Self-Assembly of Cellulose in Super-Cooled Ionic Liquid under the Impact of Decelerated Antisolvent Infusion: An Approach toward Anisotropic Gels and Aerogels.


:Assembly of (bio)polymers into long-range anisotropic nanostructured gels and aerogels is of great interest in advanced material engineering since it enables directional tuning of properties, such as diffusivity, light, heat, and sound propagation, cell proliferation, and mechanical properties. Here we present an approach toward anisotropic cellulose II gels and aerogels that employs specific diffusion and phase separation phenomena occurring during decelerated infusion of an antisolvent into isotropic supercooled solutions of cellulose in an ionic liquid to effectuate supramolecular assembly of cellulose in anisotropic colloidal network structures. At the example of the distillable ionic liquid 1,1,3,3-tetramethylguanidinium acetate, the antisolvent ethanol, and spherocylindrical porous molds, we demonstrate that the proposed facile, environmental-benign and versatile route affords gels and aerogels whose specific anisotropic nanomorphology and properties reflect the preferred supramolecular cellulose orientation during phase separation, which is perpendicular to the direction of antisolvent diffusion. Comprehensive X-ray scattering experiments revealed that the (aero)gels are composed of an interconnected, fibrous, highly crystalline (CrI ≈ 72%), cellulose II with a cross-sectional Guinier radius of the struts of about 2.5 nm, and an order parameter gradient from about 0.1 to 0.2. The obtained gels and aerogels feature high specific surface areas (350-630 m2 g-1) and excellent mechanical properties like high toughness (up to 471 kJ m-3 for a 60% compression, ρB = 80 mg cm-3) and resilience (up to 13.4 kJ m-3, ρB = 65 mg cm-3).






Plappert SF,Nedelec JM,Rennhofer H,Lichtenegger HC,Bernstorff S,Liebner FW




Has Abstract


2018-11-12 00:00:00












  • Structural analysis of enzyme-resistant isomaltooligosaccharides reveals the elongation of α-(1→3)-linked branches in Weissella confusa dextran.

    abstract::Weissella confusa VTT E-90392 is an efficient producer of a dextran that is mainly composed of α-(1→6)-linked D-glucosyl units and very few α-(1→3) branch linkages. A mixture of the Chaetomium erraticum endodextranase and the Aspergillus niger α-glucosidase was used to hydrolyze W. confusa dextran to glucose and a set...


    pub_type: 杂志文章


    authors: Maina NH,Virkki L,Pynnönen H,Maaheimo H,Tenkanen M

    更新日期:2011-02-14 00:00:00

  • Microstructure and rheological behavior of pure and mixed pectin gels.

    abstract::The microstructure and the rheological properties of pure HM (high methoxyl) and LM (low methoxyl) pectin gels and of mixed HM/LM pectin gels have been investigated. Gel formation of either the HM or LM pectin, or both, was initiated in the mixed gels by varying the sucrose and Ca(2+) content. The microstructure was c...


    pub_type: 杂志文章


    authors: Löfgren C,Walkenström P,Hermansson AM

    更新日期:2002-11-01 00:00:00

  • Rheological study of genipin cross-linked chitosan hydrogels.

    abstract::This paper reports the rheological behavior of chitosan solutions that have been cross-linked with different amounts of genipin, at body temperature and physiological pH. The effect of the cross-linker loading on the rheological properties of hydrogels has been evaluated. The oscillatory time sweep method was used to ...


    pub_type: 杂志文章


    authors: Moura MJ,Figueiredo MM,Gil MH

    更新日期:2007-12-01 00:00:00

  • Poly(ortho ester amides): acid-labile temperature-responsive copolymers for potential biomedical applications.

    abstract::A new, convenient pathway is developed to synthesize highly hydrolytically labile poly(ortho ester amide) (POEA) copolymers that overcomes some of the major weaknesses of the traditional methods of synthesizing poly(ortho esters) and their derivatives. A diamine monomer containing a built-in, stabilized ortho ester gr...


