Polymerization Induced Self-Assembly of Alginate Based Amphiphilic Graft Copolymers Synthesized by Single Electron Transfer Living Radical Polymerization.

Abstract:

:Alginate-based amphiphilic graft copolymers were synthesized by single electron transfer living radical polymerization (SET-LRP), forming stable micelles during polymerization induced self-assembly (PISA). First, alginate macroinitiator was prepared by partial depolymerization of native alginate, solubility modification and attachment of initiator. Depolymerized low molecular weight alginate (∼12 000 g/mol) was modified with tetrabutylammonium, enabling miscibility in anhydrous organic solvents, followed by initiator attachment via esterification yielding a macroinitiator with a degree of substitution of 0.02, or 1-2 initiator groups per alginate chain. Then, methyl methacrylate was polymerized from the alginate macroinitiator in mixtures of water and methanol, forming poly(methyl methacrylate) grafts, prior to self-assembly, of ∼75 000 g/mol and polydispersity of 1.2. PISA of the amphiphilic graft-copolymer resulted in the formation of micelles with diameters of 50-300 nm characterized by light scattering and electron microscopy. As the first reported case of LRP from alginate, this work introduces a synthetic route to a preparation of alginate-based hybrid polymers with a precise macromolecular architecture and desired functionalities. The intended application is the preparation of micelles for drug delivery; however, LRP from alginate can also be applied in the field of biomaterials to the improvement of alginate-based hydrogel systems such as nano- and microhydrogel particles, islet encapsulation materials, hydrogel implants, and topical applications. Such modified alginates can also improve the function and application of native alginates in food and agricultural applications.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Kapishon V,Whitney RA,Champagne P,Cunningham MF,Neufeld RJ

doi

10.1021/acs.biomac.5b00470

subject

Has Abstract

pub_date

2015-07-13 00:00:00

pages

2040-8

issue

7

eissn

1525-7797

issn

1526-4602

journal_volume

16

pub_type

杂志文章
  • Core-Shell-Shell Nanoparticles for NIR Fluorescence Imaging and NRET Swelling Reporting of Injectable or Implantable Gels.

    abstract::Injectable gels that support load are desirable for restoring the mechanical properties of degenerated load-bearing tissue. As these gels become increasingly sophisticated, the need to remotely image them and monitor their swelling increases. However, imaging such gels and monitoring their swelling using noninvasive m...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b00463

    authors: Shanks HR,Milani AH,Lu D,Saunders BR,Carney L,Adlam DJ,Hoyland JA,Blount C,Dickinson M

    更新日期:2019-07-08 00:00:00

  • Typical physicochemical behaviors of chitosan in aqueous solution.

    abstract::Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer. Techniques such as interferometry, static light scattering (in batch or coupled on line with a chromatographic system), and...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm025724c

    authors: Schatz C,Viton C,Delair T,Pichot C,Domard A

    更新日期:2003-05-01 00:00:00

  • Synthesis of amylose-polystyrene inclusion complexes by a facile preparation route.

    abstract::The formation of amylose-polystyrene inclusion complexes via a novel two-step approach is described. In the first-step, styrene was inserted inside the amylose helical cavity, followed by free radical polymerization in the second step. The inclusion complexes were characterized by attenuated total reflection fourier t...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm400340k

    authors: Kumar K,Woortman AJ,Loos K

    更新日期:2013-06-10 00:00:00

  • Structure-function relationship in the antifreeze activity of synthetic alanine-lysine antifreeze polypeptides.

    abstract::Recently antifreeze proteins (AFP) have been the subject of many structure-function relationship studies regarding their antifreeze activity. Attempts have been made to elucidate the structure-function relationship by various amino acid substitutions, but to our knowledge there has been no successful from first princi...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm000004w

    authors: Wierzbicki A,Knight CA,Rutland TJ,Muccio DD,Pybus BS,Sikes CS

    更新日期:2000-07-01 00:00:00

  • Pressure cell assisted solution characterization of polysaccharides. 2. Locust bean gum and tara gum.

    abstract::Following the work carried out on guar gum in our first paper of a series, the "pressure cell" solubilization method was applied to two other less highly substituted galactomannans: locust bean gum (LBG) and tara gum. True molecular solution of the polymers was achieved using appropriate temperature, time, and pressur...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm025517c

    authors: Picout DR,Ross-Murphy SB,Jumel K,Harding SE

    更新日期:2002-07-01 00:00:00

  • Effect of chitosan chain architecture on gene delivery: comparison of self-branched and linear chitosans.

