当前位置： SCI文献检索 > BIOMACROMOLECULES期刊下所有文献 > Core-Shell-Shell Nanoparticles for NIR Fluorescence Imaging and NRET Swelling Reporting of Injectable or Implantable Gels.

Core-Shell-Shell Nanoparticles for NIR Fluorescence Imaging and NRET Swelling Reporting of Injectable or Implantable Gels.

Abstract：

:Injectable gels that support load are desirable for restoring the mechanical properties of degenerated load-bearing tissue. As these gels become increasingly sophisticated, the need to remotely image them and monitor their swelling increases. However, imaging such gels and monitoring their swelling using noninvasive means is challenging. Here, we use a very low concentration of near-infrared (NIR) core-shell-shell (CSS) reporter nanoparticles to both image and monitor swelling changes of two load-supporting gels. The load-supporting injectable gel consisted of covalently interlinked pH-responsive microgel (MG) particles. The latter gel was not cytotoxic and is termed a doubly cross-linked microgel (DX MG). Inclusion of a complementary fluorescent dye enabled ratiometric monitoring of gel swelling changes in response to pH via nonradiative resonance energy transfer (NRET). In addition, changes in the CSS nanoparticle emission intensity provided a NIR-only method that could also be used to monitor gel swelling. The gel was able to be imaged using NIR light, after being subcutaneously injected into a tissue model. To demonstrate versatility of our approach, CSS and the dye were included within a model implantable gel (poly(acrylamide/acrylic acid)) and fluorescent detection of swelling investigated. Because the concentrations of the reporting species were too low to affect the mechanical properties, our approach to remote gel imaging and swelling monitoring has good potential for application in injectable gels and implants.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Shanks HR,Milani AH,Lu D,Saunders BR,Carney L,Adlam DJ,Hoyland JA,Blount C,Dickinson M

doi

10.1021/acs.biomac.9b00463

subject

Has Abstract

pub_date

2019-07-08 00:00:00

pages

2694-2702

issue

7

eissn

1525-7797

issn

1526-4602

journal_volume

20

pub_type

杂志文章

相关文献

BIOMACROMOLECULES文献大全
  • Terminally alkylated heparin. 2. Potent antiproliferative agent for vascular smooth muscle cells.

    abstract：:The antiproliferative activity of alkylated heparin, in which the terminal end of heparin is derivatized with an alkyl group (butyl, octyl, lauryl, stearyl), was examined using vascular smooth muscle cells. The proliferation of cells, which were growth-arrested prior to addition of heparin, was inhibited in proportion...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm010097x

    authors： Gohda M,Magoshi T,Kato S,Noguchi T,Yasuda S,Nonogi H,Matsuda T

    更新日期：2001-01-01 00:00:00

  • Silk Sericin-Functionalized Bacterial Cellulose as a Potential Wound-Healing Biomaterial.

    abstract：:Bacterial cellulose (BC) is a polysaccharide known as a suitable matrix for proper wound healing. To improve this ability, BC was functionalized with silk sericin (SS) that has cytoprotective and mitogenic effects. The composites obtained by solution impregnation were stabilized by hydrogen bonds, and SS could be rele...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.6b00995

    authors： Lamboni L,Li Y,Liu J,Yang G

    更新日期：2016-09-12 00:00:00

  • Synthesis of photodegradable macromers for conjugation and release of bioactive molecules.

    abstract：:Hydrogel scaffolds are used in biomedicine to study cell differentiation and tissue evolution, where it is critical to control the delivery of chemical cues both spatially and temporally. While large molecules can be physically entrapped in a hydrogel, moderate molecular weight therapeutics must be tethered to the hyd...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm400169d

    authors： Griffin DR,Schlosser JL,Lam SF,Nguyen TH,Maynard HD,Kasko AM

    更新日期：2013-04-08 00:00:00

  • Chromatographic and enzymatic strategies to reveal differences between amidated pectins on a molecular level.

