"Tandem" Nanomedicine Approach against Osteoclastogenesis: Polysulfide Micelles Synergically Scavenge ROS and Release Rapamycin.

abstract：:An artificial spinning system using regenerated silk fibroin solutions is adopted to produce high-performance silk fibers. In previous studies, alcohol-based agents, such as methanol or ethanol, were used to coagulate silk dope solutions, producing silk fiber with poor mechanical properties compared with those of nati...

journal_title：Biomacromolecules

authors： Yazawa K,Malay AD,Ifuku N,Ishii T,Masunaga H,Hikima T,Numata K

更新日期：2018-06-11 00:00:00

abstract：:Limited studies have been done on the interactions between subunits of self-assembling protein cages. E2 protein cage from Bacillus stearothermophilus was investigated in this work to impart pH-sensitive disassembly profile. Key amino acids were identified at the intratrimer and intertrimer interfaces, and histidine r...

journal_title：Biomacromolecules

authors： Peng T,Lim S

更新日期：2011-09-12 00:00:00

abstract：:The lack of selectivity and low solubility of many chemotherapeutics impels the development of different biocompatible nanosized drug carriers. Amphiphilic block copolymers, composed of a hydrophilic and hydrophobic domain, show great potential because of their small size, large solubilizing power and loading capacity...

journal_title：Biomacromolecules

authors： Kasmi S,Louage B,Nuhn L,Van Driessche A,Van Deun J,Karalic I,Risseeuw M,Van Calenbergh S,Hoogenboom R,De Rycke R,De Wever O,Hennink WE,De Geest BG

更新日期：2016-01-11 00:00:00

abstract：:This study presents an efficient and systematic approach to synthesize bioapplicable porous hollow polymeric capsules (HPCs). The hydroxyl-functionalized nanoporous polymers with hollow capsular shapes could be generated via the moderate Friedel-Crafts reaction without using any hard or soft template. The numerous pri...

journal_title：Biomacromolecules

authors： Song W,Zhang Y,Yu DG,Tran CH,Wang M,Varyambath A,Kim J,Kim I

更新日期：2020-12-17 00:00:00

abstract：:An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol-ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed ex...

journal_title：Biomacromolecules

authors： Han J,Chen Q,Shen Y,Liu Z,Hao X,Zhong M,Zhao Z,Bockstaller MR

更新日期：2020-09-14 00:00:00

abstract：:Reversible stereoselective complexes were spontaneously obtained from mixing acetonitrile solutions of enatiomeric d-poly(lactic acid) (d-PLA), l-poly(lactic acid) (l-PLA), and leuprolide, a l-configured nonapeptide LHRH analogue. The complex spontaneously aggregated and precipitated in high yields (>90%) from acetoni...

journal_title：Biomacromolecules

authors： Slager J,Domb AJ

更新日期：2003-09-01 00:00:00

abstract：:Poly(L-lactide)-based microspheres having cationic or anionic surfaces were prepared using polydepsipeptide-block-poly(L-lactide)s as surfactants. Polydepsipeptide-block-poly(L-lactide)s having amino or carboxylic acid groups on their side chains were synthesized through anionic ring-opening polymerizations of L-lacti...

journal_title：Biomacromolecules

authors： Ouchi T,Toyohara M,Arimura H,Ohya Y

更新日期：2002-09-01 00:00:00

abstract：:Synthetic lethality is a molecular-targeted therapy for selective killing of cancer cells. We exploited a lethal interaction between superoxide dismutase 1 inhibition and Bloom syndrome gene product (BLM) defect for the treatment of colorectal cancer (CRC) cells (HCT 116) with a customized lung cancer screen-1-loaded ...

journal_title：Biomacromolecules

authors： Gupta A,Ahmad A,Singh H,Kaur S,K M N,Ansari MM,Jayamurugan G,Khan R

更新日期：2018-03-12 00:00:00

abstract：:Introducing exogenous genes into plant cells is essential for a wide range of applications in agriculture and plant biotechnology fields. Cationic peptide carriers with cell-penetrating and DNA-binding domains successfully deliver exogenous genes into plants. However, their cell-penetrating activity may be attenuated ...

journal_title：Biomacromolecules

authors： Miyamoto T,Tsuchiya K,Numata K

更新日期：2019-02-11 00:00:00

abstract：:Highly cross-linked networks formed by the photoinitiated polymerization of multifunctional monomers are finding application in the field of biomaterials because of their chemical versatility, reaction control, and ability to polymerize under physiological conditions. Typically, degradation is introduced into these ne...

