Abstract:
:Phase separation mechanisms and kinetics were studied using small-angle light scattering in a gelatin/maltodextrin system where phase separation could be studied in both liquid and gelled states. Nucleation and growth or spinodal decomposition occurred, depending on the quench depth. The transition between the two mechanisms occurred relatively sharply. The different mechanisms were distinguishable by the different behavior of the scattering function even though a peak was observed in both cases. Particular differences were the different evolution of the peak intensity and position, the absence of dynamic scaling of the nucleation and growth scattering function, and the final coarsening exponent of 1/3 that was measured when spinodal decomposition occurred but not for nucleation and growth. Gelation severely reduced the coarsening rate and initially placed the phase compositions far from their equilibrium values. Despite the loss of molecular mobility caused by gelation, the gelled systems did continue to evolve, albeit much more slowly than in the liquid case. Multiple coarsening rates were observed for some of the gelled samples, which were ascribed to the gradual movement of these systems toward the equilibrium compositions.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Butler MFdoi
10.1021/bm025501mkeywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
676-83issue
4eissn
1525-7797issn
1526-4602pii
bm025501mjournal_volume
3pub_type
杂志文章abstract::The ability to adopt at least two different stable conformations is a common feature of proteins involved in many neurodegenerative diseases. The involved molecules undergo a conformational transition from native, mainly helical states to insoluble amyloid structures that have high β-sheet content. A detailed characte...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200587m
更新日期:2011-08-08 00:00:00
abstract::Preparations of the highly ordered monoantennary, homofunctional diantennary, and heterofunctional diantennary neoglycopolymers of α-d-mannose and β-d-glucose residues were achieved via ring-opening metathesis polymerization. Isothermal titration calorimetry measurements of these synthetic neoglycopolymers with Concan...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b01380
更新日期:2015-12-14 00:00:00
abstract::Self-cross-linking polyelectrolytes are used to strengthen the surface of calcium alginate beads for cell encapsulation. Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride), containing 30 mol % 2-aminoethyl methacrylate, and poly(sodium methacrylate), containing 30 mol % 2-(methacryloyloxy)ethyl acetoacetate, w...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm800580c
更新日期:2008-09-01 00:00:00
abstract::Amphiphilic ABC triblock copolymers composed of monomethoxy-capped poly(ethylene glycol) (MPEG), poly(2-(dimethylamino)ethyl methacrylate) (DMA), and poly(2-(diethylamino)ethyl methacrylate) (DEA) have been synthesized by atom transfer radical polymerization (ATRP). These copolymers dissolve molecularly in acidic aque...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm030026t
更新日期:2003-11-01 00:00:00
abstract::Self-assembly in aqueous solution of two oppositely charged globular proteins, hen egg white lysozyme (LYS) and bovine calcium-depleted α-lactalbumin (apo α-LA), was investigated at pH 7.5. The aggregation rate of equimolar mixtures of the two proteins was determined using static and dynamic light scattering as a func...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200264m
更新日期:2011-05-09 00:00:00
abstract::Softwood and hardwood celluloses were oxidized by 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation. The TEMPO-oxidized cellulose fibers were converted to transparent dispersions in water, which consisted of individual nanofibers 3-4 nm in width. Films were then prepared from the TEMPO-oxidized c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801065u
更新日期:2009-01-12 00:00:00
abstract::Saccharide-functionalized shell cross-linked (SCK) polymer micelles designed as polyvalent nanoscaffolds for selective interactions with receptors on Gram negative bacteria were constructed from mixed micelles composed of poly(acrylic acid-b-methyl acrylate) and mannosylated poly(acrylic acid-b-methyl acrylate). The m...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0344710
更新日期:2004-05-01 00:00:00
abstract::Enzymatic hydrolysis of selected copolymers of cellulose diacetate-graft-poly(L-lactide)s (CDA-g-PLLAs) were conducted with proteinase K for film specimens, which were solely quenched from the molten state or, further, annealed at temperatures below or above their glass transition temperatures. The hydrolysis rates de...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034453i
更新日期:2004-03-01 00:00:00
abstract::Feasibility of using amphiphilic block copolymers composed of polylactide (PLA) and poly(ethylene oxide) (PEO) blocks for biomimetic surface modification of polylactide-based biomaterials for tissue engineering was investigated. PEO-b-PLA copolymers were deposited on the PLA surface from a solution in PEO-selective so...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900889b
更新日期:2010-01-11 00:00:00
abstract::The coefficient of thermal expansion (CTE) of cellulose nanocrystal (CNC) films was characterized using novel experimental techniques complemented by molecular simulations. The characteristic birefringence exhibited by CNC films was utilized to calculate the in-plane CTE of self-organized and shear-oriented self-stand...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm400794e
更新日期:2013-08-12 00:00:00
abstract::Algae constitute a largely available, low value material from renewable resources of marine origin to be used for the production of eco-compatible composites. Fibers of the green alga Ulva armoricana from the French coast were positively evaluated for the production of composites with a hydrophilic, eco-compatible pol...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm701041e
更新日期:2008-03-01 00:00:00
abstract::This study presents an efficient and systematic approach to synthesize bioapplicable porous hollow polymeric capsules (HPCs). The hydroxyl-functionalized nanoporous polymers with hollow capsular shapes could be generated via the moderate Friedel-Crafts reaction without using any hard or soft template. The numerous pri...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01520
更新日期:2020-12-17 00:00:00
abstract::The stability of internally cross-linked casein micelles against disruption by urea (which disrupts hydrogen bonds and hydrophobic interactions) and trisodium citrate (which sequesters micellar calcium phosphate) was investigated. Addition of urea (0-6 mol L-1) and/or citrate (0-50 mmol L-1) progressively reduced the ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm061070m
更新日期:2007-04-01 00:00:00
