Abstract：
:Hydrogel forming polysaccharides, such as the seaweed derived agarose, are well suited for wound dressing applications as they have excellent cell and soft tissue compatibility. For wound dressings, fibrous structure is desirable as the high surface area can favor adsorption of wound exudate and promote drug delivery. Although electrospinning offers a straightforward means to produce nonwoven fibrous polymeric structures, processing agarose and its derivatives into fibers through electrospinning is challenging as it has limited solubility in solvents other than water. In this study we describe the processing of carboxylated agarose (CA) fibers with antibacterial properties by electrospinning from a solution of the ionic liquid (IL) 1-butyl-3-methylimidazolium chloride ([Bmim]+Cl-) possessing antimicrobial properties. The extent of carboxylation was found to impact fiber diameter, mesh elastic modulus, fiber swelling, and the loading and release of IL. IL-bearing CA fibers inhibited the growth of Staphylococcus aureus and Pseudomonas aeruginosa, bacteria commonly found in wound exudate. In sum, nonwoven CA fibers processed from IL are promising as biomaterials for wound dressing applications.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Forget A,Arya N,Randriantsilefisoa R,Miessmer F,Buck M,Ahmadi V,Jonas D,Blencowe A,Shastri VPdoi
10.1021/acs.biomac.6b01401subject
Has Abstractpub_date
2016-12-12 00:00:00pages
4021-4026issue
12eissn
1525-7797issn
1526-4602journal_volume
17pub_type
杂志文章abstract：:Water-soluble, degradable polymers based on poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) with low cytotoxicity and good p-DNA transfection efficiency are highlighted in this article. To solve the nondegradability issue of PDMAEMA, new polymers based on DMAEMA and 5,6-benzo-2-methylene-1,3-dioxepane (BMDO) for g...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm2015174
更新日期：2012-02-13 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章,评审
doi：10.1021/acs.biomac.8b00264
更新日期：2018-06-11 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm010163v
更新日期：2002-05-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm301826m
更新日期：2013-03-11 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章,评审
doi：10.1021/bm201020h
更新日期：2011-10-10 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm201170h
更新日期：2011-11-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm500168s
更新日期：2014-06-09 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm200587m
更新日期：2011-08-08 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm034477p
更新日期：2004-07-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm015606+
更新日期：2002-05-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm700906k
更新日期：2008-01-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm200899h
更新日期：2011-10-10 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm401616n
更新日期：2014-03-10 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm900571b
更新日期：2009-09-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0609691
更新日期：2007-05-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm800724q
更新日期：2008-11-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm070091t
更新日期：2007-07-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b00993
更新日期：2019-10-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2016-03-14 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2012-03-12 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2015-06-08 00:00:00
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pub_type： 杂志文章
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更新日期：2003-05-01 00:00:00
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更新日期：2017-04-10 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm300518e
更新日期：2012-08-13 00:00:00
abstract：:Reversible stereoselective complexes were spontaneously obtained from mixing acetonitrile solutions of enatiomeric d-poly(lactic acid) (d-PLA), l-poly(lactic acid) (l-PLA), and leuprolide, a l-configured nonapeptide LHRH analogue. The complex spontaneously aggregated and precipitated in high yields (>90%) from acetoni...
journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2003-09-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2017-04-10 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
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更新日期：2008-04-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm800580c
更新日期：2008-09-01 00:00:00