journal_title：Biomacromolecules

authors： Burdick JA,Lovestead TM,Anseth KS

更新日期：2003-01-01 00:00:00

abstract：:Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential to offer cures for previously untreatable diseases. However, they present an enormous delivery challenge due to poor absorption and rapid me...

journal_title：Biomacromolecules

authors： Iqbal S,Blenner M,Alexander-Bryant A,Larsen J

更新日期：2020-04-13 00:00:00

abstract：:A multiple targeted drug carrying bilayer membrane for preventing an abdominal adhesion is prepared by electrospinning. Two bioactive drugs were successfully incorporated into this bilayer membrane and can be independently released from nanofibrous scaffolds without losing structural integrity and functionality of the...

journal_title：Biomacromolecules

authors： Wang H,Li M,Hu J,Wang C,Xu S,Han CC

更新日期：2013-04-08 00:00:00

abstract：:The oxidation-responsive behaviors of OEGylated poly-L-cysteine homopolypeptides, that is, poly(L-EG(x)MA-C)n, were investigated. These poly-L-cysteine derivatives adopted mixed conformation in water, in which the β-sheet accounted for a significant proportion. Upon oxidation, the thioethers in polypeptide side chains...

journal_title：Biomacromolecules

authors： Fu X,Ma Y,Shen Y,Fu W,Li Z

更新日期：2014-03-10 00:00:00

abstract：:The electrospinning of polymer melts can offer an advantage over solution electrospinning, in the development of layered tissue constructs for tissue engineering. Melt electrospinning does not require a solvent, of which many are cytotoxic in nature, and the use of nonwater soluble polymers allows the collection of fi...

journal_title：Biomacromolecules

authors： Dalton PD,Klinkhammer K,Salber J,Klee D,Möller M

更新日期：2006-03-01 00:00:00

abstract：:In this work we describe the application of amphiphilic N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers as polymeric surfactants in miniemulsion techniques. HPMA-based copolymers with different ratios of HPMA (hydrophilic) to laurylmethacrylate (LMA; hydrophobic) units were synthesized by RAFT polymerization...

journal_title：Biomacromolecules

authors： Kelsch A,Tomcin S,Rausch K,Barz M,Mailänder V,Schmidt M,Landfester K,Zentel R

更新日期：2012-12-10 00:00:00

abstract：:Atomic force microscopy (AFM) was used to assess a new chimeric protein consisting of a fusion protein of the consensus repeat for Nephila clavipes spider dragline protein and bone sialoprotein (6mer+BSP). The elastic modulus of this protein in film form was assessed through force curves, and film surface roughness wa...

journal_title：Biomacromolecules

authors： Gomes S,Numata K,Leonor IB,Mano JF,Reis RL,Kaplan DL

更新日期：2011-05-09 00:00:00

abstract：:For efficient reversal of multidrug resistance (MDR) in chemotherapy for breast cancer, multifunctional self-assembled nanoparticles (MSN) based on a new amphiphilic copolymer consisting of bioreducible poly[bis(2-hydroxylethyl)-disulfide-diacrylate-β-tetraethylenepentamine] and polycaprolactone (PBD-PCL) were constru...

journal_title：Biomacromolecules

authors： Yin Q,Shen J,Zhang Z,Yu H,Chen L,Gu W,Li Y

更新日期：2013-07-08 00:00:00

abstract：:On the basis of their versatile structure and chemistry as well as tunable mechanical properties, polymer brushes are well-suited as supports for enzyme immobilization. However, a robust surface design is hindered by an inadequate understanding of the impact on activity from the coupling motif and enzyme distribution ...

journal_title：Biomacromolecules

authors： Lane SM,Kuang Z,Yom J,Arifuzzaman S,Genzer J,Farmer B,Naik R,Vaia RA

更新日期：2011-05-09 00:00:00

abstract：:The conformation of a single elastin-like peptide GVG(VPGVG)3 in liquid water is studied by computer simulations in the temperature interval between 280 and 440 K. Two main conformational states of the peptide can be distinguished: a rigid conformational state, dominating at low temperatures, and a flexible conformati...

journal_title：Biomacromolecules

authors： Krukau A,Brovchenko I,Geiger A

更新日期：2007-07-01 00:00:00

abstract：:Thanks to chemical stabilization, aldehyde-assisted fractionation (AAF) of lignocellulosic biomass has recently emerged as a powerful tool for the production of largely uncondensed lignin. Depolymerization of AAF lignin via ether cleavage provides aromatic monomers at near theoretical yields based on ether cleavage an...

