Antiadhesive polymer brush coating functionalized with antimicrobial and RGD peptides to reduce biofilm formation and enhance tissue integration.

abstract：:The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26-44% yield demonstrating the u...

journal_title：Biomacromolecules

authors： Eniade A,Ben RN

更新日期：2001-07-01 00:00:00

abstract：:For efficient reversal of multidrug resistance (MDR) in chemotherapy for breast cancer, multifunctional self-assembled nanoparticles (MSN) based on a new amphiphilic copolymer consisting of bioreducible poly[bis(2-hydroxylethyl)-disulfide-diacrylate-β-tetraethylenepentamine] and polycaprolactone (PBD-PCL) were constru...

journal_title：Biomacromolecules

authors： Yin Q,Shen J,Zhang Z,Yu H,Chen L,Gu W,Li Y

更新日期：2013-07-08 00:00:00

abstract：:We describe the synthesis of hydrophilic poly(poly(ethylene glycol) methyl ether methacrylate) (PmPEGMA) and hydrophobic poly(methyl methacrylate) (PMMA) caspofungin conjugates by a post-polymerization modification of copolymers containing 10 mol % pentafluorophenyl methacrylate (PFPMA), which were obtained via revers...

journal_title：Biomacromolecules

authors： Alex J,González K,Kindel T,Bellstedt P,Weber C,Heinekamp T,Orasch T,Guerrero-Sanchez C,Schubert US,Brakhage AA

更新日期：2020-06-08 00:00:00

abstract：:An appropriate modification technique for silk materials is needed to effectively improve their physical properties for specific applications. A telechelic-type polyalanine (T-polyA) was synthesized by papain-catalyzed polymerization as a novel reinforcing agent for silk materials. A silk fibroin obtained from Bombyx ...

journal_title：Biomacromolecules

authors： Tsuchiya K,Masunaga H,Numata K

更新日期：2017-03-13 00:00:00

abstract：:We show the first example of a synergic approach of oxidant (ROS) scavenging carrier and ROS-responsive drug release in the context of a potential therapy against osteoporosis, aiming to inhibit the differentiation of inflammatory cells into osteoclasts. In our "tandem" approach, a branched amphiphilic, PEGylated poly...

journal_title：Biomacromolecules

authors： El Mohtadi F,d'Arcy R,Burke J,Rios De La Rosa JM,Gennari A,Marotta R,Francini N,Donno R,Tirelli N

更新日期：2020-02-10 00:00:00

abstract：:Degradable polymers with specifically designed functionality have wide applications in biomedical fields. We reported herein the synthesis and characterization of a water-soluble and fast-degradable polycarbonate, functionalized with tertiary amine groups in the backbone. A novel cyclic carbonate monomer, namely, 6,14...

journal_title：Biomacromolecules

authors： Wang HF,Su W,Zhang C,Luo XH,Feng J

更新日期：2010-10-11 00:00:00

abstract：:Neutral cellulose nanocrystals dispersed in water were shown in a previous work to stabilize oil/water interfaces and produce Pickering emulsions with outstanding stability, whereas sulfated nanocrystals obtained from cotton did not show interfacial properties. To develop a better understanding of the stabilization me...

journal_title：Biomacromolecules

authors： Kalashnikova I,Bizot H,Cathala B,Capron I

更新日期：2012-01-09 00:00:00

abstract：:The intermolecular interactions of lignin with a hydrophilic polymer, poly(vinyl alcohol) (PVA), were studied using thermal analyses and FT-IR spectroscopy of a series of PVA/hardwood kraft lignin blend fibers prepared by thermal extrusion. Although two phases are observed in this blend system, some of the lignin was ...

journal_title：Biomacromolecules

authors： Kubo S,Kadla JF

更新日期：2003-05-01 00:00:00

abstract：:Electrically conductive hydrogel composites consisting of oligo(polyethylene glycol) fumarate (OPF) and polypyrrole (PPy) were developed for applications in nerve regeneration. OPF-PPy scaffolds were synthesized using three different anions: naphthalene-2-sulfonic acid sodium salt (NSA), dodecylbenzenesulfonic acid so...

journal_title：Biomacromolecules

authors： Runge MB,Dadsetan M,Baltrusaitis J,Ruesink T,Lu L,Windebank AJ,Yaszemski MJ

更新日期：2010-11-08 00:00:00

abstract：:Spider dragline silk exhibits an extraordinary toughness and is typically composed of two types of major ampullate spidroins (MaSp1 and MaSp2), differing in their proline content and hydrophobicity. In this paper, we recombinantly produced an unusual but naturally occurring short major ampullate spidroin (MaSp1s) as a...

