Abstract:
:Many polymers, including polyethylene, feature a relatively low melting point and hence must be cross-linked to make them viable for applications that demand a high stiffness and creep resistance at elevated temperatures. The resulting thermoset plastics cannot be recycled, and therefore alternative materials with a reconfigurable internal network structure are in high demand. Here, we establish that such a thermoset-like yet recyclable material can be realized through the addition of a nanocellulose reinforcing agent. A network consisting of cellulose nanocrystals, nano- or microfibrils imparts many of the characteristics that are usually achieved through chemical cross-linking. For instance, the addition of only 7.5 wt % of either nanocellulose material significantly enhances the melt stiffness of an otherwise molten ethylene-acrylate copolymer by at least 1 order of magnitude. At the same time, the nanocellulose network reduces the melt creep elongation to less than 10%, whereas the neat molten matrix would rupture. At high shear rates, however, the molten composites do not display a significantly higher viscosity than the copolymer matrix, and therefore retain the processability of a thermoplastic material. Repeated re-extrusion at 140 °C does not compromise the thermomechanical properties, which indicates a high degree of recyclability. The versatility of dynamic nanocellulose networks is illustrated by 3D printing of a cellulose composite, where the high melt stiffness improves the printability of the resin.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Peterson A,Östergren I,Lotsari A,Venkatesh A,Thunberg J,Ström A,Rojas R,Andersson M,Berglund LA,Boldizar A,Müller Cdoi
10.1021/acs.biomac.9b00993subject
Has Abstractpub_date
2019-10-14 00:00:00pages
3924-3932issue
10eissn
1525-7797issn
1526-4602journal_volume
20pub_type
杂志文章abstract::The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26-44% yield demonstrating the u...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0155120
更新日期:2001-07-01 00:00:00
abstract::Ruthenium(II) tris(bipyridine)-centered poly(ethylenimine) (Ru PEI) was synthesized via acid hydrolysis of Ru tris(bipyridine)-centered poly(2-ethyl-2-oxazoline) (Ru PEOX), and the luminescence, DNA entrapment, and transfection efficiencies were evaluated. Emission maxima for Ru PEI samples are red-shifted compared to...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm700481h
更新日期:2007-09-01 00:00:00
abstract::In biomedicine, PEGylation is one of the most successful strategies to modify the physicochemical and biological properties of peptides, proteins, and other biomacromolecules. Because of the polydisperse nature of regular PEGs and limited PEGylation strategies, it is challenging to quantitatively fine-tune and accurat...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01425
更新日期:2020-02-10 00:00:00
abstract::The complement system is a powerful mechanism of the innate immune defense system. Dysregulation may contribute to several diseases. Heparin is a known regulator of the complement system, but its application is limited due to its anticoagulative activity. A promising alternative is the synthetic analogue dendritic pol...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00889
更新日期:2019-10-14 00:00:00
abstract::The aim of this investigation was to understand and engineer the interactions between endothelial cells and the electrospun (ES) polyvinylidene fluoride-co-hexafluoropropylene (PVDF-HFP) nanofiber surfaces and evaluate their potential for endothelialization. Elastomeric PVDF-HFP samples were electrospun to evaluate th...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm401825c
更新日期:2014-04-14 00:00:00
abstract::Poloxamer thermoresponsive gels are widely explored in controlled drug delivery. Nevertheless, these gels possess inadequate mechanical properties, poor bioadhesiveness, and high permeability to water. To overcome these issues, we blended mucoadhesive hyaluronic acid (HA) with poloxamer analogs. This study aimed to in...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm1008958
更新日期:2011-01-10 00:00:00
abstract::Bone-marrow-derived mesenchymal stem cells (BMSCs) possess vast potential for tissue engineering and regenerative medicine. In this study, an injectable hydrogel comprising poly(l-glutamic acid)-graft-tyramine (PLG-g-TA) with tunable microenvironment was developed via enzyme-catalyzed cross-linking and used as an arti...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.6b00884
更新日期:2016-12-12 00:00:00
abstract::Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization o...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm901235g
更新日期:2010-02-08 00:00:00
abstract::Reversible stereoselective complexes were spontaneously obtained from mixing acetonitrile solutions of enatiomeric d-poly(lactic acid) (d-PLA), l-poly(lactic acid) (l-PLA), and leuprolide, a l-configured nonapeptide LHRH analogue. The complex spontaneously aggregated and precipitated in high yields (>90%) from acetoni...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0300249
更新日期:2003-09-01 00:00:00
abstract::The ability of small interfering RNA (siRNA) to efficiently silence the expression of specific genes provides the basis for exciting new therapies based on RNA interference (RNAi). The efficient intracellular delivery of siRNA from cell uptake through the endosomal trafficking pathways into the cytoplasm remains a sig...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm100652w
更新日期:2010-11-08 00:00:00
abstract::Ionic liquids (ILs) are composed only of ions. Of special interest to this review are those where at least one ion (the cation) is organic and whose melting points are below or not far above room temperature. ILs are designated as "green" solvents because they have extremely low vapor pressure, are non-inflammable, an...
