Effects of polymer molecular weight on the size, activity, and stability of PEG-functionalized trypsin.

abstract：:We report the rational design of a chitosan-based drug delivery system. The chitosan derivative N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride (HTCC) was ionically cross-linked by sodium tripolyphosphate (TPP) to form sub-200-nm microgels that are responsive to pH changes. When these microgels were loaded ...

journal_title：Biomacromolecules

authors： Zhang H,Mardyani S,Chan WC,Kumacheva E

更新日期：2006-05-01 00:00:00

abstract：:We have designed, synthesized, and characterized peptides containing four repeats of the sequences VAALEKE (peptide E) or VAALKEK (peptide K). While the peptides alone adopt in aqueous solutions a random coil conformation, their equimolar mixture forms heterodimeric coiled coils as confirmed by CD spectroscopy. 5-Azid...

journal_title：Biomacromolecules

authors： Pechar M,Pola R,Laga R,Ulbrich K,Bednárová L,Maloň P,Sieglová I,Král V,Fábry M,Vaněk O

更新日期：2011-10-10 00:00:00

abstract：:Smart nanocarriers for the transport of drugs to tumor cells are nowadays of great interest for treating cancer. The use of enzymatic stimuli to cleave peptide-based drug nanocapsules for the selective release of nanocapsule cargo in close proximity to tumor cells opens new possibilities in cancer research. In the pre...

journal_title：Biomacromolecules

authors： Knaff PM,Kersten C,Willbold R,Champanhac C,Crespy D,Wittig R,Landfester K,Mailänder V

更新日期：2020-04-13 00:00:00

abstract：:It is well-known that 3D in vitro cell cultures provide a much better model than 2D cell cultures for understanding the in vivo microenvironment of cells. However, significant technical challenges in handling and analyzing 3D cell cultures remain, which currently limits their widespread application. Herein, we demonst...

journal_title：Biomacromolecules

authors： Simon KA,Warren NJ,Mosadegh B,Mohammady MR,Whitesides GM,Armes SP

更新日期：2015-12-14 00:00:00

abstract：:Low molecular weight random copolymers bearing protonated primary amine groups and hydrophobic alkyl groups in the side chains were synthesized and their activities against E. coli , S. aureus , human red blood cells, and human epithelial carcinoma cells (HEp-2) were quantified. The mole fraction of alkyl side chains ...

journal_title：Biomacromolecules

authors： Palermo EF,Sovadinova I,Kuroda K

更新日期：2009-11-09 00:00:00

abstract：:Oriented immobilization of proteins is an important step in creating protein-based functional materials. In this study, a method was developed to orient proteins on hydroxyapatite (HA) surfaces, a widely used bone implant material, to improve protein bioactivity by employing enhanced green fluorescent protein (EGFP) a...

journal_title：Biomacromolecules

authors： Yewle JN,Wei Y,Puleo DA,Daunert S,Bachas LG

更新日期：2012-06-11 00:00:00

abstract：:Coiled coils are a common structural motif in many natural proteins that can also be utilized in the design and preparation of drug delivery systems for the noncovalent connection of two macromolecules. In this work, two different pairs of peptides forming coiled coil hetero-oligomers were designed, synthesized, and c...

journal_title：Biomacromolecules

authors： Pechar M,Pola R,Laga R,Braunová A,Filippov SK,Bogomolova A,Bednárová L,Vaněk O,Ulbrich K

更新日期：2014-07-14 00:00:00

abstract：:Numerous catechol-containing polymers, including biodegradable polymers, are currently heavily discussed for modern biomaterials. However, there is no report combining poly(phosphoester)s (PPEs) with catechols. Adhesive PPEs have been prepared via acyclic diene metathesis polymerization. A novel acetal-protected catec...

journal_title：Biomacromolecules

authors： Becker G,Ackermann LM,Schechtel E,Klapper M,Tremel W,Wurm FR

更新日期：2017-03-13 00:00:00

abstract：:Native hemicellulose lacks many of the properties that make fossil fuel-based polymers excellent for use in today's industrial products and processes. The mechanical and thermal properties of the hemicellulose can, however, be modified, and its processability increased. We functionalized galactoglucomannan to lower it...

