Abstract:
:We have found that dialysis of 5 mg/mL collagen solution into the phosphate solution with a pH of 7.1 and an ionic strength of 151 mM [corrected] at 25 °C results in a collagen gel with a birefringence and tubular pores aligned parallel to the growth direction of the gel. The time course of averaged diameter of tubular pores during the anisotropic gelation was expressed by a power law with an exponent of 1/3, suggesting that the formation of tubular pores is attributed to a spinodal decomposition-like phase separation. Small angle light scattering patterns and high resolution confocal laser scanning microscope images of the anisotropic collagen gel suggested that the collagen fibrils are aligned perpendicular to the growth direction of the gel. The positional dependence of the order parameter of the collagen fibrils showed that the anisotropic collagen gel has an orientation gradient.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Furusawa K,Sato S,Masumoto J,Hanazaki Y,Maki Y,Dobashi T,Yamamoto T,Fukui A,Sasaki Ndoi
10.1021/bm200869psubject
Has Abstractpub_date
2012-01-09 00:00:00pages
29-39issue
1eissn
1525-7797issn
1526-4602journal_volume
13pub_type
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