Heparin as a Bundler in a Self-Assembled Fibrous Network of Functionalized Protein-Based Polymers.

abstract：:Nowadays, active targeting of nanotherapeutics is a challenging issue. Here, we propose a rational design of a ternary nanoassembly (SAP) composed of nonionic amphiphilic β-cyclodextrins (amphiphilic CD) incorporating pheophorbide (Pheo) as a phototherapeutic and an adamantanyl-folic acid conjugate (Ada-FA) to target ...

journal_title：Biomacromolecules

authors： Zagami R,Rapozzi V,Piperno A,Scala A,Triolo C,Trapani M,Xodo LE,Monsù Scolaro L,Mazzaglia A

更新日期：2019-07-08 00:00:00

abstract：:A novel pH-sensitive amphiphilic copolymer brush poly(methyl methacrylate-co-methacrylic acid)-b-poly(poly(ethylene glycol) methyl ether monomethacrylate) [P(MMA-co-MAA)-b-PPEGMA] was defined and synthesized by atom transfer radical polymerization (ATRP) technique. The molecular structures and characteristics of this ...

journal_title：Biomacromolecules

authors： Yang YQ,Zheng LS,Guo XD,Qian Y,Zhang LJ

更新日期：2011-01-10 00:00:00

abstract：:Biocompatible photoresponsive materials are of interest for targeted drug delivery, tissue engineering, 2D and 3D protein patterning, and other biomedical applications. We prepared light degradable hydrogels using a natural alginate polysaccharide cross-linked with iron(III) cations. The "hard" iron(III) cations used ...

journal_title：Biomacromolecules

authors： Narayanan RP,Melman G,Letourneau NJ,Mendelson NL,Melman A

更新日期：2012-08-13 00:00:00

abstract：:Bacterial biofilms tolerate extreme levels of antibiotics. Treatment of biofilm infections therefore requires the development of new or modified antimicrobials that can penetrate biofilms and are effective against dormant persistent cells. One such new approach uses the biodegradable biopolymer chitosan and its deriva...

journal_title：Biomacromolecules

authors： Sahariah P,Másson M,Meyer RL

更新日期：2018-09-10 00:00:00

abstract：:It is demonstrated that the molecular solubility of softwood hemicelluloses is significantly influenced by pretreatment of the fibers, extraction, and downstream processing. To quantify these effects, four hemicellulose samples were extracted from different thermomechanical pulps of Norway spruce. The molecular solubi...

journal_title：Biomacromolecules

authors： Kishani S,Vilaplana F,Xu W,Xu C,Wågberg L

更新日期：2018-04-09 00:00:00

abstract：:The ability of microbally produced poly(gamma,d-glutamic acid) to form stable polyelectrolyte-opposite charged surfactant complexes was investigated. A sonicated sample of polyacid with a molecular weight about 10(5) Da and a content of d enantiomer higher than 90% was used in this study. Nearly stoichiometric complex...

journal_title：Biomacromolecules

authors： Pérez-Camero G,García-Alvarez M,Martínez De Ilarduya A,Fernández C,Campos L,Muñoz-Guerra S

更新日期：2004-01-01 00:00:00

abstract：:Imbalanced homeostasis and oligomerization of the amyloid-β (Aβ) peptide in the brain are hallmarks of Alzheimer's disease (AD). Microglia and macrophages play a critical role in the etiology of AD either by clearing Aβ from the brain or inducing inflammation. Recent evidence suggests that clearance of Aβ by microglia...

journal_title：Biomacromolecules

authors： Richman M,Perelman A,Gertler A,Rahimipour S

更新日期：2013-01-14 00:00:00

abstract：:The conformational behavior of a long single-chain double-stranded DNA in solutions of free silver ions and silver nanoparticles generated via the reduction of AgNO3 by NaBH4 was monitored by fluorescence and electron microscopies and UV spectroscopy. The interaction of monovalent silver ions with DNA induces shrinkin...

journal_title：Biomacromolecules

authors： Zinchenko AA,Baigl D,Chen N,Pyshkina O,Endo K,Sergeyev VG,Yoshikawa K

更新日期：2008-07-01 00:00:00

abstract：:A surface force balance was used to measure the normal and shear forces between two mica surfaces each bearing an adsorbed layer of porcine gastric mucin ("Orthana" mucin), genetically similar to human MUC6. This mucin is a highly purified, 546 kDa, weakly negative, polyampholytic molecule with a "dumbbell" structure....

journal_title：Biomacromolecules

authors： Harvey NM,Yakubov GE,Stokes JR,Klein J

更新日期：2011-04-11 00:00:00

abstract：:Novel biodegradable poly(carbonate ester)s with photolabile protecting groups were synthesized by ring-opening copolymerization of L-lactide (LA) with 5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one (MNC) with diethyl zinc (Et2Zn) as catalyst. The poly(L-lactide-co-5-methyl-5-carboxyl-1,3-dioxan-2-one) (P(LA-co-...

