Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media.

abstract：:New silk-like recombinant proteins, [(AAG)(6)ASTGRGDSPAAS](n) and [(AG)(9)ASTGRGDSPAAS](n), with high cell adhesive activities were designed and produced from E. coli. These are recombinant proteins with characteristic sequences from the silk fibroin of a wild silkworm, Anaphe , and the cell adhesive region, including...

journal_title：Biomacromolecules

authors： Tanaka C,Asakura T

更新日期：2009-04-13 00:00:00

abstract：:Imbalanced homeostasis and oligomerization of the amyloid-β (Aβ) peptide in the brain are hallmarks of Alzheimer's disease (AD). Microglia and macrophages play a critical role in the etiology of AD either by clearing Aβ from the brain or inducing inflammation. Recent evidence suggests that clearance of Aβ by microglia...

journal_title：Biomacromolecules

authors： Richman M,Perelman A,Gertler A,Rahimipour S

更新日期：2013-01-14 00:00:00

abstract：:There is a lack of hydrogel materials whose properties can be tuned at the point of use. Biological hydrogels, such as collagen, gelate at physiological temperatures; however, they are not always ideal as scaffolds because of their low mechanical strength. Their mechanics can be improved through cross-linking and chem...

journal_title：Biomacromolecules

authors： Barnes AL,Genever PG,Rimmer S,Coles MC

更新日期：2016-03-14 00:00:00

abstract：:A series of structurally diverse polymers, containing either peptide or vinyl-derived backbones, was tested for ice recrystallization inhibition activity, which is commonly associated with antifreeze (glyco)proteins. It was revealed that only polymers bearing hydroxyl groups in the side chain could inhibit ice growth....

journal_title：Biomacromolecules

authors： Gibson MI,Barker CA,Spain SG,Albertin L,Cameron NR

更新日期：2009-02-09 00:00:00

abstract：:By monitoring the thermally driven displacements of imbedded polystyrene microspheres via video fluorescence microscopy, we quantified the microstructural and micromechanical heterogeneities of wheat gliadin suspensions. We found that the degree of heterogeneity of the suspensions, as measured by the width and skewnes...

journal_title：Biomacromolecules

authors： Xu J,Tseng Y,Carriere CJ,Wirtz D

更新日期：2002-01-01 00:00:00

abstract：:Regulating cell migration dynamics is of significance in tissue engineering and regenerative medicine. A 3D scaffold was created to provide various topographies based on a poly(ε-caprolactone) (PCL) self-induced nanohybrid shish-kebab structure, which consisted of aligned PCL nanofibers and spaced PCL crystal lamellae...

journal_title：Biomacromolecules

authors： Guo X,Wang X,Li X,Jiang YC,Han S,Ma L,Guo H,Wang Z,Li Q

更新日期：2020-03-09 00:00:00

abstract：:Collagen fibrils were obtained in vitro by aggregation from acid-soluble type I collagen at different initial concentrations and with the addition of decorin core or intact decorin. All specimens were observed by scanning electron microscopy and atomic force microscopy. In line with the findings of other authors, lack...

journal_title：Biomacromolecules

authors： Raspanti M,Viola M,Sonaggere M,Tira ME,Tenni R

更新日期：2007-07-01 00:00:00

abstract：:Polycations often suffer from the irreconcilable inconsistency between transfection efficiency and toxicity. Polymers with high molecular weight (MW) and cationic charge feature potent gene delivery capabilities, while in the meantime suffer from strong chemotoxicity, restricted intracellular DNA release, and low stab...

journal_title：Biomacromolecules

authors： He H,Bai Y,Wang J,Deng Q,Zhu L,Meng F,Zhong Z,Yin L

更新日期：2015-04-13 00:00:00

abstract：:A recombinant silk-elastin-like protein copolymer SELP-47K containing tandemly repeated amino acid sequence blocks from silk, GAGAGS, and elastin, GVGVP, was fabricated into microdiameter fibers using a wet-spinning technique. Raman spectral analysis revealed the formation of antiparallel beta-sheet crystals of the si...

journal_title：Biomacromolecules

authors： Qiu W,Teng W,Cappello J,Wu X

更新日期：2009-03-09 00:00:00

abstract：:Despite the good clinical efficacy of interferon-alpha (IFNα) to treat some types of cancer and viral infections, this biological drug is underused given its severe adverse effects and high dosing parenteral regimens. Aiming to achieve a breakthrough in therapy with IFNα, this work reports for the first time on the de...

journal_title：Biomacromolecules

authors： Cánepa C,Imperiale JC,Berini CA,Lewicki M,Sosnik A,Biglione MM

更新日期：2017-10-09 00:00:00

abstract：:Surface pressure isotherms and structural and surface dilatational properties of three hydroxypropylmethycelluloses (HPMCs, called E4M, E50LV, and F4M) adsorbed films at the air-water interface were determined. In this work we present evidence that HPMC molecules are able to diffuse and saturate the air-water interfac...

