Altering peptide fibrillization by polymer conjugation.

abstract：:Consensus motifs for sequences of both crystallizable and amorphous blocks in silks and natural structural analogues of silks vary widely. To design novel silklike polypeptides, an important question is therefore how the nature of either the crystallizable or the amorphous block affects the self-assembly and resulting...

journal_title：Biomacromolecules

authors： Willems L,van Westerveld L,Roberts S,Weitzhandler I,Calcines Cruz C,Hernandez-Garcia A,Chilkoti A,Mastrobattista E,van der Oost J,de Vries R

更新日期：2019-10-14 00:00:00

abstract：:Feasibility of using amphiphilic block copolymers composed of polylactide (PLA) and poly(ethylene oxide) (PEO) blocks for biomimetic surface modification of polylactide-based biomaterials for tissue engineering was investigated. PEO-b-PLA copolymers were deposited on the PLA surface from a solution in PEO-selective so...

journal_title：Biomacromolecules

authors： Tresohlavá E,Popelka S,Machová L,Rypácek F

更新日期：2010-01-11 00:00:00

abstract：:Many biological processes are regulated by reversible binding events, with these interactions between macromolecules representing the core of dynamic chemistry. As such, any attempt to gain a better understanding of such interactions, which would pave the way to the extrapolation of natural designs to create new advan...

journal_title：Biomacromolecules

authors： Fernández-Colino A,Arias FJ,Alonso M,Rodríguez-Cabello JC

更新日期：2015-10-12 00:00:00

abstract：:Several alternatives to the conventional alginate beads formulation were studied for encapsulation of invertase. Pectin was added to the alginate/enzyme solution while trehalose and β-cyclodextrin were added to the calcium gelation media. The effect of composition changes, freezing, drying methods (freeze, vacuum, or ...

journal_title：Biomacromolecules

authors： Santagapita PR,Mazzobre MF,Buera MP

更新日期：2011-09-12 00:00:00

abstract：:Periodic patterns resembling spirals were observed to form spontaneously upon unassisted cooling of d-glucaric acid- and d-galactaric acid-based polyamide solutions in N-methyl-N-morpholine oxide (NMMO) monohydrate. Similar observations were made in d-galactaric acid-based polyamide/ionic liquid (IL) solutions. The mo...

journal_title：Biomacromolecules

authors： Rosu C,Russo PS,Daly WH,Cueto R,Pople JA,Laine RA,Negulescu II

更新日期：2015-09-14 00:00:00

abstract：:The competing mechanisms that regulate adhesion of bacteria to surfaces and subsequent biofilm formation remain unclear, though nearly all studies have focused on the role of physical and chemical properties of the material surface. Given the large monetary and health costs of medical-device colonization and hospital-...

journal_title：Biomacromolecules

authors： Lichter JA,Thompson MT,Delgadillo M,Nishikawa T,Rubner MF,Van Vliet KJ

更新日期：2008-06-01 00:00:00

abstract：:Shear flow is indirectly implicated in amyloid formation in vitro. Despite the association between amyloid fibrils and disease, and the prevalence of flow in physiological systems, the effect of this parameter is uncharacterized. We designed a novel Couette cell to quantitatively investigate shear exposure during fibr...

journal_title：Biomacromolecules

authors： Hill EK,Krebs B,Goodall DG,Howlett GJ,Dunstan DE

更新日期：2006-01-01 00:00:00

abstract：:Incorporating charged amino acid side chains in polypeptide polymer backbones to improve solubility usually leads to reduced secondary structuring. Here we show that highly water soluble (>15 mg.mL-1) β-sheets can be obtained via nucleotide monophosphate grafting onto simple poly(γ-propargyl- L-glutamate) backbone. Th...

journal_title：Biomacromolecules

authors： Nguyen M,Stigliani JL,Bijani C,Verhaeghe P,Pratviel G,Bonduelle C

更新日期：2018-10-08 00:00:00

abstract：:Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization o...

journal_title：Biomacromolecules

authors： Brandl F,Hammer N,Blunk T,Tessmar J,Goepferich A

更新日期：2010-02-08 00:00:00

abstract：:Glycerol derivatives of cutin and suberin monomers were synthesized by acid catalysis. Their dispersion in an aqueous solution was examined by phase contrast microscopy, neutron scattering, and solid state NMR. It is shown that the phase behavior strongly depends on the nature of the derivatives forming either lumps o...

journal_title：Biomacromolecules

authors： Douliez JP,Barrault J,Jerome F,Heredia A,Navailles L,Nallet F

更新日期：2005-01-01 00:00:00

abstract：:The copolymer of methyl methacrylate (MMA) and 2-[2',3',5'-triiodobenzoyl]oxoethyl methacrylate (1), ratio 3:1 (mass:mass), was prepared via a free-radical polymerization in bulk. The copolymer (M(w) = 97.8 kD and M(n) = 41.5 kD) was dissolved in chloroform and subsequently transformed into beads with a diameter in th...

