Superstrong and Tough Hydrogel through Physical Cross-Linking and Molecular Alignment.

abstract：:Ambidextrous supergelators are developed through structure-gelation screening of rationally designed cyclic dipeptides (CDPs). The organo- and hydrogels of CDPs were thoroughly characterized by their minimal gelation concentration (MGC) for organic and aqueous solvents, thermal stability (Tg), and viscoelastic propert...

journal_title：Biomacromolecules

authors： Manchineella S,Murugan NA,Govindaraju T

更新日期：2017-11-13 00:00:00

abstract：:Shear flow is indirectly implicated in amyloid formation in vitro. Despite the association between amyloid fibrils and disease, and the prevalence of flow in physiological systems, the effect of this parameter is uncharacterized. We designed a novel Couette cell to quantitatively investigate shear exposure during fibr...

journal_title：Biomacromolecules

authors： Hill EK,Krebs B,Goodall DG,Howlett GJ,Dunstan DE

更新日期：2006-01-01 00:00:00

abstract：:A challenge in the development of multifunctional drug delivery systems is to establish a reasonable and effective synthetic route for multifunctional polymer preparation. Herein, we propose a unique protocol to prepare multifunctional micelles by a cross-assembly process using three different functional polyurethanes...

journal_title：Biomacromolecules

authors： Pan Z,Ren Y,Song N,Song Y,Li J,He X,Luo F,Tan H,Fu Q

更新日期：2016-06-13 00:00:00

abstract：:Minimally invasive implants and/or scaffolds integrated with multiple functionalities are of interest in the clinical settings. In this paper, chitosan (CTS) functionalized poly(lactic-co-glycolic acid) (PLGA) microspheres containing a model payload, lysozyme (Lyz), were prepared by a water-in-oil-in-water emulsion me...

journal_title：Biomacromolecules

authors： Bao M,Zhou Q,Dong W,Lou X,Zhang Y

更新日期：2013-06-10 00:00:00

abstract：:Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine. Current treatments are suboptimal, and thus the development of an enzyme replacement therapy based on PEGylated human truncated CBS (PEG-CBS) has been initiated. Attenuation of potency was obs...

journal_title：Biomacromolecules

authors： Majtan T,Park I,Carrillo RS,Bublil EM,Kraus JP

更新日期：2017-06-12 00:00:00

abstract：:Images of high methoxyl orange pectin deposited from solution and high methoxyl sugar acid gels (HMSAG) were obtained by atomic force microscopy (AFM) in the tapping mode. For the first time, images of pectin deposited from water revealed that the transition from pectin networks to individual molecules or aggregates t...

journal_title：Biomacromolecules

authors： Fishman ML,Cooke PH,Chau HK,Coffin DR,Hotchkiss AT Jr

更新日期：2007-02-01 00:00:00

abstract：:The electrospinning of polymer melts can offer an advantage over solution electrospinning, in the development of layered tissue constructs for tissue engineering. Melt electrospinning does not require a solvent, of which many are cytotoxic in nature, and the use of nonwater soluble polymers allows the collection of fi...

journal_title：Biomacromolecules

authors： Dalton PD,Klinkhammer K,Salber J,Klee D,Möller M

更新日期：2006-03-01 00:00:00

abstract：:Reversible stereoselective complexes were spontaneously obtained from mixing acetonitrile solutions of enatiomeric d-poly(lactic acid) (d-PLA), l-poly(lactic acid) (l-PLA), and leuprolide, a l-configured nonapeptide LHRH analogue. The complex spontaneously aggregated and precipitated in high yields (>90%) from acetoni...

journal_title：Biomacromolecules

authors： Slager J,Domb AJ

更新日期：2003-09-01 00:00:00

abstract：:In this study, we demonstrate for the first time the fabrication of carboxylated chitosan nanocrystals (ChsNC) with high degree of deacetylation (DDA) at >80% and narrow size distribution. We also studied its application as a sustainable support material for metal-based catalysts. Carboxylated chitin nanocrystals (ChN...

journal_title：Biomacromolecules

authors： Jin T,Kurdyla D,Hrapovic S,Leung ACW,Régnier S,Liu Y,Moores A,Lam E

更新日期：2020-06-08 00:00:00

abstract：:Subunit vaccines can have excellent safety profiles, but their ability to give rise to robust immune responses is often compromised. For glycan-based vaccines, insufficient understanding of B and T cell epitope combinations that yield optimal immune activation hinders optimization. To determine which antigen features ...

journal_title：Biomacromolecules

authors： Bennett NR,Jarvis CM,Alam MM,Zwick DB,Olson JM,Nguyen HV,Johnson JA,Cook ME,Kiessling LL

