当前位置： SCI文献检索 > BIOMACROMOLECULES期刊下所有文献 > Preparation and evaluation of polyvinyl alcohol-co-oleylvinyl ether derivatives as tumor-specific cytotoxic systems.

Preparation and evaluation of polyvinyl alcohol-co-oleylvinyl ether derivatives as tumor-specific cytotoxic systems.

Abstract：

:A series of poly(vinyl alcohol) amphiphilic derivatives have been prepared to obtain polymeric aggregates in aqueous phase holding thermodynamic instability. The aim was to evaluate their ability to interact with tumor cells eliciting selective cytotoxicity. The poly(vinyl alcohol) derivatives were prepared by partial substitution of poly(vinyl alcohol) (MW 10 kDa) with both oleyl chains and poly(ethylene glycol) monoethyl ethers (PEGMEE) of different molecular weights. The substitution degree was 1.5% for the oleyl chains and 1% for the PEGMEE chains (moles of substituent per 100 mol of hydroxyvinyl monomer). The polyvinyl derivatives obtained easily dissolved in water. Dynamic and static light scattering measurements on the polymer aqueous solutions indicated the formation of polymeric aggregates characterized by low polydispersity (0.232-0.299) and mean size (218-382 nm) in the range suitable for intravenous administration. Moreover, they were characterized by different packing densities and thermodynamic instabilities driving the polymers to interact with hydrophobic membranes. Among the analyzed polymers, the poly(vinyl alcohol)-co-oleylvinyl ether substituted with triethylene glycol monoethyl ether (P10(4)) provided in solution the highest affinity for hydrophobic membranes. P10(4), moreover, was the most cytotoxic toward the tumor cell lines analyzed (neuroblastoma: SH-SY5Y, IMR-32, HTLA-230. melanoma: MZ2-MEL, RPMI7932.), while it did not appreciably alter the viability of the normal resting lymphocytes. The peculiar behavior of the P10(4) aggregates has been correlated to their high thermodynamic instability in solution due to the high packing density that triggers the polymeric aggregates to interact with hydrophobic membranes such as the tumor cell membranes, thus eliciting cytotoxicity.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Orienti I,Zuccari G,Carosio R,Montaldo PG

doi

10.1021/bm0504328

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

2875-80

issue

5

eissn

1525-7797

issn

1526-4602

journal_volume

6

pub_type

杂志文章

相关文献

BIOMACROMOLECULES文献大全
  • DNA is wrapped by the nuclear aggregates of polyamines: the imaging evidence.

    abstract：:In the cell nucleus, putrescine, spermidine, and spermine self-assemble with phosphate ions to generate three forms of compounds, named nuclear aggregates of polyamines (NAPs), which may interact with DNA. In an in vitro setting mimicking the cell nucleus milieu, this molecular aggregation occurs within well-defined r...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm101478j

    authors： Iacomino G,Picariello G,Sbrana F,Di Luccia A,Raiteri R,D'Agostino L

    更新日期：2011-04-11 00:00:00

  • Control of cell cultivation and cell sheet detachment on the surface of polymer/clay nanocomposite hydrogels.

    abstract：:Cell cultivation on the surface of a novel poly(N-isopropylacrylamide) (PNIPA) hydrogel (N-NC gel), consisting of a specific type of organic (PNIPA)/inorganic (clay) network, was studied using three cell types; HepG2 human hepatoma cells, human dermal fibroblasts, and human umbilical vein endothelial cells. For the fi...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm060549b

    authors： Haraguchi K,Takehisa T,Ebato M

    更新日期：2006-11-01 00:00:00

  • Stereocomplex formation by enantiomeric poly(lactic acid) graft-type phospholipid polymers for tissue engineering.

    abstract：:A porous scaffold as a cell-compatible material was designed and prepared using a phospholipid copolymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate, and enantiomeric macromonomers, the poly(L-lactic acid) (PLLA) macromonomer, and poly(D-lactic acid) (PDLA) macromonomer. On the bas...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm025586r

    authors： Watanabe J,Eriguchi T,Ishihara K

    更新日期：2002-09-01 00:00:00

  • Synthesis and characterization of bionanocomposites with tunable properties from poly(lactic acid) and acetylated microfibrillated cellulose.

    abstract：:In the present study, novel bionanocomposite materials with tunable properties were successfully prepared using a poly(lactic acid) (PLA) matrix and acetylated microfibrillated cellulose (MFC) as reinforcing agent. The acetylation of MFC was confirmed by FTIR and (13)C CP-MAS NMR spectroscopies. The grafting of acetyl...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm901186u

    authors： Tingaut P,Zimmermann T,Lopez-Suevos F

    更新日期：2010-02-08 00:00:00

  • Candida antarctica lipase B chemically immobilized on epoxy-activated micro- and nanobeads: catalysts for polyester synthesis.

    abstract：:Candida antarctica Lipase B (CALB) was covalently immobilized onto epoxy-activated macroporous poly(methyl methacrylate) Amberzyme beads (235 microm particle size, 220 A pore size) and nanoparticles (nanoPSG, diameter 68 nm) with a poly(glycidyl methacrylate) outer region. Amberzyme beads allowed CALB loading up to 0....

