journal_title：Biomacromolecules

authors： Mathews PD,Fernandes Patta ACM,Gonçalves JV,Gama GDS,Garcia ITS,Mertins O

更新日期：2018-02-12 00:00:00

abstract：:Poly(L-lactide) (PLLA) with various alkyl ester chain end groups were synthesized by ring-opening polymerization of L-lactide in the presence of zinc alkoxide as a catalyst. The structural effect of chain end groups on the rate of enzymatic and nonenzymatic degradations for amorphous films of PLLA were investigated at...

journal_title：Biomacromolecules

authors： Kurokawa K,Yamashita K,Doi Y,Abe H

更新日期：2008-03-01 00:00:00

abstract：:Nature shows excellent control over the mechanics of fibrous hydrogels by assembling protein fibers into bundles of well-defined dimensions. Yet, obtaining artificial materials displaying controlled bundling remains a challenge. Here, we developed genetically engineered protein-based polymers functionalized with hepar...

journal_title：Biomacromolecules

authors： Włodarczyk-Biegun MK,Slingerland CJ,Werten MW,van Hees IA,de Wolf FA,de Vries R,Stuart MA,Kamperman M

更新日期：2016-06-13 00:00:00

abstract：:Prevention of biofouling and microbial contamination of implanted biomedical devices is essential to maintain their functionality and biocompatibility. For this purpose, polypept(o)ide block copolymers have been developed, in which a protein-resistant polysarcosine (pSar) block is combined with a dopamine-modified pol...

journal_title：Biomacromolecules

authors： Yoo J,Birke A,Kim J,Jang Y,Song SY,Ryu S,Kim BS,Kim BG,Barz M,Char K

更新日期：2018-05-14 00:00:00

abstract：:The dynamics of bacterial colonies is complex in nature because it correlates the behavior of numerous individual cells in space and time and is characterized by emergent properties such as virulence or antibiotics resistance. Because there is no clear-cut evidence that periodic swarming of P. mirabilis colonies is ru...

journal_title：Biomacromolecules

authors： Lahaye E,Aubry T,Kervarec N,Douzenel P,Sire O

更新日期：2007-04-01 00:00:00

abstract：:Herein we report the synthesis of biodegradable hyperbranched polyglycerols (BHPGs) having acid-cleavable core structure by anionic ring-opening multibranching polymerization (ROMBP) of glycidol using initiators bearing dimethyl and cyclohexyl ketal groups. Five different multifunctional initiators carrying one to fou...

journal_title：Biomacromolecules

authors： Shenoi RA,Lai BF,Kizhakkedathu JN

更新日期：2012-10-08 00:00:00

abstract：:Hollow poly(6-O-acryloyl-alpha-D-galactopyranose) (PAGP) nanospheres were prepared in a facile manner using the RAFT (reversible addition fragmentation chain transfer) process. Initially, an amphiphilic block copolymer, poly(lactide)-block-poly(6-O-acryloyl-alpha-D-galactopyranose) (PLA-b-PAGP), was synthesized using ...

journal_title：Biomacromolecules

authors： Ting SR,Gregory AM,Stenzel MH

更新日期：2009-02-09 00:00:00

abstract：:Dynamic shear oscillation measurements at small strain were used to characterize the viscoelastic properties and related differences in the molecular structure of hydrogels based on gelatin methacrylamide. Gelatin was derivatized with methacrylamide side groups and was subsequently cross-linked by radical polymerizati...

journal_title：Biomacromolecules

authors： Van Den Bulcke AI,Bogdanov B,De Rooze N,Schacht EH,Cornelissen M,Berghmans H

更新日期：2000-04-01 00:00:00

abstract：:(1,3)(1,4)-β-D-Glucan (mixed-linkage glucan or MLG), a characteristic hemicellulose in primary cell walls of grasses, was investigated to determine both its role in cell walls and its interaction with cellulose and other cell wall polysaccharides in vitro. Binding isotherms showed that MLG adsorption onto microcrystal...

