Influence of Molecular Structure on the In Vivo Performance of Flexible Rod Polyrotaxanes.

abstract：:Optimal curcumin delivery for medicinal applications requires a drug delivery system that both solubilizes curcumin and prevents degradation. To achieve this, curcumin has been encapsulated in submicrometer chitosan/Tween 20 particles via a benchtop spray-drying process. Spray-drying parameters have been optimized usi...

journal_title：Biomacromolecules

authors： O'Toole MG,Henderson RM,Soucy PA,Fasciotto BH,Hoblitzell PJ,Keynton RS,Ehringer WD,Gobin AS

更新日期：2012-08-13 00:00:00

abstract：:A novel linear multifunctional polyethylene glycol (PEG)-dexamethasone (Dex) conjugate (click PEG-Dex) was synthesized using facile Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (a click reaction). Dex was conjugated to the click PEG via an acid-labile hydrazone bond to allow the drug release in a pathophysiologic...

journal_title：Biomacromolecules

authors： Liu XM,Quan LD,Tian J,Laquer FC,Ciborowski P,Wang D

更新日期：2010-10-11 00:00:00

abstract：:Microgels based on poly(vinyl alcohol), PVA, grafted with methacrylate side chains, MA, incorporating N-isopropylacrylamide, NiPAAm, monomer, were prepared by water-in-water emulsion polymerization method. These systems exhibit a spherical shape and a volume-phase transition, that is, shrinking, below physiological te...

journal_title：Biomacromolecules

authors： Ghugare SV,Mozetic P,Paradossi G

更新日期：2009-06-08 00:00:00

abstract：:Selectively spooling single plasmid DNA (pDNA), as a giant polyelectrolyte, into a nanosized toroidal structure or folding it into a rod-like structure has been accomplished by polyion complexation with block catiomers to form polymeric micelles in varying NaCl concentrations. The interactive potency between the pDNA ...

journal_title：Biomacromolecules

authors： Li Y,Osada K,Chen Q,Tockary TA,Dirisala A,Takeda KM,Uchida S,Nagata K,Itaka K,Kataoka K

更新日期：2015-09-14 00:00:00

abstract：:In this work we describe the application of amphiphilic N-(2-hydroxypropyl)methacrylamide (HPMA)-based copolymers as polymeric surfactants in miniemulsion techniques. HPMA-based copolymers with different ratios of HPMA (hydrophilic) to laurylmethacrylate (LMA; hydrophobic) units were synthesized by RAFT polymerization...

journal_title：Biomacromolecules

authors： Kelsch A,Tomcin S,Rausch K,Barz M,Mailänder V,Schmidt M,Landfester K,Zentel R

更新日期：2012-12-10 00:00:00

abstract：:The oxidation-responsive behaviors of OEGylated poly-L-cysteine homopolypeptides, that is, poly(L-EG(x)MA-C)n, were investigated. These poly-L-cysteine derivatives adopted mixed conformation in water, in which the β-sheet accounted for a significant proportion. Upon oxidation, the thioethers in polypeptide side chains...

journal_title：Biomacromolecules

authors： Fu X,Ma Y,Shen Y,Fu W,Li Z

更新日期：2014-03-10 00:00:00

abstract：:An enzymatically cross-linked polyethylene glycol (PEG)-based hydrogel was engineered to promote and align nerve cells in a three-dimensional manner. To render the injectable, otherwise bioinert, PEG-based material supportive for cell growth, its mechanical and biochemical properties were optimized. A recombinant fibr...

journal_title：Biomacromolecules

authors： Licht C,Rose JC,Anarkoli AO,Blondel D,Roccio M,Haraszti T,Gehlen DB,Hubbell JA,Lutolf MP,De Laporte L

更新日期：2019-11-11 00:00:00

abstract：:Cellulose-based dendrimerized material was prepared and its quality was assessed by determining the number of amine functional groups incorporated. Based on the results for a series of preparations, the material was obtained in a highly reproducible manner thanks to the particular chemical construction method used. Th...

journal_title：Biomacromolecules

authors： Montañez MI,Perez-Inestrosa E,Suau R,Mayorga C,Torres MJ,Blanca M

更新日期：2008-05-01 00:00:00

abstract：:We investigate the effects of mixing a colloidal suspension of tunicate-derived cellulose nanocrystals (t-CNCs) with aqueous colloidal suspensions of two protein diblock copolymers, EC and CE, which bear two different self-assembling domains (SADs) derived from elastin (E) and the coiled-coil region of cartilage oligo...

journal_title：Biomacromolecules

authors： Haghpanah JS,Tu R,Da Silva S,Yan D,Mueller S,Weder C,Foster EJ,Sacui I,Gilman JW,Montclare JK

更新日期：2013-12-09 00:00:00

abstract：:Despite the good clinical efficacy of interferon-alpha (IFNα) to treat some types of cancer and viral infections, this biological drug is underused given its severe adverse effects and high dosing parenteral regimens. Aiming to achieve a breakthrough in therapy with IFNα, this work reports for the first time on the de...