journal_title：Biomacromolecules

authors： Härdelin L,Bernin D,Börjesson M,Ström A,Larsson A

更新日期：2020-05-11 00:00:00

abstract：:The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26-44% yield demonstrating the u...

journal_title：Biomacromolecules

authors： Eniade A,Ben RN

更新日期：2001-07-01 00:00:00

abstract：:Tannic acid (TA) can form stable complexes with proteins, attracting significant attention as protein delivery systems. However, its systemic application has been limited due to nonspecific interaction. Here, we report a simple technique to prepare systemically applicable protein delivery systems using sequential self...

journal_title：Biomacromolecules

authors： Honda Y,Nomoto T,Matsui M,Takemoto H,Kaihara Y,Miura Y,Nishiyama N

更新日期：2020-09-14 00:00:00

abstract：:We report the preparation, characterization, and mechanical properties of DNA/poly(allylamine hydrochloride) (PAH) multilayer microcapsules. The DNA/PAH multilayers were first constructed on a planar support to examine their layer-by-layer buildup. Surface plasmon resonance spectroscopy (SPR) showed a nonlinear growth...

journal_title：Biomacromolecules

authors： Vinogradova OI,Lebedeva OV,Vasilev K,Gong H,Garcia-Turiel J,Kim BS

更新日期：2005-05-01 00:00:00

abstract：:Nowadays, active targeting of nanotherapeutics is a challenging issue. Here, we propose a rational design of a ternary nanoassembly (SAP) composed of nonionic amphiphilic β-cyclodextrins (amphiphilic CD) incorporating pheophorbide (Pheo) as a phototherapeutic and an adamantanyl-folic acid conjugate (Ada-FA) to target ...

journal_title：Biomacromolecules

authors： Zagami R,Rapozzi V,Piperno A,Scala A,Triolo C,Trapani M,Xodo LE,Monsù Scolaro L,Mazzaglia A

更新日期：2019-07-08 00:00:00

abstract：:The interaction of neuropeptides, vasoactive intestinal peptide (VIP), or growth hormone-releasing hormone (GHRH), with a cationic carbosilane dendrimer forms dendriplexes with antitumoral behavior in advanced prostate cancer cells PC3. At the concentrations used for dendriplexes formation, the free peptides were prot...

journal_title：Biomacromolecules

authors： Sánchez-Milla M,Muñoz-Moreno L,Sánchez-Nieves J,Malý M,Gómez R,Carmena MJ,de la Mata FJ

更新日期：2019-03-11 00:00:00

abstract：:Recombinant spider silk proteins mimicking the properties of dragline silk proteins represent a class of materials that hold great potential for future high-performance applications. Here we explore the self-assembly behavior of a recombinantly produced spider silk protein based on the dragline silk of the Araneus di...

journal_title：Biomacromolecules

authors： Young SL,Gupta M,Hanske C,Fery A,Scheibel T,Tsukruk VV

更新日期：2012-10-08 00:00:00

abstract：:A simple, sequential approach for creation of hydrolytically degradable poly(ethylene glycol) (PEG) hydrogels has been developed and characterized. The chemistry involves an initial step growth polymerization reaction between PEG-diacrylate and dithiothreitol (DTT) to form acrylate-terminated (-PEG-DTT-)n PEG chains, ...

journal_title：Biomacromolecules

authors： Hudalla GA,Eng TS,Murphy WL

更新日期：2008-03-01 00:00:00

abstract：:In this work, 6-phosphogluconic trisodium salt (6-PG-Na+) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan cross-linked with 6-PG-Na+. This formulation is obtained by ionic interaction of cationic groups of polymer...

journal_title：Biomacromolecules

authors： Martínez-Martínez M,Rodríguez-Berna G,Gonzalez-Alvarez I,Hernández MJ,Corma A,Bermejo M,Merino V,Gonzalez-Alvarez M

