Abstract：
:pH-dependent release from monoolein (MO) cubic phase was obtained by taking advantage of complex coacervation between hydrophobically modified alginate (HmAL) and hydrophobically modified silk fibroin (HmSF) in the water channels. The degree of coacervation was investigated at pH 3.0 by a light scattering method and the maximum coacervation was observed when the ratio of HmAL to HmSF was 1:15. The degree of coacervation dramatically decreased (from 581.2 to 5.2 nm in size and from 267.9 to 12.3 nm in Kcps) when the pH of medium increased from 3.0 to 5.0. The % release in 100 h of FITC-dextran increased from 2.42 to 7.20% when pH of release medium increased from 3.0 to 9.0. Under acidic conditions, coacervate will block the water channels of cubic phase, suppressing the release. As the pH of release medium increases, the coacervate will dissolve, resulting in a higher release. The cubic phase could be exploited as a pH-sensitive carrier for the oral delivery of an acid-labile drug.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Kwon TK,Kim JCdoi
10.1021/bm101249esubject
Has Abstractpub_date
2011-02-14 00:00:00pages
466-71issue
2eissn
1525-7797issn
1526-4602journal_volume
12pub_type
杂志文章abstract：:Highly fluorescent N-substituted 1-cyanobenz[f]isoindole chitosans (CBI-CSs) with various degrees of N-substitution (DS) were synthesized by reacting chitosan (CS) with naphthalene-2,3-dicarboxaldehyde (NDA) in the presence of cyanide under mild acidic conditions. Introduction of 1-cyanobenz[f]isoindole moieties into ...
journal_title：Biomacromolecules
pub_type： 杂志文章
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
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更新日期：2011-11-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2020-09-14 00:00:00
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journal_title：Biomacromolecules
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更新日期：2007-12-01 00:00:00
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更新日期：2016-02-08 00:00:00
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更新日期：2013-01-14 00:00:00
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更新日期：2006-06-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2019-07-08 00:00:00
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pub_type： 杂志文章
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更新日期：2017-09-11 00:00:00
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journal_title：Biomacromolecules
pub_type：
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更新日期：2005-05-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0504328
更新日期：2005-09-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2003-11-01 00:00:00
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journal_title：Biomacromolecules
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journal_title：Biomacromolecules
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更新日期：2010-12-13 00:00:00
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更新日期：2018-07-09 00:00:00
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更新日期：2010-12-13 00:00:00
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journal_title：Biomacromolecules
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更新日期：2018-06-11 00:00:00
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更新日期：2016-10-10 00:00:00
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更新日期：2008-07-01 00:00:00
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更新日期：2007-09-01 00:00:00
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journal_title：Biomacromolecules
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更新日期：2021-01-11 00:00:00
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更新日期：2007-01-01 00:00:00
abstract：:Electrochemically controlled, reversible assembly of biopolymers into hydrogel structures is a promising technique for on-demand cell or drug encapsulation and release systems. An electrochemically sol-gel transition has been demonstrated in regenerated Bombyx mori silk fibroin, offering a controllable way to generate...
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更新日期：2013-08-12 00:00:00