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm700949x

    authors： Chen B,Hu J,Miller EM,Xie W,Cai M,Gross RA

    更新日期：2008-02-01 00:00:00

  • Contrasting biofunctionalization strategies for the enhanced endothelialization of biodegradable vascular grafts.

    abstract：:Surface modification of biodegradable vascular grafts is an important strategy to improve the in situ endothelialization of tissue engineered vascular grafts (TEVGs) and prevent major complications associated with current synthetic grafts. Important strategies for improving endothelialization include increasing endoth...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm501853s

    authors： Melchiorri AJ,Hibino N,Yi T,Lee YU,Sugiura T,Tara S,Shinoka T,Breuer C,Fisher JP

    更新日期：2015-02-09 00:00:00

  • Formation of a novel heparin-based hydrogel in the presence of heparin-binding biomolecules.

    abstract：:An injectable, heparin-based hydrogel system with the potential to be gelled with cells was developed. First, heparin was modified to have thiol groups by the modification of carboxylic groups of heparin with cysteamine using carbodiimide chemistry. Thiol functionalization of heparin carboxylic groups was controlled f...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm0701189

    authors： Tae G,Kim YJ,Choi WI,Kim M,Stayton PS,Hoffman AS

    更新日期：2007-06-01 00:00:00

  • Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells.

    abstract：:Synthetic lethality is a molecular-targeted therapy for selective killing of cancer cells. We exploited a lethal interaction between superoxide dismutase 1 inhibition and Bloom syndrome gene product (BLM) defect for the treatment of colorectal cancer (CRC) cells (HCT 116) with a customized lung cancer screen-1-loaded ...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.7b01607

    authors： Gupta A,Ahmad A,Singh H,Kaur S,K M N,Ansari MM,Jayamurugan G,Khan R

    更新日期：2018-03-12 00:00:00

  • Nanometer to millimeter scale peptide-porphyrin materials.

    abstract：:AQ-Pal14 is a 30-residue polypeptide that was designed to form an α-helical coiled coil that contains a metal-binding 4-pyridylalanine residue on its solvent-exposed surface. However, characterization of this peptide shows that it exists as a three-stranded coiled coil, not a two-stranded one as predicted from its des...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm100540t

    authors： Zaytsev DV,Xie F,Mukherjee M,Bludin A,Demeler B,Breece RM,Tierney DL,Ogawa MY

    更新日期：2010-10-11 00:00:00

  • Toroidal Packaging of pDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression.

    abstract：:Selectively spooling single plasmid DNA (pDNA), as a giant polyelectrolyte, into a nanosized toroidal structure or folding it into a rod-like structure has been accomplished by polyion complexation with block catiomers to form polymeric micelles in varying NaCl concentrations. The interactive potency between the pDNA ...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.5b00491

    authors： Li Y,Osada K,Chen Q,Tockary TA,Dirisala A,Takeda KM,Uchida S,Nagata K,Itaka K,Kataoka K

    更新日期：2015-09-14 00:00:00

  • Swelling and mechanical properties of biopolymer hydrogels containing chitosan and bovine serum albumin.

    abstract：:Experimental and theoretical investigations of the swelling and mechanical properties of hydrogels formed from chitosan, bovine serum albumin (BSA), and chitosan/BSA mixtures cross-linked with genipin were performed. The properties of cross-linked chitosan hydrogels were explained in terms of its polyelectrolyte behav...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm060133y

    authors： Butler MF,Clark AH,Adams S

    更新日期：2006-11-01 00:00:00

  • Direct amidation of poly(gamma-glutamic acid) with benzylamine in dimethyl sulfoxide.

    abstract：:Partially benzylamidated, amphipathic poly(gamma-glutamic acid) (BzPGA) was synthesized from poly(gamma-glutamic acid) (PGA) and benzylamine by direct amidation in dimethyl sulfoxide (DMSO). Benzylamine and PGA were heated in DMSO for 1 to 26 h at temperatures between 110 and 130 degrees C, producing derivatives of va...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm0612182

    authors： Novak L,Banyai I,Fleischer-Radu JE,Borbély J

    更新日期：2007-05-01 00:00:00

  • Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice.

