Self-Assembly of Cellulose in Super-Cooled Ionic Liquid under the Impact of Decelerated Antisolvent Infusion: An Approach toward Anisotropic Gels and Aerogels.


:Assembly of (bio)polymers into long-range anisotropic nanostructured gels and aerogels is of great interest in advanced material engineering since it enables directional tuning of properties, such as diffusivity, light, heat, and sound propagation, cell proliferation, and mechanical properties. Here we present an approach toward anisotropic cellulose II gels and aerogels that employs specific diffusion and phase separation phenomena occurring during decelerated infusion of an antisolvent into isotropic supercooled solutions of cellulose in an ionic liquid to effectuate supramolecular assembly of cellulose in anisotropic colloidal network structures. At the example of the distillable ionic liquid 1,1,3,3-tetramethylguanidinium acetate, the antisolvent ethanol, and spherocylindrical porous molds, we demonstrate that the proposed facile, environmental-benign and versatile route affords gels and aerogels whose specific anisotropic nanomorphology and properties reflect the preferred supramolecular cellulose orientation during phase separation, which is perpendicular to the direction of antisolvent diffusion. Comprehensive X-ray scattering experiments revealed that the (aero)gels are composed of an interconnected, fibrous, highly crystalline (CrI ≈ 72%), cellulose II with a cross-sectional Guinier radius of the struts of about 2.5 nm, and an order parameter gradient from about 0.1 to 0.2. The obtained gels and aerogels feature high specific surface areas (350-630 m2 g-1) and excellent mechanical properties like high toughness (up to 471 kJ m-3 for a 60% compression, ρB = 80 mg cm-3) and resilience (up to 13.4 kJ m-3, ρB = 65 mg cm-3).






Plappert SF,Nedelec JM,Rennhofer H,Lichtenegger HC,Bernstorff S,Liebner FW




Has Abstract


2018-11-12 00:00:00












  • Collagen cross-linking with Au nanoparticles.

    abstract::Tiopronin (N-(2-mercaptopropionyl)glycine)-protected gold nanoparticles (TPAu) were cross-linked to collagen via EDC (1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide) coupling. On average, each TPAu forms eight amide bonds with collagen lysine moieties. The resulting gels were studied with environmental SEM, TEM, micr...


    pub_type: 杂志文章


    authors: Castaneda L,Valle J,Yang N,Pluskat S,Slowinska K

    更新日期:2008-12-01 00:00:00

  • AFM study of morphology and mechanical properties of a chimeric spider silk and bone sialoprotein protein for bone regeneration.

    abstract::Atomic force microscopy (AFM) was used to assess a new chimeric protein consisting of a fusion protein of the consensus repeat for Nephila clavipes spider dragline protein and bone sialoprotein (6mer+BSP). The elastic modulus of this protein in film form was assessed through force curves, and film surface roughness wa...


    pub_type: 杂志文章


    authors: Gomes S,Numata K,Leonor IB,Mano JF,Reis RL,Kaplan DL

    更新日期:2011-05-09 00:00:00

  • Cyclic Dipeptide-Based Ambidextrous Supergelators: Minimalistic Rational Design, Structure-Gelation Studies, and In Situ Hydrogelation.

    abstract::Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic propert...


    pub_type: 杂志文章


    authors: Manchineella S,Murugan NA,Govindaraju T

    更新日期:2017-11-13 00:00:00

  • EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer.

    abstract::The objective of this study was to design GE11 peptide (YHWYGYTPQNVI) linked micelles of poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-gemcitabine-graft-dodecanol (PEG-b-PCC-g-GEM-g-DC) for enhanced stability and target specificity of gemcitabine (GEM) to EGFR-positive pancreatic cance...


    pub_type: 杂志文章


    authors: Mondal G,Kumar V,Shukla SK,Singh PK,Mahato RI

    更新日期:2016-01-11 00:00:00

  • Ultrasensitive Detection of MicroRNA in Tumor Cells and Tissues via Continuous Assembly of DNA Probe.

    abstract::Nucleic acids have been engineered to participate in a wide variety of tasks. Among them, the enzyme-free amplification modes, enzyme-free DNA circuits (EFDCs), and hybridization chain reactions (HCRs) have been widely applied in a series of studies of bioanalysis. We demonstrated here an ultrasensitive hairpin probe-...


    pub_type: 杂志文章


    authors: Liao Y,Fu Y,Wu Y,Huang R,Zhou X,Xing D

    更新日期:2015-11-09 00:00:00

  • Rational design of targeted cancer therapeutics through the multiconjugation of folate and cleavable siRNA to RAFT-synthesized (HPMA-s-APMA) copolymers.

