Hyperbranched poly(amino ester)s with different terminal amine groups for DNA delivery.

abstract：:Thanks to chemical stabilization, aldehyde-assisted fractionation (AAF) of lignocellulosic biomass has recently emerged as a powerful tool for the production of largely uncondensed lignin. Depolymerization of AAF lignin via ether cleavage provides aromatic monomers at near theoretical yields based on ether cleavage an...

journal_title：Biomacromolecules

authors： Vendamme R,Behaghel de Bueren J,Gracia-Vitoria J,Isnard F,Mulunda MM,Ortiz P,Wadekar M,Vanbroekhoven K,Wegmann C,Buser R,Héroguel F,Luterbacher JS,Eevers W

更新日期：2020-10-12 00:00:00

abstract：:We report the engineering of intracellular redox-responsive nanoporous poly(ethylene glycol)-poly(l-lysine) particles (NPEG-PLLs). The obtained particles exhibit no toxicity while maintaining the capability to deliver a small interfering RNA sequence (siRNA) targeting the anti-apoptotic factor, survivin, in prostate c...

journal_title：Biomacromolecules

authors： Cavalieri F,Beretta GL,Cui J,Braunger JA,Yan Y,Richardson JJ,Tinelli S,Folini M,Zaffaroni N,Caruso F

更新日期：2015-07-13 00:00:00

abstract：:Six methyl celluloses (MCs), one with a degree of substitution (DS) of 1.32 and five with DS between 1.83 and 1.88, were thoroughly investigated. Monomer composition and methyl distribution in the polymer chain were analyzed after total or partial random hydrolysis and appropriate derivatization with gas chromatograph...

journal_title：Biomacromolecules

authors： Adden R,Melander C,Brinkmalm G,Gorton L,Mischnick P

更新日期：2006-05-01 00:00:00

abstract：:The electrospinning of polymer melts can offer an advantage over solution electrospinning, in the development of layered tissue constructs for tissue engineering. Melt electrospinning does not require a solvent, of which many are cytotoxic in nature, and the use of nonwater soluble polymers allows the collection of fi...

journal_title：Biomacromolecules

authors： Dalton PD,Klinkhammer K,Salber J,Klee D,Möller M

更新日期：2006-03-01 00:00:00

abstract：:Deep eutectic solvents promoted the stabilization of the collapsed state of elastin-like recombinamers - and the subsequent formation of aggregates - upon the loss of the structural water molecules involved in hydrophobic hydration. Cryo-etch scanning electron microscopy allowed the observation of these aggregates i...

journal_title：Biomacromolecules

authors： Nardecchia S,Gutiérrez MC,Ferrer ML,Alonso M,López IM,Rodríguez-Cabello JC,del Monte F

更新日期：2012-07-09 00:00:00

abstract：:Binding of a poly(amido amine) dendrimer with salmon testes DNA in an aqueous solution of 0.01 M NaCl at pH 6.5 has been investigated. It was shown from the physicochemical experiments of static light scattering and ultra-violet and circular dichroism spectroscopy that at a 0.2 mixing ratio of dendrimer/DNA (number ra...

journal_title：Biomacromolecules

authors： Mitra A,Imae T

更新日期：2004-01-01 00:00:00

abstract：:Antifreeze glycoproteins (AFGPs) are a subclass of biological antifreezes found in deep sea Teleost fish. These compounds have the ability to depress the freezing point of the organism such that it can survive the subzero temperatures encountered in its environment. This physical property is very attractive for the cr...

journal_title：Biomacromolecules

authors： Liu S,Wang W,Moos Ev,Jackman J,Mealing G,Monette R,Ben RN

更新日期：2007-05-01 00:00:00

abstract：:A well-defined fluorescent conjugated polyfluorene with pendant lactopyranosyl ligands was easily prepared through Cu(I)-catalyzed azide/alkyne "click" ligation and Suzuki coupling polymerization. As a fluorescent multivalent model system of glycoconjugates, the polymer was first used for studies of metal ion-mediated...

journal_title：Biomacromolecules

authors： Chen Q,Cui Y,Zhang TL,Cao J,Han BH

更新日期：2010-01-11 00:00:00

abstract：:We studied methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-dimethylaminoethyl methacrylate) (mPEG-b-PCL-b-PDMAEMA) nanoparticles as the codelivery vector of hydrophobic drug and pDNA by employing dynamic light scattering (DLS), ζ potential, transmission electron microscopy (TEM), gel retardation assay, a...

journal_title：Biomacromolecules

authors： Yue X,Qiao Y,Qiao N,Guo S,Xing J,Deng L,Xu J,Dong A

更新日期：2010-09-13 00:00:00

abstract：:Silk fibroin (SF) protein, produced by silkworm Bombyx mori, is a promising biomaterial, while sophorolipid (SL) is an amphiphilic functional biosurfactant synthesized by nonpathogenic yeast Candida bombicola. SL is a mixture of two forms, acidic (ASL) and lactonic (LSL), which when added to SF results in accelerated ...