    abstract::Chitosan possesses many characteristics of an ideal gene delivery system. However, the transfection efficiency of conventional chitosans is generally found to be low. In this study, we investigated the self-branching of chitosans as a strategy to improve its gene transfer properties without compromising its safety pro...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm1013525

    authors: Malmo J,Vårum KM,Strand SP

    更新日期:2011-03-14 00:00:00

  • Polyol synthesis of silver nanoparticles: mechanism of reduction by alditol bearing polysaccharides.

    abstract::Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the polyol. The close and multivalent ar...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm801253c

    authors: Donati I,Travan A,Pelillo C,Scarpa T,Coslovi A,Bonifacio A,Sergo V,Paoletti S

    更新日期:2009-02-09 00:00:00

  • Structural and Mechanical Properties of Silk from Different Instars of Bombyx mori.

    abstract::Silkworm silk has excellent mechanical properties, biocompatibility, and promising applications in the biomedical sector. Silkworms spin silk at the beginning and end of each of their five instar stages, as well as spinning mature silk after the fifth instar. We evaluated the mechanical properties and structure of 10 ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.8b01576

    authors: Peng Z,Yang X,Liu C,Dong Z,Wang F,Wang X,Hu W,Zhang X,Zhao P,Xia Q

    更新日期:2019-03-11 00:00:00

  • Modification of cellulose films by adsorption of CMC and chitosan for controlled attachment of biomolecules.

    abstract::The adsorption of human immunoglobulin G (hIgG) and bovine serum albumin (BSA) on cellulose supports were investigated. The dynamics and extent of related adsorption processes were monitored by surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D). Amine groups were instal...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm201236a

    authors: Orelma H,Filpponen I,Johansson LS,Laine J,Rojas OJ

    更新日期:2011-12-12 00:00:00

  • Holmium-loaded poly(L-lactic acid) microspheres: in vitro degradation study.

    abstract::The clinical application of holmium-loaded poly(L-lactic acid) (PLLA) microspheres for the radionuclide treatment of liver malignancies requires in depth understanding of the degradation characteristics of the microspheres. To this end, an in-vitro degradation study was conducted. PLLA-microspheres with and without Ho...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm060230r

    authors: Zielhuis SW,Nijsen JF,Krijger GC,van het Schip AD,Hennink WE

    更新日期:2006-07-01 00:00:00

  • Polyhydroxybutyrate and its copolymer with polyhydroxyvalerate as biomaterials: influence on progression of stem cell cycle.

    abstract::Poly(3-hydroxybutyrate) (PHB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) are biopolyesters reported to provide favorable microenvironments for cell culture and possess potential for tissue engineering applications. Both biopolymers have been investigated for applications in a variety of medical scenarios,...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm1007579

    authors: Ahmed T,Marçal H,Lawless M,Wanandy NS,Chiu A,Foster LJ

    更新日期:2010-10-11 00:00:00

  • Emulsifying properties of biodegradable polylactide-grafted dextran copolymers.

    abstract::Amphiphilic glycopolymers, polylactide-grafted dextran copolymers (Dex-g-PLA), were synthesized with a well-controlled architecture obtained through a three-step procedure: partial silylation of the dextran hydroxyl groups, ring-opening polymerization of D,L-lactide initiated from remaining hydroxyl groups, silylether...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm701101n

    authors: Raynaud J,Choquenet B,Marie E,Dellacherie E,Nouvel C,Six JL,Durand A

    更新日期:2008-03-01 00:00:00

  • Rational protein modification leading to resistance of enzymes to TiO2-UV irradiation-induced inactivation.

    abstract::Photoexcited TiO2 degrades biomolecules such as nucleic acids, cell membrane proteins, and enzymes. Stabilization of enzyme activity against the deactivation caused by the combination of TiO2-UV is essential if we are to develop novel hybrid materials exhibiting photocatalytic and biocatalytic activities useful for de...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm049728o

    authors: Lele BS,Russell AJ

    更新日期:2004-09-01 00:00:00

  • Preparation of Dental Resins Resistant to Enzymatic and Hydrolytic Degradation in Oral Environments.

    abstract::The short average service life of traditional dental composite restorative materials and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting compositions. Novel monomers and their polymers, reinforcing fillers, and adhesive ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b01069

    authors: Gonzalez-Bonet A,Kaufman G,Yang Y,Wong C,Jackson A,Huyang G,Bowen R,Sun J

