Cross-linked poly(trimethylene carbonate-co-L-lactide) as a biodegradable, elastomeric scaffold for vascular engineering applications.

Abstract:

:A series of copolymers of trimethylene carbonate (TMC) and L-lactide (LLA) were synthesized and evaluated as scaffolds for the production of artificial blood vessels. The polymers were end-functionalized with acrylate, cast into films, and cross-linked using UV light. The mechanical, degradation, and biocompatibility properties were evaluated. High TMC polymers showed mechanical properties comparable to human arteries (Young's moduli of 1.2-1.8 MPa and high elasticity with repeated cycling at 10% strain). Over 84 days degradation in PBS, the modulus and material strength decreased gradually. The polymers were nontoxic and showed good cell adhesion and proliferation over 7 days using human mesenchymal stem cells. When implanted into the rat peritoneal cavity, the polymers elicited formation of tissue capsules composed of myofibroblasts, resembling immature vascular smooth muscle cells. Thus, these polymers showed properties which were tunable and favorable for vascular tissue engineering, specifically, the growth of artificial blood vessels in vivo.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Dargaville BL,Vaquette C,Peng H,Rasoul F,Chau YQ,Cooper-White JJ,Campbell JH,Whittaker AK

doi

10.1021/bm201291e

subject

Has Abstract

pub_date

2011-11-14 00:00:00

pages

3856-69

issue

11

eissn

1525-7797

issn

1526-4602

journal_volume

12

pub_type

杂志文章
  • Biodegradable fumarate-based polyHIPEs as tissue engineering scaffolds.

    abstract::PolyHIPEs show great promise as tissue engineering scaffolds due to the tremendous control of pore size and interconnectivity afforded by this technique. Highly porous, fully biodegradable scaffolds were prepared by polymerization of the continuous phase of high internal phase emulsions (HIPEs) containing the macromer...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm7007235

    authors: Christenson EM,Soofi W,Holm JL,Cameron NR,Mikos AG

    更新日期:2007-12-01 00:00:00

  • Enzymatically Debranched Xylans in Graft Copolymerization.

    abstract::Wheat arabinoxylan was treated with two α-arabinofuranosidases exhibiting different mode of action to create three different polymeric substrates. These three substrate preparations were characterized by xylopyranose backbone sugars that are (1) singly substituted by arabinose at C2 or C3, (2) doubly substituted by ar...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00229

    authors: Littunen K,Mai-Gisondi G,Seppälä J,Master ER

    更新日期:2017-05-08 00:00:00

  • In situ cross-linkable novel alginate-dextran methacrylate IPN hydrogels for biomedical applications: mechanical characterization and drug delivery properties.

    abstract::In situ polymerizable hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. In the present paper a novel polysaccharidic matrix based on calcium alginate (Ca(II)-Alg) hydrogel and dextran methacrylate derivative (Dex-MA), showing potential applicability in the field of pharm...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm800252c

    authors: Matricardi P,Pontoriero M,Coviello T,Casadei MA,Alhaique F

    更新日期:2008-07-01 00:00:00

  • A Mössbauer study of the interaction of chitosan and D-glucosamine with iron and its relevance to other metalloenzymes.

    abstract::The interaction of iron with water-soluble polymer chitosan and monomer d-glucosamine is investigated by Mössbauer spectroscopy. The 4.2 K Mössbauer spectrum of Fe-water-soluble chitosan complex indicates the presence of a magnetic pattern and a quadrupole doublet, and analysis of the spectral data leads to the conclu...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm020131n

    authors: Bhatia SC,Ravi N

    更新日期:2003-05-01 00:00:00

  • Adhesion properties of catechol-based biodegradable amino acid-based poly(ester urea) copolymers inspired from mussel proteins.

    abstract::Amino acid-based poly(ester urea) (PEU) copolymers functionalized with pendant catechol groups that address the need for strongly adhesive yet degradable biomaterials have been developed. Lap-shear tests with aluminum adherends demonstrated that these polymers have lap-shear adhesion strengths near 1 MPa. An increase ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm501456g

    authors: Zhou J,Defante AP,Lin F,Xu Y,Yu J,Gao Y,Childers E,Dhinojwala A,Becker ML

    更新日期:2015-01-12 00:00:00

  • Self-cross-linking polyelectrolyte complexes for therapeutic cell encapsulation.