journal_title:Biomacromolecules
pub_type: 杂志文章,评审
doi:10.1021/bm070062i
更新日期:2007-09-01 00:00:00
abstract::We have designed, synthesized, and characterized peptides containing four repeats of the sequences VAALEKE (peptide E) or VAALKEK (peptide K). While the peptides alone adopt in aqueous solutions a random coil conformation, their equimolar mixture forms heterodimeric coiled coils as confirmed by CD spectroscopy. 5-Azid...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200897b
更新日期:2011-10-10 00:00:00
abstract::The layer-by-layer technique has been used as a powerful method to produce multilayer thin films with tunable properties. When natural polymers are employed, complicated phenomena such as self-aggregation and fibrilogenesis can occur, making it more difficult to obtain and characterize high-quality films. The weak aci...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm5012135
更新日期:2015-01-12 00:00:00
abstract::We report a biodegradable fluorescent theranostic nanoprobe design strategy for simultaneous visualization and quantitative determination of antibacterial activity for the treatment of bacterial infections. Cationic-charged polycaprolactone (PCL) was tailor-made through ring-opening polymerization methodology, and it ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c00653
更新日期:2020-07-13 00:00:00
abstract::This work demonstrates that hydrogen peroxide (H2O2) is generated in weak polyacrylamide hydrogels due to mechanochemical reactions to osmotic swelling. Hydrogels are important tools and materials for many biomedical applications, particularly for growth of stem cells. However, swollen gels are under constant tension,...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.8b00743
更新日期:2018-08-13 00:00:00
abstract::In this study, generation 5 (G5) polyamidoamine (PAMAM) dendrimers with two different surface groups, G4.5-COOH and G5-OH, were investigated for their protective effects on pancreas injury in a caerulein-induced acute pancreatitis (AP) mouse model. Both dendrimers significantly decreased pathological changes in the pa...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm501390d
更新日期:2015-01-12 00:00:00
abstract::Polypeptide-based formulations that undergo liquid to hydrogel transitions upon change in temperature have become desirable targets since they can be mixed with cells or injected into tissues as liquids, and subsequently transform into rigid scaffolds or depots. Such materials have been challenging to prepare using sy...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b00124
更新日期:2015-04-13 00:00:00
abstract::The currently used hemostatic agents are highly effective in stopping hemorrhages but have a limited role in the modulation of the wound-healing environment. Herein, we propose an intrinsically bioactive hemostatic cryogel based on platelet lysate (PL) and aldehyde-functionalized cellulose nanocrystals (a-CNCs). PL ha...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.0c00787
更新日期:2020-09-14 00:00:00
abstract::A lamellar compound resulted from reaction of acrylic acid inside crystalline beta-chitin and the structure was investigated. Beta-chitin acts like a layered crystal, having stacked molecular sheets composed of parallel chains bound in one direction by intermolecular amide hydrogen bonding. Small guest molecules can b...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm060643s
更新日期:2007-04-01 00:00:00
abstract::Subunit vaccines can have excellent safety profiles, but their ability to give rise to robust immune responses is often compromised. For glycan-based vaccines, insufficient understanding of B and T cell epitope combinations that yield optimal immune activation hinders optimization. To determine which antigen features ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b01049
更新日期:2019-12-09 00:00:00