    pub_type: 杂志文章


    authors: Tang R,Palumbo RN,Ji W,Wang C

    更新日期:2009-04-13 00:00:00

  • Two-Dimensional Supramolecular Assemblies from pH-Responsive Poly(ethyl glycol)-b-poly(l-glutamic acid)-b-poly(N-octylglycine) Triblock Copolymer.

    abstract::Amphiphilic block copolymers containing polypeptides can self-assemble into a variety of nonspherical structures arising from strong interactions between peptide units. Here, we report the synthesis of a pH-responsive poly(ethyl glycol)-block-poly(l-glutamic acid)-block-poly(N-octylglycine) (PEG-b-PGA-b-PNOG) triblock...


    pub_type: 杂志文章


    authors: Ni Y,Sun J,Wei Y,Fu X,Zhu C,Li Z

    更新日期:2017-10-09 00:00:00

  • Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media.

    abstract::We report here the first evidence for the interaction of poly(ethylene glycol) (PEG) with hyaluronan (HA) in aqueous solutions. PEG-HA complexes (Kapp = 45,000 ± 8000 M-1) contained about 3.3 ± 0.1 of ethylene glycol units per disaccharide of HA. The carboxyl of the D-glucuronic acid and the amide of the N-acetyl-D-gl...


    pub_type: 杂志文章


    authors: Le-Deygen IM,Musatova OE,Orlov VN,Melik-Nubarov NS,Grozdova ID

    更新日期:2020-12-16 00:00:00

  • Effect of Assembly pH on Polyelectrolyte Multilayer Surface Properties and BMP-2 Release.

    abstract::The effect of solution pH during layer-by-layer assembly of polyelectrolyte multilayer (PEM) coatings on properties relevant to orthopedic implant success was investigated. Bone morphogenetic protein 2 (BMP-2), a potent osteoconductive growth factor, was adsorbed onto the surface of anodized titanium, and PEM coatings...


    pub_type: 杂志文章


    authors: Salvi C,Lyu X,Peterson AM

    更新日期:2016-06-13 00:00:00

  • Enhancement of Loading Efficiency by Coloading of Doxorubicin and Quercetin in Thermoresponsive Polymeric Micelles.

    abstract::Chemotherapy faces challenges, including poor aqueous solubility of the drugs, and cardiotoxicity. Micellar drug delivery systems (DDS) are used to encapsulate anticancer drugs for better therapeutic effects, however, with poor loading content. Herein, we synthesized a micellar DDS using γ-benzyloxy substituted poly(ε...


    pub_type: 杂志文章


    authors: Soltantabar P,Calubaquib EL,Mostafavi E,Biewer MC,Stefan MC

    更新日期:2020-04-13 00:00:00

  • Ultra-sub-stoichiometric "Dynamic" Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization.

    abstract::Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy their entire life, there is currently a great desire to formulate antibodies for bolus injection ...


    pub_type: 杂志文章


    authors: Gong Y,Soleymani Abyaneh H,Drossis N,Niederquell A,Kuentz M,Leroux JC,de Haan HW,Gauthier MA

    更新日期:2019-09-09 00:00:00

  • Determination of the glycosaminoglycan and collagen contents in tissue samples by high-resolution 1H NMR spectroscopy after DCl-induced hydrolysis.

    abstract::The determination of the collagen and glycosaminoglycan (GAG) contents of native and particularly bioengineered tissues is of considerable interest because the collagen-to-GAG ratio determines the water content of the tissue, which is crucial regarding its mechanical properties. (1)H NMR spectroscopy subsequent to the...


    pub_type: 杂志文章


    authors: Riemer T,Nimptsch A,Nimptsch K,Schiller J

    更新日期:2012-07-09 00:00:00

  • Living polypeptides.

