Self-assembled pH-responsive hydrogels composed of the RATEA16 peptide.

Abstract:

:Peptide RATEA16 spontaneously self-assembled into higher-order nanofiber hydrogels with extremely high water content (>99.5% (wt/vol)) under physiological condition. The hydrogels could undergo pH-reversible transitions from viscous solution to elastic hydrogel and to precipitate. The supramolecular self-assembly and the three phase transitions are driven by hydrophobic interactions, intermolecular hydrogen bonds, and a combination of attractive or repulsive electrostatic interactions. These hydrogels are rich in beta-sheet nanofibers, as demonstrated by CD and FTIR data. Rheological measurements reveal that the viscoelasticity of the material can be tuned by environmental pH and peptide concentration. The storage modulus of the hydrogels increases with increasing peptide concentration, and the self-assembled hydrogels are able to recover from mechanical breakdowns. AFM images show that the elasticity is attributed to a network nanostructure consisting of fibrous self-assemblies. The hydrogels are promising for a variety of possible biomedical applications, including drug delivery.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Zhao Y,Yokoi H,Tanaka M,Kinoshita T,Tan T

doi

10.1021/bm701143g

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

1511-8

issue

6

eissn

1525-7797

issn

1526-4602

journal_volume

9

pub_type

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