Engineered Polymeric Micelles for Combinational Oxidation Anticancer Therapy through Concurrent HO-1 Inhibition and ROS Generation.

abstract：:Binding human serum albumin (HSA) of three polyoxometalates (POMs) with the Wells-Dawson structure, alpha(2)-[P2W17O61]10- (abbreviated as alpha(2)-P2W17) and two of its metal-substituted derivatives, alpha(2)-[NiP2W17O61]8- and alpha(2)-[CuP2W17O61]8- (alpha(2)-P2W17Ni and alpha(2)-P2W17Cu, respectively) was studied ...

journal_title：Biomacromolecules

authors： Zhang G,Keita B,Craescu CT,Miron S,de Oliveira P,Nadjo L

更新日期：2008-03-01 00:00:00

abstract：:Spider dragline silk exhibits an extraordinary toughness and is typically composed of two types of major ampullate spidroins (MaSp1 and MaSp2), differing in their proline content and hydrophobicity. In this paper, we recombinantly produced an unusual but naturally occurring short major ampullate spidroin (MaSp1s) as a...

journal_title：Biomacromolecules

authors： Thamm C,Scheibel T

更新日期：2017-04-10 00:00:00

abstract：:We have designed, synthesized, and characterized peptides containing four repeats of the sequences VAALEKE (peptide E) or VAALKEK (peptide K). While the peptides alone adopt in aqueous solutions a random coil conformation, their equimolar mixture forms heterodimeric coiled coils as confirmed by CD spectroscopy. 5-Azid...

journal_title：Biomacromolecules

authors： Pechar M,Pola R,Laga R,Ulbrich K,Bednárová L,Maloň P,Sieglová I,Král V,Fábry M,Vaněk O

更新日期：2011-10-10 00:00:00

abstract：:Bovine hemoglobin (Hb) was encapsulated inside polymer vesicles (polymersomes) to form polymersome encapsulated Hb (PEH) dispersions. PEH particles are 100% surface PEGylated with longer PEG chains and possess thicker hydrophobic membranes as compared to conventional liposomes. Polymersomes were self-assembled from po...

journal_title：Biomacromolecules

authors： Arifin DR,Palmer AF

更新日期：2005-07-01 00:00:00

abstract：:Water-soluble T-antigen containing glycopolymers [Gal beta(1,3)-GalNAc alpha) having a high degree of lipophilicity were synthesized from poly[N-(acryloxy)succinimide] (6-10) by amidation with an amine-ending T-antigen derivative (3) and various amines of increasing alkyl chain length (ammonia and methyl-, ethyl-, and...

journal_title：Biomacromolecules

authors： Baek MG,Roy R

更新日期：2000-01-01 00:00:00

abstract：:The development of polymers that are both bactericidal and biocompatible would have many applications and are currently of research interest. Following the development of strongly bactericidal copolymers of 4-vinylpyridine and poly(ethylene glycol) methyl ether methacrylate, biocompatibility assays have been completed...

journal_title：Biomacromolecules

authors： Stratton TR,Howarter JA,Allison BC,Applegate BM,Youngblood JP

更新日期：2010-05-10 00:00:00

abstract：:Peptide RATEA16 spontaneously self-assembled into higher-order nanofiber hydrogels with extremely high water content (>99.5% (wt/vol)) under physiological condition. The hydrogels could undergo pH-reversible transitions from viscous solution to elastic hydrogel and to precipitate. The supramolecular self-assembly and ...

journal_title：Biomacromolecules

authors： Zhao Y,Yokoi H,Tanaka M,Kinoshita T,Tan T

更新日期：2008-06-01 00:00:00

abstract：:Despite great potential, the delivery of genetic materials into cells or tissues of interest remains challenging owing to their susceptibility to nuclease degradation, lack of permeability to the cell membrane, and short in vivo half-life, which severely restrict their widespread use in therapeutics. To surmount these...

journal_title：Biomacromolecules

authors： Le TMD,Duong HTT,Thambi T,Giang Phan VH,Jeong JH,Lee DS

更新日期：2018-08-13 00:00:00

abstract：:The adsorption of human immunoglobulin G (hIgG) and bovine serum albumin (BSA) on cellulose supports were investigated. The dynamics and extent of related adsorption processes were monitored by surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D). Amine groups were instal...

journal_title：Biomacromolecules

authors： Orelma H,Filpponen I,Johansson LS,Laine J,Rojas OJ

更新日期：2011-12-12 00:00:00

abstract：:New silk-like recombinant proteins, [(AAG)(6)ASTGRGDSPAAS](n) and [(AG)(9)ASTGRGDSPAAS](n), with high cell adhesive activities were designed and produced from E. coli. These are recombinant proteins with characteristic sequences from the silk fibroin of a wild silkworm, Anaphe , and the cell adhesive region, including...