journal_title：Biomacromolecules

authors： Xie Z,Hu X,Chen X,Sun J,Shi Q,Jing X

更新日期：2008-01-01 00:00:00

abstract：:As a first step toward utilizing self-assembling peptide scaffolds to create tunable matrices for drug delivery, peptide RADAFI and RADAFII, containing the same amino acid composition but different positions of one phenylalanine residue, scaffolds were prepared for controlled release of chiral enantiomers. The release...

journal_title：Biomacromolecules

authors： Zhao Y,Tanaka M,Kinoshita T,Higuchi M,Tan T

更新日期：2009-12-14 00:00:00

abstract：:Synthesis of novel zwitterionic block copolypeptides, poly(N-isopropylacrylamide)-block-poly(L-glutamic acid-co-L-lysine) [PNiPAM(n)(PLG(x)-co-PLLys(y))m , where n is the number-average degree of polymerization (DP(n)) of PNiPAM block, x and y are the mole fraction of glutamic acid and lysine residues, respectively, a...

journal_title：Biomacromolecules

authors： Li J,Wang T,Wu D,Zhang X,Yan J,Du S,Guo Y,Wang J,Zhang A

更新日期：2008-10-01 00:00:00

abstract：:Bovine hemoglobin (Hb) was encapsulated inside polymer vesicles (polymersomes) to form polymersome encapsulated Hb (PEH) dispersions. PEH particles are 100% surface PEGylated with longer PEG chains and possess thicker hydrophobic membranes as compared to conventional liposomes. Polymersomes were self-assembled from po...

journal_title：Biomacromolecules

authors： Arifin DR,Palmer AF

更新日期：2005-07-01 00:00:00

abstract：:The detection of phase separation and identification of miscibility in biopolymer blends is an important aspect for the improvement of their physical properties. In this article, the phase separation in blends of poly(3-hydroxybutyrate) (PHB) with poly(L-lactic acid) (PLA) and poly(epsilon-caprolactone) (PCL), respect...

journal_title：Biomacromolecules

authors： Vogel C,Wessel E,Siesler HW

更新日期：2008-02-01 00:00:00

abstract：:Tiopronin (N-(2-mercaptopropionyl)glycine)-protected gold nanoparticles (TPAu) were cross-linked to collagen via EDC (1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide) coupling. On average, each TPAu forms eight amide bonds with collagen lysine moieties. The resulting gels were studied with environmental SEM, TEM, micr...

journal_title：Biomacromolecules

authors： Castaneda L,Valle J,Yang N,Pluskat S,Slowinska K

更新日期：2008-12-01 00:00:00

abstract：:We report the facile preparation of gels from the hydrothermal treatment of suspensions of cellulose nanocrystals (CNCs). The properties of the hydrogels have been investigated by rheology, electron microscopy, and spectroscopy with respect to variation in the temperature, time, and CNC concentration used in preparati...

journal_title：Biomacromolecules

authors： Lewis L,Derakhshandeh M,Hatzikiriakos SG,Hamad WY,MacLachlan MJ

更新日期：2016-08-08 00:00:00

abstract：:Twenty-five kDa polyethylenimine (PEI) is one of the most efficient nonviral gene transfer agents currently applied as a golden standard for in vitro transfection. In this study, novel 25 kDa PEI derivatives with reductively cleavable cystamine periphery (PEI-Cys) were designed to reduce carrier-associated cytotoxicit...

journal_title：Biomacromolecules

authors： Wang Y,Zheng M,Meng F,Zhang J,Peng R,Zhong Z

更新日期：2011-04-11 00:00:00

abstract：:The long-term stability and success of orthopedic implants depend on the osseointegration process, which is strongly influenced by the biomaterial surface. A promising approach to enhance implant integration involves the modification of the surface of the implant by means of polymers that mimic the natural components ...

journal_title：Biomacromolecules

authors： Travan A,Marsich E,Donati I,Foulc MP,Moritz N,Aro HT,Paoletti S

更新日期：2012-05-14 00:00:00

abstract：:In this paper we extend our previous experimental work on interaction between polyelectrolytes and liposomes. First, the adsorption of chitosan and alkylated chitosan (cationic polyelectrolytes) with different alkyl chain lengths on lipid membranes of liposomes is examined. The amount of both chitosans adsorbed remain...

journal_title：Biomacromolecules

authors： Quemeneur F,Rinaudo M,Pépin-Donat B

更新日期：2008-08-01 00:00:00

abstract：:We have found that dialysis of 5 mg/mL collagen solution into the phosphate solution with a pH of 7.1 and an ionic strength of 151 mM [corrected] at 25 °C results in a collagen gel with a birefringence and tubular pores aligned parallel to the growth direction of the gel. The time course of averaged diameter of tubula...

journal_title：Biomacromolecules

authors： Furusawa K,Sato S,Masumoto J,Hanazaki Y,Maki Y,Dobashi T,Yamamoto T,Fukui A,Sasaki N

