Synthesis of poly[(R)-3-hydroxybutyric acid) in the cytoplasm of Pichia pastoris under oxygen limitation.

abstract：:Intraneuronal aggregation of the intrinsically disordered protein α-synuclein is at the core of Parkinson's disease and related neurodegenerative disorders. Several reports show that the concentration of salts in the medium heavily affects its aggregation rate and fibril morphology, but a characterization of the indiv...

journal_title：Biomacromolecules

authors： Ramis R,Ortega-Castro J,Vilanova B,Adrover M,Frau J

更新日期：2020-12-14 00:00:00

abstract：:Hydrogels constructed from folded protein domains are of increasing interest as resilient and responsive biomaterials, but their optimization for applications requires time-consuming and costly molecular design. Here, we explore a complementary approach to control their properties by examining the influence of crossli...

journal_title：Biomacromolecules

authors： Aufderhorst-Roberts A,Hughes MDG,Hare A,Head DA,Kapur N,Brockwell DJ,Dougan L

更新日期：2020-10-12 00:00:00

abstract：:Immunological detection has been developed into a sensitive and versatile technique and is based on two requisite elements: targeting antibodies and an indicator, usually in the form of horseradish peroxidase or alkaline phosphatase. The specificity and turnover rate of these enzymes provide an efficient means of sign...

journal_title：Biomacromolecules

authors： Wurtzler EM,Wendell D

更新日期：2014-01-13 00:00:00

abstract：:Immobilizing zwitterionic molecules on material surfaces has been a promising strategy for creating antifouling surfaces. Herein, we show the ability to surface derivatize an allyl-ether-functionalized thermoplastic polyurethane (TPU) with a zwitterionic thiol in a radically induced thiol-ene reaction. The thermoplast...

journal_title：Biomacromolecules

authors： Nikam SP,Chen P,Nettleton K,Hsu YH,Becker ML

更新日期：2020-07-13 00:00:00

abstract：:Restorative medicine has a constant need for improved scaffold materials. Degradable biopolymers often suffer from uncontrolled chemical or enzymatic hydrolysis by the host. The need for a second surgery on the other hand is a major drawback for nondegradable scaffold materials. In this paper we report the design and ...

journal_title：Biomacromolecules

authors： Berski S,van Bergeijk J,Schwarzer D,Stark Y,Kasper C,Scheper T,Grothe C,Gerardy-Schahn R,Kirschning A,Dräger G

更新日期：2008-09-01 00:00:00

abstract：:X-ray analytical techniques are increasingly being used to study manuscripts and works of art on paper, whether with laboratory equipment or synchrotron sources. However, it is difficult to anticipate the impact of X-ray photons on paper- and cellulose-based artifacts, particularly due to the large variety of their co...

journal_title：Biomacromolecules

authors： Gimat A,Schöder S,Thoury M,Missori M,Paris-Lacombe S,Dupont AL

更新日期：2020-07-13 00:00:00

abstract：:Candida antarctica Lipase B (CALB) was covalently immobilized onto epoxy-activated macroporous poly(methyl methacrylate) Amberzyme beads (235 microm particle size, 220 A pore size) and nanoparticles (nanoPSG, diameter 68 nm) with a poly(glycidyl methacrylate) outer region. Amberzyme beads allowed CALB loading up to 0....

journal_title：Biomacromolecules

authors： Chen B,Hu J,Miller EM,Xie W,Cai M,Gross RA

更新日期：2008-02-01 00:00:00

abstract：:Poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) are biopolyesters reported to provide favorable microenvironments for cell culture and possess potential for tissue engineering applications. Both biopolymers have been investigated for applications in a variety of medical scenarios,...

journal_title：Biomacromolecules

authors： Ahmed T,Marçal H,Lawless M,Wanandy NS,Chiu A,Foster LJ

更新日期：2010-10-11 00:00:00

abstract：:Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) was applied to investigate the interaction of bovine serum albumin (BSA) and fibrinogen with a biomedical-grade 316LVM stainless steel surface, in terms of the adsorption thermodynamics and adsorption-induced secondary structure changes of ...

journal_title：Biomacromolecules

authors： Desroches MJ,Chaudhary N,Omanovic S

更新日期：2007-09-01 00:00:00

abstract：:Biobased poly(γ-butyrolactone) (PγBL) as a fully biodegradable and bioabsorbable biomaterial has shown superior properties compared to those of other aliphatic polyesters. It is of great importance to prepare amphiphilic block copolymer containing PγBL block to make ordered nano-objects for biomedical applications suc...