    abstract::Block copolypeptides, which combine the self-assembly of block copolymers and the highly ordered 3D structures of proteins, are potential candidates for novel supramolecular structures and biotech applications, such as biosensors, tissue engineering, and selective drug delivery. The synthesis of model block copolypept...


    pub_type: 杂志文章


    authors: Aliferis T,Iatrou H,Hadjichristidis N

    更新日期:2004-09-01 00:00:00

  • Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control.

    abstract::Liver glycogen, a highly branched polymer of glucose, is important for maintaining blood-glucose homeostasis. It was recently shown that db/db mice, a model for Type 2 diabetes, are unable to form the large composite glycogen α particles present in normal, healthy mice. In this study, the structure of healthy mouse-li...


    pub_type: 杂志文章


    authors: Sullivan MA,Aroney ST,Li S,Warren FJ,Joo JS,Mak KS,Stapleton DI,Bell-Anderson KS,Gilbert RG

    更新日期:2014-02-10 00:00:00

  • Self-assembled pH-responsive hydrogels composed of the RATEA16 peptide.

    abstract::Peptide RATEA16 spontaneously self-assembled into higher-order nanofiber hydrogels with extremely high water content (>99.5% (wt/vol)) under physiological condition. The hydrogels could undergo pH-reversible transitions from viscous solution to elastic hydrogel and to precipitate. The supramolecular self-assembly and ...


    pub_type: 杂志文章


    authors: Zhao Y,Yokoi H,Tanaka M,Kinoshita T,Tan T

    更新日期:2008-06-01 00:00:00

  • Material stiffness effects on neurite alignment to photopolymerized micropatterns.

    abstract::The ability to direct neurite growth into a close proximity of stimulating elements of a neural prosthesis, such as a retinal or cochlear implant (CI), may enhance device performance and overcome current spatial signal resolution barriers. In this work, spiral ganglion neurons (SGNs), which are the target neurons to b...


    pub_type: 杂志文章


    authors: Tuft BW,Zhang L,Xu L,Hangartner A,Leigh B,Hansen MR,Guymon CA

    更新日期:2014-10-13 00:00:00

  • Direct amidation of poly(gamma-glutamic acid) with benzylamine in dimethyl sulfoxide.

    abstract::Partially benzylamidated, amphipathic poly(gamma-glutamic acid) (BzPGA) was synthesized from poly(gamma-glutamic acid) (PGA) and benzylamine by direct amidation in dimethyl sulfoxide (DMSO). Benzylamine and PGA were heated in DMSO for 1 to 26 h at temperatures between 110 and 130 degrees C, producing derivatives of va...


    pub_type: 杂志文章


    authors: Novak L,Banyai I,Fleischer-Radu JE,Borbély J

    更新日期:2007-05-01 00:00:00

  • Grafting of oligosaccharides onto synthetic polymer colloids.

    abstract::A new method to form colloidally stable oligosaccharide-grafted synthetic polymer particles has been developed. The oligosaccharides, of weight-average degree of polymerization approximately 38, were obtained by enzymatic debranching of amylopectin. Through the use of a cerium(IV)-based redox initiation process, oligo...


    pub_type: 杂志文章


    authors: Mange S,Dever C,De Bruyn H,Gaborieau M,Castignolles P,Gilbert RG

    更新日期:2007-06-01 00:00:00

  • Electrospinning Nanofibers from Chitosan/Hyaluronic Acid Complex Coacervates.

    abstract::Electrospun biopolyelectrolyte nanofibers hold potential for use in a range of biomedical applications, but eliminating toxic chemicals involved in their production remains a key challenge. In this study, we successfully electrospun nanofibers from an aqueous complex coacervate solution composed of chitosan and hyalur...


    pub_type: 杂志文章


    authors: Sun J,Perry SL,Schiffman JD

    更新日期:2019-11-11 00:00:00

  • Click-Chemistry Approach toward Antibacterial and Degradable Hybrid Hydrogels Based on Octa-Betaine Ester Polyhedral Oligomeric Silsesquioxane.