    abstract::A well-defined N-(2-hydroxypropyl)methacrylamide-s-N-(3-aminopropyl)methacrylamide (HPMA-s-APMA) copolymer, synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, was utilized for the rational design of multiconjugates containing both a gene therapeutic, small interfering RNA (siRNA), ...


    pub_type: 杂志文章


    authors: York AW,Huang F,McCormick CL

    更新日期:2010-02-08 00:00:00

  • The Influence of Biomaterials on Cytokine Production in 3D Cultures.

    abstract::As a result of improved relevance to in vivo physiology, in vitro studies are increasingly performed in diverse, three-dimensional (3D) biomaterials. However, material-cell type pairing effects on cytokine availability remain unclear. We cultured five cell types in agarose, alginate, collagen, Matrigel, or RGD-functio...


    pub_type: 杂志文章


    authors: Regier MC,Montanez-Sauri SI,Schwartz MP,Murphy WL,Beebe DJ,Sung KE

    更新日期:2017-03-13 00:00:00

  • Reinforcement Effects from Nanodiamond in Cellulose Nanofibril Films.

    abstract::Although research on nanopaper structures from cellulose nanofibrils (CNFs) is well established, the mechanical behavior is not well understood, especially not when CNF is combined with hard nanoparticles. Cationic CNF (Q-CNF) was prepared and successfully decorated by anionic nanodiamond (ND) nanoparticles in hydroco...


    pub_type: 杂志文章


    authors: Morimune-Moriya S,Salajkova M,Zhou Q,Nishino T,Berglund LA

    更新日期:2018-07-09 00:00:00

  • Novel genipin-cross-linked chitosan/silk fibroin sponges for cartilage engineering strategies.

    abstract::The positive interaction of materials with tissues is an important step in regenerative medicine strategies. Hydrogels that are obtained from polysaccharides and proteins are expected to mimic the natural cartilage environment and thus provide an optimum milleu for tissue growth and regeneration. In this work, novel h...


    pub_type: 杂志文章


    authors: Silva SS,Motta A,Rodrigues MT,Pinheiro AF,Gomes ME,Mano JF,Reis RL,Migliaresi C

    更新日期:2008-10-01 00:00:00

  • Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region.

    abstract::Eosinophil cationic protein (ECP) is an antimicrobial protein belonging to the superfamily of RNase A. ECP exhibits a broad spectrum of action against bacteria and, at higher concentrations, displays cytotoxic activity to eukaryotic cells. Recently, a powerful aggregation activity for lipid vesicles and for the gram-n...


    pub_type: 杂志文章


    authors: Torrent M,Odorizzi F,Nogués MV,Boix E

    更新日期:2010-08-09 00:00:00

  • Synthesis and Characterization of Silk Ionomers for Layer-by-Layer Electrostatic Deposition on Individual Mammalian Cells.

    abstract::Nanocoating of individual mammalian cells with polymer layers has been of increasing interest in biotechnology and biomedical engineering applications. Electrostatic layer-by-layer (LbL) deposition of polyelectrolytes on negatively charged cell surfaces has been utilized for cell nanocoatings using synthetic or natura...


    pub_type: 杂志文章


    authors: Hasturk O,Sahoo JK,Kaplan DL

    更新日期:2020-07-13 00:00:00

  • Supramolecular GAG-like Self-Assembled Glycopeptide Nanofibers Induce Chondrogenesis and Cartilage Regeneration.

    abstract::Glycosaminoglycans (GAGs) and glycoproteins are vital components of the extracellular matrix, directing cell proliferation, differentiation, and migration and tissue homeostasis. Here, we demonstrate supramolecular GAG-like glycopeptide nanofibers mimicking bioactive functions of natural hyaluronic acid molecules. Sel...


    pub_type: 杂志文章


    authors: Ustun Yaylaci S,Sardan Ekiz M,Arslan E,Can N,Kilic E,Ozkan H,Orujalipoor I,Ide S,Tekinay AB,Guler MO

    更新日期:2016-02-08 00:00:00

  • Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide.

    abstract::Consensus motifs for sequences of both crystallizable and amorphous blocks in silks and natural structural analogues of silks vary widely. To design novel silklike polypeptides, an important question is therefore how the nature of either the crystallizable or the amorphous block affects the self-assembly and resulting...


    pub_type: 杂志文章


    authors: Willems L,van Westerveld L,Roberts S,Weitzhandler I,Calcines Cruz C,Hernandez-Garcia A,Chilkoti A,Mastrobattista E,van der Oost J,de Vries R

    更新日期:2019-10-14 00:00:00

  • Ultra-sub-stoichiometric "Dynamic" Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization.

    abstract::Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy their entire life, there is currently a great desire to formulate antibodies for bolus injection ...