journal_title：Biomacromolecules

authors： Shen Y,Zhang J,Zhao Z,Zhao N,Liu F,Li Z

更新日期：2019-01-14 00:00:00

abstract：:Sequential copolymerizations of trimethylene carbonate (TMC) and l-lactide (LLA) were performed with 2,2-dibutyl-2-stanna-1,3-oxepane as a bifunctional cyclic initiator. The block lengths were varied via the monomer/initiator and via the TMC/l-lactide ratio. The cyclic triblock copolymers were transformed in situ into...

journal_title：Biomacromolecules

authors： Pospiech D,Komber H,Jehnichen D,Häussler L,Eckstein K,Scheibner H,Janke A,Kricheldorf HR,Petermann O

更新日期：2005-01-01 00:00:00

abstract：:A major challenge in drug delivery is the internalization through the apical plasma membrane of the polarized epithelial cells lining organs facing the external environment, e.g., lungs and the gastrointestinal tract. The reduced permeation of drugs entering through this pathway is in part due to the mucosal barrier a...

journal_title：Biomacromolecules

authors： Harush-Frenkel O,Rozentur E,Benita S,Altschuler Y

更新日期：2008-02-01 00:00:00

abstract：:Evidence is presented that the polysaccharide rhamnogalacturonan I (RGI) can be biosynthesized in remarkably organized branched configurations and surprisingly long versions and can self-assemble into a plethora of structures. AFM imaging has been applied to study the outer mucilage obtained from wild-type (WT) and mu...

journal_title：Biomacromolecules

authors： Williams MAK,Cornuault V,Irani AH,Symonds VV,Malmström J,An Y,Sims IM,Carnachan SM,Sallé C,North HM

更新日期：2020-04-13 00:00:00

abstract：:C13-dipeptides that did not gel on their own were found to form hydrogels when combined with mixtures (coassembly). At pH = 4.6, by mixing negatively charged C13-WD (C13-WD2- and/or C13-WD-) with C13-KW or C13-YK, where the side chain of K carried positive charge, two composite hydrogels with different mechanical prop...

journal_title：Biomacromolecules

authors： Hu T,Zhang Z,Euston SR,Geng M,Pan S

更新日期：2020-12-14 00:00:00

abstract：:Poly(lactide)-block-poly(ethylene oxide)-block-poly(lactide) (PLA-PEO-PLA) triblock copolymers are known to form physical hydrogels in water as a result of the polymer's amphiphilicity. Their mechanical properties, biocompatibility, and biodegradability have made them attractive for use as soft tissue scaffolds. Howev...

journal_title：Biomacromolecules

authors： Sanabria-DeLong N,Crosby AJ,Tew GN

更新日期：2008-10-01 00:00:00

abstract：:Peak force infrared (PFIR) microscopy is a recently developed approach to acquire multiple chemical and physical material properties simultaneously and with nanometer resolution: topographical features, infrared (IR)-sensitive maps, adhesion, stiffness, and locally resolved IR spectra. This multifunctional mapping is ...

journal_title：Biomacromolecules

authors： Gusenbauer C,Jakob DS,Xu XG,Vezenov DV,Cabane É,Konnerth J

更新日期：2020-10-12 00:00:00

abstract：:We report a simple and novel top-down method based on a drop-casting process for the controlled synthesis of all-bone-minerals biomimetic multicomponent bionanocomposites. Integration of micro- and nanoscale binary features into nanofibrous biocompatible polymer scaffold structures is successfully demonstrated. Compos...

journal_title：Biomacromolecules

authors： Biswas A,Bayer IS,Zhao H,Wang T,Watanabe F,Biris AS

更新日期：2010-10-11 00:00:00

abstract：:The currently used hemostatic agents are highly effective in stopping hemorrhages but have a limited role in the modulation of the wound-healing environment. Herein, we propose an intrinsically bioactive hemostatic cryogel based on platelet lysate (PL) and aldehyde-functionalized cellulose nanocrystals (a-CNCs). PL ha...

journal_title：Biomacromolecules

authors： Mendes BB,Gómez-Florit M,Araújo AC,Prada J,Babo PS,Domingues RMA,Reis RL,Gomes ME

更新日期：2020-09-14 00:00:00

abstract：:Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow tumorigenic behaviors to be observed and manipulated, we cultured related MCF10 breast cell lines on fibers composed of the Drosophila protein Ultrabithorax (Ubx). These...

journal_title：Biomacromolecules

authors： Hsiao HC,Santos A,Howell DW,Patterson JL,Fuchs-Young RS,Bondos SE

更新日期：2016-11-14 00:00:00

abstract：:Hierarchical nanocomposite films with Pd-PdO nanoparticles anchored uniformly on the inner surface of TiO2 nanotubes were achieved through a stepwise bioredox/artificial oxygenation approach by using the natural eggshell membrane (ESM) as a template. The Pd content ratio of Pd-PdO loading could be arbitrarily varied f...

