Curcumin encapsulation in submicrometer spray-dried chitosan/Tween 20 particles.

Abstract:

:Optimal curcumin delivery for medicinal applications requires a drug delivery system that both solubilizes curcumin and prevents degradation. To achieve this, curcumin has been encapsulated in submicrometer chitosan/Tween 20 particles via a benchtop spray-drying process. Spray-drying parameters have been optimized using a Taguchi statistical approach to minimize particle size and to favor spheroid particles with smooth surfaces, as evaluated with scanning electron microscopy (SEM) imaging. Nearly spherical particles with 285 ± 30 nm diameter and 1.21 axial ratio were achieved. Inclusion of curcumin in the spray-drying solution results in complete encapsulation of curcumin within the chitosan/Tween 20 particles. Release studies confirm that curcumin can be released completely from the particles over a 2 h period.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

O'Toole MG,Henderson RM,Soucy PA,Fasciotto BH,Hoblitzell PJ,Keynton RS,Ehringer WD,Gobin AS

doi

10.1021/bm300564v

subject

Has Abstract

pub_date

2012-08-13 00:00:00

pages

2309-14

issue

8

eissn

1525-7797

issn

1526-4602

journal_volume

13

pub_type

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