journal_title：Biomacromolecules

authors： Cánepa C,Imperiale JC,Berini CA,Lewicki M,Sosnik A,Biglione MM

更新日期：2017-10-09 00:00:00

abstract：:The present study focuses on the formation of microcapsules containing catalytically active L-asparaginase (L-ASNase), a protein drug of high value in antileukemic therapy. We make use of the layer-by-layer (LbL) technique to coat protein-loaded calcium carbonate (CaCO3) particles with two or three poly dextran/poly-L...

journal_title：Biomacromolecules

authors： Karamitros CS,Yashchenok AM,Möhwald H,Skirtach AG,Konrad M

更新日期：2013-12-09 00:00:00

abstract：:Biocatalytic pulp fibers were prepared using surface functionalization of bleached kraft pulp with amino groups (F) and further immobilization of a cross-linked glucose oxidase (G*) from Aspergillus niger. The cross-linked enzymes (G*) were characterized using X-ray spectroscopy, Fourier transform infrared spectroscop...

journal_title：Biomacromolecules

authors： Vega Erramuspe IB,Fazeli E,Näreoja T,Trygg J,Hänninen P,Heinze T,Fardim P

更新日期：2016-10-10 00:00:00

abstract：:Thin films of a biocompatible and nonbiofouling poly(oligo(ethylene glycol) methacrylate) ( pOEGMA) with various thicknesses were formed on gold and Si/SiO 2 substrates by a combination of the formation of self-assembled monolayers (SAMs) terminating in bromoester-an initiator of atom transfer radical polymerization (...

journal_title：Biomacromolecules

authors： Lee BS,Chi YS,Lee KB,Kim YG,Choi IS

更新日期：2007-12-01 00:00:00

abstract：:PLGA nanoparticles are among the most studied polymer nanoformulations for several drugs against different kinds of malignant diseases, thanks to their in vivo stability and tumor localization exploiting the well-documented "enhanced permeation and retention" (EPR) effect. In this paper, we have developed uniform curc...

journal_title：Biomacromolecules

authors： Verderio P,Bonetti P,Colombo M,Pandolfi L,Prosperi D

更新日期：2013-03-11 00:00:00

abstract：:Glycosidases have long been used for the synthesis of glycosides by transglycosylation reactions. Especially glycosidases from hyperthermophilic bacteria are useful for reactions under extreme reaction conditions, e.g., in the presence of organic solvents. We herein report the facile enzymatic synthesis and purificati...

journal_title：Biomacromolecules

authors： Hoffmann M,Gau E,Braun S,Pich A,Elling L

更新日期：2020-02-10 00:00:00

abstract：:The polarity of polymer-actin complexes obtained by mixing F-actin with synthetic polymers carrying positive charges such as poly(L-lysine), x,y-ionene bromide polymers, and poly(N-[3-(dimethylamino)propyl]acrylamide) (PDMAPAA-Q) have been investigated. Actin complexes formed with poly(L-lysine) and PDMAPAA-Q, which c...

journal_title：Biomacromolecules

authors： Kakugo A,Shikinaka K,Takekawa N,Sugimoto S,Osada Y,Gong JP

更新日期：2005-03-01 00:00:00

abstract：:Peak force infrared (PFIR) microscopy is a recently developed approach to acquire multiple chemical and physical material properties simultaneously and with nanometer resolution: topographical features, infrared (IR)-sensitive maps, adhesion, stiffness, and locally resolved IR spectra. This multifunctional mapping is ...

journal_title：Biomacromolecules

authors： Gusenbauer C,Jakob DS,Xu XG,Vezenov DV,Cabane É,Konnerth J

更新日期：2020-10-12 00:00:00

abstract：:Here we present time-resolved in situ transmission electron microscopy (TEM) observations and real-time manipulation of nematic ordered cellulose and ultradrawn polyethylene films. Drawn films of these two polymers exhibited a unique response to the low-dose electron beam. Electron beam damage was minimal based on ret...

journal_title：Biomacromolecules

authors： Brown RM Jr,Barnes Z,Sawatari C,Kondo T

更新日期：2007-01-01 00:00:00

abstract：:Dextran surface grafting density was systematically varied via a two-step process involving SiO(2) amination by aminopropyltriethoxy silane (APTES) followed by oxidized dextran (M(w) = 110 kDa) chemisorption. Dextran oxidation kinetics with sodium metaperiodate (NaIO(4)) were quantified by (1)H NMR and pH measurements...

journal_title：Biomacromolecules

authors： Miksa D,Irish ER,Chen D,Composto RJ,Eckmann DM

更新日期：2006-02-01 00:00:00

abstract：:Atomic force microscopy (AFM) was used to assess a new chimeric protein consisting of a fusion protein of the consensus repeat for Nephila clavipes spider dragline protein and bone sialoprotein (6mer+BSP). The elastic modulus of this protein in film form was assessed through force curves, and film surface roughness wa...

