Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications.

abstract：:Dragline silk from orb-weaving spiders is a copolymer of two large proteins, major ampullate spidroin 1 (MaSp1) and 2 (MaSp2). The ratio of these proteins is known to have a large variation across different species of orb-weaving spiders. NMR results from gland material of two different species of spiders, N. clavipe...

journal_title：Biomacromolecules

authors： An B,Jenkins JE,Sampath S,Holland GP,Hinman M,Yarger JL,Lewis R

更新日期：2012-12-10 00:00:00

abstract：:Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer. Techniques such as interferometry, static light scattering (in batch or coupled on line with a chromatographic system), and...

journal_title：Biomacromolecules

authors： Schatz C,Viton C,Delair T,Pichot C,Domard A

更新日期：2003-05-01 00:00:00

abstract：:The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials. In this study, we explored the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow eva...

journal_title：Biomacromolecules

authors： Walters CM,Boott CE,Nguyen TD,Hamad WY,MacLachlan MJ

更新日期：2020-03-09 00:00:00

abstract：:The viscous mucus coating that adheres to the epithelial surfaces of mammalian organs provides protection for the underlying tissues and is an efficient barrier to drug delivery. Pulsed-gradient spin-echo NMR and small-angle neutron scattering have been used to study the aqueous solution interaction of various model p...

journal_title：Biomacromolecules

authors： Griffiths PC,Occhipinti P,Morris C,Heenan RK,King SM,Gumbleton M

更新日期：2010-01-11 00:00:00

abstract：:Recently, some attempts have been made to enhance the gas barrier properties of semicrystalline polymers by precisely controlling the arrangement of their impermeable crystalline lamellae. However, it is still a great challenge to achieve regular arrangement of the lamellae along the direction perpendicular to the gas...

journal_title：Biomacromolecules

authors： Bai H,Huang C,Xiu H,Zhang Q,Deng H,Wang K,Chen F,Fu Q

更新日期：2014-04-14 00:00:00

abstract：:Bone fractures constitute a major cause of morbidity and mortality especially in the elderly. Complications associated with osteoporosis drugs and the age of the patient slow bone turnover and render such fractures difficult to heal. Increasing the speed of fracture repair by administration of a fracture-targeted bone...

journal_title：Biomacromolecules

authors： Low SA,Galliford CV,Yang J,Low PS,Kopeček J

更新日期：2015-10-12 00:00:00

abstract：:Synthetic and natural mucoadhesive biomaterials in optimized galenical formulations are potentially useful for the transmucosal delivery of active ingredients to improve their localized and prolonged effects. Chitosans (CS) have potent mucoadhesive characteristics, but the exact mechanisms underpinning such interactio...

journal_title：Biomacromolecules

authors： Menchicchi B,Fuenzalida JP,Bobbili KB,Hensel A,Swamy MJ,Goycoolea FM

更新日期：2014-10-13 00:00:00

abstract：:Nearly monodispersed silica nanoparticles having a controlled size from 5 to 450 nm were synthesized via a sol-gel process, and then the optimum conditions for the surface treatment of the synthesized silica nanoparticles with a silane coupling agent (i.e., 3-methacryloxypropyltrimethoxysilane (gamma-MPS)) were explor...

journal_title：Biomacromolecules

authors： Kim JW,Kim LU,Kim CK

更新日期：2007-01-01 00:00:00

abstract：:Biofilm formation, in which bacteria are embedded within an extracellular matrix, is the default form of microbial life in most natural and engineered habitats. In this work, atomistic molecular dynamics simulations were employed to examine the self-assembly of the polysaccharide Granulan to provide insight into the m...

journal_title：Biomacromolecules

authors： Seviour T,Malde AK,Kjelleberg S,Yuan Z,Mark AE

更新日期：2012-06-11 00:00:00

abstract：:Visible light-induced hydrogelation is attractive for various biomedical applications. In this study, hydrogels of alginate with phenolic hydroxyl groups (Alg-Ph) were obtained by irradiating a solution containing the polymer, ruthenium II trisbipyridyl chloride ([Ru(bpy)3]2+) and sodium persulfate (SPS), with visible...

journal_title：Biomacromolecules

authors： Sakai S,Kamei H,Mori T,Hotta T,Ohi H,Nakahata M,Taya M

更新日期：2018-02-12 00:00:00

abstract：:DC and AC electrical conductivity of bionanocomposites based on the immiscible polymer blend poly(epsilon-caprolactone)/polylactide (PCL/PLA, w/w 70/30), loaded with multiwall carbon nanotubes (CNT), were studied in a wide frequency range, 10(-3) < or = f < or = 10(7) Hz from 143 to 313 K. The nanofiller concentration...