journal_title：Biomacromolecules

authors： Saralidze K,Aldenhoff YB,Knetsch ML,Koole LH

更新日期：2003-05-01 00:00:00

abstract：:A novel methacrylate monomer containing a quinolone moiety was synthesized and homopolymerized in N,N-dimethylformamide (DMF) by using azobisisobutyronitrile (AIBN) as an initiator. The new monomer was copolymerized with poly(ethylene glycol) methyl ether methacrylate (MPEGMA) in DMF using the same initiator. The mono...

journal_title：Biomacromolecules

authors： Dizman B,Elasri MO,Mathias LJ

更新日期：2005-01-01 00:00:00

abstract：:A new α-amylase from Rhizomucor sp. (RA) was studied in detail due to its very efficient hydrolysis of raw starch granules at low temperature (32 °C). RA contains a starch binding domain (SBD) connected to the core amylase catalytic domain by a O-glycosylated linker. The mode of degradation of native maize starch gran...

journal_title：Biomacromolecules

authors： Tawil G,Viksø-Nielsen A,Rolland-Sabaté A,Colonna P,Buléon A

更新日期：2011-01-10 00:00:00

abstract：:Hydrophilic copolymers with high refractive index and bactericide properties based on quaternary ammonium salts monomers and methacrylates bearing benzothiazole moieties have been developed for application as foldable intraocular lenses. Composition of the systems was adjusted to get materials with optimized flexibili...

journal_title：Biomacromolecules

authors： Parra F,Vázquez B,Benito L,Barcenilla J,San Román J

更新日期：2009-11-09 00:00:00

abstract：:Polymers are appealing as pH-responsive elements of multicomponent systems designed to promote cytosolic delivery of macromolecular drugs (including proteins and genes), but so far the delivery efficiency achieved has been relatively modest. Therefore, the aim of this study was to apply several physicochemical techniq...

journal_title：Biomacromolecules

authors： Griffiths PC,Khayat Z,Tse S,Heenan RK,King SM,Duncan R

更新日期：2007-03-01 00:00:00

abstract：:The water-soluble arabinoxylans from wheat flour (high, medium, and low viscosity samples) and rye flour (high viscosity sample) were characterized by (1)H NMR spectroscopy and HPSEC with refractive index, light scattering, and viscometric detectors. These cereal arabinoxylans have recently been used as model arabinox...

journal_title：Biomacromolecules

authors： Pitkänen L,Virkki L,Tenkanen M,Tuomainen P

更新日期：2009-07-13 00:00:00

abstract：:The single and triple helical organization of protein chains strongly influences the mechanical properties of gelatin-based materials. A chemical method for obtaining different degrees of helical organization in gelatin is covalent functionalization, while a physical method for achieving the same goal is the variation...

journal_title：Biomacromolecules

authors： Zaupa A,Neffe AT,Pierce BF,Nöchel U,Lendlein A

更新日期：2011-01-10 00:00:00

abstract：:Super-resolution fluorescence microscopy, specifically stochastic reconstruction microscopy (STORM), and atomic force microscopy (AFM) were used to image the self-assembly processes of the peptide surfactant I3K. The peptide surfactants self-assembled into giant helical fibrils with diameters between 5 and 10 nm with ...

journal_title：Biomacromolecules

authors： Cox H,Georgiades P,Xu H,Waigh TA,Lu JR

更新日期：2017-11-13 00:00:00

abstract：:A cellulose macromonomer, N-(15-methacryloyloxypentadecanoyl)-tri-O-acetyl-beta-cellulosylamine (CTA-C15-MA (2); M(2)) with number averaged degree of polymerization (DP(n)) = 13), was copolymerized with methyl methacrylate (MMA; M(1)) to give cellulosic copolymer with CTA side chains, PMMA-g-(CTA-C15) (3-A). An absolu...

journal_title：Biomacromolecules

authors： Enomoto-Rogers Y,Kamitakahara H,Takano T,Nakatsubo F

更新日期：2009-08-10 00:00:00

abstract：:Dual-cross-linked network (DCN) hydrogels with multiresponsive and self-healing properties are attracting intensive interests due to their enhanced mechanical strength for a wide range of applications. Herein, we developed a DCN hydrogel that combines a dynamic imine and a benzoxaboronic ester with a neutral pKa value...

journal_title：Biomacromolecules

authors： Zhao J,Diaz-Dussan D,Wu M,Peng YY,Wang J,Zeng H,Duan W,Kong L,Hao X,Narain R

更新日期：2020-12-15 00:00:00

abstract：:Novel biodegradable materials with tunable hydrolytic degradation rate are prepared by grafting of phosphonoethylated polyglycidols with polyesters. First, the hydrolytically degradable polyester grafts are attached to polyglycidols partially grafted with phosphonoethylated diethyl esters through chemical-catalyzed gr...