journal_title：Biomacromolecules

authors： Dubey P,Kumar S,Aswal VK,Ravindranathan S,Rajamohanan PR,Prabhune A,Nisal A

更新日期：2016-10-10 00:00:00

abstract：:Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization o...

journal_title：Biomacromolecules

authors： Brandl F,Hammer N,Blunk T,Tessmar J,Goepferich A

更新日期：2010-02-08 00:00:00

abstract：:The interaction of iron with water-soluble polymer chitosan and monomer d-glucosamine is investigated by Mössbauer spectroscopy. The 4.2 K Mössbauer spectrum of Fe-water-soluble chitosan complex indicates the presence of a magnetic pattern and a quadrupole doublet, and analysis of the spectral data leads to the conclu...

journal_title：Biomacromolecules

authors： Bhatia SC,Ravi N

更新日期：2003-05-01 00:00:00

abstract：:PEO-PPO-PEO triblock copolymers have opposing effects on lipid membrane integrity: they can behave either as membrane sealants or as membrane permeabilizers. To gain insights into their biomembrane activities, the fundamental interactions between a series of PEO-based polymers and phospholipid vesicles were investigat...

journal_title：Biomacromolecules

authors： Wang JY,Marks J,Lee KY

更新日期：2012-09-10 00:00:00

abstract：:In this study, an novel amphiphilic block copolymer P[PEGMA-b-(DEMA-co-APMA)]-FA and its cross-linker uracil-(CH2)6-uracil (U-(CH2)6-U) were synthesized and used as the targeted and pH-responsive nanocarriers for anticancer drug delivery. The hydrophobic block of the copolymer contains adenine (A) and tertiary amine m...

journal_title：Biomacromolecules

authors： Fan J,Zeng F,Wu S,Wang X

更新日期：2012-12-10 00:00:00

abstract：:The ability of small interfering RNA (siRNA) to efficiently silence the expression of specific genes provides the basis for exciting new therapies based on RNA interference (RNAi). The efficient intracellular delivery of siRNA from cell uptake through the endosomal trafficking pathways into the cytoplasm remains a sig...

journal_title：Biomacromolecules

authors： Convertine AJ,Diab C,Prieve M,Paschal A,Hoffman AS,Johnson PH,Stayton PS

更新日期：2010-11-08 00:00:00

abstract：:Heparin, a sulfated polysaccharide derived from animal sources, is the most commonly used parenteral anticoagulant drug, but it suffers from significant safety and supply issues. Herein, we describe the preparation of heparin mimetic homo- and copolymers via the reversible addition-fragmentation chain transfer (RAFT) ...

journal_title：Biomacromolecules

authors： Nahain AA,Ignjatovic V,Monagle P,Tsanaktsidis J,Vamvounis G,Ferro V

更新日期：2020-02-10 00:00:00

abstract：:The proteinaceous material present in beta-lactoglobulin fibrils formed after heating (20 h at 85 degrees C) at pH 2 was identified during this study. Fibrils were separated from the nonaggregated material, and the fibrils were dissociated using 8 M guanidine chloride and 0.1 M 1,4-dithiothreitol (pH 8). Characterizat...

journal_title：Biomacromolecules

authors： Akkermans C,Venema P,van der Goot AJ,Gruppen H,Bakx EJ,Boom RM,van der Linden E

更新日期：2008-05-01 00:00:00

abstract：:Human serum albumin (HSA) is known to exist as N (pH approximately 7), B (pH approximately 9), and F (pH approximately 3.5) isomeric forms and an equilibrium intermediate state (I) accumulate in the urea induced unfolding pathway of HSA around 4.8-5.2 M urea concentrations. These states displayed characteristic struct...

journal_title：Biomacromolecules

authors： Ahmad B,Parveen S,Khan RH

更新日期：2006-04-01 00:00:00

abstract：:Biobased poly(γ-butyrolactone) (PγBL) as a fully biodegradable and bioabsorbable biomaterial has shown superior properties compared to those of other aliphatic polyesters. It is of great importance to prepare amphiphilic block copolymer containing PγBL block to make ordered nano-objects for biomedical applications suc...

journal_title：Biomacromolecules

authors： Shen Y,Zhang J,Zhao Z,Zhao N,Liu F,Li Z

更新日期：2019-01-14 00:00:00

abstract：:Spherulites of poly(L-lactic acid) (PLLA) and of its blends with atactic poly(3-hydroxybutyrate) (a-PHB, from 10 to 75 wt %) were investigated by microfocus X-ray diffraction using synchrotron radiation. Radial scans in 5 microm steps with 3 microm beam diameter were performed. In PLLA, tens of identical diffraction i...

