Engineered polymeric nanoparticles for receptor-targeted blockage of oxidized low density lipoprotein uptake and atherogenesis in macrophages.

abstract：:In a previous study, we have reported chemical synthesis of novel aliphatic poly(butylene succinate-co-cyclic carbonate) P(BS-co-CC)s bearing various functionalizable carbonate building blocks, and this work will continue to present our new studies on their enzymatic degradation and in vitro cell biocompatibility assa...

journal_title：Biomacromolecules

authors： Yang J,Tian W,Li Q,Li Y,Cao A

更新日期：2004-11-01 00:00:00

abstract：:Ephemeral gels, called Enzgels, successively undergo sol-gel and then gel-sol transition under the action of two antagonistic enzymes, transglutaminase and protease. Molecular and macroscopic properties of Enzgels are directly dependent on the enzymatic activities and their ratios. This work studies the characteristic...

journal_title：Biomacromolecules

authors： Picard J,Giraudier S,Larreta-Garde V

更新日期：2008-01-01 00:00:00

abstract：:The effect of increasing water composition on the rheological and microstructural behavior of a ternary cellulose acetate (CA)/N,N-dimethylacetamide (DMA)/water system is examined. Addition of water to the CA/DMA system results in enhanced steady shear viscosity and dynamic viscoelastic properties and ultimately to ph...

journal_title：Biomacromolecules

authors： Appaw C,Gilbert RD,Khan SA,Kadla JF

更新日期：2007-05-01 00:00:00

abstract：:Oral delivery remains a challenge for poorly permeable hydrophilic macromolecules. Poly(amido amine) (PAMAM) dendrimers have shown potential for their possible oral delivery. Transepithelial transport of carboxyl-terminated G3.5 and amine-terminated G4 PAMAM dendrimers was assessed using isolated rat jejunal mucosae m...

journal_title：Biomacromolecules

authors： Hubbard D,Ghandehari H,Brayden DJ

更新日期：2014-08-11 00:00:00

abstract：:Bioresponsive poly(amidoamine)s (PAA)s are currently under development as endosomolytic polymers for intracellular delivery of proteins and genes. Here for the first time, small-angle neutron scattering (SANS) is used to systematically investigate the pH-dependent conformational change of an endosomolytic polymer, the...

journal_title：Biomacromolecules

authors： Griffiths PC,Paul A,Khayat Z,Wan KW,King SM,Grillo I,Schweins R,Ferruti P,Franchini J,Duncan R

更新日期：2004-07-01 00:00:00

abstract：:Novel biodegradable materials with tunable hydrolytic degradation rate are prepared by grafting of phosphonoethylated polyglycidols with polyesters. First, the hydrolytically degradable polyester grafts are attached to polyglycidols partially grafted with phosphonoethylated diethyl esters through chemical-catalyzed gr...

journal_title：Biomacromolecules

authors： Köhler J,Marquardt F,Teske M,Keul H,Sternberg K,Möller M

更新日期：2013-11-11 00:00:00

abstract：:Injectable in situ crosslinkable biomaterials seeded with multipotent progenitor cells and coupled with minimally invasive arthroscopic techniques are an attractive alternative for treating irregularly shaped osteochondral defects. An in situ crosslinkable poly(lactide-co-ethylene oxide-co-fumarate) (PLEOF) macromer h...

journal_title：Biomacromolecules

authors： He X,Jabbari E

更新日期：2007-03-01 00:00:00

abstract：:An enzymatically cross-linked polyethylene glycol (PEG)-based hydrogel was engineered to promote and align nerve cells in a three-dimensional manner. To render the injectable, otherwise bioinert, PEG-based material supportive for cell growth, its mechanical and biochemical properties were optimized. A recombinant fibr...

journal_title：Biomacromolecules

authors： Licht C,Rose JC,Anarkoli AO,Blondel D,Roccio M,Haraszti T,Gehlen DB,Hubbell JA,Lutolf MP,De Laporte L

更新日期：2019-11-11 00:00:00

abstract：:New silk-like recombinant proteins, [(AAG)(6)ASTGRGDSPAAS](n) and [(AG)(9)ASTGRGDSPAAS](n), with high cell adhesive activities were designed and produced from E. coli. These are recombinant proteins with characteristic sequences from the silk fibroin of a wild silkworm, Anaphe , and the cell adhesive region, including...

journal_title：Biomacromolecules

authors： Tanaka C,Asakura T

更新日期：2009-04-13 00:00:00

abstract：:Alginate-based amphiphilic graft copolymers were synthesized by single electron transfer living radical polymerization (SET-LRP), forming stable micelles during polymerization induced self-assembly (PISA). First, alginate macroinitiator was prepared by partial depolymerization of native alginate, solubility modificati...

