Studies on the formation mechanism and the structure of the anisotropic collagen gel prepared by dialysis-induced anisotropic gelation.

Abstract:

:We have found that dialysis of 5 mg/mL collagen solution into the phosphate solution with a pH of 7.1 and an ionic strength of 151 mM [corrected] at 25 °C results in a collagen gel with a birefringence and tubular pores aligned parallel to the growth direction of the gel. The time course of averaged diameter of tubular pores during the anisotropic gelation was expressed by a power law with an exponent of 1/3, suggesting that the formation of tubular pores is attributed to a spinodal decomposition-like phase separation. Small angle light scattering patterns and high resolution confocal laser scanning microscope images of the anisotropic collagen gel suggested that the collagen fibrils are aligned perpendicular to the growth direction of the gel. The positional dependence of the order parameter of the collagen fibrils showed that the anisotropic collagen gel has an orientation gradient.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Furusawa K,Sato S,Masumoto J,Hanazaki Y,Maki Y,Dobashi T,Yamamoto T,Fukui A,Sasaki N

doi

10.1021/bm200869p

subject

Has Abstract

pub_date

2012-01-09 00:00:00

pages

29-39

issue

1

eissn

1525-7797

issn

1526-4602

journal_volume

13

pub_type

杂志文章
  • Enhanced Fluorescence Emission and Singlet Oxygen Generation of Photosensitizers Embedded in Injectable Hydrogels for Imaging-Guided Photodynamic Cancer Therapy.

    abstract::Benefiting from their inherent localized and controlled release properties, hydrogels are ideal delivery systems for therapeutic drugs or nanoparticles. In particular, applications of hydrogels for the delivery and release of photoresponsive drugs or nanoparticles are receiving increasing attention. However, the effec...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00725

    authors: Xia LY,Zhang X,Cao M,Chen Z,Wu FG

    更新日期:2017-10-09 00:00:00

  • Construction, molecular modeling, and simulation of Mycobacterium tuberculosis cell walls.

    abstract::The mycobacterial cell wall is extraordinarily thick and tight consisting mainly of (1). long chain fatty acids, the mycolic acids, and (2). a unique polysaccharide, arabinogalactan (AG). These two chemical constituents are covalently linked through ester bonds. Minnikin (The Biology of the Mycobacteria; Academic: Lon...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm034514c

    authors: Hong X,Hopfinger AJ

    更新日期:2004-05-01 00:00:00

  • Multifunctional Polymeric Micelles with Amplified Fenton Reaction for Tumor Ablation.

    abstract::Relative to normal cells, tumor cells lack adequate capability of reactive oxygen scavenging. Thus, tumor cells can be selectively killed by increasing the concentration of reactive oxygen species in tumor tissue. In this report, we construct an integrated multifunctional polymeric nanoparticle which can selectively i...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b01777

    authors: Wang Y,Yin W,Ke W,Chen W,He C,Ge Z

    更新日期:2018-06-11 00:00:00

  • Single-walled carbon nanotube as a unique scaffold for the multivalent display of sugars.

    abstract::Single-walled carbon nanotube (SWNT) is a pseudo-one-dimensional nanostructure capable of carrying/displaying a large number of bioactive molecules and species in aqueous solution. In this work, a series of dendritic beta-D-galactopyranosides and alpha-D-mannopyranosides with a terminal amino group were synthesized an...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm800395e

    authors: Gu L,Luo PG,Wang H,Meziani MJ,Lin Y,Veca LM,Cao L,Lu F,Wang X,Quinn RA,Wang W,Zhang P,Lacher S,Sun YP

    更新日期:2008-09-01 00:00:00

  • Biodistribution of Filamentous Plant Virus Nanoparticles: Pepino Mosaic Virus versus Potato Virus X.

    abstract::Nanoparticles with high aspect ratios have favorable attributes for drug delivery and bioimaging applications based on their enhanced tissue penetration and tumor homing properties. Here, we investigated a novel filamentous viral nanoparticle (VNP) based on the Pepino mosaic virus (PepMV), a relative of the establishe...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.8b01365

    authors: Le DHT,Méndez-López E,Wang C,Commandeur U,Aranda MA,Steinmetz NF

    更新日期:2019-01-14 00:00:00

  • Role of (1,3)(1,4)-β-glucan in cell walls: interaction with cellulose.