journal_title：Biomacromolecules

authors： Laredo E,Grimau M,Bello A,Wu DF,Zhang YS,Lin DP

更新日期：2010-05-10 00:00:00

abstract：:A novel pH and temperature sensitive block copolymer was prepared by adding pH sensitive moiety to temperature sensitive block copolymer. This block copolymer solution showed a reversible sol-gel transition by a small pH change in the range of pH 7.4-8.0 and also by the temperature change in the region of body tempera...

journal_title：Biomacromolecules

authors： Shim WS,Yoo JS,Bae YH,Lee DS

更新日期：2005-11-01 00:00:00

abstract：:l-Proline is the only, out of 20 essential, amino acid that contains a cyclized substituted α-amino group (is formally an imino acid), which restricts its conformational shape. The synthesis of well-defined homo- and copolymers of l-proline has been plagued either by the low purity of the monomer or the inability of m...

journal_title：Biomacromolecules

authors： Gkikas M,Iatrou H,Thomaidis NS,Alexandridis P,Hadjichristidis N

更新日期：2011-06-13 00:00:00

abstract：:One of the major drawbacks found in most bone tissue engineering approaches developed so far consists in the lack of strategies to promote vascularisation. Some studies have addressed different issues that may enhance vascularisation in tissue engineered constructs, most of them involving the use of growth factors (GF...

journal_title：Biomacromolecules

authors： Santo VE,Frias AM,Carida M,Cancedda R,Gomes ME,Mano JF,Reis RL

更新日期：2009-06-08 00:00:00

abstract：:In this work we describe the application of amphiphilic N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers as polymeric surfactants in miniemulsion techniques. HPMA-based copolymers with different ratios of HPMA (hydrophilic) to laurylmethacrylate (LMA; hydrophobic) units were synthesized by RAFT polymerization...

journal_title：Biomacromolecules

authors： Kelsch A,Tomcin S,Rausch K,Barz M,Mailänder V,Schmidt M,Landfester K,Zentel R

更新日期：2012-12-10 00:00:00

abstract：:The aggregation of meso-tetra(4-sulfonatophenyl)porphyrin (H(2)TPPS(4-)) in phosphate solutions was investigated as a function of pH, concentration, time, ionic strength, and solution preparation (either from dilution of a freshly prepared 2 mM stock or by direct preparation of μM solution concentrations) using a comb...

journal_title：Biomacromolecules

authors： Hollingsworth JV,Richard AJ,Vicente MG,Russo PS

更新日期：2012-01-09 00:00:00

abstract：:In situ forming reduction-sensitive degradable nanogels were designed and developed based on poly(ethylene glycol)-b-poly(2-(hydroxyethyl) methacrylate-co-acryloyl carbonate) (PEG-P(HEMA-co-AC)) block copolymers for efficient loading as well as triggered intracellular release of proteins. PEG-P(HEMA-co-AC) copolymers ...

journal_title：Biomacromolecules

authors： Chen W,Zheng M,Meng F,Cheng R,Deng C,Feijen J,Zhong Z

更新日期：2013-04-08 00:00:00

abstract：:The structure of three types of liposomes (egg yolk phosphatidylcholine (EPC) without modification and EPC vesicles containing cross-linked N-isopropylacrylamide (NIPAM) networks of low and a high concentration inside the vesicles) were analyzed by static and dynamic light scattering. Upon polymerization the network w...

journal_title：Biomacromolecules

authors： Stauch O,Schubert R,Savin G,Burchard W

更新日期：2002-05-01 00:00:00

abstract：:Electrospun biopolyelectrolyte nanofibers hold potential for use in a range of biomedical applications, but eliminating toxic chemicals involved in their production remains a key challenge. In this study, we successfully electrospun nanofibers from an aqueous complex coacervate solution composed of chitosan and hyalur...

journal_title：Biomacromolecules

authors： Sun J,Perry SL,Schiffman JD

更新日期：2019-11-11 00:00:00

abstract：:This study investigated the impact of the protein adsorption mechanism(s) on the efficiency of thermally controlled cell adhesion and release from poly(N-isopropyl acrylamide) brushes. Large format polymer gradients were used to screen for grafting densities and substrate chemistries that alter both cell adhesion at 3...

journal_title：Biomacromolecules

authors： Choi S,Choi BC,Xue C,Leckband D

更新日期：2013-01-14 00:00:00

abstract：:The SEC-MALS-QELS (size-exclusion chromatography equipped with multiangle light scattering and quasi-elastic light scattering detectors) method using lithium chloride/N,N-dimethylacetamide (LiCl/DMAc) and LiCl/1,3-dimethyl-2-imidazolidinone (LiCl/DMI) as mobile phases was applied to cellulose and cellulose tricarbanil...

