Abstract:
:A series of copolymers of trimethylene carbonate (TMC) and L-lactide (LLA) were synthesized and evaluated as scaffolds for the production of artificial blood vessels. The polymers were end-functionalized with acrylate, cast into films, and cross-linked using UV light. The mechanical, degradation, and biocompatibility properties were evaluated. High TMC polymers showed mechanical properties comparable to human arteries (Young's moduli of 1.2-1.8 MPa and high elasticity with repeated cycling at 10% strain). Over 84 days degradation in PBS, the modulus and material strength decreased gradually. The polymers were nontoxic and showed good cell adhesion and proliferation over 7 days using human mesenchymal stem cells. When implanted into the rat peritoneal cavity, the polymers elicited formation of tissue capsules composed of myofibroblasts, resembling immature vascular smooth muscle cells. Thus, these polymers showed properties which were tunable and favorable for vascular tissue engineering, specifically, the growth of artificial blood vessels in vivo.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Dargaville BL,Vaquette C,Peng H,Rasoul F,Chau YQ,Cooper-White JJ,Campbell JH,Whittaker AKdoi
10.1021/bm201291esubject
Has Abstractpub_date
2011-11-14 00:00:00pages
3856-69issue
11eissn
1525-7797issn
1526-4602journal_volume
12pub_type
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