Abstract:
:A strategy to light-trigger ionic cross-linking of alginates by incorporating a photosensitive Ca2+ cage (nitr-T) is presented. Upon irradiation, free Ca2+ was released, and this caused gelation of the alginate solution. Addition of Ca2+ "on-demand" allowed us to obtain homogeneous alginate (ALG) gels using concentrated initial ALG solutions (10%), not possible with other ionic gelation approaches. The cross-linking degree and derived mechanical properties of the hydrogel were modulated by the exposure dose. The light-mediated cross-linked alginate hydrogel displayed a significant improvement in the mechanical properties and homogeneity when compared to mixtures of alginate and soluble Ca2+ at comparable concentrations.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Cui J,Wang M,Zheng Y,Rodríguez Muñiz GM,del Campo Adoi
10.1021/bm400022hsubject
Has Abstractpub_date
2013-05-13 00:00:00pages
1251-6issue
5eissn
1525-7797issn
1526-4602journal_volume
14pub_type
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