journal_title：Biomacromolecules

authors： Kapishon V,Whitney RA,Champagne P,Cunningham MF,Neufeld RJ

更新日期：2015-07-13 00:00:00

abstract：:Mechanically fibrillated cellulose nanofibrils (CNFs) have attracted special attention as building blocks for the development of advanced materials and composites. A correlation exists between CNF morphology and the properties of the materials they form. However, this correlation is often evaluated indirectly by proce...

journal_title：Biomacromolecules

authors： Mattos BD,Tardy BL,Rojas OJ

更新日期：2019-07-08 00:00:00

abstract：:Hydrogel forming polysaccharides, such as the seaweed derived agarose, are well suited for wound dressing applications as they have excellent cell and soft tissue compatibility. For wound dressings, fibrous structure is desirable as the high surface area can favor adsorption of wound exudate and promote drug delivery....

journal_title：Biomacromolecules

authors： Forget A,Arya N,Randriantsilefisoa R,Miessmer F,Buck M,Ahmadi V,Jonas D,Blencowe A,Shastri VP

更新日期：2016-12-12 00:00:00

abstract：:The drying dynamics of protein coatings is of importance for many applications. The main focus of research so far was to investigate macroscopic properties of protein coatings, leaving drying dynamics virtually unexplored. A unique combination of techniques is used to monitor drying of a coating containing the protein...

journal_title：Biomacromolecules

authors： Bouman J,de Vries R,Venema P,Belton P,Baukh V,Huinink HP,van der Linden E

更新日期：2015-01-12 00:00:00

abstract：:Acrylic acid (AAc) has been utilized to introduce reactive carboxyl groups to a temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). However, AAc introduction shifts the copolymer phase transition temperatures higher and dampens the steep homopolymer phase transition with increasing AAc content. We pr...

journal_title：Biomacromolecules

authors： Ebara M,Yamato M,Hirose M,Aoyagi T,Kikuchi A,Sakai K,Okano T

更新日期：2003-03-01 00:00:00

abstract：:Minimization of drug side effects is a hallmark of advanced targeted therapy. Herein we describe the synthesis of polysaccharide-based nanocapsules prepared from furcellaran and chitosan via layer-by-layer deposition using electrostatic interaction. Using doxorubicin as a model drug, prepared nanocapsules showed excel...

journal_title：Biomacromolecules

authors： Milosavljevic V,Jamroz E,Gagic M,Haddad Y,Michalkova H,Balkova R,Tesarova B,Moulick A,Heger Z,Richtera L,Kopel P,Adam V

更新日期：2020-02-10 00:00:00

abstract：:Relative to normal cells, tumor cells lack adequate capability of reactive oxygen scavenging. Thus, tumor cells can be selectively killed by increasing the concentration of reactive oxygen species in tumor tissue. In this report, we construct an integrated multifunctional polymeric nanoparticle which can selectively i...

journal_title：Biomacromolecules

authors： Wang Y,Yin W,Ke W,Chen W,He C,Ge Z

更新日期：2018-06-11 00:00:00

abstract：:We study the self-assembly of genetically engineered protein-based triblock copolymers consisting of a central pH-responsive silk-like middle block (S(H)n, where S(H) is a silk-like octapeptide, (GA)3GH and n is the number of repeats) flanked by hydrophilic random coil outer blocks (C2). Our previous work has already ...

journal_title：Biomacromolecules

authors： Beun LH,Storm IM,Werten MW,de Wolf FA,Cohen Stuart MA,de Vries R

更新日期：2014-09-08 00:00:00

abstract：:Aberrant expression of histone deacetylases (HDACs) is related to various types of cancer and is associated with increased proliferation of tumor cells. Hence, the detection of HDAC activities is of great significance for medical sciences as well as biological diagnostics. Herein, we report a hyperbranched polyester-b...

journal_title：Biomacromolecules

authors： Yu C,Wu Y,Zeng F,Li X,Shi J,Wu S

更新日期：2013-12-09 00:00:00

abstract：:The adhesion of wet regenerated cellulose to colloidal complexes formed between carboxymethyl cellulose (CMC) and polyvinylamine (PVAm) was evaluated by measuring the force to delaminate pairs of regenerated cellulose membranes bound together with polyelectrolyte complex. The most important parameter was the surface c...

journal_title：Biomacromolecules

authors： Feng X,Pouw K,Leung V,Pelton R

更新日期：2007-07-01 00:00:00

abstract：:The production of large quantities of artificial spider silk fibers that match the mechanical properties of the native material has turned out to be challenging. Recent advancements in the field make biomimetic spinning approaches an attractive way forward since they allow the spider silk proteins to assemble into the...

journal_title：Biomacromolecules

authors： Gonska N,López PA,Lozano-Picazo P,Thorpe M,Guinea GV,Johansson J,Barth A,Pérez-Rigueiro J,Rising A