    abstract：:The intermolecular distributions of amide groups within two commercial LMA pectins was studied after removal of the methyl esters followed by fractionation of the different populations by anion exchange chromatography. The populations obtained had almost equal degrees of amidation while the values of the degree of blo...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm050960j

    authors： Guillotin SE,Mey N,Ananta E,Boulenguer P,Schols HA,Voragen AG

    更新日期：2006-06-01 00:00:00

  • Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice.

    abstract：:A polyethylene glycol (PEG) retinylamine (Ret-NH2) conjugate PEG-GFL-NH-Ret with a glycine-phenylalanine-leucine (GFL) spacer was synthesized for controlled oral delivery of Ret-NH2 to treat retinal degenerative diseases, including Stargardt disease (STGD) and age-related macular degeneration (AMD). The peptide spacer...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm501352s

    authors： Yu G,Wu X,Ayat N,Maeda A,Gao SQ,Golczak M,Palczewski K,Lu ZR

    更新日期：2014-12-08 00:00:00

  • Tethered lipid bilayers on electrolessly deposited gold for bioelectronic applications.

    abstract：:This paper presents the formation of a novel biomimetic interface consisting of an electrolessly deposited gold film overlaid with a tethered bilayer lipid membrane (tBLM). Self-assembly of colloidal gold particles was used to create an electrolessly deposited gold film on a glass slide. The properties of the film wer...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm0603995

    authors： Kohli N,Hassler BL,Parthasarathy L,Richardson RJ,Ofoli RY,Worden RM,Lee I

    更新日期：2006-12-01 00:00:00

  • Engineering interaction between bone marrow derived endothelial cells and electrospun surfaces for artificial vascular graft applications.

    abstract：:The aim of this investigation was to understand and engineer the interactions between endothelial cells and the electrospun (ES) polyvinylidene fluoride-co-hexafluoropropylene (PVDF-HFP) nanofiber surfaces and evaluate their potential for endothelialization. Elastomeric PVDF-HFP samples were electrospun to evaluate th...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm401825c

    authors： Ahmed F,Dutta NK,Zannettino A,Vandyke K,Choudhury NR

    更新日期：2014-04-14 00:00:00

  • Bait-and-Switch Supramolecular Strategy To Generate Noncationic RNA-Polymer Complexes for RNA Delivery.

    abstract：:RNA interference (RNAi) requires the intracellular delivery of RNA molecules to initiate the neutralization of targeted mRNA molecules, inhibiting the expression or translation of the targeted gene. Current polymers and lipids that are used to deliver RNA molecules are generally required to be positively charged, to a...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.8b01321

    authors： Jiang Z,Cui W,Prasad P,Touve MA,Gianneschi NC,Mager J,Thayumanavan S

    更新日期：2019-01-14 00:00:00

  • Structure-function relationship in the antifreeze activity of synthetic alanine-lysine antifreeze polypeptides.

    abstract：:Recently antifreeze proteins (AFP) have been the subject of many structure-function relationship studies regarding their antifreeze activity. Attempts have been made to elucidate the structure-function relationship by various amino acid substitutions, but to our knowledge there has been no successful from first princi...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm000004w

    authors： Wierzbicki A,Knight CA,Rutland TJ,Muccio DD,Pybus BS,Sikes CS

    更新日期：2000-07-01 00:00:00

  • Heterofunctional supports in enzyme immobilization: from traditional immobilization protocols to opportunities in tuning enzyme properties.

    abstract：:A heterofunctional support for enzyme immobilization may be defined as that which possesses several distinct functionalities on its surface able to interact with a protein. We will focus on those supports in which a final covalent attachment between the enzyme and the support is achieved. Heterofunctionality sometimes...

    journal_title：Biomacromolecules

    pub_type： 杂志文章,评审

    doi：10.1021/bm400762h

    authors： Barbosa O,Torres R,Ortiz C,Berenguer-Murcia A,Rodrigues RC,Fernandez-Lafuente R

    更新日期：2013-08-12 00:00:00

  • Shear-induced self-assembly of native silk proteins into fibrils studied by atomic force microscopy.