journal_title：Biomacromolecules

authors： Pérez OE,Sánchez CC,Rodríguez Patino JM,Pilosof AM

更新日期：2006-01-01 00:00:00

abstract：:The synergistic interaction between xanthan and glucomannan in solution and in the gel phase has been studied by circular dichroism spectroscopy and differential scanning calorimetry. The study in solution of the polysaccharidic mixture indicates a preferred stoichiometry of the interaction corresponding to a weight f...

journal_title：Biomacromolecules

authors： Paradossi G,Chiessi E,Barbiroli A,Fessas D

更新日期：2002-05-01 00:00:00

abstract：:Positive strand RNA viruses replicate in specialized niches called membranous web within the cytoplasm of host cells. These virus replication organelles sequester viral proteins, RNA, and a variety of host factors within a fluid, amorphous matrix of clusters of endoplasmic reticulum (ER) derived vesicles. They are tho...

journal_title：Biomacromolecules

authors： Ho JCS,Steininger C,Hiew SH,Kim MC,Reimhult E,Miserez A,Cho N,Parikh AN,Liedberg B

更新日期：2019-04-08 00:00:00

abstract：:Although doxorubicin (Dox) has been widely used in the treatment of different types of cancer, its insufficient cellular uptake and intracellular release is still a limitation. Herein, we report an easy process for the preparation of redox-sensitive nanogels that were shown to be highly efficient in the intracellular ...

journal_title：Biomacromolecules

authors： Maciel D,Figueira P,Xiao S,Hu D,Shi X,Rodrigues J,Tomás H,Li Y

更新日期：2013-09-09 00:00:00

abstract：:Heparins are widely used to prevent blood clotting during surgeries and for the treatment of thrombosis. However, bleeding associated with heparin therapy is a concern. Protamine, the only approved antidote for unfractionated heparin (UFH) could cause adverse cardiovascular events. Here, we describe a unique molecular...

journal_title：Biomacromolecules

authors： Kalathottukaren MT,Abbina S,Yu K,Shenoi RA,Creagh AL,Haynes C,Kizhakkedathu JN

更新日期：2017-10-09 00:00:00

abstract：:In this work, we have applied an electrospinning method to control wettability and further hydrophobic modification of a hydrophobic polymer mat of poly(vinylidene fluoride-co-hexafluoropropylene). A correlation between the processing parameters, rheological properties of polymer solutions, and electrospinning ability...

journal_title：Biomacromolecules

authors： Ahmed F,Choudhury NR,Dutta NK,Zannettino A,Knott R

更新日期：2013-11-11 00:00:00

abstract：:Macromolecular dynamics in biological systems, which play a crucial role for biomolecular function and activity at ambient temperature, depend strongly on moisture content. Yet, a generally accepted quantitative model of hydration-dependent phenomena based on local relaxation and diffusive dynamics of both polymer and...

journal_title：Biomacromolecules

authors： Chen P,Terenzi C,Furó I,Berglund LA,Wohlert J

更新日期：2018-07-09 00:00:00

abstract：:Tumor targeting has revolutionized cancer research, especially active cellular targeting of nanoparticles, where they are specifically homed to the pathological site to deliver the therapeutics. This strategy, which involves the utilization of affinity ligands on the surface of the nanocarriers, minimizes the nonspeci...

journal_title：Biomacromolecules

authors： Raveendran R,Chen F,Kent B,Stenzel MH

更新日期：2020-03-09 00:00:00

abstract：:The synthesis of poly(methyl methacrylate-co-methacryloxysuccinimide-graft-poly(ethylene glycol)) (PMMA-co-PMASI-g-PEG) via living free radical polymerization provides a convenient route to well-defined amphiphilic graft copolymers having a controllable number of reactive functional groups, variable length PEG grafts,...

journal_title：Biomacromolecules

authors： Pressly ED,Rossin R,Hagooly A,Fukukawa K,Messmore BW,Welch MJ,Wooley KL,Lamm MS,Hule RA,Pochan DJ,Hawker CJ

更新日期：2007-10-01 00:00:00

abstract：:Nearly monodispersed silica nanoparticles having a controlled size from 5 to 450 nm were synthesized via a sol-gel process, and then the optimum conditions for the surface treatment of the synthesized silica nanoparticles with a silane coupling agent (i.e., 3-methacryloxypropyltrimethoxysilane (gamma-MPS)) were explor...