    abstract::Self-cross-linking polyelectrolytes are used to strengthen the surface of calcium alginate beads for cell encapsulation. Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride), containing 30 mol % 2-aminoethyl methacrylate, and poly(sodium methacrylate), containing 30 mol % 2-(methacryloyloxy)ethyl acetoacetate, w...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm800580c

    authors: Mazumder MA,Shen F,Burke NA,Potter MA,Stöver HD

    更新日期:2008-09-01 00:00:00

  • Thermodynamic and dynamic characteristics of hydroxypropylmethylcellulose adsorbed films at the air-water interface.

    abstract::Surface pressure isotherms and structural and surface dilatational properties of three hydroxypropylmethycelluloses (HPMCs, called E4M, E50LV, and F4M) adsorbed films at the air-water interface were determined. In this work we present evidence that HPMC molecules are able to diffuse and saturate the air-water interfac...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm050757o

    authors: Pérez OE,Sánchez CC,Rodríguez Patino JM,Pilosof AM

    更新日期:2006-01-01 00:00:00

  • Multifunctional nanoparticles improve therapeutic effect for breast cancer by simultaneously antagonizing multiple mechanisms of multidrug resistance.

    abstract::For efficient reversal of multidrug resistance (MDR) in chemotherapy for breast cancer, multifunctional self-assembled nanoparticles (MSN) based on a new amphiphilic copolymer consisting of bioreducible poly[bis(2-hydroxylethyl)-disulfide-diacrylate-β-tetraethylenepentamine] and polycaprolactone (PBD-PCL) were constru...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm400378x

    authors: Yin Q,Shen J,Zhang Z,Yu H,Chen L,Gu W,Li Y

    更新日期:2013-07-08 00:00:00

  • Phage-bacterium war on polymeric surfaces: can surface-anchored bacteriophages eliminate microbial infections?

    abstract::These studies illustrate synthetic paths to covalently attach T1 and Φ11 bacteriophages (phages) to inert polymeric surfaces while maintaining the bacteriophage's biological activities capable of killing deadly human pathogens. The first step involved the formation of acid (COOH) groups on polyethylene (PE) and polyte...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm400290u

    authors: Pearson HA,Sahukhal GS,Elasri MO,Urban MW

    更新日期:2013-05-13 00:00:00

  • Silica condensation by a silicatein α homologue involves surface-induced transition to a stable structural intermediate forming a saturated monolayer.

    abstract::Silicatein α exists within the protein filament of silica spicules of the marine sponge Tethya aurantium in a predominantly β-sheet structure. However, it is produced in a soluble form with mixed α-helix/β-sheet structure akin to its cathepsin L homologue. To understand this conformational transition in the context of...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm100932e

    authors: Patwardhan SV,Holt SA,Kelly SM,Kreiner M,Perry CC,van der Walle CF

    更新日期:2010-11-08 00:00:00

  • EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer.

    abstract::The objective of this study was to design GE11 peptide (YHWYGYTPQNVI) linked micelles of poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-gemcitabine-graft-dodecanol (PEG-b-PCC-g-GEM-g-DC) for enhanced stability and target specificity of gemcitabine (GEM) to EGFR-positive pancreatic cance...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b01419

    authors: Mondal G,Kumar V,Shukla SK,Singh PK,Mahato RI

    更新日期:2016-01-11 00:00:00

  • Diepoxide-triggered conformational transition of silk fibroin: formation of hydrogels.

    abstract::Silk fibroin hydrogels with tunable properties could be obtained from aqueous fibroin solutions (4.2 w/v %) in a short period of time. This was achieved by the addition of ethylene glycol diglycidyl ether (EGDE) into the reaction solution. Introduction of EGDE cross-links between the fibroin molecules decreases the mo...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm300006r

    authors: Karakutuk I,Ak F,Okay O

    更新日期:2012-04-09 00:00:00

  • Characterization of gels composed of blends of collagen I, collagen III, and chondroitin sulfate.

    abstract::Type I collagen is explored heavily for use in biomaterials, but the role of other extracellular matrix components in regulating collagen organization is gaining attention. We show that as the ratio of type III to type I collagen increases, fibril diameter decreases. A mixture of the two collagen types results in a mo...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm800888u

    authors: Stuart K,Panitch A

    更新日期:2009-01-12 00:00:00

  • Carrageenan-based hydrogels for the controlled delivery of PDGF-BB in bone tissue engineering applications.

    abstract::One of the major drawbacks found in most bone tissue engineering approaches developed so far consists in the lack of strategies to promote vascularisation. Some studies have addressed different issues that may enhance vascularisation in tissue engineered constructs, most of them involving the use of growth factors (GF...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm8014973

    authors: Santo VE,Frias AM,Carida M,Cancedda R,Gomes ME,Mano JF,Reis RL

    更新日期:2009-06-08 00:00:00

  • Ruthenium(II) tris(bipyridine)-centered poly(ethylenimine) for gene delivery.