    abstract：:Noncontact mode atomic force microscopy was used to investigate native silk proteins prepared in different ways. Low protein concentrations revealed that single protein molecules exhibit a simple, round shape with apparent diameters of 20-25 nm. Shearing the native protein solutions after extraction from the gland and...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm201509b

    authors： Greving I,Cai M,Vollrath F,Schniepp HC

    更新日期：2012-03-12 00:00:00

  • Kinetics of protein-protein complex coacervation and biphasic release of salbutamol sulfate from coacervate matrix.

    abstract：:Turbidimetric titration was used to initiate associative intermolecular interactions between a pair of protein molecules, gelatin-A and gelatin-B, having complementary charges that led to pH-induced liquid-liquid phase separation and the formation of complex coacervate. The stoichiometric binding ratio was found to be...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm801160s

    authors： Tiwari A,Bindal S,Bohidar HB

    更新日期：2009-01-12 00:00:00

  • Polyacrylamide Hydrogels Produce Hydrogen Peroxide from Osmotic Swelling in Aqueous Media.

    abstract：:This work demonstrates that hydrogen peroxide (H2O2) is generated in weak polyacrylamide hydrogels due to mechanochemical reactions to osmotic swelling. Hydrogels are important tools and materials for many biomedical applications, particularly for growth of stem cells. However, swollen gels are under constant tension,...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.8b00743

    authors： Parameswar AV,Fitch KR,Bull DS,Duke VR,Goodwin AP

    更新日期：2018-08-13 00:00:00

  • Carboxylated Chitosan Nanocrystals: A Synthetic Route and Application as Superior Support for Gold-Catalyzed Reactions.

    abstract：:In this study, we demonstrate for the first time the fabrication of carboxylated chitosan nanocrystals (ChsNC) with high degree of deacetylation (DDA) at >80% and narrow size distribution. We also studied its application as a sustainable support material for metal-based catalysts. Carboxylated chitin nanocrystals (ChN...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.0c00201

    authors： Jin T,Kurdyla D,Hrapovic S,Leung ACW,Régnier S,Liu Y,Moores A,Lam E

    更新日期：2020-06-08 00:00:00

  • Force spectroscopy of LFA-1 and its ligands, ICAM-1 and ICAM-2.

    abstract：:Single-molecule measurements of the interaction of leukocyte function-associated antigen-1 (LFA-1), expressed on Jurkat T cells, with intercellular adhesion molecules-1 and -2 (ICAM-1 and ICAM-2) were conducted using atomic force microscopy (AFM). The force spectra (i.e., unbinding force versus loading rate) of both t...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm060559c

    authors： Wojcikiewicz EP,Abdulreda MH,Zhang X,Moy VT

    更新日期：2006-11-01 00:00:00

  • Study of the structure and properties of native and hydrothermally processed wild-type, lam and r variant pea starches that affect amylolysis of these starches.

    abstract：:Starches from WT, lam, and r pea mutants differing in amylopectin/amylose contents (70, 90, and 28% amylopectin, respectively) were used in kinetic studies of pancreatic α-amylase action at 37 °C and for investigations of their supramolecular structure and physicochemical properties during heating. For WT and lam star...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm101070r

    authors： Tahir R,Ellis PR,Bogracheva TY,Meares-Taylor C,Butterworth PJ

    更新日期：2011-01-10 00:00:00

  • Self-Assembly of Cellulose in Super-Cooled Ionic Liquid under the Impact of Decelerated Antisolvent Infusion: An Approach toward Anisotropic Gels and Aerogels.

    abstract：:Assembly of (bio)polymers into long-range anisotropic nanostructured gels and aerogels is of great interest in advanced material engineering since it enables directional tuning of properties, such as diffusivity, light, heat, and sound propagation, cell proliferation, and mechanical properties. Here we present an appr...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.8b01278

    authors： Plappert SF,Nedelec JM,Rennhofer H,Lichtenegger HC,Bernstorff S,Liebner FW