journal_title：Biomacromolecules

authors： Gomes S,Numata K,Leonor IB,Mano JF,Reis RL,Kaplan DL

更新日期：2011-05-09 00:00:00

abstract：:Glycogen is mainly found as the principal storage form of glucose in cells. Many bacteria are able to synthesize large amounts of glycogen under unfavorable life conditions. By combining infrared spectroscopy, single molecule force spectroscopy (SMFS) and immuno-staining technique, we evidenced that planktonic P. flu...

journal_title：Biomacromolecules

authors： Quilès F,Polyakov P,Humbert F,Francius G

更新日期：2012-07-09 00:00:00

abstract：:Although doxorubicin (Dox) has been widely used in the treatment of different types of cancer, its insufficient cellular uptake and intracellular release is still a limitation. Herein, we report an easy process for the preparation of redox-sensitive nanogels that were shown to be highly efficient in the intracellular ...

journal_title：Biomacromolecules

authors： Maciel D,Figueira P,Xiao S,Hu D,Shi X,Rodrigues J,Tomás H,Li Y

更新日期：2013-09-09 00:00:00

abstract：:Silkworm silk has excellent mechanical properties, biocompatibility, and promising applications in the biomedical sector. Silkworms spin silk at the beginning and end of each of their five instar stages, as well as spinning mature silk after the fifth instar. We evaluated the mechanical properties and structure of 10 ...

journal_title：Biomacromolecules

authors： Peng Z,Yang X,Liu C,Dong Z,Wang F,Wang X,Hu W,Zhang X,Zhao P,Xia Q

更新日期：2019-03-11 00:00:00

abstract：:A well-defined N-(2-hydroxypropyl)methacrylamide-s-N-(3-aminopropyl)methacrylamide (HPMA-s-APMA) copolymer, synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, was utilized for the rational design of multiconjugates containing both a gene therapeutic, small interfering RNA (siRNA), ...

journal_title：Biomacromolecules

authors： York AW,Huang F,McCormick CL

更新日期：2010-02-08 00:00:00

abstract：:This study investigated the impact of the protein adsorption mechanism(s) on the efficiency of thermally controlled cell adhesion and release from poly(N-isopropyl acrylamide) brushes. Large format polymer gradients were used to screen for grafting densities and substrate chemistries that alter both cell adhesion at 3...

journal_title：Biomacromolecules

authors： Choi S,Choi BC,Xue C,Leckband D

更新日期：2013-01-14 00:00:00

abstract：:Celluloses from different origins were dissolved stepwise in N,N-dimethylacetamide/lithium chloride (9% v/w; DMAc/LiCl) with the aim to study the time course of the dissolution process, completeness of dissolution in the dissolved fractions, possible discrimination effects, and differences between the celluloses. Cell...

journal_title：Biomacromolecules

authors： Henniges U,Kostic M,Borgards A,Rosenau T,Potthast A

更新日期：2011-04-11 00:00:00

abstract：:The microstructure and the rheological properties of pure HM (high methoxyl) and LM (low methoxyl) pectin gels and of mixed HM/LM pectin gels have been investigated. Gel formation of either the HM or LM pectin, or both, was initiated in the mixed gels by varying the sucrose and Ca(2+) content. The microstructure was c...

journal_title：Biomacromolecules

authors： Löfgren C,Walkenström P,Hermansson AM

更新日期：2002-11-01 00:00:00

abstract：:Decomposable hollow capsules based on deoxyribonucleic acid (DNA) and a low molecular weight organic molecule, a naturally occurring polyamine, spermidine (SP), were formed by applying the layer-by-layer adsorption strategy to colloid particles, viz., assembling DNA/SP multilayers on colloids and subsequently removing...

journal_title：Biomacromolecules

authors： Schüler C,Caruso F

更新日期：2001-10-01 00:00:00

abstract：:This paper reports the rheological behavior of chitosan solutions that have been cross-linked with different amounts of genipin, at body temperature and physiological pH. The effect of the cross-linker loading on the rheological properties of hydrogels has been evaluated. The oscillatory time sweep method was used to ...

journal_title：Biomacromolecules

authors： Moura MJ,Figueiredo MM,Gil MH

更新日期：2007-12-01 00:00:00

abstract：:On-line size-exclusion chromatography monitoring of potato phosphorylase catalyzed amylose synthesis--starting from alpha-D-glucose-1-P and maltohexaose--revealed rather monodisperse amylose populations. In the presence of lipids, amylose-lipid complexes spontaneously formed and precipitated. They were recovered by ce...

journal_title：Biomacromolecules

authors： Gelders GG,Goesaert H,Delcour JA

更新日期：2005-09-01 00:00:00