    abstract::An efficient process for the synthesis of degradable hydrogels containing octa-betaine ester polyhedral oligomeric silsesquioxane (POSS) through efficient thiol-ene and Menschutkin click reactions was developed. The hydrogels exhibited a yield strength of 0.36 MPa and a compressive modulus of 4.38 MPa and displayed ex...


    pub_type: 杂志文章


    authors: Han J,Chen Q,Shen Y,Liu Z,Hao X,Zhong M,Zhao Z,Bockstaller MR

    更新日期:2020-09-14 00:00:00

  • Polymeric nanoparticle engineering: from temperature-responsive polymer mesoglobules to gene delivery systems.

    abstract::A novel approach for the preparation of nano- and microcapsules in aqueous solutions by using thermoresponsive polymer (TRP) templates (mesoglobules) is described. The method comprised three steps: formation of mesoglobules, coating the templates by seeded radical copolymerization, followed by core dissolution and cor...


    pub_type: 杂志文章,评审


    authors: Haladjova E,Toncheva-Moncheva N,Apostolova MD,Trzebicka B,Dworak A,Petrov P,Dimitrov I,Rangelov S,Tsvetanov CB

    更新日期:2014-12-08 00:00:00

  • Binding between proteins and cationic spherical polyelectrolyte brushes: effect of pH, ionic strength, and stoichiometry.

    abstract::Cationic spherical polyelectrolyte brushes (SPBs) were synthesized by photoemulsion polymerization, consisting of a polystyrene core with a diameter around 80 nm and a poly(2-aminoethylmethacrylate hydrochloride) (PAEMH) shell with a thickness from 10 to 50 nm densely grafted on the core surface. The binding of variou...


    pub_type: 杂志文章


    authors: Wang S,Chen K,Li L,Guo X

    更新日期:2013-03-11 00:00:00

  • In vitro evaluation of textile chitosan scaffolds for tissue engineering using human bone marrow stromal cells.

    abstract::Textile chitosan fiber scaffolds were developed and tested in terms of biocompatibility for human bone marrow stromal cells (hBMSCs). A part of the scaffolds was further modified by coating with fibrillar collagen type I in order to biologize the surface. hBMSCs of two donors were used for cell culture experiments in ...


    pub_type: 杂志文章


    authors: Heinemann C,Heinemann S,Lode A,Bernhardt A,Worch H,Hanke T

    更新日期:2009-05-11 00:00:00

  • Enhanced antitumor activity of the photosensitizer meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate through encapsulation in antibody-targeted chitosan/alginate nanoparticles.

    abstract::meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate (TMP) is a photosensitizer that can be used in photodynamic therapy (PDT) to induce cell death through generation of reactive oxygen species in targeted tumor cells. However, TMP is highly hydrophilic, and therefore, its ability to accumulate intracellularly is li...


    pub_type: 杂志文章


    authors: Abdelghany SM,Schmid D,Deacon J,Jaworski J,Fay F,McLaughlin KM,Gormley JA,Burrows JF,Longley DB,Donnelly RF,Scott CJ

    更新日期:2013-02-11 00:00:00

  • Enzyme responsive hyaluronic acid nanocapsules containing polyhexanide and their exposure to bacteria to prevent infection.

    abstract::Antibacterial nanodevices could bring coatings of plastic materials and wound dressings a big step forward if the release of the antibacterial agents could be triggered by the presence of the bacteria themselves. Here, we show that novel hyaluronic acid (HA)-based nanocapsules containing the antimicrobial agent polyhe...


    pub_type: 杂志文章


    authors: Baier G,Cavallaro A,Vasilev K,Mailänder V,Musyanovych A,Landfester K

    更新日期:2013-04-08 00:00:00

  • Modulating Antimicrobial Activity and Mammalian Cell Biocompatibility with Glucosamine-Functionalized Star Polymers.