journal_title：Biomacromolecules

authors： Kim JW,Kim LU,Kim CK

更新日期：2007-01-01 00:00:00

abstract：:Angiogenesis has long been a desired therapeutic approach to improve clinical outcomes of conditions typified by ischemia. Vascular endothelial growth factor (VEGF) has demonstrated the ability to generate new blood vessels in vivo, but trials using intravenous delivery have not yet produced clinical success. Localize...

journal_title：Biomacromolecules

authors： Huang M,Vitharana SN,Peek LJ,Coop T,Berkland C

更新日期：2007-05-01 00:00:00

abstract：:Utilization of reversible interactions as sacrificial bonds in biopolymers is critical for the integral synthesis of mechanically superior biological materials. In this work, cellulose nanofibrils (CNFs) reinforced covalent polyacrylamide (PAAm) composite hydrogels are immersed into multivalent cation (Ca2+, Zn2+, Al3...

journal_title：Biomacromolecules

authors： Yang J,Xu F,Han CR

更新日期：2017-03-13 00:00:00

abstract：:Inulin, the polydisperse polyfructose, extracted from chicory, has been modified via transesterification, using fatty acid methyl esters (FAME). The grafting of an alkyl chain onto the inulin backbone under different conditions for the development of potential tensio-active derivatives is described. The modification o...

journal_title：Biomacromolecules

authors： Rogge TM,Stevens CV

更新日期：2004-09-01 00:00:00

abstract：:An enzymatically cross-linked polyethylene glycol (PEG)-based hydrogel was engineered to promote and align nerve cells in a three-dimensional manner. To render the injectable, otherwise bioinert, PEG-based material supportive for cell growth, its mechanical and biochemical properties were optimized. A recombinant fibr...

journal_title：Biomacromolecules

authors： Licht C,Rose JC,Anarkoli AO,Blondel D,Roccio M,Haraszti T,Gehlen DB,Hubbell JA,Lutolf MP,De Laporte L

更新日期：2019-11-11 00:00:00

abstract：:Electrospinning of cellulose nanocrystals (CNC)/poly(lactic acid) (PLA) emulsions has been demonstrated to be an effective dispersion and alignment method to control assembly of CNC into continuous composite ultrafine fibers. CNC-PLA nanocomposite random-fiber mats and aligned-fiber yarns were prepared by emulsion ele...

journal_title：Biomacromolecules

authors： Li Y,Ko FK,Hamad WY

更新日期：2013-11-11 00:00:00

abstract：:We report a robust method to manufacture polyacrylamide-based functional hydrogel microspheres with readily tunable macroporous structures by utilizing a simple micromolding-based technique. Specifically, surface tension-induced droplet formation of aqueous solutions of chitosan and acrylamide in 2D-shaped micromolds ...

journal_title：Biomacromolecules

authors： Jung S,Abel JH,Starger JL,Yi H

更新日期：2016-07-11 00:00:00

abstract：:This paper describes the synthesis and characterization of polymer-peptide conjugates to be used as infection-resistant coating for biomaterial implants and devices. Antiadhesive polymer brushes composed of block copolymer Pluronic F-127 (PF127) were functionalized with antimicrobial peptides (AMP), able to kill bacte...

journal_title：Biomacromolecules

authors： Muszanska AK,Rochford ET,Gruszka A,Bastian AA,Busscher HJ,Norde W,van der Mei HC,Herrmann A

更新日期：2014-06-09 00:00:00

abstract：:A novel methacrylate monomer containing a quinolone moiety was synthesized and homopolymerized in N,N-dimethylformamide (DMF) by using azobisisobutyronitrile (AIBN) as an initiator. The new monomer was copolymerized with poly(ethylene glycol) methyl ether methacrylate (MPEGMA) in DMF using the same initiator. The mono...

journal_title：Biomacromolecules

authors： Dizman B,Elasri MO,Mathias LJ

更新日期：2005-01-01 00:00:00

abstract：:A library-orientated approach is used to gain understanding of the interactions of well-defined nanoparticles with primary human endothelial cells, which are a key component of the vasculature. Fifteen sequentially modified gold nanoparticles (AuNPs) based on three different core sizes (18, 35, 65 nm) and five polymer...

journal_title：Biomacromolecules

authors： Freese C,Gibson MI,Klok HA,Unger RE,Kirkpatrick CJ

更新日期：2012-05-14 00:00:00

abstract：:The outcome for glioblastoma patients remains dismal for its invariably recrudesces within 2 cm of the resection cavity. Local immunotherapy has the potential to eradicate the residual infiltrative component of these tumors. Here, we report the development of a biodegradable hydrogel containing therapeutic T lymphocyt...

journal_title：Biomacromolecules

authors： Tsao CT,Kievit FM,Ravanpay A,Erickson AE,Jensen MC,Ellenbogen RG,Zhang M

更新日期：2014-07-14 00:00:00