Abstract:
:This paper describes the synthesis and cytotoxicity of poly(anhydride esters) that are composed of several salicylate derivatives, including halogenated salicylates, aminosalicylates, salicylsalicylic acid, and thiolsalicylic acid. The incorporation of these nonsteroidal antiinflammatory drugs (NSAIDs) into a biodegradable polymer backbone yields drug-based polymers that have potential for a variety of applications. The poly(anhydride esters) were synthesized by melt condensation polymerization. The halogenated salicylate derivatives yielded the highest molecular polymers as well as the highest glass transition temperatures. All polymers displayed in vitro degradation lag times from 1 to 3 days, depending on the water solubility of the salicylate derivative. Cell viability and proliferation were determined with L929 fibroblast cells in serum-containing medium to assess the polymer cytotoxicities, which varied as a function of the saliyclate chemistry. Cell morphology was normal for most of the polymers evaluated.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Schmeltzer RC,Schmalenberg KE,Uhrich KEdoi
10.1021/bm049544+keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
359-67issue
1eissn
1525-7797issn
1526-4602journal_volume
6pub_type
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