    pub_type: 杂志文章


    authors: Gong Y,Soleymani Abyaneh H,Drossis N,Niederquell A,Kuentz M,Leroux JC,de Haan HW,Gauthier MA

    更新日期:2019-09-09 00:00:00

  • Improved chemical analysis of cellulose ethers using dialkylamine derivatization and mass spectrometry.

    abstract::Oligosaccharides of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, and methyl cellulose were investigated by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The cellulose ether oligosaccharides were produced either by enzymatic depolymerization utilizing the purified family 5 endoglu...


    pub_type: 杂志文章


    authors: Momcilovic D,Schagerlöf H,Wittgren B,Wahlund KG,Brinkmalm G

    更新日期:2005-09-01 00:00:00

  • Cationic dendron-bearing lipids: investigating structure-activity relationships for small interfering RNA delivery.

    abstract::A new family of cationic dendron-bearing lipids (CDLs) with poly(amidoamine) dendrons of first to third generation (named as A1, A2, and A3, respectively) was synthesized through a synthesis approach that permits facile variation of chemical structures. All CDLs could effectively bind small interfering RNA (siRNA) to ...


    pub_type: 杂志文章


    authors: Zhang Y,Chen J,Xiao C,Li M,Tian H,Chen X

    更新日期:2013-12-09 00:00:00

  • Controlled synthesis and inclusion ability of a hyaluronic acid derivative bearing beta-cyclodextrin molecules.

    abstract::A new synthetic route to beta-cyclodextrin-linked hyaluronic acid (HA-CD) was developed. This was based on the preparation of a HA derivative selectively modified with adipic dihydrazide (HA-ADH) and a beta-cyclodextrin derivative possessing an aldehyde function on the primary face, followed by their coupling by a red...


    pub_type: 杂志文章


    authors: Charlot A,Heyraud A,Guenot P,Rinaudo M,Auzély-Velty R

    更新日期:2006-03-01 00:00:00

  • From micelles to fibers: balancing self-assembling and random coiling domains in pH-responsive silk-collagen-like protein-based polymers.

    abstract::We study the self-assembly of genetically engineered protein-based triblock copolymers consisting of a central pH-responsive silk-like middle block (S(H)n, where S(H) is a silk-like octapeptide, (GA)3GH and n is the number of repeats) flanked by hydrophilic random coil outer blocks (C2). Our previous work has already ...


    pub_type: 杂志文章


    authors: Beun LH,Storm IM,Werten MW,de Wolf FA,Cohen Stuart MA,de Vries R

    更新日期:2014-09-08 00:00:00

  • Synthesis and characterization of peptide grafted porous polymer microstructures.

    abstract::A scanning laser system has been used to generate three-dimensional trimethylolpropane trimethacrylate (TRIM) cross-linked poly(2-hydroxylethyl methacrylate) polymer microstructures through azo-bis(isobutyro)nitrile (AIBN) photopolymerization using a 20 x 0.5 NA microscope objective and 365 nm laser excitation. Macrop...


    pub_type: 杂志文章


    authors: Northen TR,Brune DC,Woodbury NW

    更新日期:2006-03-01 00:00:00

  • Porosity-Tuned Chitosan-Polyacrylamide Hydrogel Microspheres for Improved Protein Conjugation.

    abstract::We report a robust method to manufacture polyacrylamide-based functional hydrogel microspheres with readily tunable macroporous structures by utilizing a simple micromolding-based technique. Specifically, surface tension-induced droplet formation of aqueous solutions of chitosan and acrylamide in 2D-shaped micromolds ...


    pub_type: 杂志文章


    authors: Jung S,Abel JH,Starger JL,Yi H

    更新日期:2016-07-11 00:00:00

  • Structural and Mechanical Roles for the C-Terminal Nonrepetitive Domain Become Apparent in Recombinant Spider Aciniform Silk.

    abstract::Spider aciniform (or wrapping) silk is the toughest of the seven types of spider silks/glue due to a combination of high elasticity and strength. Like most spider silk proteins (spidroins), aciniform spidroin (AcSp1) has a large core repetitive domain flanked by relatively short N- and C-terminal nonrepetitive domains...


    pub_type: 杂志文章


    authors: Xu L,Lefèvre T,Orrell KE,Meng Q,Auger M,Liu XQ,Rainey JK

    更新日期:2017-11-13 00:00:00

  • Hemocompatible poly(NIPAm-MBA-AMPS) colloidal nanoparticles as carriers of anti-inflammatory cell penetrating peptides.

    abstract::Anionic copolymer systems containing sulfated monomers have great potential for delivery of cationic therapeutics, but N-isopropylacrylamide (NIPAm) 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) copolymer nanoparticles have seen limited characterization to date with regard to physical properties relevant to load...