journal_title：Biomacromolecules

authors： Gazzano M,Focarete ML,Riekel C,Scandola M

更新日期：2004-03-01 00:00:00

abstract：:Herein we present an innovative approach to produce biocompatible, degradable, and stealth polymeric nanoparticles based on poly(lipoic acid), stabilized by a PEG-ended surfactant. Taking advantage of the well-known thiol-induced polymerization of lipoic acid, a universal and nontoxic nanovector consisted of a solid c...

journal_title：Biomacromolecules

authors： Trzciński JW,Morillas-Becerril L,Scarpa S,Tannorella M,Muraca F,Rastrelli F,Castellani C,Fedrigo M,Angelini A,Tavano R,Papini E,Mancin F

更新日期：2020-12-21 00:00:00

abstract：:A variety of natural polymers and proteins are considered to be 3D cell culture structures able to mimic the extracellular matrix (ECM) to promote bone tissue regeneration. Pectin, a natural polysaccharide extracted from the plant cell walls and having a chemical structure similar to alginate, provides interesting pro...

journal_title：Biomacromolecules

authors： Munarin F,Guerreiro SG,Grellier MA,Tanzi MC,Barbosa MA,Petrini P,Granja PL

更新日期：2011-03-14 00:00:00

abstract：:Polymer therapeutics, including polymeric drugs and polymer-protein conjugates, are clinically established as first-generation nanomedicines. Knowing that the coiled-coil peptide motif is fundamentally important in the regulation of many cellular and pathological processes, the aim of these studies was to examine the ...

journal_title：Biomacromolecules

authors： Deacon SP,Apostolovic B,Carbajo RJ,Schott AK,Beck K,Vicent MJ,Pineda-Lucena A,Klok HA,Duncan R

更新日期：2011-01-10 00:00:00

abstract：:pH-dependent release from monoolein (MO) cubic phase was obtained by taking advantage of complex coacervation between hydrophobically modified alginate (HmAL) and hydrophobically modified silk fibroin (HmSF) in the water channels. The degree of coacervation was investigated at pH 3.0 by a light scattering method and t...

journal_title：Biomacromolecules

authors： Kwon TK,Kim JC

更新日期：2011-02-14 00:00:00

abstract：:Multifunctional cellulose nanocrystals have been synthesized and applied as a new type of glyconanomaterial in lectin binding and bacterial imaging. The cellulose nanocrystals were prepared by TEMPO-mediated oxidation and acidic hydrolysis, followed by functionalization with a quinolone fluorophore and carbohydrate li...

journal_title：Biomacromolecules

authors： Zhou J,Butchosa N,Jayawardena HS,Park J,Zhou Q,Yan M,Ramström O

更新日期：2015-04-13 00:00:00

abstract：:A successful strategy for the immobilization of rennet from Mucor miehei has been developed. The strategy is based on the immobilization of the enzyme, via their sugar chains at high ionic strength on aminated supports having primary amino groups with a very low pK value. The rennet was covalently immobilized via suga...

journal_title：Biomacromolecules

authors： Pessela BC,Torres R,Fuentes M,Mateo C,Fernandez-Lafuente R,Guisán JM

更新日期：2004-09-01 00:00:00

abstract：:Ferulic acid-based polymers with aliphatic linkages have been previously synthesized via solution polymerization methods, yet they feature relatively slow ferulic acid release rates (∼11 months to 100% completion). To achieve a more rapid release rate as required in skin care formulations, ferulic acid-based polymers ...

journal_title：Biomacromolecules

authors： Ouimet MA,Faig JJ,Yu W,Uhrich KE

更新日期：2015-09-14 00:00:00

abstract：:A multifunctional macromolecular thiol (TPVA) obtained by esterification of poly(vinyl alcohol) (PVA) with 3-mercaptopropionic acid was characterized by a combination of NMR, IR, transmission electron microscopy (TEM), and differential scanning calorimetry (DSC), and was used as a wheat gluten (WG) reactive modifier. ...

journal_title：Biomacromolecules

authors： Dicharry RM,Ye P,Saha G,Waxman E,Asandei AD,Parnas RS

更新日期：2006-10-01 00:00:00

abstract：:Electrospun biopolyelectrolyte nanofibers hold potential for use in a range of biomedical applications, but eliminating toxic chemicals involved in their production remains a key challenge. In this study, we successfully electrospun nanofibers from an aqueous complex coacervate solution composed of chitosan and hyalur...

journal_title：Biomacromolecules

authors： Sun J,Perry SL,Schiffman JD

更新日期：2019-11-11 00:00:00

abstract：:Recent findings suggest that visible light-promoted photooxidative processes mediated by sensitizers of appropriate chemical structure could represent a useful tool for properly addressing the problem of the increasing occurrence of infectious diseases caused by multiantibiotic-resistant microbial pathogens. The monoc...

journal_title：Biomacromolecules

authors： Ferro S,Jori G,Sortino S,Stancanelli R,Nikolov P,Tognon G,Ricchelli F,Mazzaglia A

更新日期：2009-09-14 00:00:00