journal_title：Biomacromolecules

authors： Kiemle SN,Zhang X,Esker AR,Toriz G,Gatenholm P,Cosgrove DJ

更新日期：2014-05-12 00:00:00

abstract：:Candida antarctica Lipase B (CALB) was covalently immobilized onto epoxy-activated macroporous poly(methyl methacrylate) Amberzyme beads (235 microm particle size, 220 A pore size) and nanoparticles (nanoPSG, diameter 68 nm) with a poly(glycidyl methacrylate) outer region. Amberzyme beads allowed CALB loading up to 0....

journal_title：Biomacromolecules

authors： Chen B,Hu J,Miller EM,Xie W,Cai M,Gross RA

更新日期：2008-02-01 00:00:00

abstract：:The interaction between positively charged poly(amido amine) (PAMAM) dendrimers of generation 4 and DNA has been investigated for two DNA lengths; 2000 basepairs (bp; L = 680 nm) and 4331 bp (L = 1472.5 nm) using a theoretical model by Schiessel for a semiflexible polyelectrolyte and hard spheres. The model was modifi...

journal_title：Biomacromolecules

authors： Qamhieh K,Nylander T,Ainalem ML

更新日期：2009-07-13 00:00:00

abstract：:The viscous mucus coating that adheres to the epithelial surfaces of mammalian organs provides protection for the underlying tissues and is an efficient barrier to drug delivery. Pulsed-gradient spin-echo NMR and small-angle neutron scattering have been used to study the aqueous solution interaction of various model p...

journal_title：Biomacromolecules

authors： Griffiths PC,Occhipinti P,Morris C,Heenan RK,King SM,Gumbleton M

更新日期：2010-01-11 00:00:00

abstract：:Amino groups were covalently introduced onto a polycaprolactone (PCL) surface by the reaction between 1,6-hexanediamine and the ester groups of PCL. The occurrence of the aminolysis and the introduction of free NH(2) groups were verified qualitatively by fluorescence spectroscopy, where rhodamine B isothiocyanate was ...

journal_title：Biomacromolecules

authors： Zhu Y,Gao C,Liu X,Shen J

更新日期：2002-11-01 00:00:00

abstract：:Electrospun biopolyelectrolyte nanofibers hold potential for use in a range of biomedical applications, but eliminating toxic chemicals involved in their production remains a key challenge. In this study, we successfully electrospun nanofibers from an aqueous complex coacervate solution composed of chitosan and hyalur...

journal_title：Biomacromolecules

authors： Sun J,Perry SL,Schiffman JD

更新日期：2019-11-11 00:00:00

abstract：:Combining poly(ethylene glycol) (PEG) with sequence-defined peptides in PEG-peptide conjugates offers opportunities to realize next-generation drug formulation additives for overcoming undesired pharmacological profiles of difficult small molecule drugs. The tailored peptide segments provide sequence-specific, noncova...

journal_title：Biomacromolecules

authors： Wieczorek S,Schwaar T,Senge MO,Börner HG

更新日期：2015-10-12 00:00:00

abstract：:Oligopeptide hydrogels are emerging as useful matrices for cell culture with commercial products on the market, but L-oligopeptides are labile to proteases. An obvious solution is to create D-oligopeptide hydrogels, which lack enzymatic recognition. However, D-oligopeptide matrices do not support cell growth as well a...

journal_title：Biomacromolecules

authors： Hyland LL,Twomey JD,Vogel S,Hsieh AH,Yu YB

更新日期：2013-02-11 00:00:00

abstract：:Numerous catechol-containing polymers, including biodegradable polymers, are currently heavily discussed for modern biomaterials. However, there is no report combining poly(phosphoester)s (PPEs) with catechols. Adhesive PPEs have been prepared via acyclic diene metathesis polymerization. A novel acetal-protected catec...

journal_title：Biomacromolecules

authors： Becker G,Ackermann LM,Schechtel E,Klapper M,Tremel W,Wurm FR

更新日期：2017-03-13 00:00:00

abstract：:Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer. Techniques such as interferometry, static light scattering (in batch or coupled on line with a chromatographic system), and...

