Biodegradable cellulose diacetate-graft-poly(L-lactide)s: enzymatic hydrolysis behavior and surface morphological characterization.

abstract：:We report a robust method to manufacture polyacrylamide-based functional hydrogel microspheres with readily tunable macroporous structures by utilizing a simple micromolding-based technique. Specifically, surface tension-induced droplet formation of aqueous solutions of chitosan and acrylamide in 2D-shaped micromolds ...

journal_title：Biomacromolecules

authors： Jung S,Abel JH,Starger JL,Yi H

更新日期：2016-07-11 00:00:00

abstract：:Multicomponent poly(ethylene glycol) (PEG) brushes (i.e., ≥ 2 adjacent PEG brushes) can be used to engineer culture substrates with microscale, nonfouling regions decorated with covalently immobilized ligands that mediate biospecific interactions. However, synthesizing such brushes with orthogonal immobilization chemi...

journal_title：Biomacromolecules

authors： Sha J,Lippmann ES,McNulty J,Ma Y,Ashton RS

更新日期：2013-09-09 00:00:00

abstract：:Electrically conductive hydrogel composites consisting of oligo(polyethylene glycol) fumarate (OPF) and polypyrrole (PPy) were developed for applications in nerve regeneration. OPF-PPy scaffolds were synthesized using three different anions: naphthalene-2-sulfonic acid sodium salt (NSA), dodecylbenzenesulfonic acid so...

journal_title：Biomacromolecules

authors： Runge MB,Dadsetan M,Baltrusaitis J,Ruesink T,Lu L,Windebank AJ,Yaszemski MJ

更新日期：2010-11-08 00:00:00

abstract：:The stability of internally cross-linked casein micelles against disruption by urea (which disrupts hydrogen bonds and hydrophobic interactions) and trisodium citrate (which sequesters micellar calcium phosphate) was investigated. Addition of urea (0-6 mol L-1) and/or citrate (0-50 mmol L-1) progressively reduced the ...

journal_title：Biomacromolecules

authors： Huppertz T,Smiddy MA,de Kruif CG

更新日期：2007-04-01 00:00:00

abstract：:Bioresponsive polymers can enable the development of more effective drug delivery vehicles and medical materials. Acetal-modified polysaccharides allow pH-triggered solubility switching in a versatile and effective manner, but prior work has been limited to a combination of acyclic alkoxyisopropyl and cyclic isopropyl...

journal_title：Biomacromolecules

authors： Graham ET,Broaders KE

更新日期：2019-05-13 00:00:00

abstract：:Nowadays, active targeting of nanotherapeutics is a challenging issue. Here, we propose a rational design of a ternary nanoassembly (SAP) composed of nonionic amphiphilic β-cyclodextrins (amphiphilic CD) incorporating pheophorbide (Pheo) as a phototherapeutic and an adamantanyl-folic acid conjugate (Ada-FA) to target ...

journal_title：Biomacromolecules

authors： Zagami R,Rapozzi V,Piperno A,Scala A,Triolo C,Trapani M,Xodo LE,Monsù Scolaro L,Mazzaglia A

更新日期：2019-07-08 00:00:00

abstract：:Self-assembled hydrogen-bonded networks of the polysaccharide pectin, a mechanically functional component of plant cell walls, have been of recent interest as biomimetic exemplars of physical gels, and the microrheological and strain-stiffening behaviors have been previously investigated. Despite this detailed rheolog...

journal_title：Biomacromolecules

authors： Mansel BW,Chu CY,Leis A,Hemar Y,Chen HL,Lundin L,Williams MA

更新日期：2015-10-12 00:00:00

abstract：:Limited studies have been done on the interactions between subunits of self-assembling protein cages. E2 protein cage from Bacillus stearothermophilus was investigated in this work to impart pH-sensitive disassembly profile. Key amino acids were identified at the intratrimer and intertrimer interfaces, and histidine r...

journal_title：Biomacromolecules

authors： Peng T,Lim S

更新日期：2011-09-12 00:00:00

abstract：:There is a distinct need for antimicrobial compounds that can act at surfaces without leaching into the environment. Such materials should be easy to synthesize, be easy to apply to surfaces, and display reasonable levels of antimicrobial and antifungal activity. Here we describe such a surface-active compound and dem...

journal_title：Biomacromolecules

authors： Ravikumar T,Murata H,Koepsel RR,Russell AJ

更新日期：2006-10-01 00:00:00

abstract：:Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could b...

journal_title：Biomacromolecules

authors： Kostina NY,Rodriguez-Emmenegger C,Houska M,Brynda E,Michálek J

更新日期：2012-12-10 00:00:00

abstract：:Nanoparticles with high aspect ratios have favorable attributes for drug delivery and bioimaging applications based on their enhanced tissue penetration and tumor homing properties. Here, we investigated a novel filamentous viral nanoparticle (VNP) based on the Pepino mosaic virus (PepMV), a relative of the establishe...