journal_title：Biomacromolecules

authors： Yanagisawa M,Isogai A

更新日期：2005-05-01 00:00:00

abstract：:Binding human serum albumin (HSA) of three polyoxometalates (POMs) with the Wells-Dawson structure, alpha(2)-[P2W17O61]10- (abbreviated as alpha(2)-P2W17) and two of its metal-substituted derivatives, alpha(2)-[NiP2W17O61]8- and alpha(2)-[CuP2W17O61]8- (alpha(2)-P2W17Ni and alpha(2)-P2W17Cu, respectively) was studied ...

journal_title：Biomacromolecules

authors： Zhang G,Keita B,Craescu CT,Miron S,de Oliveira P,Nadjo L

更新日期：2008-03-01 00:00:00

abstract：:A series of poly(vinyl alcohol) amphiphilic derivatives have been prepared to obtain polymeric aggregates in aqueous phase holding thermodynamic instability. The aim was to evaluate their ability to interact with tumor cells eliciting selective cytotoxicity. The poly(vinyl alcohol) derivatives were prepared by partial...

journal_title：Biomacromolecules

authors： Orienti I,Zuccari G,Carosio R,Montaldo PG

更新日期：2005-09-01 00:00:00

abstract：:The average pore size of hydrated dextran microspheres is derived from rheological and protein release data. The microspheres were prepared by cross-linking an aqueous solution of methacrylated dextran emulsified in a continuous poly(ethylene glycol) phase. The rheological data were obtained using a novel micromanipul...

journal_title：Biomacromolecules

authors： Stenekes RJ,De Smedt SC,Demeester J,Sun G,Zhang Z,Hennink WE

更新日期：2000-01-01 00:00:00

abstract：:Bioresponsive poly(amidoamine)s (PAA)s are currently under development as endosomolytic polymers for intracellular delivery of proteins and genes. Here for the first time, small-angle neutron scattering (SANS) is used to systematically investigate the pH-dependent conformational change of an endosomolytic polymer, the...

journal_title：Biomacromolecules

authors： Griffiths PC,Paul A,Khayat Z,Wan KW,King SM,Grillo I,Schweins R,Ferruti P,Franchini J,Duncan R

更新日期：2004-07-01 00:00:00

abstract：:The present study focuses on the formation of microcapsules containing catalytically active L-asparaginase (L-ASNase), a protein drug of high value in antileukemic therapy. We make use of the layer-by-layer (LbL) technique to coat protein-loaded calcium carbonate (CaCO3) particles with two or three poly dextran/poly-L...

journal_title：Biomacromolecules

authors： Karamitros CS,Yashchenok AM,Möhwald H,Skirtach AG,Konrad M

更新日期：2013-12-09 00:00:00

abstract：:Agmatine-containing bioreducible polymer, poly(cystaminebis(acrylamide)-agmatine) (poly(CBA-AG)) was synthesized for gene delivery systems. It could form 200-300 nm sized and positively charged polyplexes with pDNA, which could release pDNA in reducing the environment due to the internal disulfide bonds cleavage. Poly...

journal_title：Biomacromolecules

authors： Choi JY,Ryu K,Lee GJ,Kim K,Kim TI

更新日期：2015-09-14 00:00:00

abstract：:Single-molecule measurements of the interaction of leukocyte function-associated antigen-1 (LFA-1), expressed on Jurkat T cells, with intercellular adhesion molecules-1 and -2 (ICAM-1 and ICAM-2) were conducted using atomic force microscopy (AFM). The force spectra (i.e., unbinding force versus loading rate) of both t...

journal_title：Biomacromolecules

authors： Wojcikiewicz EP,Abdulreda MH,Zhang X,Moy VT

更新日期：2006-11-01 00:00:00

abstract：:Coniferyl alcohol was polymerized in pectin solution in order to mimic the lignification that is the final step of biosynthesis of plant cell wall. Dehydrogenated polymers (DHP = coniferyl alcohol polymers = synthetic lignin) interact with pectin to form hydrophobic clusters as monitored by pyrene fluorescence spectro...

journal_title：Biomacromolecules

authors： Lairez D,Cathala B,Monties B,Bedos-Belval F,Duran H,Gorrichon L

更新日期：2005-03-01 00:00:00

abstract：:As a programmable biopolymer, DNA has shown great potential in the fabrication and construction of nanometer-scale assemblies and devices. In this report, we described a strategy for efficient manipulation of gold nanoparticle-bound DNA using restriction endonuclease. The digestion efficiency of this restriction enzym...

journal_title：Biomacromolecules

authors： Qin WJ,Yung LY

更新日期：2006-11-01 00:00:00