Enzymatic methods for in situ cell entrapment and cell release.

abstract：:Silkworm silk has excellent mechanical properties, biocompatibility, and promising applications in the biomedical sector. Silkworms spin silk at the beginning and end of each of their five instar stages, as well as spinning mature silk after the fifth instar. We evaluated the mechanical properties and structure of 10 ...

journal_title：Biomacromolecules

authors： Peng Z,Yang X,Liu C,Dong Z,Wang F,Wang X,Hu W,Zhang X,Zhao P,Xia Q

更新日期：2019-03-11 00:00:00

abstract：:Bacterial cellulose (BC) is a polysaccharide known as a suitable matrix for proper wound healing. To improve this ability, BC was functionalized with silk sericin (SS) that has cytoprotective and mitogenic effects. The composites obtained by solution impregnation were stabilized by hydrogen bonds, and SS could be rele...

journal_title：Biomacromolecules

authors： Lamboni L,Li Y,Liu J,Yang G

更新日期：2016-09-12 00:00:00

abstract：:This paper describes the synthesis and evaluation of a series of multifunctional poly-l-glutamic acid derivatives that can be used as vectors for gene delivery. They readily form polyelectrolyte complexes with DNA, resulting in a reduced surface charge and size of the DNA. The formation of a polymer-DNA complex and th...

journal_title：Biomacromolecules

authors： Dubruel P,Dekie L,Schacht E

更新日期：2003-09-01 00:00:00

abstract：:Poly(lactide)-block-poly(ethylene oxide)-block-poly(lactide) (PLA-PEO-PLA) triblock copolymers are known to form physical hydrogels in water as a result of the polymer's amphiphilicity. Their mechanical properties, biocompatibility, and biodegradability have made them attractive for use as soft tissue scaffolds. Howev...

journal_title：Biomacromolecules

authors： Sanabria-DeLong N,Crosby AJ,Tew GN

更新日期：2008-10-01 00:00:00

abstract：:Bovine serum albumin (BSA) and poly(diallyldimethylammonium chloride) (PDADMAC) spontaneously form, over a range of ionic strength I and pH, dense fluids rich in both macroions. To study their nanostructure, these coacervates were prepared at low I and high pH (strong interaction) or at high I and lower pH (weaker int...

journal_title：Biomacromolecules

authors： Bohidar H,Dubin PL,Majhi PR,Tribet C,Jaeger W

更新日期：2005-05-01 00:00:00

abstract：:Polymer conjugation increases an enzyme's circulation time and stability for use as a therapeutic agent, but this attachment indubitably affects its properties. Covalent attachment of multiple polyethylene glycol chains with sizes of either 2, 5, 10, or 20 kDa increases the molecular weight and hydrodynamic radius of ...

journal_title：Biomacromolecules

authors： Chiu K,Agoubi LL,Lee I,Limpar MT,Lowe JW Jr,Goh SL

更新日期：2010-12-13 00:00:00

abstract：:In situ polymerizable hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. In the present paper a novel polysaccharidic matrix based on calcium alginate (Ca(II)-Alg) hydrogel and dextran methacrylate derivative (Dex-MA), showing potential applicability in the field of pharm...

journal_title：Biomacromolecules

authors： Matricardi P,Pontoriero M,Coviello T,Casadei MA,Alhaique F

更新日期：2008-07-01 00:00:00

abstract：:In this work, we have analyzed the structural, topographical, and surface dilatational characteristics of pure beta-lactoglobulin adsorbed films and the effect of the self-assembly of monoglycerides (monopalmitin or monoolein) in beta-lactoglobulin films at the air-water interface. Measurements were performed in a sin...

journal_title：Biomacromolecules

authors： Rodríguez Patino JM,Fernandez MC,Rodríguez Niño MR,Sanchez CC

更新日期：2006-09-01 00:00:00

abstract：:A new PPF-BCN/hyPCL32-N3 injectable system that can be cross-linked by catalyst-free, strain promoted alkyne-azide cycloaddition (SPAAC) click chemistry was developed for tissue engineering applications. The system consisted of two components: PPF-BCN, poly(propylene fumarate) (PPF) functionalized with (1R,8S,9s)-bicy...

journal_title：Biomacromolecules

authors： Liu X,Miller AL 2nd,Xu H,Waletzki BE,Lu L

更新日期：2019-09-09 00:00:00

abstract：:The time-dependent diffusion and mechanical properties of gelatin in solution, in the gel state, and during the sol/gel transition were determined using fluorescence recovery after photobleaching (FRAP) and rheology. The parameters in the experimental design were 2% w/w and 5% w/w gelatin concentration; 15, 20, and 25...