journal_title：Biomacromolecules

authors： Le DHT,Méndez-López E,Wang C,Commandeur U,Aranda MA,Steinmetz NF

更新日期：2019-01-14 00:00:00

abstract：:A strategy is presented that exploits the ability of synthetic polymers of different nature to disturb the strong self-assembly capabilities of amyloid based β-sheet forming peptides. Following a convergent approach, the peptides of interest were synthesized via solid-phase peptide synthesis (SPPS) and the polymers vi...

journal_title：Biomacromolecules

authors： Dehn S,Castelletto V,Hamley IW,Perrier S

更新日期：2012-09-10 00:00:00

abstract：:Synthetic lethality is a molecular-targeted therapy for selective killing of cancer cells. We exploited a lethal interaction between superoxide dismutase 1 inhibition and Bloom syndrome gene product (BLM) defect for the treatment of colorectal cancer (CRC) cells (HCT 116) with a customized lung cancer screen-1-loaded ...

journal_title：Biomacromolecules

authors： Gupta A,Ahmad A,Singh H,Kaur S,K M N,Ansari MM,Jayamurugan G,Khan R

更新日期：2018-03-12 00:00:00

abstract：:Development of versatile nanoscale platforms for cancer diagnosis and therapy is of great importance for applications in translational medicine. In this work, we present the use of γ-polyglutamic acid (γ-PGA) nanogels (NGs) to load polypyrrole (PPy) for thermal/photoacoustic (PA) imaging and radiotherapy (RT)-sensitiz...

journal_title：Biomacromolecules

authors： Zhou Y,Hu Y,Sun W,Lu S,Cai C,Peng C,Yu J,Popovtzer R,Shen M,Shi X

更新日期：2018-06-11 00:00:00

abstract：:As a result of improved relevance to in vivo physiology, in vitro studies are increasingly performed in diverse, three-dimensional (3D) biomaterials. However, material-cell type pairing effects on cytokine availability remain unclear. We cultured five cell types in agarose, alginate, collagen, Matrigel, or RGD-functio...

journal_title：Biomacromolecules

authors： Regier MC,Montanez-Sauri SI,Schwartz MP,Murphy WL,Beebe DJ,Sung KE

更新日期：2017-03-13 00:00:00

abstract：:Recent years have seen rapid growth in utilizing vegetable oils to derive a wide variety of polymers to replace petroleum-based polymers for minimizing environmental impact. Nonedible castor oil (CO) can be extracted from castor plants that grow easily, even in an arid land. CO is a promising source for developing sev...

journal_title：Biomacromolecules

authors： Chakraborty I,Chatterjee K

更新日期：2020-12-14 00:00:00

abstract：:Receptor-mediated, cell-specific delivery of siRNA enables silencing of target genes in specific tissues, opening the door to powerful therapeutic options for a multitude of diseases. However, the development of delivery systems capable of targeted and effective siRNA delivery typically requires multiple steps and the...

journal_title：Biomacromolecules

authors： Benoit DS,Srinivasan S,Shubin AD,Stayton PS

更新日期：2011-07-11 00:00:00

abstract：:Exendin-4 (EX4), a glucagon-like peptide-1 receptor (GLP-1R) agonist that regulates blood glucose levels, has been used in the management of type-2 diabetes mellitus. EX4 can be PEGylated to improve its antidiabetic effects by enhancing its stability and extending the circulation half-life. Here, to determine whether ...

journal_title：Biomacromolecules

authors： Lee W,Park EJ,Kwak S,Lee KC,Na DH,Bae JS

更新日期：2016-03-14 00:00:00

abstract：:Gene therapy is rapidly regaining traction in terms of research activity and investment across the globe, with clear potential to revolutionize medicine and tissue regeneration. Viral vectors remain the most commonly utilized gene delivery vehicles, due to their high efficiency, however, they are acknowledged to have ...

journal_title：Biomacromolecules

authors： Wong LY,Xia B,Wolvetang E,Cooper-White J

更新日期：2018-02-12 00:00:00

abstract：:The mucilaginous viscin tissue within mistletoe berries possesses an extraordinary ability to be rapidly processed under ambient conditions into stiff cellulosic fibers (>14 GPa) through simple mechanical drawing. This rapid and extreme transformation process is hydration-dependent and involves an astonishing >200-fol...