journal_title：Biomacromolecules

authors： Su H,Dong Q,Han J,Zhang D,Guo Q

更新日期：2008-02-01 00:00:00

abstract：:Combining poly(ethylene glycol) (PEG) with sequence-defined peptides in PEG-peptide conjugates offers opportunities to realize next-generation drug formulation additives for overcoming undesired pharmacological profiles of difficult small molecule drugs. The tailored peptide segments provide sequence-specific, noncova...

journal_title：Biomacromolecules

authors： Wieczorek S,Schwaar T,Senge MO,Börner HG

更新日期：2015-10-12 00:00:00

abstract：:By monitoring the thermally driven displacements of imbedded polystyrene microspheres via video fluorescence microscopy, we quantified the microstructural and micromechanical heterogeneities of wheat gliadin suspensions. We found that the degree of heterogeneity of the suspensions, as measured by the width and skewnes...

journal_title：Biomacromolecules

authors： Xu J,Tseng Y,Carriere CJ,Wirtz D

更新日期：2002-01-01 00:00:00

abstract：:A variety of natural polymers and proteins are considered to be 3D cell culture structures able to mimic the extracellular matrix (ECM) to promote bone tissue regeneration. Pectin, a natural polysaccharide extracted from the plant cell walls and having a chemical structure similar to alginate, provides interesting pro...

journal_title：Biomacromolecules

authors： Munarin F,Guerreiro SG,Grellier MA,Tanzi MC,Barbosa MA,Petrini P,Granja PL

更新日期：2011-03-14 00:00:00

abstract：:pH-dependent release from monoolein (MO) cubic phase was obtained by taking advantage of complex coacervation between hydrophobically modified alginate (HmAL) and hydrophobically modified silk fibroin (HmSF) in the water channels. The degree of coacervation was investigated at pH 3.0 by a light scattering method and t...

journal_title：Biomacromolecules

authors： Kwon TK,Kim JC

更新日期：2011-02-14 00:00:00

abstract：:Imbalanced homeostasis and oligomerization of the amyloid-β (Aβ) peptide in the brain are hallmarks of Alzheimer's disease (AD). Microglia and macrophages play a critical role in the etiology of AD either by clearing Aβ from the brain or inducing inflammation. Recent evidence suggests that clearance of Aβ by microglia...

journal_title：Biomacromolecules

authors： Richman M,Perelman A,Gertler A,Rahimipour S

更新日期：2013-01-14 00:00:00

abstract：:A novel cellulose derivative, 6-O-dihydrophytylcellulose (DHPC), was first synthesized via a ring-opening polymerization and allowed to self-assemble onto an air-water interface. Langmuir-Blodgett (LB) films were characterized with atomic force microscope (AFM), UV-vis spectroscopy, and Fourier transform infrared spec...

journal_title：Biomacromolecules

authors： Sakakibara K,Ifuku S,Tsujii Y,Kamitakahara H,Takano T,Nakatsubo F

更新日期：2006-06-01 00:00:00

abstract：:Alginate-based amphiphilic graft copolymers were synthesized by single electron transfer living radical polymerization (SET-LRP), forming stable micelles during polymerization induced self-assembly (PISA). First, alginate macroinitiator was prepared by partial depolymerization of native alginate, solubility modificati...

journal_title：Biomacromolecules

authors： Kapishon V,Whitney RA,Champagne P,Cunningham MF,Neufeld RJ

更新日期：2015-07-13 00:00:00

abstract：:We synthesized extremely deformable red blood cell-like microgel particles and loaded them with bovine hemoglobin (Hb) to potentiate oxygen transport. With similar shape and size as red blood cells (RBCs), the particles were fabricated using the PRINT (particle replication in nonwetting templates) technique. Low cross...

journal_title：Biomacromolecules

authors： Chen K,Merkel TJ,Pandya A,Napier ME,Luft JC,Daniel W,Sheiko S,DeSimone JM

更新日期：2012-09-10 00:00:00

abstract：:Protein transduction domains (PTDs) that readily transverse cellular membranes are of great interest and are attractive tools for the intracellular delivery of bioactive molecules. Learning to program synthetic polymers and oligomers with the appropriate chemical information to capture adequately the biological activi...

journal_title：Biomacromolecules

authors： Tezgel AÖ,Telfer JC,Tew GN

更新日期：2011-08-08 00:00:00

abstract：:Despite the wide interest raised by lung administration of nanoparticles (NPs) for the treatment of various diseases, little information is available on their effect toward the airway epithelial barrier function. In this study, the potential damage of the pulmonary epithelium upon exposure to poly(lactide-co-glycolide...

journal_title：Biomacromolecules

authors： Mura S,Hillaireau H,Nicolas J,Kerdine-Römer S,Le Droumaguet B,Deloménie C,Nicolas V,Pallardy M,Tsapis N,Fattal E

更新日期：2011-11-14 00:00:00