    更新日期：2018-11-12 00:00:00

  • Hierarchical Collagen-Hydroxyapatite Nanostructures Designed through Layer-by-Layer Assembly of Crystal-Decorated Fibrils.

    abstract：:A comprehensive understanding of the mechanism by which type I collagen (Col) interacts with hydroxyapatite nanoparticles (Hap NPs) in aqueous solutions is a pivotal step for guiding the design of biologically relevant nanocomposites with controlled hierarchical structure. In this paper we use a variety of Hap NPs dif...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.9b01299

    authors： Colaço E,Brouri D,Aissaoui N,Cornette P,Dupres V,Domingos RF,Lambert JF,Maisonhaute E,Kirat KE,Landoulsi J

    更新日期：2019-12-09 00:00:00

  • Sugar-Based Polyamides: Self-Organization in Strong Polar Organic Solvents.

    abstract：:Periodic patterns resembling spirals were observed to form spontaneously upon unassisted cooling of d-glucaric acid- and d-galactaric acid-based polyamide solutions in N-methyl-N-morpholine oxide (NMMO) monohydrate. Similar observations were made in d-galactaric acid-based polyamide/ionic liquid (IL) solutions. The mo...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.5b00977

    authors： Rosu C,Russo PS,Daly WH,Cueto R,Pople JA,Laine RA,Negulescu II

    更新日期：2015-09-14 00:00:00

  • Coating electrospun collagen and gelatin fibers with perlecan domain I for increased growth factor binding.

    abstract：:Electrospun natural polymer membranes were fabricated from collagen or gelatin coated with a bioactive recombinant fragment of perlecan, a natural heparan sulfate proteoglycan. The electrospinning process allowed the facile processing of a three-dimensional, porous fibril (2-6 microm in diameter) matrix suitable for t...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm061003s

    authors： Casper CL,Yang W,Farach-Carson MC,Rabolt JF

    更新日期：2007-04-01 00:00:00

  • Wheat germ agglutinin functionalized complexation hydrogels for oral insulin delivery.

    abstract：:Insulin was loaded into hydrogel microparticles after two hours with loading efficiencies greater than 70% for both poly(methacrylic acid-grafted-ethylene glycol) (P(MAA-g-EG)) and poly(methacrylic acid-grafted-ethylene glycol) functionalized with wheat germ agglutinin (P(MAA-g-EG) WGA). The pH-responsive release resu...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm701274p

    authors： Wood KM,Stone GM,Peppas NA

    更新日期：2008-04-01 00:00:00

  • Compatible ternary blends of chitosan/poly(vinyl alcohol)/poly(lactic acid) produced by oil-in-water emulsion processing.

    abstract：:Ternary compatible blends of chitosan, poly(vinyl alcohol), and poly(lactic acid) were prepared by an oil-in-water (O/W) emulsion process. Solutions of chitosan in aqueous acetic acid, poly(vinyl alcohol) (PVA) in water, and poly(lactic acid) (PLA) in chloroform were blended with a high-shear mixer. PVA was used as an...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm101227q

    authors： Grande R,Carvalho AJ

    更新日期：2011-04-11 00:00:00

  • Modification of cellulose films by adsorption of CMC and chitosan for controlled attachment of biomolecules.

    abstract：:The adsorption of human immunoglobulin G (hIgG) and bovine serum albumin (BSA) on cellulose supports were investigated. The dynamics and extent of related adsorption processes were monitored by surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D). Amine groups were instal...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm201236a

    authors： Orelma H,Filpponen I,Johansson LS,Laine J,Rojas OJ

    更新日期：2011-12-12 00:00:00

  • Gas-in-liquid foam templating as a method for the production of highly porous scaffolds.

    abstract：:In the present work, a novel synthetic methodology for the preparation of scaffold of biopolymeric nature is described. In particular, a porous gelatin scaffold was prepared by foam templating. The gas phase, nitrogen, was generated by means of the reaction between sulfamic acid and sodium nitrite in situ a concentrat...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm901051c

    authors： Barbetta A,Gumiero A,Pecci R,Bedini R,Dentini M

    更新日期：2009-12-14 00:00:00

  • SEC-MALS-QELS study on the molecular conformation of cellulose in LiCl/amide solutions.