journal_title：Biomacromolecules

authors： Thamm C,Scheibel T

更新日期：2017-04-10 00:00:00

abstract：:We report a facile method of generating ultradense poly(l-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) surface by using high temperature alone, which in turn provides dramatic improvement in resisting nonspecific bioadsorption. X-ray photoelectron spectroscopy (XPS) revealed that the surface graft density increased...

journal_title：Biomacromolecules

authors： Ogaki R,Zoffmann Andersen O,Jensen GV,Kolind K,Kraft DC,Pedersen JS,Foss M

更新日期：2012-11-12 00:00:00

abstract：:Covalently modified albumin (BSA) microparticles were developed for potential use as an adjuvant in mucosal vaccines against hepatitis B. To synthesize consistent protein particles, a covalent approach was proposed to modify BSA. Our strategy was to bond maleic anhydride (MA) molecules to BSA structure by nucleophilic...

journal_title：Biomacromolecules

authors： Sitta DL,Guilherme MR,Garcia FP,Cellet TS,Nakamura CV,Muniz EC,Rubira AF

更新日期：2013-09-09 00:00:00

abstract：:Enzyme-responsive polypeptide vesicles have attracted considerable attention for precision theranostics because of their biocompatibility, biodegradability, and unique secondary conformation transition triggered by the catalytic actions of enzymes. These promising potentials of polypeptide vesicles could be limited in...

journal_title：Biomacromolecules

authors： Duan W,Ji S,Guan Y,Mu X,Fang S,Lu Y,Zhou X,Sun J,Li Z

更新日期：2020-12-14 00:00:00

abstract：:The synthesis of quaternary ammonium (QA)-functionalized silica nanoparticles with and without nitric oxide (NO) release capabilities is described. Glycidyltrialkylammonium chlorides of varied alkyl chain lengths (i.e., methyl, butyl, octyl, and dodecyl) were tethered to the surface of amine-containing silica nanopart...

journal_title：Biomacromolecules

authors： Carpenter AW,Worley BV,Slomberg DL,Schoenfisch MH

更新日期：2012-10-08 00:00:00

abstract：:Glycogen is mainly found as the principal storage form of glucose in cells. Many bacteria are able to synthesize large amounts of glycogen under unfavorable life conditions. By combining infrared spectroscopy, single molecule force spectroscopy (SMFS) and immuno-staining technique, we evidenced that planktonic P. flu...

journal_title：Biomacromolecules

authors： Quilès F,Polyakov P,Humbert F,Francius G

更新日期：2012-07-09 00:00:00

abstract：:PolyHIPEs show great promise as tissue engineering scaffolds due to the tremendous control of pore size and interconnectivity afforded by this technique. Highly porous, fully biodegradable scaffolds were prepared by polymerization of the continuous phase of high internal phase emulsions (HIPEs) containing the macromer...

journal_title：Biomacromolecules

authors： Christenson EM,Soofi W,Holm JL,Cameron NR,Mikos AG

更新日期：2007-12-01 00:00:00

abstract：:Wheat arabinoxylan was treated with two α-arabinofuranosidases exhibiting different mode of action to create three different polymeric substrates. These three substrate preparations were characterized by xylopyranose backbone sugars that are (1) singly substituted by arabinose at C2 or C3, (2) doubly substituted by ar...

journal_title：Biomacromolecules

authors： Littunen K,Mai-Gisondi G,Seppälä J,Master ER

更新日期：2017-05-08 00:00:00

abstract：:Combining molecular weight distribution (MWD) data for linear chains of debranched starch from capillary electrophoresis and from size exclusion chromatography (SEC) with detection by differential refractive index and by multi-angle laser light scattering has enabled Mark-Houwink parameters to be determined for linear...

journal_title：Biomacromolecules

authors： Castro JV,Ward RM,Gilbert RG,Fitzgerald MA

更新日期：2005-07-01 00:00:00

abstract：:Recent findings suggest that visible light-promoted photooxidative processes mediated by sensitizers of appropriate chemical structure could represent a useful tool for properly addressing the problem of the increasing occurrence of infectious diseases caused by multiantibiotic-resistant microbial pathogens. The monoc...

journal_title：Biomacromolecules

authors： Ferro S,Jori G,Sortino S,Stancanelli R,Nikolov P,Tognon G,Ricchelli F,Mazzaglia A

更新日期：2009-09-14 00:00:00

abstract：:Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution ...

journal_title：Biomacromolecules

authors： Celli JP,Turner BS,Afdhal NH,Ewoldt RH,McKinley GH,Bansil R,Erramilli S

更新日期：2007-05-01 00:00:00

abstract：:A new synthetic route to beta-cyclodextrin-linked hyaluronic acid (HA-CD) was developed. This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a red...