更新日期：2020-06-08 00:00:00

abstract：:The effect of guluronate oligomers on the barrier properties of mucous matrices was investigated in terms of the mobility of nanoparticles in mucous matrices by fluorescence recovery after photobleaching (FRAP), cellular uptake of nanoparticles in mucus secreting cells (HT29-MTX), and mucin matrix architecture by scan...

journal_title：Biomacromolecules

authors： Nordgård CT,Nonstad U,Olderøy MØ,Espevik T,Draget KI

更新日期：2014-06-09 00:00:00

abstract：:In this work, cell-responsive polysaccharide hydrogels were prepared by a simple procedure based on the sequential bioconjugation and cross-linking of the polysaccharide backbone with bioactive peptides and poly(ethylene glycol)-bis(thiol) (PEG-(SH)2), respectively. Using thiol-ene reactions, we successfully functiona...

journal_title：Biomacromolecules

authors： Jing J,Fournier A,Szarpak-Jankowska A,Block MR,Auzély-Velty R

更新日期：2015-03-09 00:00:00

abstract：:Six methyl celluloses (MCs), one with a degree of substitution (DS) of 1.32 and five with DS between 1.83 and 1.88, were thoroughly investigated. Monomer composition and methyl distribution in the polymer chain were analyzed after total or partial random hydrolysis and appropriate derivatization with gas chromatograph...

journal_title：Biomacromolecules

authors： Adden R,Melander C,Brinkmalm G,Gorton L,Mischnick P

更新日期：2006-05-01 00:00:00

abstract：:To continue expanding the use of Single Electron Transfer-Living Radical Polymerization (SET-LRP) in applications at the interface between macromolecular science, biomacromolecules, biology and medicine, it is essential to develop novel initiators that do not compromise the structural stability of synthesized polymers...

journal_title：Biomacromolecules

authors： Lligadas G,Enayati M,Grama S,Smail R,Sherman SE,Percec V

更新日期：2017-08-14 00:00:00

abstract：:The synthesis of core-shell star copolymers via living free radical polymerization provides a convenient route to three-dimensional nanostructures having a poly(ethylene glycol) outer shell, a hydrophilic inner shell bearing reactive functional groups, and a central hydrophobic core. By starting with well-defined line...

journal_title：Biomacromolecules

authors： Fukukawa K,Rossin R,Hagooly A,Pressly ED,Hunt JN,Messmore BW,Wooley KL,Welch MJ,Hawker CJ

更新日期：2008-04-01 00:00:00

abstract：:The morphology of silk produced by recluse spiders (Loxosceles arizonica) was investigated by scanning electron microscopy, atomic force microscopy, and transmission electron microscopy. This silk consisted entirely of very long, thin ribbons of width 2-4 microm and thicknesses of no more than 40 nm. The correspondenc...

journal_title：Biomacromolecules

authors： Coddington JA,Chanzy HD,Jackson CL,Raty G,Gardner KH

更新日期：2002-01-01 00:00:00

abstract：:Oligopeptide hydrogels are emerging as useful matrices for cell culture with commercial products on the market, but L-oligopeptides are labile to proteases. An obvious solution is to create D-oligopeptide hydrogels, which lack enzymatic recognition. However, D-oligopeptide matrices do not support cell growth as well a...

journal_title：Biomacromolecules

authors： Hyland LL,Twomey JD,Vogel S,Hsieh AH,Yu YB

更新日期：2013-02-11 00:00:00

abstract：:Electrospun biopolyelectrolyte nanofibers hold potential for use in a range of biomedical applications, but eliminating toxic chemicals involved in their production remains a key challenge. In this study, we successfully electrospun nanofibers from an aqueous complex coacervate solution composed of chitosan and hyalur...

journal_title：Biomacromolecules

authors： Sun J,Perry SL,Schiffman JD

更新日期：2019-11-11 00:00:00

abstract：:Intraneuronal aggregation of the intrinsically disordered protein α-synuclein is at the core of Parkinson's disease and related neurodegenerative disorders. Several reports show that the concentration of salts in the medium heavily affects its aggregation rate and fibril morphology, but a characterization of the indiv...

journal_title：Biomacromolecules

authors： Ramis R,Ortega-Castro J,Vilanova B,Adrover M,Frau J

更新日期：2020-12-14 00:00:00

abstract：:We examined the antibacterial and hemolytic activities in a series of amphiphilic block and random copolymers of poly(vinyl ether) derivatives prepared by base-assisting living cationic polymerization. Block and random amphiphilic copolymers with similar monomer compositions showed the same level of activity against ...

journal_title：Biomacromolecules

authors： Oda Y,Kanaoka S,Sato T,Aoshima S,Kuroda K

更新日期：2011-10-10 00:00:00