    abstract::The development of novel reagents and antibiotics for combating multidrug resistance bacteria has received significant attention in recent years. In this study, new antimicrobial star polymers (14-26 nm in diameter) that consist of mixtures of polylysine and glycopolymer arms were developed and were shown to possess a...


    pub_type: 杂志文章


    authors: Wong EH,Khin MM,Ravikumar V,Si Z,Rice SA,Chan-Park MB

    更新日期:2016-03-14 00:00:00

  • Cross-Linking Chemistry of Tyramine-Modified Hyaluronan Hydrogels Alters Mesenchymal Stem Cell Early Attachment and Behavior.

    abstract::Given the significance of hydrogels as cell-instructive materials, it is important to understand how differences in their chemical and physical properties are able to direct cell fate. For example, it remains unclear how different hydrogel cross-linking chemistries and gelation mechanisms influence cell behavior. Here...


    pub_type: 杂志文章


    authors: Loebel C,Szczesny SE,Cosgrove BD,Alini M,Zenobi-Wong M,Mauck RL,Eglin D

    更新日期:2017-03-13 00:00:00

  • Preparation of Dental Resins Resistant to Enzymatic and Hydrolytic Degradation in Oral Environments.

    abstract::The short average service life of traditional dental composite restorative materials and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting compositions. Novel monomers and their polymers, reinforcing fillers, and adhesive ...


    pub_type: 杂志文章


    authors: Gonzalez-Bonet A,Kaufman G,Yang Y,Wong C,Jackson A,Huyang G,Bowen R,Sun J

    更新日期:2015-10-12 00:00:00

  • Bioinspired pH- and Temperature-Responsive Injectable Adhesive Hydrogels with Polyplexes Promotes Skin Wound Healing.

    abstract::Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these...


    pub_type: 杂志文章


    authors: Le TMD,Duong HTT,Thambi T,Giang Phan VH,Jeong JH,Lee DS

    更新日期:2018-08-13 00:00:00

  • Interaction of human plasma proteins with thin gelatin-based hydrogel films: a QCM-D and ToF-SIMS study.

    abstract::In the fields of surgery and regenerative medicine, it is crucial to understand the interactions of proteins with the biomaterials used as implants. Protein adsorption directly influences cell-material interactions in vivo and, as a result, regulates, for example, cell adhesion on the surface of the implant. Therefore...


    pub_type: 杂志文章


    authors: Schönwälder SM,Bally F,Heinke L,Azucena C,Bulut ÖD,Heißler S,Kirschhöfer F,Gebauer TP,Neffe AT,Lendlein A,Brenner-Weiß G,Lahann J,Welle A,Overhage J,Wöll C

    更新日期:2014-07-14 00:00:00

  • Dissolution behavior of different celluloses.

    abstract::Celluloses from different origins were dissolved stepwise in N,N-dimethylacetamide/lithium chloride (9% v/w; DMAc/LiCl) with the aim to study the time course of the dissolution process, completeness of dissolution in the dissolved fractions, possible discrimination effects, and differences between the celluloses. Cell...


    pub_type: 杂志文章


    authors: Henniges U,Kostic M,Borgards A,Rosenau T,Potthast A

    更新日期:2011-04-11 00:00:00

  • Homogeneous esterification of xylan-rich hemicelluloses with maleic anhydride in ionic liquid.

    abstract::Generation of bioenergy, new functional polymers, or chemicals and biomaterials from hemicelluloses are important uses for biomass. In this paper, a novel functional biopolymer with carbon-carbon double bond and carboxyl groups was prepared by a homogeneous esterification of xylan-rich hemicelluloses (XH) with maleic ...


    pub_type: 杂志文章


    authors: Peng XW,Ren JL,Sun RC

    更新日期:2010-12-13 00:00:00