Abstract：
:As a biomaterial, silk presents unique features with a combination of excellent mechanical properties, biocompatibility, and biodegradability. The biodegradability aspects of silk biomaterials, especially with options to control the rate from short (days) to long (years) time frames in vivo, make this protein-based biopolymer a good candidate for developing biodegradable devices used for tissue repairs and tissue engineering, as well as medical device implants. Silk materials, including native silk fibers and a broad spectrum of regenerated silk materials, have been investigated in vitro and in vivo to demonstrate degradation by proteolytic enzymes. In this Review, we summarize the findings on these studies on the enzymatic degradation of Bombyx mori (B. mori) silk materials. We also present a discussion on the factors that dictate the degradation properties of silk materials. Finally, in future perspectives, we highlight some key challenges and potential directions toward the future study of the degradation of silk materials.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Guo C,Li C,Kaplan DLdoi
10.1021/acs.biomac.0c00090subject
Has Abstractpub_date
2020-05-11 00:00:00pages
1678-1686issue
5eissn
1525-7797issn
1526-4602journal_volume
21pub_type
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm501549b
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pub_type： 杂志文章
doi：10.1021/acs.biomac.9b01211
更新日期：2019-10-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2013-07-08 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm049577p
更新日期：2005-01-01 00:00:00
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