journal_title：Biomacromolecules

authors： Vendamme R,Behaghel de Bueren J,Gracia-Vitoria J,Isnard F,Mulunda MM,Ortiz P,Wadekar M,Vanbroekhoven K,Wegmann C,Buser R,Héroguel F,Luterbacher JS,Eevers W

更新日期：2020-10-12 00:00:00

abstract：:Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer. Techniques such as interferometry, static light scattering (in batch or coupled on line with a chromatographic system), and...

journal_title：Biomacromolecules

authors： Schatz C,Viton C,Delair T,Pichot C,Domard A

更新日期：2003-05-01 00:00:00

abstract：:(1,3)(1,4)-β-D-Glucan (mixed-linkage glucan or MLG), a characteristic hemicellulose in primary cell walls of grasses, was investigated to determine both its role in cell walls and its interaction with cellulose and other cell wall polysaccharides in vitro. Binding isotherms showed that MLG adsorption onto microcrystal...

journal_title：Biomacromolecules

authors： Kiemle SN,Zhang X,Esker AR,Toriz G,Gatenholm P,Cosgrove DJ

更新日期：2014-05-12 00:00:00

abstract：:Recently antifreeze proteins (AFP) have been the subject of many structure-function relationship studies regarding their antifreeze activity. Attempts have been made to elucidate the structure-function relationship by various amino acid substitutions, but to our knowledge there has been no successful from first princi...

journal_title：Biomacromolecules

authors： Wierzbicki A,Knight CA,Rutland TJ,Muccio DD,Pybus BS,Sikes CS

更新日期：2000-07-01 00:00:00

abstract：:As a first step toward utilizing self-assembling peptide scaffolds to create tunable matrices for drug delivery, peptide RADAFI and RADAFII, containing the same amino acid composition but different positions of one phenylalanine residue, scaffolds were prepared for controlled release of chiral enantiomers. The release...

journal_title：Biomacromolecules

authors： Zhao Y,Tanaka M,Kinoshita T,Higuchi M,Tan T

更新日期：2009-12-14 00:00:00

abstract：:A systematic study is carried out to understand how physical and covalent crosslinks affect the mechanical properties of an eight-arm poly(ethyleneglycol)-based hydrogel. Heparin and heparin-binding peptide are used as a physical crosslinker, and an enzymatically cleavable peptide with a cysteine on each end serves as...

journal_title：Biomacromolecules

authors： Jeong KJ,Panitch A

更新日期：2009-05-11 00:00:00

abstract：:Poly(epsilon-caprolactone)/polylactide blend (PCL/PLA) is an interesting biomaterial because PCL and PLA present good complementarity in their physical properties and biodegradability. However, the thermodynamic incompatibility between two component polymers restricts further applications of their blend. In this work,...

journal_title：Biomacromolecules

authors： Wu D,Zhang Y,Zhang M,Yu W

更新日期：2009-02-09 00:00:00

abstract：:This paper describes the synthesis and cytotoxicity of poly(anhydride esters) that are composed of several salicylate derivatives, including halogenated salicylates, aminosalicylates, salicylsalicylic acid, and thiolsalicylic acid. The incorporation of these nonsteroidal antiinflammatory drugs (NSAIDs) into a biodegra...

journal_title：Biomacromolecules

authors： Schmeltzer RC,Schmalenberg KE,Uhrich KE

更新日期：2005-01-01 00:00:00

abstract：:The layer-by-layer technique has been used as a powerful method to produce multilayer thin films with tunable properties. When natural polymers are employed, complicated phenomena such as self-aggregation and fibrilogenesis can occur, making it more difficult to obtain and characterize high-quality films. The weak aci...

journal_title：Biomacromolecules

authors： de Moraes MA,Crouzier T,Rubner M,Beppu MM

更新日期：2015-01-12 00:00:00

abstract：:The mucilaginous viscin tissue within mistletoe berries possesses an extraordinary ability to be rapidly processed under ambient conditions into stiff cellulosic fibers (>14 GPa) through simple mechanical drawing. This rapid and extreme transformation process is hydration-dependent and involves an astonishing >200-fol...

journal_title：Biomacromolecules

authors： Horbelt N,Eder M,Bertinetti L,Fratzl P,Harrington MJ

更新日期：2019-08-12 00:00:00

abstract：:In this paper we extend our previous experimental work on interaction between polyelectrolytes and liposomes. First, the adsorption of chitosan and alkylated chitosan (cationic polyelectrolytes) with different alkyl chain lengths on lipid membranes of liposomes is examined. The amount of both chitosans adsorbed remain...

journal_title：Biomacromolecules

authors： Quemeneur F,Rinaudo M,Pépin-Donat B

更新日期：2008-08-01 00:00:00