Natural polypeptide-based supramolecular nanogels for stable noncovalent encapsulation.

Abstract:

:Supramolecular nanogel, a physically cross-linked nanosize hydrogel, spontaneously self-assembles in aqueous solution via secondary interactions and is thus of great interest in nanomedicine as a drug carrier. We developed a versatile method for supramolecular nanogel self-assembled by electrostatic interaction between positive surfactant micelles and negative polypeptides. Core-shell-like structures of supramolecular nanogels provide stable hydrophobic pockets that prevent simple diffusion of hydrophobic guest molecules, resulting in high encapsulation stability. The size of the supramolecular nanogels can be systematically controlled by varying the size of the surfactant micelles. Furthermore, noncovalently encapsulated dye molecules can be released in response to matrix metalloproteinases highly overexpressed in tumor tissues, potentially providing tumor-triggered targeting.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Kim K,Bae B,Kang YJ,Nam JM,Kang S,Ryu JH

doi

10.1021/bm400846h

subject

Has Abstract

pub_date

2013-10-14 00:00:00

pages

3515-22

issue

10

eissn

1525-7797

issn

1526-4602

journal_volume

14

pub_type

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