journal_title：Biomacromolecules

authors： Schatz C,Viton C,Delair T,Pichot C,Domard A

更新日期：2003-05-01 00:00:00

abstract：:We present a synthetic approach toward soft, glycooligomer-functionalized microgel particles mimicking carbohydrate presenting cell surfaces and analyze their specific binding to a model lectin (Concanavalin A, ConA). Focusing on multivalent presentation, a series of sequence-controlled glycooligomers with varying spa...

journal_title：Biomacromolecules

authors： Jacobi F,Camaleño de la Calle A,Boden S,Grafmüller A,Hartmann L,Schmidt S

更新日期：2018-08-13 00:00:00

abstract：:Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine. Current treatments are suboptimal, and thus the development of an enzyme replacement therapy based on PEGylated human truncated CBS (PEG-CBS) has been initiated. Attenuation of potency was obs...

journal_title：Biomacromolecules

authors： Majtan T,Park I,Carrillo RS,Bublil EM,Kraus JP

更新日期：2017-06-12 00:00:00

abstract：:Steady state shear flow of different types of cellulose (microcrystalline, spruce sulfite and bacterial) dissolved in 1-ethyl-3-methylimidazolium acetate was studied in a large range of concentrations (0-15%) and temperatures (0-100 degrees C). Newtonian flow was recorded for all experimental conditions; these viscosi...

journal_title：Biomacromolecules

authors： Gericke M,Schlufter K,Liebert T,Heinze T,Budtova T

更新日期：2009-05-11 00:00:00

abstract：:Amino acid-based poly(ester urea) (PEU) copolymers functionalized with pendant catechol groups that address the need for strongly adhesive yet degradable biomaterials have been developed. Lap-shear tests with aluminum adherends demonstrated that these polymers have lap-shear adhesion strengths near 1 MPa. An increase ...

journal_title：Biomacromolecules

authors： Zhou J,Defante AP,Lin F,Xu Y,Yu J,Gao Y,Childers E,Dhinojwala A,Becker ML

更新日期：2015-01-12 00:00:00

abstract：:A well-defined N-(2-hydroxypropyl)methacrylamide-s-N-(3-aminopropyl)methacrylamide (HPMA-s-APMA) copolymer, synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, was utilized for the rational design of multiconjugates containing both a gene therapeutic, small interfering RNA (siRNA), ...

journal_title：Biomacromolecules

authors： York AW,Huang F,McCormick CL

更新日期：2010-02-08 00:00:00

abstract：:Ruthenium(II) tris(bipyridine)-centered poly(ethylenimine) (Ru PEI) was synthesized via acid hydrolysis of Ru tris(bipyridine)-centered poly(2-ethyl-2-oxazoline) (Ru PEOX), and the luminescence, DNA entrapment, and transfection efficiencies were evaluated. Emission maxima for Ru PEI samples are red-shifted compared to...

journal_title：Biomacromolecules

authors： Fiore GL,Edwards JM,Payne SJ,Klinkenberg JL,Gioeli DG,Demas JN,Fraser CL

更新日期：2007-09-01 00:00:00

abstract：:Solid films of deoxyribonucleic acid (DNA) containing a hydrated ionic liquid, choline dihydrogen phosphate (CDP), were prepared by a solvent-casting method. Thermal properties, aggregation structure, thermal molecular motion, and tensile properties of CDP-containing DNA films were examined by thermogravimetry (TG), w...

journal_title：Biomacromolecules

authors： Morimitsu Y,Matsuno H,Ohta N,Sekiguchi H,Takahara A,Tanaka K

更新日期：2020-02-10 00:00:00

abstract：:An injectable, heparin-based hydrogel system with the potential to be gelled with cells was developed. First, heparin was modified to have thiol groups by the modification of carboxylic groups of heparin with cysteamine using carbodiimide chemistry. Thiol functionalization of heparin carboxylic groups was controlled f...

journal_title：Biomacromolecules

authors： Tae G,Kim YJ,Choi WI,Kim M,Stayton PS,Hoffman AS

更新日期：2007-06-01 00:00:00