更新日期：2012-01-09 00:00:00

abstract：:The synthesis of biocompatible, thermo-responsive ABA triblock copolymers in which the outer A blocks comprise poly(N-isopropylacrylamide) and the central B block is poly(2-methacryloyloxyethyl phosphorylcholine) is achieved using atom transfer radical polymerization with a commercially available bifunctional initiato...

journal_title：Biomacromolecules

authors： Li C,Tang Y,Armes SP,Morris CJ,Rose SF,Lloyd AW,Lewis AL

更新日期：2005-03-01 00:00:00

abstract：:A new method to form colloidally stable oligosaccharide-grafted synthetic polymer particles has been developed. The oligosaccharides, of weight-average degree of polymerization approximately 38, were obtained by enzymatic debranching of amylopectin. Through the use of a cerium(IV)-based redox initiation process, oligo...

journal_title：Biomacromolecules

authors： Mange S,Dever C,De Bruyn H,Gaborieau M,Castignolles P,Gilbert RG

更新日期：2007-06-01 00:00:00

abstract：:Cardiovascular diseases plague human health because of the lack of transplantable small-diameter blood vessel (SDBV) grafts. Although expanded polytetrafluoroethylene (ePTFE) has the potential to be used as a biocompatible material for SDBV grafts, long-term patency is still the biggest challenge. As discussed in this...

journal_title：Biomacromolecules

authors： Wang D,Xu Y,Lin YJ,Yilmaz G,Zhang J,Schmidt G,Li Q,Thomson JA,Turng LS

更新日期：2020-09-14 00:00:00

abstract：:A new, convenient pathway is developed to synthesize highly hydrolytically labile poly(ortho ester amide) (POEA) copolymers that overcomes some of the major weaknesses of the traditional methods of synthesizing poly(ortho esters) and their derivatives. A diamine monomer containing a built-in, stabilized ortho ester gr...

journal_title：Biomacromolecules

authors： Tang R,Palumbo RN,Ji W,Wang C

更新日期：2009-04-13 00:00:00

abstract：:Hydrogel fibers that possessed a cell-adhesive surface and were degradable via enzymatic reactions were developed for fabricating tubular constructs with smooth muscle cell (SMC) and endothelial cell (EC) layers, similar to native blood vessels, in collagen gels. The fibers were prepared by soaking hydrogel fibers pre...

journal_title：Biomacromolecules

authors： Sakai S,Yamaguchi S,Takei T,Kawakami K

更新日期：2008-07-01 00:00:00

abstract：:We report a simple and novel top-down method based on a drop-casting process for the controlled synthesis of all-bone-minerals biomimetic multicomponent bionanocomposites. Integration of micro- and nanoscale binary features into nanofibrous biocompatible polymer scaffold structures is successfully demonstrated. Compos...

journal_title：Biomacromolecules

authors： Biswas A,Bayer IS,Zhao H,Wang T,Watanabe F,Biris AS

更新日期：2010-10-11 00:00:00

abstract：:Dextran surface grafting density was systematically varied via a two-step process involving SiO(2) amination by aminopropyltriethoxy silane (APTES) followed by oxidized dextran (M(w) = 110 kDa) chemisorption. Dextran oxidation kinetics with sodium metaperiodate (NaIO(4)) were quantified by (1)H NMR and pH measurements...

journal_title：Biomacromolecules

authors： Miksa D,Irish ER,Chen D,Composto RJ,Eckmann DM

更新日期：2006-02-01 00:00:00

abstract：:The proteinaceous material present in beta-lactoglobulin fibrils formed after heating (20 h at 85 degrees C) at pH 2 was identified during this study. Fibrils were separated from the nonaggregated material, and the fibrils were dissociated using 8 M guanidine chloride and 0.1 M 1,4-dithiothreitol (pH 8). Characterizat...

journal_title：Biomacromolecules

authors： Akkermans C,Venema P,van der Goot AJ,Gruppen H,Bakx EJ,Boom RM,van der Linden E

更新日期：2008-05-01 00:00:00

abstract：:We report the rational design of a chitosan-based drug delivery system. The chitosan derivative N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride (HTCC) was ionically cross-linked by sodium tripolyphosphate (TPP) to form sub-200-nm microgels that are responsive to pH changes. When these microgels were loaded ...

journal_title：Biomacromolecules

authors： Zhang H,Mardyani S,Chan WC,Kumacheva E

更新日期：2006-05-01 00:00:00

abstract：:The synergistic interaction between xanthan and glucomannan in solution and in the gel phase has been studied by circular dichroism spectroscopy and differential scanning calorimetry. The study in solution of the polysaccharidic mixture indicates a preferred stoichiometry of the interaction corresponding to a weight f...

journal_title：Biomacromolecules

authors： Paradossi G,Chiessi E,Barbiroli A,Fessas D

更新日期：2002-05-01 00:00:00