    abstract：:The SEC-MALS-QELS (size-exclusion chromatography equipped with multiangle light scattering and quasi-elastic light scattering detectors) method using lithium chloride/N,N-dimethylacetamide (LiCl/DMAc) and LiCl/1,3-dimethyl-2-imidazolidinone (LiCl/DMI) as mobile phases was applied to cellulose and cellulose tricarbanil...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm049386m

    authors： Yanagisawa M,Isogai A

    更新日期：2005-05-01 00:00:00

  • Single-walled carbon nanotube as a unique scaffold for the multivalent display of sugars.

    abstract：:Single-walled carbon nanotube (SWNT) is a pseudo-one-dimensional nanostructure capable of carrying/displaying a large number of bioactive molecules and species in aqueous solution. In this work, a series of dendritic beta-D-galactopyranosides and alpha-D-mannopyranosides with a terminal amino group were synthesized an...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm800395e

    authors： Gu L,Luo PG,Wang H,Meziani MJ,Lin Y,Veca LM,Cao L,Lu F,Wang X,Quinn RA,Wang W,Zhang P,Lacher S,Sun YP

    更新日期：2008-09-01 00:00:00

  • Injectable Catalyst-Free Poly(Propylene Fumarate) System Cross-Linked by Strain Promoted Alkyne-Azide Cycloaddition Click Chemistry for Spine Defect Filling.

    abstract：:A new PPF-BCN/hyPCL32-N3 injectable system that can be cross-linked by catalyst-free, strain promoted alkyne-azide cycloaddition (SPAAC) click chemistry was developed for tissue engineering applications. The system consisted of two components: PPF-BCN, poly(propylene fumarate) (PPF) functionalized with (1R,8S,9s)-bicy...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/acs.biomac.9b00133

    authors： Liu X,Miller AL 2nd,Xu H,Waletzki BE,Lu L

    更新日期：2019-09-09 00:00:00

  • Simultaneous enhancement of cell proliferation and thermally induced harvest efficiency based on temperature-responsive cationic copolymer-grafted microcarriers.

    abstract：:The development of large-scale suspension cell cultures using microcarriers has long been a focus of attention in the fields of pharmacy and biotechnology. Previously, we developed cell-detachable microcarriers based on temperature-responsive poly(N-isopropylacrylamide) (PIPAAm)-grafted beads, on which adhering cells ...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm300256e

    authors： Tamura A,Nishi M,Kobayashi J,Nagase K,Yajima H,Yamato M,Okano T

    更新日期：2012-06-11 00:00:00

  • Structural analysis of enzyme-resistant isomaltooligosaccharides reveals the elongation of α-(1→3)-linked branches in Weissella confusa dextran.

    abstract：:Weissella confusa VTT E-90392 is an efficient producer of a dextran that is mainly composed of α-(1→6)-linked D-glucosyl units and very few α-(1→3) branch linkages. A mixture of the Chaetomium erraticum endodextranase and the Aspergillus niger α-glucosidase was used to hydrolyze W. confusa dextran to glucose and a set...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm1011536

    authors： Maina NH,Virkki L,Pynnönen H,Maaheimo H,Tenkanen M

    更新日期：2011-02-14 00:00:00

  • Novel genipin-cross-linked chitosan/silk fibroin sponges for cartilage engineering strategies.

    abstract：:The positive interaction of materials with tissues is an important step in regenerative medicine strategies. Hydrogels that are obtained from polysaccharides and proteins are expected to mimic the natural cartilage environment and thus provide an optimum milleu for tissue growth and regeneration. In this work, novel h...

    journal_title：Biomacromolecules

    pub_type： 杂志文章

    doi：10.1021/bm800874q

    authors： Silva SS,Motta A,Rodrigues MT,Pinheiro AF,Gomes ME,Mano JF,Reis RL,Migliaresi C

    更新日期：2008-10-01 00:00:00