Abstract:
:Oligopeptide hydrogels are emerging as useful matrices for cell culture with commercial products on the market, but L-oligopeptides are labile to proteases. An obvious solution is to create D-oligopeptide hydrogels, which lack enzymatic recognition. However, D-oligopeptide matrices do not support cell growth as well as L-oligopeptide matrices. In addition to chiral interactions, many cellular activities are strongly governed by charge-charge interactions. In this work, the effects of chirality and charge on human mesenchymal stem cell (hMSC) behavior were studied using hydrogels assembled from oppositely charged oligopeptides. It was found that negative charges significantly improved hMSC viability and proliferation in D-oligopeptide gels but had little effect on their interactions with L-oligopeptide gels. This result points to the possibility of using charge and other factors to engineer biomaterials whose chirality is distinct from that of natural biomaterials, but whose performance is close to that of natural biomaterials.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Hyland LL,Twomey JD,Vogel S,Hsieh AH,Yu YBdoi
10.1021/bm301598gsubject
Has Abstractpub_date
2013-02-11 00:00:00pages
406-12issue
2eissn
1525-7797issn
1526-4602journal_volume
14pub_type
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