    abstract::(1,3)(1,4)-β-D-Glucan (mixed-linkage glucan or MLG), a characteristic hemicellulose in primary cell walls of grasses, was investigated to determine both its role in cell walls and its interaction with cellulose and other cell wall polysaccharides in vitro. Binding isotherms showed that MLG adsorption onto microcrystal...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm5001247

    authors: Kiemle SN,Zhang X,Esker AR,Toriz G,Gatenholm P,Cosgrove DJ

    更新日期:2014-05-12 00:00:00

  • Biodendrimer-based hydrogel scaffolds for cartilage tissue repair.

    abstract::Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated, mechanically stable, and well-integrated hydrogel scaffolds supporting chondrocytes and chondrogenesis. We designed and synthesize...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm050663e

    authors: Söntjens SH,Nettles DL,Carnahan MA,Setton LA,Grinstaff MW

    更新日期:2006-01-01 00:00:00

  • Wormlike Nanovector with Enhanced Drug Loading Using Blends of Biodegradable Block Copolymers.

    abstract::The application of nanoparticles comprising amphiphilic block copolymers for the delivery of drugs is a subject of great interest as they hold promise for more effective and selective therapies. In order to achieve this ambition, it is of critical importance to develop our understanding of the self-assembly mechanisms...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.0c00169

    authors: Ridolfo R,Arends JJ,van Hest JCM,Williams DS

    更新日期:2020-06-08 00:00:00

  • Effects of protein-polyelectrolyte affinity and polyelectrolyte molecular weight on dynamic properties of bovine serum albumin-poly(diallyldimethylammonium chloride) coacervates.

    abstract::Bovine serum albumin (BSA) and poly(diallyldimethylammonium chloride) (PDADMAC) spontaneously form, over a range of ionic strength I and pH, dense fluids rich in both macroions. To study their nanostructure, these coacervates were prepared at low I and high pH (strong interaction) or at high I and lower pH (weaker int...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm049174p

    authors: Bohidar H,Dubin PL,Majhi PR,Tribet C,Jaeger W

    更新日期:2005-05-01 00:00:00

  • Interplay between viscoelastic and chemical tunings in fatty-acid-based polyester adhesives: engineering biomass toward functionalized step-growth polymers and soft networks.

    abstract::This Article describes the synthesis and characterization of renewable self-adhesive coatings with tunable viscoelastic properties and equipped with well-defined amounts of carboxylic acid "sticker" groups with adhesion promoting characteristics. Hydroxyl-ended polyesters with various architectures (linear, branched) ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm300523e

    authors: Vendamme R,Olaerts K,Gomes M,Degens M,Shigematsu T,Eevers W

    更新日期:2012-06-11 00:00:00

  • Solubilization and controlled release of a hydrophobic drug using novel micelle-forming ABC triblock copolymers.

    abstract::Amphiphilic ABC triblock copolymers composed of monomethoxy-capped poly(ethylene glycol) (MPEG), poly(2-(dimethylamino)ethyl methacrylate) (DMA), and poly(2-(diethylamino)ethyl methacrylate) (DEA) have been synthesized by atom transfer radical polymerization (ATRP). These copolymers dissolve molecularly in acidic aque...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm030026t

    authors: Tang Y,Liu SY,Armes SP,Billingham NC

    更新日期:2003-11-01 00:00:00

  • De novo designed protein transduction domain mimics from simple synthetic polymers.

    abstract::Protein transduction domains (PTDs) that readily transverse cellular membranes are of great interest and are attractive tools for the intracellular delivery of bioactive molecules. Learning to program synthetic polymers and oligomers with the appropriate chemical information to capture adequately the biological activi...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm200694u

    authors: Tezgel AÖ,Telfer JC,Tew GN

    更新日期:2011-08-08 00:00:00

  • Enzyme responsive hyaluronic acid nanocapsules containing polyhexanide and their exposure to bacteria to prevent infection.

    abstract::Antibacterial nanodevices could bring coatings of plastic materials and wound dressings a big step forward if the release of the antibacterial agents could be triggered by the presence of the bacteria themselves. Here, we show that novel hyaluronic acid (HA)-based nanocapsules containing the antimicrobial agent polyhe...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm302003m

    authors: Baier G,Cavallaro A,Vasilev K,Mailänder V,Musyanovych A,Landfester K

    更新日期:2013-04-08 00:00:00

  • Peptide Anchor for Folate-Targeted Liposomal Delivery.

