Polyelectrolyte complexes stabilize and controllably release vascular endothelial growth factor.

abstract：:The antiproliferative activity of alkylated heparin, in which the terminal end of heparin is derivatized with an alkyl group (butyl, octyl, lauryl, stearyl), was examined using vascular smooth muscle cells. The proliferation of cells, which were growth-arrested prior to addition of heparin, was inhibited in proportion...

journal_title：Biomacromolecules

authors： Gohda M,Magoshi T,Kato S,Noguchi T,Yasuda S,Nonogi H,Matsuda T

更新日期：2001-01-01 00:00:00

abstract：:In situ polymerizable hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. In the present paper a novel polysaccharidic matrix based on calcium alginate (Ca(II)-Alg) hydrogel and dextran methacrylate derivative (Dex-MA), showing potential applicability in the field of pharm...

journal_title：Biomacromolecules

authors： Matricardi P,Pontoriero M,Coviello T,Casadei MA,Alhaique F

更新日期：2008-07-01 00:00:00

abstract：:It is recognized that topographical features such as ridges and grooves can dramatically influence cell phenotype, motivating the development of substrates with precisely biomimetic topography for study of the influence on cultured cells. Intestinal basement membrane topography has been precisely replicated using plas...

journal_title：Biomacromolecules

authors： Pfluger CA,Burkey DD,Wang L,Sun B,Ziemer KS,Carrier RL

更新日期：2010-06-14 00:00:00

abstract：:Relative to normal cells, tumor cells lack adequate capability of reactive oxygen scavenging. Thus, tumor cells can be selectively killed by increasing the concentration of reactive oxygen species in tumor tissue. In this report, we construct an integrated multifunctional polymeric nanoparticle which can selectively i...

journal_title：Biomacromolecules

authors： Wang Y,Yin W,Ke W,Chen W,He C,Ge Z

更新日期：2018-06-11 00:00:00

abstract：:A comprehensive knowledge of the in vivo fate of polymers is essential for their potential application in humans. In this study, the body distribution, accumulation, and elimination processes of intraperitoneally (ip) administered poly(vinyl alcohol) (PVA) in mice were investigated in detail. Two derivatives of PVA (1...

journal_title：Biomacromolecules

authors： Schädlich A,Naolou T,Amado E,Schöps R,Kressler J,Mäder K

更新日期：2011-10-10 00:00:00

abstract：:Their physicochemical properties and relatively low cost make cellulose nanocrystals (CNCs) a potential candidate for future large-scale production in many fields including nanomedicine. Prior to a sustained and responsible development as theranostic agents, robust and reliable data concerning their safety, biocompati...

journal_title：Biomacromolecules

authors： Colombo L,Zoia L,Violatto MB,Previdi S,Talamini L,Sitia L,Nicotra F,Orlandi M,Salmona M,Recordati C,Bigini P,La Ferla B

更新日期：2015-09-14 00:00:00

abstract：:The structure of an extracellular polysaccharide (EPS) from Streptococcus thermophilus THS has been determined. A combination of component analysis, methylation analysis and NMR spectroscopy shows that the polysaccharide is composed of pentasaccharide repeating units. Sequential information was obtained by two-dimensi...

journal_title：Biomacromolecules

authors： Nordmark EL,Yang Z,Huttunen E,Widmalm G

更新日期：2005-01-01 00:00:00

abstract：:The barrier functions of the stratum corneum and the epidermal layers present a tremendous challenge in achieving effective transdermal delivery of drug molecules. Although a few reports have shown that poly(amidoamine) (PAMAM) dendrimers are effective skin-penetration enhancers, little is known regarding the fundamen...

journal_title：Biomacromolecules

authors： Yang Y,Sunoqrot S,Stowell C,Ji J,Lee CW,Kim JW,Khan SA,Hong S

更新日期：2012-07-09 00:00:00

abstract：:These studies illustrate synthetic paths to covalently attach T1 and Φ11 bacteriophages (phages) to inert polymeric surfaces while maintaining the bacteriophage's biological activities capable of killing deadly human pathogens. The first step involved the formation of acid (COOH) groups on polyethylene (PE) and polyte...

journal_title：Biomacromolecules

authors： Pearson HA,Sahukhal GS,Elasri MO,Urban MW

更新日期：2013-05-13 00:00:00

abstract：:Our previous studies have demonstrated the efficacy of generation 5 poly(amidoamine) dendrimers (G5-PAMAM) as a platform for the targeted delivery of chemotherapeutics. However, anticancer therapy can be subverted by anti-apoptotic changes in cancer cells. Bcl-2 and several of its peptides are commonly overexpressed i...