    abstract：:A polyethylene glycol (PEG) retinylamine (Ret-NH2) conjugate PEG-GFL-NH-Ret with a glycine-phenylalanine-leucine (GFL) spacer was synthesized for controlled oral delivery of Ret-NH2 to treat retinal degenerative diseases, including Stargardt disease (STGD) and age-related macular degeneration (AMD). The peptide spacer...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm501352s

    authors： Yu G,Wu X,Ayat N,Maeda A,Gao SQ,Golczak M,Palczewski K,Lu ZR

    更新日期：2014-12-08 00:00:00

  • An Efficient, Regioselective Pathway to Cationic and Zwitterionic N-Heterocyclic Cellulose Ionomers.

    abstract：:Cationic derivatives of cellulose and other polysaccharides are attractive targets for biomedical applications due to their propensity for electrostatically binding with anionic biomolecules, such as nucleic acids and certain proteins. To date, however, relatively few practical synthetic methods have been described fo...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.5b01416

    authors： Liu S,Liu J,Esker AR,Edgar KJ

    更新日期：2016-02-08 00:00:00

  • Ionic Polypeptide Polymers with Unusual β-Sheet Stability.

    abstract：:Incorporating charged amino acid side chains in polypeptide polymer backbones to improve solubility usually leads to reduced secondary structuring. Here we show that highly water soluble (>15 mg.mL-1) β-sheets can be obtained via nucleotide monophosphate grafting onto simple poly(γ-propargyl- L-glutamate) backbone. Th...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.8b01084

    authors： Nguyen M,Stigliani JL,Bijani C,Verhaeghe P,Pratviel G,Bonduelle C

    更新日期：2018-10-08 00:00:00

  • The unique ribbon morphology of the major ampullate silk of spiders from the genus Loxosceles (recluse spiders).

    abstract：:The morphology of silk produced by recluse spiders (Loxosceles arizonica) was investigated by scanning electron microscopy, atomic force microscopy, and transmission electron microscopy. This silk consisted entirely of very long, thin ribbons of width 2-4 microm and thicknesses of no more than 40 nm. The correspondenc...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm010108m

    authors： Coddington JA,Chanzy HD,Jackson CL,Raty G,Gardner KH

    更新日期：2002-01-01 00:00:00

  • Effect of pH on protein distribution in electrospun PVA/BSA composite nanofibers.

    abstract：:We examine the protein distribution within an electrospun polymer nanofiber using polyvinyl alcohol and bovine serum albumin as a model system. We hypothesize that the location of the protein within the nanofiber can be controlled by carefully selecting the pH and the applied polarity of the electric field as the pH a...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm2017146

    authors： Tang C,Ozcam AE,Stout B,Khan SA

    更新日期：2012-05-14 00:00:00

  • Polysaccharide-coated thermosets for orthopedic applications: from material characterization to in vivo tests.

    abstract：:The long-term stability and success of orthopedic implants depend on the osseointegration process, which is strongly influenced by the biomaterial surface. A promising approach to enhance implant integration involves the modification of the surface of the implant by means of polymers that mimic the natural components ...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm3002683

    authors： Travan A,Marsich E,Donati I,Foulc MP,Moritz N,Aro HT,Paoletti S

    更新日期：2012-05-14 00:00:00

  • Alterations in mucus barrier function and matrix structure induced by guluronate oligomers.

    abstract：:The effect of guluronate oligomers on the barrier properties of mucous matrices was investigated in terms of the mobility of nanoparticles in mucous matrices by fluorescence recovery after photobleaching (FRAP), cellular uptake of nanoparticles in mucus secreting cells (HT29-MTX), and mucin matrix architecture by scan...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm500464b

    authors： Nordgård CT,Nonstad U,Olderøy MØ,Espevik T,Draget KI

    更新日期：2014-06-09 00:00:00

  • Polymeric Materials for Eye Surface and Intraocular Applications.

    abstract：:Ocular applications of polymeric materials have been widely investigated for medical diagnostics, treatment, and vision improvement. The human eye is a vital organ that connects us to the outside world so when the eye is injured, infected, or impaired, it needs immediate medical treatment to maintain clear vision and ...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.0c01525

    authors： Karayilan M,Clamen L,Becker ML

    更新日期：2021-01-06 00:00:00

  • Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: synthesis, characterization, and dual nuclear/optical imaging.

    abstract：:We report the synthesis of PEG-coated, core-cross-linked polymeric micelles (CCPMs) derived from an amine-terminated amphiphilic block copolymer, poly(PEG-methacrylate)-b-poly(triethoxysilyl propylmethacrylate). The block copolymer self-assembled to form micellar nanoparticles, and a Cy-7-like near-infrared fluorescen...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm7005399

    authors： Yang Z,Zheng S,Harrison WJ,Harder J,Wen X,Gelovani JG,Qiao A,Li C

    更新日期：2007-11-01 00:00:00

  • Collagenase-labile polyurethane urea synthesis and processing into hollow fiber membranes.