    abstract::Specific folate receptors are abundantly overexpressed in chronically activated macrophages and in most cancer cells. Directed folate receptor targeting using liposomes is usually achieved using folate linked to a phospholipid or cholesterol anchor. This link is formed using a large spacer like polyethylene glycol. He...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b00823

    authors: Nogueira E,Mangialavori IC,Loureiro A,Azoia NG,Sárria MP,Nogueira P,Freitas J,Härmark J,Shimanovich U,Rollett A,Lacroix G,Bernardes GJ,Guebitz G,Hebert H,Moreira A,Carmo AM,Rossi JP,Gomes AC,Preto A,Cavaco-Paulo A

    更新日期:2015-09-14 00:00:00

  • New amphiphilic poly(2-ethyl-2-oxazoline)/ poly(L-lactide) triblock copolymers.

    abstract::A new series of cationic, thermo-sensitive, and biodegradable poly(L-lactide)-poly(2-ethyl-2-oxazoline)-poly(L-lactide) (PLLA-PEOz-PLLA) triblock copolymers were synthesized by ring-opening polymerization. With increasing molecular weight and crystallinity of hydrophobic PLLA blocks, the critical micellization concent...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm034190s

    authors: Wang CH,Hsiue GH

    更新日期:2003-11-01 00:00:00

  • Toroidal Packaging of pDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression.

    abstract::Selectively spooling single plasmid DNA (pDNA), as a giant polyelectrolyte, into a nanosized toroidal structure or folding it into a rod-like structure has been accomplished by polyion complexation with block catiomers to form polymeric micelles in varying NaCl concentrations. The interactive potency between the pDNA ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b00491

    authors: Li Y,Osada K,Chen Q,Tockary TA,Dirisala A,Takeda KM,Uchida S,Nagata K,Itaka K,Kataoka K

    更新日期:2015-09-14 00:00:00

  • Holmium-loaded poly(L-lactic acid) microspheres: in vitro degradation study.

    abstract::The clinical application of holmium-loaded poly(L-lactic acid) (PLLA) microspheres for the radionuclide treatment of liver malignancies requires in depth understanding of the degradation characteristics of the microspheres. To this end, an in-vitro degradation study was conducted. PLLA-microspheres with and without Ho...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm060230r

    authors: Zielhuis SW,Nijsen JF,Krijger GC,van het Schip AD,Hennink WE

    更新日期:2006-07-01 00:00:00

  • Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(epsilon-caprolactone) nanofibers for sustained release.

    abstract::As an aim toward developing biologically mimetic and functional nanofiber-based tissue engineering scaffolds, we demonstrated the encapsulation of a model protein, fluorescein isothiocyanate-conjugated bovine serum albumin (fitcBSA), along with a water-soluble polymer, poly(ethylene glycol) (PEG), within the biodegrad...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm050743i

    authors: Zhang YZ,Wang X,Feng Y,Li J,Lim CT,Ramakrishna S

    更新日期:2006-04-01 00:00:00

  • Amphiphilic Elastin-Like Block Co-Recombinamers Containing Leucine Zippers: Cooperative Interplay between Both Domains Results in Injectable and Stable Hydrogels.

    abstract::Many biological processes are regulated by reversible binding events, with these interactions between macromolecules representing the core of dynamic chemistry. As such, any attempt to gain a better understanding of such interactions, which would pave the way to the extrapolation of natural designs to create new advan...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b01103

    authors: Fernández-Colino A,Arias FJ,Alonso M,Rodríguez-Cabello JC

    更新日期:2015-10-12 00:00:00

  • Cyclic Dipeptide-Based Ambidextrous Supergelators: Minimalistic Rational Design, Structure-Gelation Studies, and In Situ Hydrogelation.

    abstract::Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic propert...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00924

    authors: Manchineella S,Murugan NA,Govindaraju T

    更新日期:2017-11-13 00:00:00

  • Binary Mixed Homopolymer Brushes Tethered to Cellulose Nanocrystals: A Step Towards Compatibilized Polyester Blends.

    abstract::This article reports on the successful preparation and characterization of cellulose nanocrystals (CNCs) surface-modified with polylactide (PLA) and poly(butylene succinate) (PBS) binary mixed homopolymer brushes. Their synthesis was designed as a three-step procedure combining polyester synthesis and surface-modifica...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.6b00932

    authors: Mincheva R,Jasmani L,Josse T,Paint Y,Raquez JM,Gerbaux P,Eyley S,Thielemans W,Dubois P

    更新日期:2016-09-12 00:00:00

  • Mechanism and kinetics of phase separation in a gelatin/maltodextrin mixture studied by small-angle light scattering.