journal_title：Biomacromolecules

authors： Hagman J,Lorén N,Hermansson AM

更新日期：2010-12-13 00:00:00

abstract：:Despite numerous strategies involving dynamic covalent bonds to produce self-healing hydrogels with similar frequency-dependent stiffness to native tissues, it remains challenging to use biologically relevant thiol/disulfide exchange to confer such properties to polymeric networks. Herein, we report a new method based...

journal_title：Biomacromolecules

authors： Casuso P,Odriozola I,Pérez-San Vicente A,Loinaz I,Cabañero G,Grande HJ,Dupin D

更新日期：2015-11-09 00:00:00

abstract：:To develop a safe, effective, and biocompatible gene delivery vector, a series of hydrophobic amino acid grafted chitosan (AGC) derivatives were synthesized by carbodiimide mediated coupling reaction. Chemical characterization of AGC polymers was performed by NMR and elemental analysis. AGC polymers demonstrated excel...

journal_title：Biomacromolecules

authors： Layek B,Singh J

更新日期：2013-02-11 00:00:00

abstract：:Supramolecular nanogel, a physically cross-linked nanosize hydrogel, spontaneously self-assembles in aqueous solution via secondary interactions and is thus of great interest in nanomedicine as a drug carrier. We developed a versatile method for supramolecular nanogel self-assembled by electrostatic interaction betwee...

journal_title：Biomacromolecules

authors： Kim K,Bae B,Kang YJ,Nam JM,Kang S,Ryu JH

更新日期：2013-10-14 00:00:00

abstract：:Multiblock copolymers (MBCs) are fascinating in the field of biology-polymer chemistry interfaces. Synthesizing libraries of MBCs with tailor-made functionality is challenging as it involves multiple steps. Herein, a simple synthesis, analogous to polyurethane/Michael addition reactions, has been introduced to obtain ...

journal_title：Biomacromolecules

authors： Nutan B,Kumar A,Jewrajka SK

更新日期：2020-12-14 00:00:00

abstract：:Bone-marrow-derived mesenchymal stem cells (BMSCs) possess vast potential for tissue engineering and regenerative medicine. In this study, an injectable hydrogel comprising poly(l-glutamic acid)-graft-tyramine (PLG-g-TA) with tunable microenvironment was developed via enzyme-catalyzed cross-linking and used as an arti...

journal_title：Biomacromolecules

authors： Ren K,Cui H,Xu Q,He C,Li G,Chen X

更新日期：2016-12-12 00:00:00

abstract：:Fluorescence and circular dichroism spectroscopy were used to monitor the conformational transition of regenerated Bombyx mori silk fibroin (RSF) in aqueous solutions under different conditions. According to the analysis of fluorescence spectra using anilinonaphthalene-8-sulfonic acid magnesium salt (ANS) as an extern...

journal_title：Biomacromolecules

authors： Yang Y,Shao Z,Chen X,Zhou P

更新日期：2004-05-01 00:00:00

abstract：:Water-soluble conjugated polymers (WCPs) composed of a hydrophobic polythiophene main chain with hydrophilic tertiary amine side-chains can directly self-assemble into sphere-like nano-objects in an aqueous solution due to phase separation between the hydrophilic and hydrophobic segments of the polymeric structure. Du...

journal_title：Biomacromolecules

authors： Cheng CC,Lai YC,Shieh YT,Chang YH,Lee AW,Chen JK,Lee DJ,Lai JY

更新日期：2020-12-14 00:00:00

abstract：:As a programmable biopolymer, DNA has shown great potential in the fabrication and construction of nanometer-scale assemblies and devices. In this report, we described a strategy for efficient manipulation of gold nanoparticle-bound DNA using restriction endonuclease. The digestion efficiency of this restriction enzym...

journal_title：Biomacromolecules

authors： Qin WJ,Yung LY

更新日期：2006-11-01 00:00:00

abstract：:An appropriate modification technique for silk materials is needed to effectively improve their physical properties for specific applications. A telechelic-type polyalanine (T-polyA) was synthesized by papain-catalyzed polymerization as a novel reinforcing agent for silk materials. A silk fibroin obtained from Bombyx ...

journal_title：Biomacromolecules

authors： Tsuchiya K,Masunaga H,Numata K

更新日期：2017-03-13 00:00:00

abstract：:A His-tagged coiled coil stem loop peptide with stable secondary structure was designed and biosynthesized. A series of oligopeptides related to the EBV envelope glycoprotein 350/220 N-terminal nonapeptide as potential CD21 receptor-binding epitopes were engineered into the loop region of the peptide scaffold. It was ...

journal_title：Biomacromolecules

authors： Tang A,Kopecek J

更新日期：2002-05-01 00:00:00

abstract：:Solid films of deoxyribonucleic acid (DNA) containing a hydrated ionic liquid, choline dihydrogen phosphate (CDP), were prepared by a solvent-casting method. Thermal properties, aggregation structure, thermal molecular motion, and tensile properties of CDP-containing DNA films were examined by thermogravimetry (TG), w...

