Abstract：
:We examine the protein distribution within an electrospun polymer nanofiber using polyvinyl alcohol and bovine serum albumin as a model system. We hypothesize that the location of the protein within the nanofiber can be controlled by carefully selecting the pH and the applied polarity of the electric field as the pH affects the net charge on the proteins. Using fluorescently labeled BSA and surface analysis, we observe that the distribution of BSA is affected by the pH of the electrospinning solution. Therefore, we further probe the relevant forces on the protein in solution during electrospinning. The role of hydrodynamic friction was assessed using glutaraldehyde and HCl as a tool to modify the viscosity of the solution during electrospinning. By varying the pH and the polarity of the applied electric field, we evaluated the effects of electrostatic forces and dielectrophoresis on the protein during fiber formation. We surmise that electrostatic forces and hydrodynamic friction are insignificant relative to dielectrophoretic forces; therefore, it is possible to separate species in a blend using polarizability contrast. A coaxial distribution of protein in the core can be obtained by electrospinning at the isoelectric point of the protein, whereas surface enrichment can be obtained when the protein carries a net charge.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Tang C,Ozcam AE,Stout B,Khan SAdoi
10.1021/bm2017146subject
Has Abstractpub_date
2012-05-14 00:00:00pages
1269-78issue
5eissn
1525-7797issn
1526-4602journal_volume
13pub_type
杂志文章abstract：:Control of the photoluminescence properties of cellulose is conducted by introduction of conducting polymers including fluorene (F) and 3-hexylthiophene (3HT) on cellulose surface through FeCl3 oxidative polymerization. The UV-vis absorption peak of cellulose grafted with the 3-hexylthiophene and fluorene copolymer wa...
journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2017-12-11 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2013-02-11 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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journal_title：Biomacromolecules
pub_type： 杂志文章
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2014-05-12 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm101110x
更新日期：2011-03-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2012-01-09 00:00:00
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journal_title：Biomacromolecules
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更新日期：2012-11-12 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2017-11-13 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm300196h
更新日期：2012-04-09 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm030002m
更新日期：2003-05-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.5b01266
更新日期：2015-12-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2017-03-13 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm901451j
更新日期：2010-04-12 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2014-06-09 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2017-03-13 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2019-01-14 00:00:00
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journal_title：Biomacromolecules
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更新日期：2018-11-12 00:00:00
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journal_title：Biomacromolecules
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更新日期：2019-05-13 00:00:00
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journal_title：Biomacromolecules
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更新日期：2014-03-10 00:00:00
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journal_title：Biomacromolecules
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更新日期：2020-02-10 00:00:00
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journal_title：Biomacromolecules
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更新日期：2010-02-08 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2005-05-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2018-07-09 00:00:00
abstract：:Polypeptide-based formulations that undergo liquid to hydrogel transitions upon change in temperature have become desirable targets since they can be mixed with cells or injected into tissues as liquids, and subsequently transform into rigid scaffolds or depots. Such materials have been challenging to prepare using sy...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.5b00124
更新日期：2015-04-13 00:00:00
abstract：:Poly(ethylene 2,5-furandicarboxylate) (PEF) is a biobased polyester characterized by high gas barrier properties as well as high tensile modulus and strength, but poor toughness. Toughening PEF without sacrificing its modulus, strength and gas barrier performance is a great challenge for PEF modification. In this stud...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b01495
更新日期：2019-01-14 00:00:00