    abstract::Ruthenium(II) tris(bipyridine)-centered poly(ethylenimine) (Ru PEI) was synthesized via acid hydrolysis of Ru tris(bipyridine)-centered poly(2-ethyl-2-oxazoline) (Ru PEOX), and the luminescence, DNA entrapment, and transfection efficiencies were evaluated. Emission maxima for Ru PEI samples are red-shifted compared to...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm700481h

    authors: Fiore GL,Edwards JM,Payne SJ,Klinkenberg JL,Gioeli DG,Demas JN,Fraser CL

    更新日期:2007-09-01 00:00:00

  • Processability of cottonseed proteins into biodegradable materials.

    abstract::The manufacture of biodegradable materials from agricultural sources is a real challenge, because of environmental concerns and the need to make full use of resources. Cottonseed is an important protein source that could be used in nonfood applications, as a substitute for synthetic polymers. For the first time, the v...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm015525d

    authors: Grevellec J,Marquié C,Ferry L,Crespy A,Vialettes V

    更新日期:2001-01-01 00:00:00

  • Hierarchical Collagen-Hydroxyapatite Nanostructures Designed through Layer-by-Layer Assembly of Crystal-Decorated Fibrils.

    abstract::A comprehensive understanding of the mechanism by which type I collagen (Col) interacts with hydroxyapatite nanoparticles (Hap NPs) in aqueous solutions is a pivotal step for guiding the design of biologically relevant nanocomposites with controlled hierarchical structure. In this paper we use a variety of Hap NPs dif...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b01299

    authors: Colaço E,Brouri D,Aissaoui N,Cornette P,Dupres V,Domingos RF,Lambert JF,Maisonhaute E,Kirat KE,Landoulsi J

    更新日期:2019-12-09 00:00:00

  • Core-Shell-Shell Nanoparticles for NIR Fluorescence Imaging and NRET Swelling Reporting of Injectable or Implantable Gels.

    abstract::Injectable gels that support load are desirable for restoring the mechanical properties of degenerated load-bearing tissue. As these gels become increasingly sophisticated, the need to remotely image them and monitor their swelling increases. However, imaging such gels and monitoring their swelling using noninvasive m...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b00463

    authors: Shanks HR,Milani AH,Lu D,Saunders BR,Carney L,Adlam DJ,Hoyland JA,Blount C,Dickinson M

    更新日期:2019-07-08 00:00:00

  • Structure-function relationship in the antifreeze activity of synthetic alanine-lysine antifreeze polypeptides.

    abstract::Recently antifreeze proteins (AFP) have been the subject of many structure-function relationship studies regarding their antifreeze activity. Attempts have been made to elucidate the structure-function relationship by various amino acid substitutions, but to our knowledge there has been no successful from first princi...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm000004w

    authors: Wierzbicki A,Knight CA,Rutland TJ,Muccio DD,Pybus BS,Sikes CS

    更新日期:2000-07-01 00:00:00

  • Glucose-responsive vehicles containing phenylborate ester for controlled insulin release at neutral pH.

    abstract::This study is devoted to developing amphiphilic block polymers based on phenylborate ester, which can self-assemble to form nanoparticles, as a glucose-sensitive drug carrier. Poly(ethylene glycol)-block-poly[(2-phenylboronic esters-1,3-dioxane-5-ethyl) methylacrylate] (MPEG5000-block-PBDEMA) was fabricated with MPEG5...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm3003286

    authors: Yao Y,Zhao L,Yang J,Yang J

    更新日期:2012-06-11 00:00:00

  • Synthesis of multifunctional cellulose nanocrystals for lectin recognition and bacterial imaging.

    abstract::Multifunctional cellulose nanocrystals have been synthesized and applied as a new type of glyconanomaterial in lectin binding and bacterial imaging. The cellulose nanocrystals were prepared by TEMPO-mediated oxidation and acidic hydrolysis, followed by functionalization with a quinolone fluorophore and carbohydrate li...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b00227

    authors: Zhou J,Butchosa N,Jayawardena HS,Park J,Zhou Q,Yan M,Ramström O

    更新日期:2015-04-13 00:00:00

  • Secondary Structure Transition and Critical Stress for a Model of Spider Silk Assembly.