abstract::Bioresponsive poly(amidoamine)s (PAA)s are currently under development as endosomolytic polymers for intracellular delivery of proteins and genes. Here for the first time, small-angle neutron scattering (SANS) is used to systematically investigate the pH-dependent conformational change of an endosomolytic polymer, the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049936g
更新日期:2004-07-01 00:00:00
abstract::Dual-cross-linked network (DCN) hydrogels with multiresponsive and self-healing properties are attracting intensive interests due to their enhanced mechanical strength for a wide range of applications. Herein, we developed a DCN hydrogel that combines a dynamic imine and a benzoxaboronic ester with a neutral pKa value...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01548
更新日期:2020-12-15 00:00:00
abstract::Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy their entire life, there is currently a great desire to formulate antibodies for bolus injection ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00867
更新日期:2019-09-09 00:00:00
abstract::The purpose of this study is to investigate the combined effects of oxygen plasma treatments and silver nanoparticles (Ag) on PLGA in order to modulate the surface antimicrobial properties through tunable bacteria adhesion mechanisms. PLGA nanocomposite films, produced by solvent casting with 1 wt % and 7 wt % of Ag n...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301524e
更新日期:2013-03-11 00:00:00
abstract::The outcome for glioblastoma patients remains dismal for its invariably recrudesces within 2 cm of the resection cavity. Local immunotherapy has the potential to eradicate the residual infiltrative component of these tumors. Here, we report the development of a biodegradable hydrogel containing therapeutic T lymphocyt...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm500502n
更新日期:2014-07-14 00:00:00
abstract::An increase in hyaluronan (HA) synthesis, cellular uptake, and metabolism occurs during the remodeling of tissue microenvironments following injury and during disease processes such as cancer. We hypothesized that multimodality HA-based probes selectively target and detectably accumulate at sites of high HA metabolism...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm201143c
更新日期:2012-01-09 00:00:00
abstract::A well-defined fluorescent conjugated polyfluorene with pendant lactopyranosyl ligands was easily prepared through Cu(I)-catalyzed azide/alkyne "click" ligation and Suzuki coupling polymerization. As a fluorescent multivalent model system of glycoconjugates, the polymer was first used for studies of metal ion-mediated...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm901165n
更新日期:2010-01-11 00:00:00
abstract::Glycerol derivatives of cutin and suberin monomers were synthesized by acid catalysis. Their dispersion in an aqueous solution was examined by phase contrast microscopy, neutron scattering, and solid state NMR. It is shown that the phase behavior strongly depends on the nature of the derivatives forming either lumps o...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049325o
更新日期:2005-01-01 00:00:00
abstract::meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate (TMP) is a photosensitizer that can be used in photodynamic therapy (PDT) to induce cell death through generation of reactive oxygen species in targeted tumor cells. However, TMP is highly hydrophilic, and therefore, its ability to accumulate intracellularly is li...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm301858a
更新日期:2013-02-11 00:00:00
abstract::Highly fluorescent N-substituted 1-cyanobenz[f]isoindole chitosans (CBI-CSs) with various degrees of N-substitution (DS) were synthesized by reacting chitosan (CS) with naphthalene-2,3-dicarboxaldehyde (NDA) in the presence of cyanide under mild acidic conditions. Introduction of 1-cyanobenz[f]isoindole moieties into ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm5004459
更新日期:2014-08-11 00:00:00
abstract::The bioconjugation of proteins and peptides with synthetic polymers is a promising method for tailoring the chemical, biological, and physical properties of both the polymeric and protein-based components. Here, we describe macromolecular assemblies of polyethylene glycol-coiled-coil alternating multiblock polymers gu...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900474k
更新日期:2009-10-12 00:00:00
abstract::Native hemicellulose lacks many of the properties that make fossil fuel-based polymers excellent for use in today's industrial products and processes. The mechanical and thermal properties of the hemicellulose can, however, be modified, and its processability increased. We functionalized galactoglucomannan to lower it...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01730
更新日期:2020-05-11 00:00:00
abstract::Shear flow is indirectly implicated in amyloid formation in vitro. Despite the association between amyloid fibrils and disease, and the prevalence of flow in physiological systems, the effect of this parameter is uncharacterized. We designed a novel Couette cell to quantitatively investigate shear exposure during fibr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0505078
更新日期:2006-01-01 00:00:00
abstract::Spidroins, the major silk proteins making up the spider's dragline silk, originate in two distinct tissue layers (A and B) in the spider's major ampullate gland. Formation of the complex thread from spidroins occurs in the lumen of the duct connected to the gland. Using pH-sensitive microelectrode probes, we showed th...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034307c
更新日期:2004-05-01 00:00:00
abstract::The complement system is a powerful mechanism of the innate immune defense system. Dysregulation may contribute to several diseases. Heparin is a known regulator of the complement system, but its application is limited due to its anticoagulative activity. A promising alternative is the synthetic analogue dendritic pol...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00889
更新日期:2019-10-14 00:00:00
abstract::Optimal curcumin delivery for medicinal applications requires a drug delivery system that both solubilizes curcumin and prevents degradation. To achieve this, curcumin has been encapsulated in submicrometer chitosan/Tween 20 particles via a benchtop spray-drying process. Spray-drying parameters have been optimized usi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm300564v
更新日期:2012-08-13 00:00:00
abstract::Ocular applications of polymeric materials have been widely investigated for medical diagnostics, treatment, and vision improvement. The human eye is a vital organ that connects us to the outside world so when the eye is injured, infected, or impaired, it needs immediate medical treatment to maintain clear vision and ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c01525
更新日期:2021-01-06 00:00:00