journal_title：Biomacromolecules

authors： Myc A,Patri AK,Baker JR Jr

更新日期：2007-10-01 00:00:00

abstract：:A comprehensive understanding of the mechanism by which type I collagen (Col) interacts with hydroxyapatite nanoparticles (Hap NPs) in aqueous solutions is a pivotal step for guiding the design of biologically relevant nanocomposites with controlled hierarchical structure. In this paper we use a variety of Hap NPs dif...

journal_title：Biomacromolecules

authors： Colaço E,Brouri D,Aissaoui N,Cornette P,Dupres V,Domingos RF,Lambert JF,Maisonhaute E,Kirat KE,Landoulsi J

更新日期：2019-12-09 00:00:00

abstract：:The elegant elasticity and toughness of muscles that are controlled by myofilament sliding, highly elastic springlike properties of titin, and Ca2+-induced conformational change of the troponin complex have been a source of inspiration to develop advanced materials for simulating elastic muscle motion. Herein, a highl...

journal_title：Biomacromolecules

authors： Zhao L,Zhang X,Luo Q,Hou C,Xu J,Liu J

更新日期：2020-10-12 00:00:00

abstract：:A series of copolymers of trimethylene carbonate (TMC) and L-lactide (LLA) were synthesized and evaluated as scaffolds for the production of artificial blood vessels. The polymers were end-functionalized with acrylate, cast into films, and cross-linked using UV light. The mechanical, degradation, and biocompatibility ...

journal_title：Biomacromolecules

authors： Dargaville BL,Vaquette C,Peng H,Rasoul F,Chau YQ,Cooper-White JJ,Campbell JH,Whittaker AK

更新日期：2011-11-14 00:00:00

abstract：:The affinity of surfaces toward proteins is found to be a key parameter to govern the synthesis of polymer brushes by surface-initiated biocatalytic atom transfer radical polymerization (SI-bioATRP). While the "ATRPase" hemoglobin (Hb) stimulates only a relatively slow growth of protein repellent brushes, the synthesi...

journal_title：Biomacromolecules

authors： Divandari M,Pollard J,Dehghani E,Bruns N,Benetti EM

更新日期：2017-12-11 00:00:00

abstract：:Synthetic lethality is a molecular-targeted therapy for selective killing of cancer cells. We exploited a lethal interaction between superoxide dismutase 1 inhibition and Bloom syndrome gene product (BLM) defect for the treatment of colorectal cancer (CRC) cells (HCT 116) with a customized lung cancer screen-1-loaded ...

journal_title：Biomacromolecules

authors： Gupta A,Ahmad A,Singh H,Kaur S,K M N,Ansari MM,Jayamurugan G,Khan R

更新日期：2018-03-12 00:00:00

abstract：:We created the dual-responsive nanovehicle that can effectively combine and abundantly utilize magnetic and glutathione (GSH)-reductive triggers to control the drug delivery and achieve more intelligent and powerful targeting. In the nanovehicles, paramagnetic fullerene (C60@CTAF) was prepared via one-step modificatio...

journal_title：Biomacromolecules

authors： Wang L,Wang Y,Hao J,Dong S

更新日期：2017-03-13 00:00:00

abstract：:Protein transduction domains (PTDs) that readily transverse cellular membranes are of great interest and are attractive tools for the intracellular delivery of bioactive molecules. Learning to program synthetic polymers and oligomers with the appropriate chemical information to capture adequately the biological activi...

journal_title：Biomacromolecules

authors： Tezgel AÖ,Telfer JC,Tew GN

更新日期：2011-08-08 00:00:00

abstract：:Softwood and hardwood celluloses were oxidized by 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation. The TEMPO-oxidized cellulose fibers were converted to transparent dispersions in water, which consisted of individual nanofibers 3-4 nm in width. Films were then prepared from the TEMPO-oxidized c...

journal_title：Biomacromolecules

authors： Fukuzumi H,Saito T,Iwata T,Kumamoto Y,Isogai A

更新日期：2009-01-12 00:00:00

abstract：:Medical glue represents a suitable tool to stop wound bleeding, seal wounds, bond tissues, or implant materials. However, the development of a medical glue for durable underwater bonding remains a challenge. Herein, we developed a hydrophobic hyperbranched polymer-based medical glue with water-resistant bonding abilit...

journal_title：Biomacromolecules

authors： Zhang Y,Li X,Zhu Q,Wei W,Liu X

更新日期：2020-12-14 00:00:00

abstract：:Antibacterial nanodevices could bring coatings of plastic materials and wound dressings a big step forward if the release of the antibacterial agents could be triggered by the presence of the bacteria themselves. Here, we show that novel hyaluronic acid (HA)-based nanocapsules containing the antimicrobial agent polyhe...

