Abstract:
:Supramolecular nanogel, a physically cross-linked nanosize hydrogel, spontaneously self-assembles in aqueous solution via secondary interactions and is thus of great interest in nanomedicine as a drug carrier. We developed a versatile method for supramolecular nanogel self-assembled by electrostatic interaction between positive surfactant micelles and negative polypeptides. Core-shell-like structures of supramolecular nanogels provide stable hydrophobic pockets that prevent simple diffusion of hydrophobic guest molecules, resulting in high encapsulation stability. The size of the supramolecular nanogels can be systematically controlled by varying the size of the surfactant micelles. Furthermore, noncovalently encapsulated dye molecules can be released in response to matrix metalloproteinases highly overexpressed in tumor tissues, potentially providing tumor-triggered targeting.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Kim K,Bae B,Kang YJ,Nam JM,Kang S,Ryu JHdoi
10.1021/bm400846hsubject
Has Abstractpub_date
2013-10-14 00:00:00pages
3515-22issue
10eissn
1525-7797issn
1526-4602journal_volume
14pub_type
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