journal_title：Biomacromolecules

authors： Horbelt N,Eder M,Bertinetti L,Fratzl P,Harrington MJ

更新日期：2019-08-12 00:00:00

abstract：:Electrospun natural polymer membranes were fabricated from collagen or gelatin coated with a bioactive recombinant fragment of perlecan, a natural heparan sulfate proteoglycan. The electrospinning process allowed the facile processing of a three-dimensional, porous fibril (2-6 microm in diameter) matrix suitable for t...

journal_title：Biomacromolecules

authors： Casper CL,Yang W,Farach-Carson MC,Rabolt JF

更新日期：2007-04-01 00:00:00

abstract：:We demonstrate the formation of polyethylene glycol (PEG) based hydrogels via oxime ligation and the photoinitiated thiol-ene 3D patterning of peptides within the hydrogel matrix postgelation. The gelation process and final mechanical strength of the hydrogels can be tuned using pH and the catalyst concentration. The ...

journal_title：Biomacromolecules

authors： Lin F,Yu J,Tang W,Zheng J,Defante A,Guo K,Wesdemiotis C,Becker ML

更新日期：2013-10-14 00:00:00

abstract：:Cell cultivation on the surface of a novel poly(N-isopropylacrylamide) (PNIPA) hydrogel (N-NC gel), consisting of a specific type of organic (PNIPA)/inorganic (clay) network, was studied using three cell types; HepG2 human hepatoma cells, human dermal fibroblasts, and human umbilical vein endothelial cells. For the fi...

journal_title：Biomacromolecules

authors： Haraguchi K,Takehisa T,Ebato M

更新日期：2006-11-01 00:00:00

abstract：:New types of hydrogels have been obtained starting from high bloom purified gelatin A, alone or in mixtures with hyaluronan and with a hyaluronan derivative bearing primary amino groups, by transglutaminase-catalyzed cross-linking. The reticulation process, carried out adopting two different temperature protocols, and...

journal_title：Biomacromolecules

authors： Crescenzi V,Francescangeli A,Taglienti A

更新日期：2002-11-01 00:00:00

abstract：:A stepwise anticancer drug delivery system based on an injectable supramolecular hydrogel was presented. In this system, poly(ethylene glycol)-b-poly(acrylic acid) (PEG-b-PAA) block copolymer nanoparticles containing cisplatin were released by erosion of the hydrogels and then the cisplatin was released from the nanop...

journal_title：Biomacromolecules

authors： Zhu W,Li Y,Liu L,Chen Y,Wang C,Xi F

更新日期：2010-11-08 00:00:00

abstract：:Enzymatic adsorption and degradation of three types of aliphatic polyester films and two types of polyolefin films by the extracellular PHB depolymerase from Alcaligenes faecalis T1 have been studied by using a quartz crystal microbalance (QCM) technique. Hydrolysis of poly[(R)-3-hydroxybutyrate] was quantitatively fo...

journal_title：Biomacromolecules

authors： Yamashita K,Aoyagi Y,Abe H,Doi Y

更新日期：2001-04-01 00:00:00

abstract：:Polymers are appealing as pH-responsive elements of multicomponent systems designed to promote cytosolic delivery of macromolecular drugs (including proteins and genes), but so far the delivery efficiency achieved has been relatively modest. Therefore, the aim of this study was to apply several physicochemical techniq...

journal_title：Biomacromolecules

authors： Griffiths PC,Khayat Z,Tse S,Heenan RK,King SM,Duncan R

更新日期：2007-03-01 00:00:00

abstract：:Vascular grafts that can support total replacement and maintenance by the body of the injured vessel would improve outcomes of major surgical reconstructions. Building scaffolds using components of the native vessel can encourage biological recognition by native cells as well as mimic mechanical characteristics of the...

journal_title：Biomacromolecules

authors： Bracaglia LG,Messina M,Winston S,Kuo CY,Lerman M,Fisher JP

更新日期：2017-11-13 00:00:00

abstract：:Oscillatory shear rheometry has been used to study the gelation of beta-lactoglobulin at ambient in 50% v/v trifluoroethanol (TFE)/pH 7 aqueous buffer and in 50% v/v ethanol (EtOH)/water at pH 2. In contrast to what was found on heating aqueous solutions at pH 2 (Part 2 of this series), a more expected "chemical gelat...

journal_title：Biomacromolecules

authors： Gosal WS,Clark AH,Ross-Murphy SB

更新日期：2004-11-01 00:00:00

abstract：:Targeted delivery of antigens to immune cells using micro/nanocarriers may serve as a therapeutic application for vaccination. However, synthetic carriers have potential drawbacks including cytotoxicity, low encapsulation efficiency of antigen, and lack of a morphological design, which limit the translation of the del...

journal_title：Biomacromolecules

authors： Nishiguchi A,Shima F,Singh S,Akashi M,Moeller M

更新日期：2020-06-08 00:00:00