journal_title：Biomacromolecules

authors： Baier G,Cavallaro A,Vasilev K,Mailänder V,Musyanovych A,Landfester K

更新日期：2013-04-08 00:00:00

abstract：:We report here the first evidence for the interaction of poly(ethylene glycol) (PEG) with hyaluronan (HA) in aqueous solutions. PEG-HA complexes (Kapp = 45,000 ± 8000 M-1) contained about 3.3 ± 0.1 of ethylene glycol units per disaccharide of HA. The carboxyl of the D-glucuronic acid and the amide of the N-acetyl-D-gl...

journal_title：Biomacromolecules

authors： Le-Deygen IM,Musatova OE,Orlov VN,Melik-Nubarov NS,Grozdova ID

更新日期：2020-12-16 00:00:00

abstract：:In the present study, novel bionanocomposite materials with tunable properties were successfully prepared using a poly(lactic acid) (PLA) matrix and acetylated microfibrillated cellulose (MFC) as reinforcing agent. The acetylation of MFC was confirmed by FTIR and (13)C CP-MAS NMR spectroscopies. The grafting of acetyl...

journal_title：Biomacromolecules

authors： Tingaut P,Zimmermann T,Lopez-Suevos F

更新日期：2010-02-08 00:00:00

abstract：:Super-resolution fluorescence microscopy, specifically stochastic reconstruction microscopy (STORM), and atomic force microscopy (AFM) were used to image the self-assembly processes of the peptide surfactant I3K. The peptide surfactants self-assembled into giant helical fibrils with diameters between 5 and 10 nm with ...

journal_title：Biomacromolecules

authors： Cox H,Georgiades P,Xu H,Waigh TA,Lu JR

更新日期：2017-11-13 00:00:00

abstract：:Cell cultivation on the surface of a novel poly(N-isopropylacrylamide) (PNIPA) hydrogel (N-NC gel), consisting of a specific type of organic (PNIPA)/inorganic (clay) network, was studied using three cell types; HepG2 human hepatoma cells, human dermal fibroblasts, and human umbilical vein endothelial cells. For the fi...

journal_title：Biomacromolecules

authors： Haraguchi K,Takehisa T,Ebato M

更新日期：2006-11-01 00:00:00

abstract：:We explore here the possibility that polypeptide chains with directional multiplicity might provide for the control of peptide self-assembly processes. We tested this new possibility using an oppositely directed peptide (ODP) supramolecular system. The ODP could make it possible to form a βαβ motif with antiparallel β...

journal_title：Biomacromolecules

authors： Jeong WJ,Han S,Park H,Jin KS,Lim YB

更新日期：2014-06-09 00:00:00

abstract：:Antifreeze glycoproteins (AFGPs) are a subclass of biological antifreezes found in deep sea Teleost fish. These compounds have the ability to depress the freezing point of the organism such that it can survive the subzero temperatures encountered in its environment. This physical property is very attractive for the cr...

journal_title：Biomacromolecules

authors： Liu S,Wang W,Moos Ev,Jackman J,Mealing G,Monette R,Ben RN

更新日期：2007-05-01 00:00:00

abstract：:In the cell nucleus, putrescine, spermidine, and spermine self-assemble with phosphate ions to generate three forms of compounds, named nuclear aggregates of polyamines (NAPs), which may interact with DNA. In an in vitro setting mimicking the cell nucleus milieu, this molecular aggregation occurs within well-defined r...

journal_title：Biomacromolecules

authors： Iacomino G,Picariello G,Sbrana F,Di Luccia A,Raiteri R,D'Agostino L

更新日期：2011-04-11 00:00:00

abstract：:In a previous study, we have reported chemical synthesis of novel aliphatic poly(butylene succinate-co-cyclic carbonate) P(BS-co-CC)s bearing various functionalizable carbonate building blocks, and this work will continue to present our new studies on their enzymatic degradation and in vitro cell biocompatibility assa...

journal_title：Biomacromolecules

authors： Yang J,Tian W,Li Q,Li Y,Cao A

更新日期：2004-11-01 00:00:00

abstract：:Hydrogels constructed from folded protein domains are of increasing interest as resilient and responsive biomaterials, but their optimization for applications requires time-consuming and costly molecular design. Here, we explore a complementary approach to control their properties by examining the influence of crossli...

journal_title：Biomacromolecules

authors： Aufderhorst-Roberts A,Hughes MDG,Hare A,Head DA,Kapur N,Brockwell DJ,Dougan L

更新日期：2020-10-12 00:00:00

abstract：:The drying dynamics of protein coatings is of importance for many applications. The main focus of research so far was to investigate macroscopic properties of protein coatings, leaving drying dynamics virtually unexplored. A unique combination of techniques is used to monitor drying of a coating containing the protein...

journal_title：Biomacromolecules

authors： Bouman J,de Vries R,Venema P,Belton P,Baukh V,Huinink HP,van der Linden E

更新日期：2015-01-12 00:00:00