更新日期：2019-12-09 00:00:00

abstract：:Peptide self-assembly is a facile route to the development of bioorganic hybrid materials that have sophisticated nanostructures toward diverse applications. Here, we report the synthesis of self-assembled peptide (Fmoc-diphenylalanine, Fmoc-FF)/graphitic carbon nitride (g-C3N4) hydrogels for light harvesting and biom...

journal_title：Biomacromolecules

authors： Ko JW,Choi WS,Kim J,Kuk SK,Lee SH,Park CB

更新日期：2017-11-13 00:00:00

abstract：:PLGA nanoparticles are among the most studied polymer nanoformulations for several drugs against different kinds of malignant diseases, thanks to their in vivo stability and tumor localization exploiting the well-documented "enhanced permeation and retention" (EPR) effect. In this paper, we have developed uniform curc...

journal_title：Biomacromolecules

authors： Verderio P,Bonetti P,Colombo M,Pandolfi L,Prosperi D

更新日期：2013-03-11 00:00:00

abstract：:The complement system plays an important role in innate and adaptive immunity, which suggests that complement activation could be exploited as a potential strategy for vaccine adjuvants. Here we explored the potential of chitosan-based microparticles (CS-NH2 MPs) as a vaccine adjuvant with an active surface for comple...

journal_title：Biomacromolecules

authors： Liu Y,Yin Y,Wang L,Zhang W,Chen X,Yang X,Xu J,Ma G

更新日期：2013-09-09 00:00:00

abstract：:Over the past 10 years, polyglycerols and their structurally related analogs have received considerable attention in the biomedical field. Poly(glycidyl methacrylate) (PGMA) is a versatile polymer because its pendant epoxide groups can be opened with different functional groups to generate poly(glycerol methacrylate)s...

journal_title：Biomacromolecules

authors： Gao H,Elsabahy M,Giger EV,Li D,Prud'homme RE,Leroux JC

更新日期：2010-04-12 00:00:00

abstract：:Nearly monodispersed silica nanoparticles having a controlled size from 5 to 450 nm were synthesized via a sol-gel process, and then the optimum conditions for the surface treatment of the synthesized silica nanoparticles with a silane coupling agent (i.e., 3-methacryloxypropyltrimethoxysilane (gamma-MPS)) were explor...

journal_title：Biomacromolecules

authors： Kim JW,Kim LU,Kim CK

更新日期：2007-01-01 00:00:00

abstract：:The helical coiled coil is a well-studied folding motif that can be used for the design of nanometer-sized bioinspired fibrous structures with potential applications as functional materials. A two-component system of coiled coil based model peptides is investigated, which forms, under acidic conditions, uniform, hundr...

journal_title：Biomacromolecules

authors： Brandenburg E,Berlepsch HV,Leiterer J,Emmerling F,Koksch B

更新日期：2012-11-12 00:00:00

abstract：:DC and AC electrical conductivity of bionanocomposites based on the immiscible polymer blend poly(epsilon-caprolactone)/polylactide (PCL/PLA, w/w 70/30), loaded with multiwall carbon nanotubes (CNT), were studied in a wide frequency range, 10(-3) < or = f < or = 10(7) Hz from 143 to 313 K. The nanofiller concentration...

journal_title：Biomacromolecules

authors： Laredo E,Grimau M,Bello A,Wu DF,Zhang YS,Lin DP

更新日期：2010-05-10 00:00:00

abstract：:Chitosan is a well sought-after polysaccharide in biomedical applications and has been blended with various macromolecules to mitigate undesirable properties. However, the effects of blending on the unique antibacterial activity of chitosan as well as changes in fatigue and degradation properties are not well understo...

journal_title：Biomacromolecules

authors： Sarasam AR,Krishnaswamy RK,Madihally SV

更新日期：2006-04-01 00:00:00

abstract：:The proteinaceous material present in beta-lactoglobulin fibrils formed after heating (20 h at 85 degrees C) at pH 2 was identified during this study. Fibrils were separated from the nonaggregated material, and the fibrils were dissociated using 8 M guanidine chloride and 0.1 M 1,4-dithiothreitol (pH 8). Characterizat...

journal_title：Biomacromolecules

authors： Akkermans C,Venema P,van der Goot AJ,Gruppen H,Bakx EJ,Boom RM,van der Linden E

更新日期：2008-05-01 00:00:00

abstract：:Polycations often suffer from the irreconcilable inconsistency between transfection efficiency and toxicity. Polymers with high molecular weight (MW) and cationic charge feature potent gene delivery capabilities, while in the meantime suffer from strong chemotoxicity, restricted intracellular DNA release, and low stab...

journal_title：Biomacromolecules

authors： He H,Bai Y,Wang J,Deng Q,Zhu L,Meng F,Zhong Z,Yin L

更新日期：2015-04-13 00:00:00

abstract：:The development of large-scale suspension cell cultures using microcarriers has long been a focus of attention in the fields of pharmacy and biotechnology. Previously, we developed cell-detachable microcarriers based on temperature-responsive poly(N-isopropylacrylamide) (PIPAAm)-grafted beads, on which adhering cells ...