journal_title：Biomacromolecules

authors： Morimitsu Y,Matsuno H,Ohta N,Sekiguchi H,Takahara A,Tanaka K

更新日期：2020-02-10 00:00:00

abstract：:Presently there is great interest in the construction of nanostructures from DNA fragments. Here we report the preparation of much larger helical textures with different shapes from pure DNA fragments. We have observed them while preparing crystals of the dodecamer d(AAAAAATTTTTT), which only contains adenine and thym...

journal_title：Biomacromolecules

authors： Subirana JA,Creixell M,Baldini R,Campos JL

更新日期：2008-01-01 00:00:00

abstract：:Encapsulation of hydrophilic cancer drugs in polymeric nanocapsules was achieved in a one-pot process via the inverse miniemulsion periphery RAFT polymerization (IMEPP) approach. The chosen guest molecule was gemcitabine hydrochloride, which is used as the first-line treatment of pancreatic cancer. The resulting nanoc...

journal_title：Biomacromolecules

authors： Utama RH,Jiang Y,Zetterlund PB,Stenzel MH

更新日期：2015-07-13 00:00:00

abstract：:Weissella confusa VTT E-90392 is an efficient producer of a dextran that is mainly composed of α-(1→6)-linked D-glucosyl units and very few α-(1→3) branch linkages. A mixture of the Chaetomium erraticum endodextranase and the Aspergillus niger α-glucosidase was used to hydrolyze W. confusa dextran to glucose and a set...

journal_title：Biomacromolecules

authors： Maina NH,Virkki L,Pynnönen H,Maaheimo H,Tenkanen M

更新日期：2011-02-14 00:00:00

abstract：:A wool fiber sample was submitted to chemical-free steam explosion in view of potential exploitation of keratin-based industrial and farm wastes. Fiber keratin was converted into a dark-yellow sludge that was submitted to phase separation by filtration, centrifugation, and precipitation of the soluble materials from t...

journal_title：Biomacromolecules

authors： Tonin C,Zoccola M,Aluigi A,Varesano A,Montarsolo A,Vineis C,Zimbardi F

更新日期：2006-12-01 00:00:00

abstract：:We have developed herein an engineered polymer-based nanoplatform showing the convergence of two-photon fluorescence imaging and bimodal phototherapeutic activity in a single nanostructure. It was achieved through the appropriate choice of three different components: a β-cyclodextrin-based polymer acting as a suitable...

journal_title：Biomacromolecules

authors： Kandoth N,Kirejev V,Monti S,Gref R,Ericson MB,Sortino S

更新日期：2014-05-12 00:00:00

abstract：:Low tolerability and tumor selectivity restricts many potent anticancer drugs including mertansine from wide clinical use. Here, glutathione-activatable hyaluronic acid-SS-mertansine prodrug (HA-SS-DM1) was designed and developed to achieve enhanced tolerability and targeted therapy of CD44+ human breast tumor xenogra...

journal_title：Biomacromolecules

authors： Zhong P,Zhang J,Deng C,Cheng R,Meng F,Zhong Z

更新日期：2016-11-14 00:00:00

abstract：:Silk fibroin (SF) protein, produced by silkworm Bombyx mori, is a promising biomaterial, while sophorolipid (SL) is an amphiphilic functional biosurfactant synthesized by nonpathogenic yeast Candida bombicola. SL is a mixture of two forms, acidic (ASL) and lactonic (LSL), which when added to SF results in accelerated ...

journal_title：Biomacromolecules

authors： Dubey P,Kumar S,Aswal VK,Ravindranathan S,Rajamohanan PR,Prabhune A,Nisal A

更新日期：2016-10-10 00:00:00

abstract：:Protein transduction domains (PTDs) that readily transverse cellular membranes are of great interest and are attractive tools for the intracellular delivery of bioactive molecules. Learning to program synthetic polymers and oligomers with the appropriate chemical information to capture adequately the biological activi...

journal_title：Biomacromolecules

authors： Tezgel AÖ,Telfer JC,Tew GN

更新日期：2011-08-08 00:00:00

abstract：:This paper reports the synthesis of hyaluronan (HA) and its derivatives via the hyaluronidase-catalyzed polymerization of 2-substituted oxazoline derivative monomers designed as "transition-state analogue substrates". Polymerization of 2-methyl oxazoline monomer from N-acetylhyalobiuronate (GlcAbeta(1-->3)GlcNAc) effe...

journal_title：Biomacromolecules

authors： Ochiai H,Ohmae M,Mori T,Kobayashi S

更新日期：2005-03-01 00:00:00