    pub_type: 杂志文章


    authors: Bartlett RL 2nd,Medow MR,Panitch A,Seal B

    更新日期:2012-04-09 00:00:00

  • Reversibly cross-linked polyplexes enable cancer-targeted gene delivery via self-promoted DNA release and self-diminished toxicity.

    abstract::Polycations often suffer from the irreconcilable inconsistency between transfection efficiency and toxicity. Polymers with high molecular weight (MW) and cationic charge feature potent gene delivery capabilities, while in the meantime suffer from strong chemotoxicity, restricted intracellular DNA release, and low stab...


    pub_type: 杂志文章


    authors: He H,Bai Y,Wang J,Deng Q,Zhu L,Meng F,Zhong Z,Yin L

    更新日期:2015-04-13 00:00:00

  • CO-Releasing Polymers Exert Antimicrobial Activity.

    abstract::Infectious diseases remain one of the leading causes of death worldwide despite the tremendous effort devoted to the design and development of antimicrobial agents. However, the decrease in the effectiveness of some antibiotics is often associated with the development of drug resistance by pathogen. This leads to an u...


    pub_type: 杂志文章


    authors: Nguyen D,Nguyen TK,Rice SA,Boyer C

    更新日期:2015-09-14 00:00:00

  • Temperature-induced ultradense PEG polyelectrolyte surface grafting provides effective long-term bioresistance against mammalian cells, serum, and whole blood.

    abstract::We report a facile method of generating ultradense poly(l-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) surface by using high temperature alone, which in turn provides dramatic improvement in resisting nonspecific bioadsorption. X-ray photoelectron spectroscopy (XPS) revealed that the surface graft density increased...


    pub_type: 杂志文章


    authors: Ogaki R,Zoffmann Andersen O,Jensen GV,Kolind K,Kraft DC,Pedersen JS,Foss M

    更新日期:2012-11-12 00:00:00

  • Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy.

    abstract::Low tolerability and tumor selectivity restricts many potent anticancer drugs including mertansine from wide clinical use. Here, glutathione-activatable hyaluronic acid-SS-mertansine prodrug (HA-SS-DM1) was designed and developed to achieve enhanced tolerability and targeted therapy of CD44+ human breast tumor xenogra...


    pub_type: 杂志文章


    authors: Zhong P,Zhang J,Deng C,Cheng R,Meng F,Zhong Z

    更新日期:2016-11-14 00:00:00

  • Engineered Polymeric Micelles for Combinational Oxidation Anticancer Therapy through Concurrent HO-1 Inhibition and ROS Generation.

    abstract::Cancer cells have a large amount of ROS (reactive oxygen species) because of disturbed ROS homeostasis. Cancer cells therefore undertake redox adaptation to drive proliferation in tumor environments and even survive during anticancer treatment by upregulating endogenous antioxidants. As one of antioxidant defense syst...


    pub_type: 杂志文章


    authors: Noh J,Jung E,Lee J,Hyun H,Hong S,Lee D

    更新日期:2019-02-11 00:00:00

  • Nanoscale Patterning of Surfaces via DNA Directed Spider Silk Assembly.

    abstract::Oligonucleotide-spider silk conjugates can be placed on silicon wafers by complementary DNA strands, which are coupled chemically to the surface. Such specific immobilization of spider silk proteins allows the nucleation and guided growth of β-sheet-rich nanofibrils in the presence of phosphate ions on the surface. Ad...


    pub_type: 杂志文章


    authors: Molina A,Scheibel T,Humenik M

    更新日期:2019-01-14 00:00:00

  • Single lipid bilayer deposition on polymer surfaces using bicelles.

    abstract::A lipid bilayer was deposited on a 3 μm diameter polystyrene (PS) bead via hydrophobic anchoring of bicelles containing oxyamine-bearing cholesteric moieties reacting with the aldehyde functionalized bead surface. Discoidal bicelles were formed by mixing dimyristoylphosphatidylcholine (DMPC), dihexanoylphosphatidylcho...


    pub_type: 杂志文章


    authors: Saleem Q,Zhang Z,Petretic A,Gradinaru CC,Macdonald PM

    更新日期:2015-03-09 00:00:00

  • Aggregation during coniferyl alcohol polymerization in pectin solution: a biomimetic approach of the first steps of lignification.

    abstract::Coniferyl alcohol was polymerized in pectin solution in order to mimic the lignification that is the final step of biosynthesis of plant cell wall. Dehydrogenated polymers (DHP = coniferyl alcohol polymers = synthetic lignin) interact with pectin to form hydrophobic clusters as monitored by pyrene fluorescence spectro...


    pub_type: 杂志文章


    authors: Lairez D,Cathala B,Monties B,Bedos-Belval F,Duran H,Gorrichon L

    更新日期:2005-03-01 00:00:00