journal_title：Biomacromolecules

authors： Tamura A,Nishi M,Kobayashi J,Nagase K,Yajima H,Yamato M,Okano T

更新日期：2012-06-11 00:00:00

abstract：:Since their discovery at the end of the previous millennium, carbon nanotubes (CNTs) have been the object of thousands of papers describing their applications in fields ranging from physics to electronics, photonics, chemistry, biology, and medicine. The development of chemical approaches to modify their graphitic sid...

journal_title：Biomacromolecules

authors： Bottini M,Rosato N,Bottini N

更新日期：2011-10-10 00:00:00

abstract：:Adhesive hydrogels were prepared by copolymerizing dopamine methacrylamide with either acrylic acid (AAc) or N-(3-aminopropyl)methacrylamide hydrochloride (APMH). The effect of incorporating the anionic and cationic side chains on the oxidation state of catechol was characterized using the FOX assay to track the produ...

journal_title：Biomacromolecules

authors： Narkar AR,Kelley JD,Pinnaratip R,Lee BP

更新日期：2018-05-14 00:00:00

abstract：:Despite the wide interest raised by lung administration of nanoparticles (NPs) for the treatment of various diseases, little information is available on their effect toward the airway epithelial barrier function. In this study, the potential damage of the pulmonary epithelium upon exposure to poly(lactide-co-glycolide...

journal_title：Biomacromolecules

authors： Mura S,Hillaireau H,Nicolas J,Kerdine-Römer S,Le Droumaguet B,Deloménie C,Nicolas V,Pallardy M,Tsapis N,Fattal E

更新日期：2011-11-14 00:00:00

abstract：:Light-harvesting antenna core (LH1-RC) complexes isolated from Rhodoseudomonas palustris were self-assembled on a gold electrode modified with self-assembled monolayers (SAMs) of the alkanethiols NH2(CH2)nSH, n = 2, 6, 8, 11; HOOC(CH2)7SH; and CH3(CH2)7SH, respectively. Adsorption of the LH1-RC complexes on the SAMs d...

journal_title：Biomacromolecules

authors： Kondo M,Nakamura Y,Fujii K,Nagata M,Suemori Y,Dewa T,Iida K,Gardiner AT,Cogdell RJ,Nango M

更新日期：2007-08-01 00:00:00

abstract：:Dragline silk from orb-weaving spiders is a copolymer of two large proteins, major ampullate spidroin 1 (MaSp1) and 2 (MaSp2). The ratio of these proteins is known to have a large variation across different species of orb-weaving spiders. NMR results from gland material of two different species of spiders, N. clavipe...

journal_title：Biomacromolecules

authors： An B,Jenkins JE,Sampath S,Holland GP,Hinman M,Yarger JL,Lewis R

更新日期：2012-12-10 00:00:00

abstract：:Spider dragline silk exhibits an extraordinary toughness and is typically composed of two types of major ampullate spidroins (MaSp1 and MaSp2), differing in their proline content and hydrophobicity. In this paper, we recombinantly produced an unusual but naturally occurring short major ampullate spidroin (MaSp1s) as a...

journal_title：Biomacromolecules

authors： Thamm C,Scheibel T

更新日期：2017-04-10 00:00:00

abstract：:Optimal curcumin delivery for medicinal applications requires a drug delivery system that both solubilizes curcumin and prevents degradation. To achieve this, curcumin has been encapsulated in submicrometer chitosan/Tween 20 particles via a benchtop spray-drying process. Spray-drying parameters have been optimized usi...

journal_title：Biomacromolecules

authors： O'Toole MG,Henderson RM,Soucy PA,Fasciotto BH,Hoblitzell PJ,Keynton RS,Ehringer WD,Gobin AS

更新日期：2012-08-13 00:00:00

abstract：:In tissue engineering, incorporation of bone morphogenetic protein-2 (BMP-2) into biomaterial scaffolds is an attractive strategy to stimulate bone repair. However, suboptimal release of BMP-2 remains a great concern, which may cause unfavorable bone formation as well as severe inflammation. In this study, genipin-cro...

journal_title：Biomacromolecules

authors： Zhang Q,Tan K,Zhang Y,Ye Z,Tan WS,Lang M

更新日期：2014-01-13 00:00:00

abstract：:New therapeutic strategies for the treatment of neoplastic pathologies and, in particular, metastasis processes are based on the inhibitory effect of angiogenic processes. The present article deals with the design, preparation, and application of new "polymer drugs" with a clear inhibitory effect of the activation of ...

journal_title：Biomacromolecules

authors： García-Fernández L,Aguilar MR,Fernández MM,Lozano RM,Giménez G,Valverde S,San Román J

更新日期：2010-07-12 00:00:00