journal_title：Biomacromolecules

authors： Tanaka C,Asakura T

更新日期：2009-04-13 00:00:00

abstract：:Spider aciniform (or wrapping) silk is the toughest of the seven types of spider silks/glue due to a combination of high elasticity and strength. Like most spider silk proteins (spidroins), aciniform spidroin (AcSp1) has a large core repetitive domain flanked by relatively short N- and C-terminal nonrepetitive domains...

journal_title：Biomacromolecules

authors： Xu L,Lefèvre T,Orrell KE,Meng Q,Auger M,Liu XQ,Rainey JK

更新日期：2017-11-13 00:00:00

abstract：:Elastin-like peptides (ELPs) have been used widely to confer thermoresponsive characteristics onto various materials, but to this point mostly linear ELPs have been studied. A class of linear and dendritic (branched) ELPs based on the GLPGL pentamer repeat unit was synthesized using an on-resin divergent strategy. The...

journal_title：Biomacromolecules

authors： Navon Y,Zhou M,Matson JB,Bitton R

更新日期：2016-01-11 00:00:00

abstract：:A series of well-defined thermoresponsive diblock copolymers (PEO45-b-PtNEAn, n=22, 44, 63, 91, 172) were prepared by the atom transfer radical polymerization of trans-N-(2-ethoxy-1,3-dioxan-5-yl) acrylamide (tNEA) using a poly(ethylene oxide) (PEO45) macroinitiator. All copolymers are water-soluble at low temperature...

journal_title：Biomacromolecules

authors： Qiao ZY,Ji R,Huang XN,Du FS,Zhang R,Liang DH,Li ZC

更新日期：2013-05-13 00:00:00

abstract：:To investigate the influence of surface-functionalized substrates with nanostructures on the behaviors of mesenchymal stem cells, we conjugated bone morphogenetic protein 2 (BMP2) onto TiO(2) nanotubes with different diameter sizes of 30, 60, and 100 nm for in vitro study. Polydopamine was employed as the intermediate...

journal_title：Biomacromolecules

authors： Lai M,Cai K,Zhao L,Chen X,Hou Y,Yang Z

更新日期：2011-04-11 00:00:00

abstract：:Fluorescence-tagged coniferyl alcohols, coniferyl alcohol γ-coupled by ethylenediamine spacers to dimethylaminocoumarin or nitrobenzofuran fluorophores, were tested as photoprobes to study the oxidase-mediated polymerization of monolignols. The fluorescent coniferyl alcohol derivatives readily underwent peroxidase-cat...

journal_title：Biomacromolecules

authors： Tobimatsu Y,Davidson CL,Grabber JH,Ralph J

更新日期：2011-05-09 00:00:00

abstract：:Microgels based on poly(vinyl alcohol), PVA, grafted with methacrylate side chains, MA, incorporating N-isopropylacrylamide, NiPAAm, monomer, were prepared by water-in-water emulsion polymerization method. These systems exhibit a spherical shape and a volume-phase transition, that is, shrinking, below physiological te...

journal_title：Biomacromolecules

authors： Ghugare SV,Mozetic P,Paradossi G

更新日期：2009-06-08 00:00:00

abstract：:Synthetic lethality is a molecular-targeted therapy for selective killing of cancer cells. We exploited a lethal interaction between superoxide dismutase 1 inhibition and Bloom syndrome gene product (BLM) defect for the treatment of colorectal cancer (CRC) cells (HCT 116) with a customized lung cancer screen-1-loaded ...

journal_title：Biomacromolecules

authors： Gupta A,Ahmad A,Singh H,Kaur S,K M N,Ansari MM,Jayamurugan G,Khan R

更新日期：2018-03-12 00:00:00

abstract：:Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could b...

journal_title：Biomacromolecules

authors： Kostina NY,Rodriguez-Emmenegger C,Houska M,Brynda E,Michálek J

更新日期：2012-12-10 00:00:00

abstract：:Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Although the present clin...

journal_title：Biomacromolecules

authors： Zhang Y,Yu J,Ren K,Zuo J,Ding J,Chen X

更新日期：2019-04-08 00:00:00

abstract：:Utilization of reversible interactions as sacrificial bonds in biopolymers is critical for the integral synthesis of mechanically superior biological materials. In this work, cellulose nanofibrils (CNFs) reinforced covalent polyacrylamide (PAAm) composite hydrogels are immersed into multivalent cation (Ca2+, Zn2+, Al3...