    abstract::Spiders spin their silk from an aqueous solution to a solid fiber in ambient conditions. However, to date, the assembly mechanism in the spider silk gland has not been satisfactorily explained. In this paper, we use molecular dynamics simulations to model Nephila clavipes MaSp1 dragline silk formation under shear flow...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b01246

    authors: Giesa T,Perry CC,Buehler MJ

    更新日期:2016-02-08 00:00:00

  • Low modulus biomimetic microgel particles with high loading of hemoglobin.

    abstract::We synthesized extremely deformable red blood cell-like microgel particles and loaded them with bovine hemoglobin (Hb) to potentiate oxygen transport. With similar shape and size as red blood cells (RBCs), the particles were fabricated using the PRINT (particle replication in nonwetting templates) technique. Low cross...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm3007242

    authors: Chen K,Merkel TJ,Pandya A,Napier ME,Luft JC,Daniel W,Sheiko S,DeSimone JM

    更新日期:2012-09-10 00:00:00

  • Chromatographic and enzymatic strategies to reveal differences between amidated pectins on a molecular level.

    abstract::The intermolecular distributions of amide groups within two commercial LMA pectins was studied after removal of the methyl esters followed by fractionation of the different populations by anion exchange chromatography. The populations obtained had almost equal degrees of amidation while the values of the degree of blo...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm050960j

    authors: Guillotin SE,Mey N,Ananta E,Boulenguer P,Schols HA,Voragen AG

    更新日期:2006-06-01 00:00:00

  • Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices.

    abstract::A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic estrogen hormone used as contraceptive, from water was tested. The yarns were prepared by spinning a deep eutec...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b01765

    authors: Orelma H,Virtanen T,Spoljaric S,Lehmonen J,Seppälä J,Rojas OJ,Harlin A

    更新日期:2018-02-12 00:00:00

  • Influence of polyelectrolyte chemical structure on their interaction with lipid membrane of zwitterionic liposomes.

    abstract::In this paper we extend our previous experimental work on interaction between polyelectrolytes and liposomes. First, the adsorption of chitosan and alkylated chitosan (cationic polyelectrolytes) with different alkyl chain lengths on lipid membranes of liposomes is examined. The amount of both chitosans adsorbed remain...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm800400y

    authors: Quemeneur F,Rinaudo M,Pépin-Donat B

    更新日期:2008-08-01 00:00:00

  • Design and Applications of Cell-Selective Surfaces and Interfaces.

    abstract::Tissue regeneration involves versatile types of cells. The accumulation and disorganized behaviors of undesired cells impair the natural healing process, leading to uncontrolled immune response, restenosis, and/or fibrosis. Cell-selective surfaces and interfaces can have specific and positive effects on desired types ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章,评审

    doi:10.1021/acs.biomac.8b00264

    authors: Zhang H,Zheng X,Ahmed W,Yao Y,Bai J,Chen Y,Gao C

    更新日期:2018-06-11 00:00:00

  • Pectin-GPTMS-Based Biomaterial: toward a Sustainable Bioprinting of 3D scaffolds for Tissue Engineering Application.

    abstract::Developing green and nontoxic biomaterials, derived from renewable sources and processable through 3D bioprinting technologies, is an emerging challenge of sustainable tissue engineering. Here, pectin from citrus peels was cross-linked for the first time with (3-glycidyloxypropyl)trimethoxysilane (GPTMS) through a one...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b01332

    authors: Lapomarda A,De Acutis A,Chiesa I,Fortunato GM,Montemurro F,De Maria C,Mattioli Belmonte M,Gottardi R,Vozzi G

    更新日期:2020-02-10 00:00:00

  • Synthesis, characterization, and in vitro degradation of a biodegradable photo-cross-linked film from liquid poly(epsilon-caprolactone-co-lactide-co-glycolide) diacrylate.

    abstract::There has been little study on the effect of composition or molecular weight on the biodegradation rate of photo-cross-linked biodegradable aliphatic polyesters though such information is important for tissue engineering scaffolds. We have synthesized a new series of photopolymerizable linear poly(epsilon-caprolactone...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm060766c

    authors: Shen JY,Pan XY,Lim CH,Chan-Park MB,Zhu X,Beuerman RW

    更新日期:2007-02-01 00:00:00

  • Controlled synthesis and inclusion ability of a hyaluronic acid derivative bearing beta-cyclodextrin molecules.

    abstract::A new synthetic route to beta-cyclodextrin-linked hyaluronic acid (HA-CD) was developed. This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a red...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm0507094

    authors: Charlot A,Heyraud A,Guenot P,Rinaudo M,Auzély-Velty R

    更新日期:2006-03-01 00:00:00