journal_title：Biomacromolecules

authors： Köhler J,Marquardt F,Teske M,Keul H,Sternberg K,Möller M

更新日期：2013-11-11 00:00:00

abstract：:Recent developments in ionic liquid electrolytes for cellulose or biomass dissolution has also allowed for high-resolution 1H and 13C NMR on very high molecular weight cellulose. This permits the development of advanced liquid-state quantitative NMR methods for characterization of unsubstituted and low degree of subst...

journal_title：Biomacromolecules

authors： King AWT,Mäkelä V,Kedzior SA,Laaksonen T,Partl GJ,Heikkinen S,Koskela H,Heikkinen HA,Holding AJ,Cranston ED,Kilpeläinen I

更新日期：2018-07-09 00:00:00

abstract：:Poly( n-butyl methacrylate) (PBMA) or poly( n-butyl acrylate) (PBA)-grafted brush coatings attached to glass were successfully prepared using atom-transfer radical polymerization "from the surface". The thicknesses and composition of the PBMA and PBA coatings were examined using ellipsometry and time-of-flight seconda...

journal_title：Biomacromolecules

authors： Awsiuk K,Stetsyshyn Y,Raczkowska J,Lishchynskyi O,Dąbczyński P,Kostruba A,Ohar H,Shymborska Y,Nastyshyn S,Budkowski A

更新日期：2019-06-10 00:00:00

abstract：:Biomaterials conceived for vectorization of bioactives are currently considered for biomedical, biological, and environmental applications. We have produced a pH-sensitive biomaterial composed of natural source alginate and chitosan polysaccharides for application as a drug delivery system via oral administration. The...

journal_title：Biomacromolecules

authors： Mathews PD,Fernandes Patta ACM,Gonçalves JV,Gama GDS,Garcia ITS,Mertins O

更新日期：2018-02-12 00:00:00

abstract：:This paper describes the synthesis and characterization of polymer-peptide conjugates to be used as infection-resistant coating for biomaterial implants and devices. Antiadhesive polymer brushes composed of block copolymer Pluronic F-127 (PF127) were functionalized with antimicrobial peptides (AMP), able to kill bacte...

journal_title：Biomacromolecules

authors： Muszanska AK,Rochford ET,Gruszka A,Bastian AA,Busscher HJ,Norde W,van der Mei HC,Herrmann A

更新日期：2014-06-09 00:00:00

abstract：:N-Acetyllactosamine (LacNAc; Galβ4GlcNAc) is a typical disaccharide ligand of galectins. The most abundant members of these human lectins, galectin-1 (Gal-1) and galectin-3 (Gal-3), participate in a number of pathologies including cancerogenesis and metastatic formation. In this study, we synthesized a series of fifte...

journal_title：Biomacromolecules

authors： Tavares MR,Bláhová M,Sedláková L,Elling L,Pelantová H,Konefał R,Etrych T,Křen V,Bojarová P,Chytil P

更新日期：2020-02-10 00:00:00

abstract：:A series of well-defined thermoresponsive diblock copolymers (PEO45-b-PtNEAn, n=22, 44, 63, 91, 172) were prepared by the atom transfer radical polymerization of trans-N-(2-ethoxy-1,3-dioxan-5-yl) acrylamide (tNEA) using a poly(ethylene oxide) (PEO45) macroinitiator. All copolymers are water-soluble at low temperature...

journal_title：Biomacromolecules

authors： Qiao ZY,Ji R,Huang XN,Du FS,Zhang R,Liang DH,Li ZC

更新日期：2013-05-13 00:00:00

abstract：:The molecular recognition features of a DNA-sensitive fluorescent bioconjugate capable of targeting a specific DNA sequence with high efficiency are described. The bioconjugate combines a polypeptide from the Tc3 transposase DNA-binding domain with the dsDNA-sensitive fluorophore thiazole orange. Fluorescence spectros...

journal_title：Biomacromolecules

authors： Thompson M

更新日期：2007-11-01 00:00:00

abstract：:Electrospinning of cellulose nanocrystals (CNC)/poly(lactic acid) (PLA) emulsions has been demonstrated to be an effective dispersion and alignment method to control assembly of CNC into continuous composite ultrafine fibers. CNC-PLA nanocomposite random-fiber mats and aligned-fiber yarns were prepared by emulsion ele...

journal_title：Biomacromolecules

authors： Li Y,Ko FK,Hamad WY

更新日期：2013-11-11 00:00:00

abstract：:The development of polymers that are both bactericidal and biocompatible would have many applications and are currently of research interest. Following the development of strongly bactericidal copolymers of 4-vinylpyridine and poly(ethylene glycol) methyl ether methacrylate, biocompatibility assays have been completed...

journal_title：Biomacromolecules

authors： Stratton TR,Howarter JA,Allison BC,Applegate BM,Youngblood JP

更新日期：2010-05-10 00:00:00