    更新日期:2015-10-12 00:00:00

  • Solubility of Softwood Hemicelluloses.

    abstract::It is demonstrated that the molecular solubility of softwood hemicelluloses is significantly influenced by pretreatment of the fibers, extraction, and downstream processing. To quantify these effects, four hemicellulose samples were extracted from different thermomechanical pulps of Norway spruce. The molecular solubi...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.8b00088

    authors: Kishani S,Vilaplana F,Xu W,Xu C,Wågberg L

    更新日期:2018-04-09 00:00:00

  • Effects of molecular size and surface hydrophobicity on oligonucleotide interfacial dynamics.

    abstract::Single-molecule total internal reflection fluorescence microscopy was used to observe the dynamic behavior of polycytosine single-stranded DNA (ssDNA) (1-50 nucleotides long) at the interface between aqueous solution and hydrophilic (oligoethylene glycol-modified fused silica, OEG) and hydrophobic (octadecyltriethoxys...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm301289n

    authors: Monserud JH,Schwartz DK

    更新日期:2012-12-10 00:00:00

  • Design of renewable hydrogel release systems from fiberboard mill wastewater.

    abstract::A new route for the design of renewable hydrogels is presented. The soluble waste from masonite production was isolated, fractionized, and upgraded. The resulting hemicellulose rich fraction was alkenyl-functionalized and used in the preparation of covalently cross-linked hydrogels capable of sustained release of inco...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm100253e

    authors: Albertsson AC,Voepel J,Edlund U,Dahlman O,Söderqvist-Lindblad M

    更新日期:2010-05-10 00:00:00

  • Injectable microgel-hydrogel composites for prolonged small-molecule drug delivery.

    abstract::The design and application of soft nanocomposite injectable hydrogels containing entrapped microgels for small-molecule drug delivery is demonstrated. Copolymer microgels based on N-isopropylacrylamide and acrylic acid were synthesized that exhibited both ionic and hydrophobic affinity for binding to bupivacaine, a ca...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm201170h

    authors: Sivakumaran D,Maitland D,Hoare T

    更新日期:2011-11-14 00:00:00

  • Digestive Enzyme Corona Formed in the Gastrointestinal Tract and Its Impact on Epithelial Cell Uptake of Nanoparticles.

    abstract::The fate of intravenously injected nanoparticles (NPs) is significantly affected by nano-protein interaction and corona formation. However, such an interaction between NPs and digestive enzymes occurring in the gastrointestinal tract (GIT) and its impacts on epithelial cell uptake are little known. We synthesized the ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b00175

    authors: Peng Q,Liu J,Zhang T,Zhang TX,Zhang CL,Mu H

    更新日期:2019-04-08 00:00:00

  • Characterization of resilin-based materials for tissue engineering applications.

    abstract::Modular proteins have emerged as powerful tools in tissue engineering because both the mechanical and biochemical properties can be precisely controlled through amino acid sequence. Resilin is an attractive candidate for use in modular proteins because it is well-known for having low stiffness, high fatigue lifetime, ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm301129b

    authors: Renner JN,Cherry KM,Su RS,Liu JC

    更新日期:2012-11-12 00:00:00

  • Artificial forisomes are ideal models of forisome assembly and activity that allow the development of technical devices.

    abstract::Forisomes are protein polymers found in leguminous plants that have the remarkable ability to undergo reversible "muscle-like" contractions in the presence of divalent cations and in extreme pH environments. To gain insight into the molecular basis of forisome structure and assembly, we used confocal laser scanning mi...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm3008499

    authors: Groscurth S,Müller B,Schwan S,Menzel M,Diekstall F,Senft M,Kendall A,Kommor BA,Neumann U,Kalischuk M,Kawchuk LM,Krzyzanek V,Heilmann A,Stubbs G,Twyman RM,Prüfer D,Noll GA

    更新日期:2012-10-08 00:00:00

  • Hyaluronic Acid Based Hydrogels Attenuate Inflammatory Receptors and Neurotrophins in Interleukin-1β Induced Inflammation Model of Nucleus Pulposus Cells.

    abstract::Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) hyaluronic acid (HA) hydrogels offers a potential therapeutic biomaterial for nucleus pulposus (NP...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b00168

    authors: Isa IL,Srivastava A,Tiernan D,Owens P,Rooney P,Dockery P,Pandit A

    更新日期:2015-06-08 00:00:00

  • Design of an injectable in situ gelation biomaterials for vitreous substitute.