abstract::A novel family of amphiphilic temperature- and pH-sensitive poly(organophosphazenes) with varying ratios of ethylene oxide, alkyl chains and free acid units was synthesized by living cationic polymerization. Depending on their composition, these poly(organophosphazenes) exhibited lower critical solution temperatures r...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0400527
更新日期:2004-11-01 00:00:00
abstract::Thermoresponsive anionic copolymer brushes, poly(N-isopropylacrylamide-co-acrylic acid-co-tert-butylacrylamide) [P(IPAAm-co-AAc-co-tBAAm)], were grafted onto a monolithic silica rod column through surface-initiated atom-transfer radical polymerization (ATRP) to prepare an effective thermoresponsive anionic chromatogra...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm401779r
更新日期:2014-04-14 00:00:00
abstract::Spherulites of poly(L-lactic acid) (PLLA) and of its blends with atactic poly(3-hydroxybutyrate) (a-PHB, from 10 to 75 wt %) were investigated by microfocus X-ray diffraction using synchrotron radiation. Radial scans in 5 microm steps with 3 microm beam diameter were performed. In PLLA, tens of identical diffraction i...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0343951
更新日期:2004-03-01 00:00:00
abstract::Preparations of the highly ordered monoantennary, homofunctional diantennary, and heterofunctional diantennary neoglycopolymers of α-d-mannose and β-d-glucose residues were achieved via ring-opening metathesis polymerization. Isothermal titration calorimetry measurements of these synthetic neoglycopolymers with Concan...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.5b01380
更新日期:2015-12-14 00:00:00
abstract::The use of polyelectrolyte surface-modified Cowpea mosaic virus (CPMV) for the templated synthesis of narrowly dispersed gold nanoparticles is described. The cationic polyelectrolyte, poly(allylamine) hydrochloride (PAH), is electrostatically bound to the external surface of the virus capsid; the polyelectrolyte promo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm200499v
更新日期:2011-07-11 00:00:00
abstract::The objective of this study was to explore the use of reverse thermo-responsive (RTG) polymers for generating implants at their site of performance, following minimally invasive surgical procedures. Aiming at combining syringability and enhanced mechanical properties, a new family of injectable RTG-displaying polymers...
journal_title:Biomacromolecules
pub_type:
doi:10.1021/bm0495250
更新日期:2005-05-01 00:00:00
abstract::Bioresponsive poly(amidoamine)s (PAA)s are currently under development as endosomolytic polymers for intracellular delivery of proteins and genes. Here for the first time, small-angle neutron scattering (SANS) is used to systematically investigate the pH-dependent conformational change of an endosomolytic polymer, the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049936g
更新日期:2004-07-01 00:00:00
abstract::The mucilaginous viscin tissue within mistletoe berries possesses an extraordinary ability to be rapidly processed under ambient conditions into stiff cellulosic fibers (>14 GPa) through simple mechanical drawing. This rapid and extreme transformation process is hydration-dependent and involves an astonishing >200-fol...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/acs.biomac.9b00648
更新日期:2019-08-12 00:00:00
abstract::The oxidation reaction of regenerated cellulose fibers mediated by N-hydroxyphthalimide (NHPI) and various cocatalysts at room temperature for different time intervals and various amounts of low concentration sodium hypochlorite solution has been investigated to produce oxidized cellulose (OC), a biocompatible and bio...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9004854
更新日期:2009-08-10 00:00:00
abstract::This paper describes the synthesis and evaluation of a series of multifunctional poly-l-glutamic acid derivatives that can be used as vectors for gene delivery. They readily form polyelectrolyte complexes with DNA, resulting in a reduced surface charge and size of the DNA. The formation of a polymer-DNA complex and th...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034014j
更新日期:2003-09-01 00:00:00