journal_title：Biomacromolecules

authors： Charlot A,Heyraud A,Guenot P,Rinaudo M,Auzély-Velty R

更新日期：2006-03-01 00:00:00

abstract：:This work reports on the effect of CO2 at subcritical conditions and the gaseous state on the telechelic poly(epsilon-caprolactone) polymers. The tested polymers are semi-crystalline in nature and thus the effect of functional groups and their overall contribution to foaming and formation of microstructures with open-...

journal_title：Biomacromolecules

authors： Nawaby AV,Farah AA,Liao X,Pietro WJ,Day M

更新日期：2005-09-01 00:00:00

abstract：:Enzymatic glyco-modification of transparent cellulose films with lactose was achieved by nonaqueous biocatalysis, and rat hepatocyte attachment behavior to the lactose-modified cellulose films was investigated. Regenerated cellulose films were incubated with lactose using a surfactant-enveloped cellulase in lithium ch...

journal_title：Biomacromolecules

authors： Esaki K,Yokota S,Egusa S,Okutani Y,Ogawa Y,Kitaoka T,Goto M,Wariishi H

更新日期：2009-05-11 00:00:00

abstract：:We report structural and dynamical aspects of DNAs from various sources including synthetic oligonucleotides in bulk buffer and as a complex with histone1 (H1). High-resolution transmission electron microscopic (HRTEM) studies reveal the structural change of the DNAs upon complexation with H1 leading to formation of c...

journal_title：Biomacromolecules

authors： Sarkar R,Pal SK

更新日期：2007-11-01 00:00:00

abstract：:Hydrogel scaffolds are used in biomedicine to study cell differentiation and tissue evolution, where it is critical to control the delivery of chemical cues both spatially and temporally. While large molecules can be physically entrapped in a hydrogel, moderate molecular weight therapeutics must be tethered to the hyd...

journal_title：Biomacromolecules

authors： Griffin DR,Schlosser JL,Lam SF,Nguyen TH,Maynard HD,Kasko AM

更新日期：2013-04-08 00:00:00

abstract：:Hydrogel forming polysaccharides, such as the seaweed derived agarose, are well suited for wound dressing applications as they have excellent cell and soft tissue compatibility. For wound dressings, fibrous structure is desirable as the high surface area can favor adsorption of wound exudate and promote drug delivery....

journal_title：Biomacromolecules

authors： Forget A,Arya N,Randriantsilefisoa R,Miessmer F,Buck M,Ahmadi V,Jonas D,Blencowe A,Shastri VP

更新日期：2016-12-12 00:00:00

abstract：:We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a facile and versatile technology to prepare engineered nanocoatings for various biomedical applications. Low-fouling coatings on particles were obtained by the formation of multicomposition...

journal_title：Biomacromolecules

authors： Guntari SN,Wong EH,Goh TK,Chandrawati R,Blencowe A,Caruso F,Qiao GG

更新日期：2013-08-12 00:00:00

abstract：:Poly(ethylene glycol) (PEG) star polymers containing GRGDS (Gly-Arg-Gly-Asp-Ser) peptide sequences on the star periphery were synthesized by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) methyl ether methacrylate (PEGMA), GRGDS modified poly(ethylene glycol) acrylate (GRGDS-PEG-Acryl), fluoresce...

journal_title：Biomacromolecules

authors： Cho HY,Gao H,Srinivasan A,Hong J,Bencherif SA,Siegwart DJ,Paik HJ,Hollinger JO,Matyjaszewski K

更新日期：2010-09-13 00:00:00

abstract：:Biomimetic nanocomposites and scaffolds hold the key to a wide range of biomedical applications. Here we show, for the first time, a facile scheme of cofibrillizing pathogenic and functional amyloid fibrils via gold nanoparticles (AuNPs) and their applications against amyloidogenesis. This scheme was realized by β-she...

journal_title：Biomacromolecules

authors： Javed I,Sun Y,Adamcik J,Wang B,Kakinen A,Pilkington EH,Ding F,Mezzenga R,Davis TP,Ke PC

更新日期：2017-12-11 00:00:00

abstract：:The inferior in vivo stability of micellar drugs has been a prime challenge for their application in targeted drug delivery. Here we report on novel galactose-decorated covalently cross-linked biodegradable micelles based on photo-cross-linkable poly(ethylene glycol)-b-poly(acryloyl carbonate)-b-poly(ε-caprolactone) (...

journal_title：Biomacromolecules

authors： Yang R,Meng F,Ma S,Huang F,Liu H,Zhong Z

更新日期：2011-08-08 00:00:00