journal_title：Biomacromolecules

authors： Yang J,Xu F,Han CR

更新日期：2017-03-13 00:00:00

abstract：:A porous scaffold as a cell-compatible material was designed and prepared using a phospholipid copolymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate, and enantiomeric macromonomers, the poly(L-lactic acid) (PLLA) macromonomer, and poly(D-lactic acid) (PDLA) macromonomer. On the bas...

journal_title：Biomacromolecules

authors： Watanabe J,Eriguchi T,Ishihara K

更新日期：2002-09-01 00:00:00

abstract：:Glycerol derivatives of cutin and suberin monomers were synthesized by acid catalysis. Their dispersion in an aqueous solution was examined by phase contrast microscopy, neutron scattering, and solid state NMR. It is shown that the phase behavior strongly depends on the nature of the derivatives forming either lumps o...

journal_title：Biomacromolecules

authors： Douliez JP,Barrault J,Jerome F,Heredia A,Navailles L,Nallet F

更新日期：2005-01-01 00:00:00

abstract：:Twenty-five kDa polyethylenimine (PEI) is one of the most efficient nonviral gene transfer agents currently applied as a golden standard for in vitro transfection. In this study, novel 25 kDa PEI derivatives with reductively cleavable cystamine periphery (PEI-Cys) were designed to reduce carrier-associated cytotoxicit...

journal_title：Biomacromolecules

authors： Wang Y,Zheng M,Meng F,Zhang J,Peng R,Zhong Z

更新日期：2011-04-11 00:00:00

abstract：:Human serum albumin (HSA) is known to exist as N (pH approximately 7), B (pH approximately 9), and F (pH approximately 3.5) isomeric forms and an equilibrium intermediate state (I) accumulate in the urea induced unfolding pathway of HSA around 4.8-5.2 M urea concentrations. These states displayed characteristic struct...

journal_title：Biomacromolecules

authors： Ahmad B,Parveen S,Khan RH

更新日期：2006-04-01 00:00:00

abstract：:Noncontact mode atomic force microscopy was used to investigate native silk proteins prepared in different ways. Low protein concentrations revealed that single protein molecules exhibit a simple, round shape with apparent diameters of 20-25 nm. Shearing the native protein solutions after extraction from the gland and...

journal_title：Biomacromolecules

authors： Greving I,Cai M,Vollrath F,Schniepp HC

更新日期：2012-03-12 00:00:00

abstract：:Oligopeptide hydrogels are emerging as useful matrices for cell culture with commercial products on the market, but L-oligopeptides are labile to proteases. An obvious solution is to create D-oligopeptide hydrogels, which lack enzymatic recognition. However, D-oligopeptide matrices do not support cell growth as well a...

journal_title：Biomacromolecules

authors： Hyland LL,Twomey JD,Vogel S,Hsieh AH,Yu YB

更新日期：2013-02-11 00:00:00

abstract：:In biomedicine, PEGylation is one of the most successful strategies to modify the physicochemical and biological properties of peptides, proteins, and other biomacromolecules. Because of the polydisperse nature of regular PEGs and limited PEGylation strategies, it is challenging to quantitatively fine-tune and accurat...

journal_title：Biomacromolecules

authors： Wang X,Li Y,Wu T,Yang Z,Zheng X,Chen S,Zhou X,Jiang ZX

更新日期：2020-02-10 00:00:00

abstract：:meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate (TMP) is a photosensitizer that can be used in photodynamic therapy (PDT) to induce cell death through generation of reactive oxygen species in targeted tumor cells. However, TMP is highly hydrophilic, and therefore, its ability to accumulate intracellularly is li...

journal_title：Biomacromolecules

authors： Abdelghany SM,Schmid D,Deacon J,Jaworski J,Fay F,McLaughlin KM,Gormley JA,Burrows JF,Longley DB,Donnelly RF,Scott CJ

更新日期：2013-02-11 00:00:00

abstract：:The order of assembly of a magnetic nanoparticle (MNP) vector comprised of the same components (MNP, PEI, and plasmid DNA) on entry mechanism, intracellular localization, and viability of BHK21 cells was investigated. Cellular uptake measurements under four different uptake inhibiting conditions, such as low temperatu...

journal_title：Biomacromolecules

authors： Arsianti M,Lim M,Marquis CP,Amal R

更新日期：2010-09-13 00:00:00

abstract：:The remarkable diversity of the self-assembly behavior of PEG-peptides is reviewed, including self-assemblies formed by PEG-peptides with β-sheet and α-helical (coiled-coil) peptide sequences. The modes of self-assembly in solution and in the solid state are discussed. Additionally, applications in bionanotechnology a...

journal_title：Biomacromolecules

authors： Hamley IW

更新日期：2014-05-12 00:00:00