    abstract::Phase separation mechanisms and kinetics were studied using small-angle light scattering in a gelatin/maltodextrin system where phase separation could be studied in both liquid and gelled states. Nucleation and growth or spinodal decomposition occurred, depending on the quench depth. The transition between the two mec...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm025501m

    authors: Butler MF

    更新日期:2002-07-01 00:00:00

  • Co-electrospun nanofiber fabrics of poly(L-lactide-co-epsilon-caprolactone) with type I collagen or heparin.

    abstract::Functionally designed elastomeric nanofiber fabrics made of the equimolar copolyester, poly(L-lactide-co-epsilon-caprolactone) (PLCL), with type I collagen or the tri-n-butylamine salt of heparin (heparin-TBA) were co-electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a solvent. The co-electrospun fabrics (...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm050086u

    authors: Kwon IK,Matsuda T

    更新日期:2005-07-01 00:00:00

  • Quaternary Ammoniumyl Chitosan Derivatives for Eradication of Staphylococcus aureus Biofilms.

    abstract::Bacterial biofilms tolerate extreme levels of antibiotics. Treatment of biofilm infections therefore requires the development of new or modified antimicrobials that can penetrate biofilms and are effective against dormant persistent cells. One such new approach uses the biodegradable biopolymer chitosan and its deriva...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.8b00718

    authors: Sahariah P,Másson M,Meyer RL

    更新日期:2018-09-10 00:00:00

  • Polymersome encapsulated hemoglobin: a novel type of oxygen carrier.

    abstract::Bovine hemoglobin (Hb) was encapsulated inside polymer vesicles (polymersomes) to form polymersome encapsulated Hb (PEH) dispersions. PEH particles are 100% surface PEGylated with longer PEG chains and possess thicker hydrophobic membranes as compared to conventional liposomes. Polymersomes were self-assembled from po...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm0501454

    authors: Arifin DR,Palmer AF

    更新日期:2005-07-01 00:00:00

  • Phase behavior of elastin-like synthetic recombinamers in deep eutectic solvents.

    abstract::Deep eutectic solvents promoted the stabilization of the collapsed state of elastin-like recombinamers - and the subsequent formation of aggregates - upon the loss of the structural water molecules involved in hydrophobic hydration. Cryo-etch scanning electron microscopy allowed the observation of these aggregates i...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm300200e

    authors: Nardecchia S,Gutiérrez MC,Ferrer ML,Alonso M,López IM,Rodríguez-Cabello JC,del Monte F

    更新日期:2012-07-09 00:00:00

  • Photosensitive Supramolecular Micelles with Complementary Hydrogen Bonding Motifs To Improve the Efficacy of Cancer Chemotherapy.

    abstract::Photosensitive supramolecular micelles, a combination of intermolecular hydrogen bonds between complementary adenine (A) and uracil (U) groups and a blend of two types of supramolecular polymers, can stably self-assemble into structurally stable, spherical micelles in aqueous solution before and after photoirradiation...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b01322

    authors: Abebe Alemayehu Y,Tewabe Gebeyehu B,Cheng CC

    更新日期:2019-12-09 00:00:00

  • Polymers and Composites Derived from Castor Oil as Sustainable Materials and Degradable Biomaterials: Current Status and Emerging Trends.

    abstract::Recent years have seen rapid growth in utilizing vegetable oils to derive a wide variety of polymers to replace petroleum-based polymers for minimizing environmental impact. Nonedible castor oil (CO) can be extracted from castor plants that grow easily, even in an arid land. CO is a promising source for developing sev...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.0c01291

    authors: Chakraborty I,Chatterjee K

    更新日期:2020-12-14 00:00:00

  • Reversibly cross-linked polyplexes enable cancer-targeted gene delivery via self-promoted DNA release and self-diminished toxicity.

    abstract::Polycations often suffer from the irreconcilable inconsistency between transfection efficiency and toxicity. Polymers with high molecular weight (MW) and cationic charge feature potent gene delivery capabilities, while in the meantime suffer from strong chemotoxicity, restricted intracellular DNA release, and low stab...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b00180

    authors: He H,Bai Y,Wang J,Deng Q,Zhu L,Meng F,Zhong Z,Yin L

    更新日期:2015-04-13 00:00:00

  • Engineering and Characterization of an Enzyme Replacement Therapy for Classical Homocystinuria.

    abstract::Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine. Current treatments are suboptimal, and thus the development of an enzyme replacement therapy based on PEGylated human truncated CBS (PEG-CBS) has been initiated. Attenuation of potency was obs...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00154

    authors: Majtan T,Park I,Carrillo RS,Bublil EM,Kraus JP

    更新日期:2017-06-12 00:00:00