    abstract：:As a means to stimulate wound healing, a hollow fiber membrane system might be placed within a wound bed to provide local and externally regulated controlled delivery of regenerative factors. After sufficient healing, it would be desirable to triggerably degrade these fibers as opposed to pulling them out. Accordingly...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm500552f

    authors： Fu HL,Hong Y,Little SR,Wagner WR

    更新日期：2014-08-11 00:00:00

  • Solid-state NMR analysis of a peptide (Gly-Pro-Gly-Gly-Ala)6-Gly derived from a flagelliform silk sequence of Nephila clavipes.

    abstract：:Solid-state NMR is especially useful when the structures of peptides and proteins should be analyzed by taking into account the structural distribution, that is, the distribution of the torsion angle of the individual residue. In this study, two-dimensional spin-diffusion solid-state NMR spectra of 13C-double-labeled ...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm0600522

    authors： Ohgo K,Kawase T,Ashida J,Asakura T

    更新日期：2006-04-01 00:00:00

  • Synthesis of adhesive peptides similar to those found in blue mussel (Mytilus edulis) using papain and tyrosinase.

    abstract：:The blue mussel (Mytilus edulis) foot protein 5 (Mefp-5) is an adhesive protein that is mainly composed of glycine, l-lysine, and 3,4-dihydroxy-l-phenylalanine (DOPA). Thousands of adhesive pads have been analyzed in previous studies, whereby it has been found that adhesion is largely achieved by the redox-chemistry o...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm5009052

    authors： Numata K,Baker PJ

    更新日期：2014-08-11 00:00:00

  • Hemocompatible poly(NIPAm-MBA-AMPS) colloidal nanoparticles as carriers of anti-inflammatory cell penetrating peptides.

    abstract：:Anionic copolymer systems containing sulfated monomers have great potential for delivery of cationic therapeutics, but N-isopropylacrylamide (NIPAm) 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) copolymer nanoparticles have seen limited characterization to date with regard to physical properties relevant to load...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm300173x

    authors： Bartlett RL 2nd,Medow MR,Panitch A,Seal B

    更新日期：2012-04-09 00:00:00

  • Heterostereocomplexes prepared from d-PLA and l-PLA and leuprolide. II. Release of leuprolide.

    abstract：:Reversible stereoselective complexes were spontaneously obtained from mixing acetonitrile solutions of enatiomeric d-poly(lactic acid) (d-PLA), l-poly(lactic acid) (l-PLA), and leuprolide, a l-configured nonapeptide LHRH analogue. The complex spontaneously aggregated and precipitated in high yields (>90%) from acetoni...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm0300249

    authors： Slager J,Domb AJ

    更新日期：2003-09-01 00:00:00

  • Biodendrimer-based hydrogel scaffolds for cartilage tissue repair.

    abstract：:Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized for in situ formation of hydrated, mechanically stable, and well-integrated hydrogel scaffolds supporting chondrocytes and chondrogenesis. We designed and synthesize...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm050663e

    authors： Söntjens SH,Nettles DL,Carnahan MA,Setton LA,Grinstaff MW

    更新日期：2006-01-01 00:00:00

  • Analysis using a linear viscoelastic model of the in vitro osmotic kinetics of polydisperse synthetic colloids.

    abstract：:This study clarifies the contribution to overall osmotic kinetics of colloid osmotic pressure (Pi) and the interaction of synthetic colloids with the membrane. Solutions (6%) of dextran with weight average molecular weight (MW(w)) 68 800 (DEX 70), dextran with MW(w) 40 000 (DEX 40), hydroxyethyl starch with MW(w) 70 0...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm0500143

    authors： Tatara T,Tashiro C

    更新日期：2005-05-01 00:00:00

  • PEG-peptide conjugates.

    abstract：:The remarkable diversity of the self-assembly behavior of PEG-peptides is reviewed, including self-assemblies formed by PEG-peptides with β-sheet and α-helical (coiled-coil) peptide sequences. The modes of self-assembly in solution and in the solid state are discussed. Additionally, applications in bionanotechnology a...

    journal_title：Biomacromolecules

    pub_type： 杂志文章,评审

    doi：10.1021/bm500246w

    authors： Hamley IW

    更新日期：2014-05-12 00:00:00

  • Injectable microgel-hydrogel composites for prolonged small-molecule drug delivery.

    abstract：:The design and application of soft nanocomposite injectable hydrogels containing entrapped microgels for small-molecule drug delivery is demonstrated. Copolymer microgels based on N-isopropylacrylamide and acrylic acid were synthesized that exhibited both ionic and hydrophobic affinity for binding to bupivacaine, a ca...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm201170h

    authors： Sivakumaran D,Maitland D,Hoare T

    更新日期：2011-11-14 00:00:00