Abstract:
:We report a robust method to manufacture polyacrylamide-based functional hydrogel microspheres with readily tunable macroporous structures by utilizing a simple micromolding-based technique. Specifically, surface tension-induced droplet formation of aqueous solutions of chitosan and acrylamide in 2D-shaped micromolds followed by photoinduced polymerization leads to monodisperse microspheres. Pore sizes of the microspheres can be readily tuned by simple addition of inert long-chain poly(ethylene glycol) porogen at low content in the prepolymer solution. The as-prepared chitosan-polyacrylamide microspheres exhibit chemical functionality through chitosan's primary amines, rapid protein conjugation with selective tetrazine-trans-cyclooctene reaction, and nonfouling property. Combined with the potential to create anisotropic network structures, we envision that our simple fabrication-conjugation method would offer a potent route to manufacture a variety of biofunctionalized hydrogel microentities.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Jung S,Abel JH,Starger JL,Yi Hdoi
10.1021/acs.biomac.6b00582subject
Has Abstractpub_date
2016-07-11 00:00:00pages
2427-36issue
7eissn
1525-7797issn
1526-4602journal_volume
17pub_type
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