    abstract::To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its im...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm201012f

    authors: Annaka M,Mortensen K,Vigild ME,Matsuura T,Tsuji S,Ueda T,Tsujinaka H

    更新日期:2011-11-14 00:00:00

  • Blending chitosan with polycaprolactone: effects on physicochemical and antibacterial properties.

    abstract::Chitosan is a well sought-after polysaccharide in biomedical applications and has been blended with various macromolecules to mitigate undesirable properties. However, the effects of blending on the unique antibacterial activity of chitosan as well as changes in fatigue and degradation properties are not well understo...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm050935d

    authors: Sarasam AR,Krishnaswamy RK,Madihally SV

    更新日期:2006-04-01 00:00:00

  • Formulation and drying of alginate beads for controlled release and stabilization of invertase.

    abstract::Several alternatives to the conventional alginate beads formulation were studied for encapsulation of invertase. Pectin was added to the alginate/enzyme solution while trehalose and β-cyclodextrin were added to the calcium gelation media. The effect of composition changes, freezing, drying methods (freeze, vacuum, or ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm2009075

    authors: Santagapita PR,Mazzobre MF,Buera MP

    更新日期:2011-09-12 00:00:00

  • In situ cross-linkable novel alginate-dextran methacrylate IPN hydrogels for biomedical applications: mechanical characterization and drug delivery properties.

    abstract::In situ polymerizable hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. In the present paper a novel polysaccharidic matrix based on calcium alginate (Ca(II)-Alg) hydrogel and dextran methacrylate derivative (Dex-MA), showing potential applicability in the field of pharm...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm800252c

    authors: Matricardi P,Pontoriero M,Coviello T,Casadei MA,Alhaique F

    更新日期:2008-07-01 00:00:00

  • Hydrogel-Based Bioinks for Cell Electrowriting of Well-Organized Living Structures with Micrometer-Scale Resolution.

    abstract::Bioprinting has become an important tool for fabricating regenerative implants and in vitro cell culture platforms. However, until today, extrusion-based bioprinting processes are limited to resolutions of hundreds of micrometers, which hamper the reproduction of intrinsic functions and morphologies of living tissues....

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.0c01577

    authors: Castilho M,Levato R,Bernal PN,de Ruijter M,Sheng CY,van Duijn J,Piluso S,Ito K,Malda J

    更新日期:2021-01-07 00:00:00

  • Investigation of layer-by-layer assembly of polyelectrolytes on fully functional human red blood cells in suspension for attenuated immune response.

    abstract::The encapsulation of live cells with polymeric coat-ings is a versatile approach to modulate or control the response cells to their environment. The layer-by-layer (LbL) self-assembly of nonimmunogenic polyelectrolytes is employed here to attenuate or suppress the binding of antibodies to live red blood cells (RBCs) a...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm101200c

    authors: Mansouri S,Merhi Y,Winnik FM,Tabrizian M

    更新日期:2011-03-14 00:00:00

  • Transiently Responsive Block Copolymer Micelles Based on N-(2-Hydroxypropyl)methacrylamide Engineered with Hydrolyzable Ethylcarbonate Side Chains.

    abstract::The lack of selectivity and low solubility of many chemotherapeutics impels the development of different biocompatible nanosized drug carriers. Amphiphilic block copolymers, composed of a hydrophilic and hydrophobic domain, show great potential because of their small size, large solubilizing power and loading capacity...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b01252

    authors: Kasmi S,Louage B,Nuhn L,Van Driessche A,Van Deun J,Karalic I,Risseeuw M,Van Calenbergh S,Hoogenboom R,De Rycke R,De Wever O,Hennink WE,De Geest BG

    更新日期:2016-01-11 00:00:00

  • Grafting of oligosaccharides onto synthetic polymer colloids.

    abstract::A new method to form colloidally stable oligosaccharide-grafted synthetic polymer particles has been developed. The oligosaccharides, of weight-average degree of polymerization approximately 38, were obtained by enzymatic debranching of amylopectin. Through the use of a cerium(IV)-based redox initiation process, oligo...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm061119o

    authors: Mange S,Dever C,De Bruyn H,Gaborieau M,Castignolles P,Gilbert RG

    更新日期:2007-06-01 00:00:00