更新日期：2018-04-09 00:00:00

abstract：:Solid-state NMR is especially useful when the structures of peptides and proteins should be analyzed by taking into account the structural distribution, that is, the distribution of the torsion angle of the individual residue. In this study, two-dimensional spin-diffusion solid-state NMR spectra of 13C-double-labeled ...

journal_title：Biomacromolecules

authors： Ohgo K,Kawase T,Ashida J,Asakura T

更新日期：2006-04-01 00:00:00

abstract：:The mechanical and melt flow properties of two thermoplastic potato starch materials with different amylose contents were evaluated. The materials were prepared by mixing starch, glycerol, and water, mainly in the weight proportions of 10:3:4.5. Compression molding was used to produce sheets/films with a thickness in ...

journal_title：Biomacromolecules

authors： Thunwall M,Boldizar A,Rigdahl M

更新日期：2006-03-01 00:00:00

abstract：:A multiple targeted drug carrying bilayer membrane for preventing an abdominal adhesion is prepared by electrospinning. Two bioactive drugs were successfully incorporated into this bilayer membrane and can be independently released from nanofibrous scaffolds without losing structural integrity and functionality of the...

journal_title：Biomacromolecules

authors： Wang H,Li M,Hu J,Wang C,Xu S,Han CC

更新日期：2013-04-08 00:00:00

abstract：:A way to convert the volume change of a biochemo-mechanical gel into the change in liquid column length was developed. Our trial sensor device consisted of a small compartment for incorporating the gel, a flow channel with a filled dye solution, and a poly(dimethylsiloxane) (PDMS) diaphragm by which the gel and the dy...

journal_title：Biomacromolecules

authors： Suzuki H,Kumagai A,Ogawa K,Kokufuta E

更新日期：2004-03-01 00:00:00

abstract：:Saccharide-functionalized shell cross-linked (SCK) polymer micelles designed as polyvalent nanoscaffolds for selective interactions with receptors on Gram negative bacteria were constructed from mixed micelles composed of poly(acrylic acid-b-methyl acrylate) and mannosylated poly(acrylic acid-b-methyl acrylate). The m...

journal_title：Biomacromolecules

authors： Joralemon MJ,Murthy KS,Remsen EE,Becker ML,Wooley KL

更新日期：2004-05-01 00:00:00

abstract：:Stability of four dissimilar basic proteins (chymotrypsinogen A, ribonuclease A, cytochrome c, lysozyme) in the complex with four polyanions (heparin, poly(vinylsulfate), poly(4-styrene-sulfonate), Nafion) has been studied by differential scanning calorimetry. The polyanions were chosen because of their different char...

journal_title：Biomacromolecules

authors： Sedlák E,Fedunová D,Veselá V,Sedláková D,Antalík M

更新日期：2009-09-14 00:00:00

abstract：:Because of their association with debilitating diseases and their potential applications in developing novel bionanomaterials, highly ordered amyloid fibrils have recently received considerable attention. While many studies have thus far focused on amyloid fibrils made with short peptides containing just one steric zi...

journal_title：Biomacromolecules

authors： Dai B,Sargent CJ,Gui X,Liu C,Zhang F

更新日期：2019-05-13 00:00:00

abstract：:The oxidation-responsive behaviors of OEGylated poly-L-cysteine homopolypeptides, that is, poly(L-EG(x)MA-C)n, were investigated. These poly-L-cysteine derivatives adopted mixed conformation in water, in which the β-sheet accounted for a significant proportion. Upon oxidation, the thioethers in polypeptide side chains...

journal_title：Biomacromolecules

authors： Fu X,Ma Y,Shen Y,Fu W,Li Z

更新日期：2014-03-10 00:00:00

abstract：:The massive use of antibiotics in healthcare and agriculture has led to their artificial accumulation in natural habitats, which risks the structure and function of the microbial communities in ecosystems, threatens food and water security, and accelerates the development of resistome. Ideally, antibiotics should rema...

journal_title：Biomacromolecules

authors： Zheng W,Anzaldua M,Arora A,Jiang Y,McIntyre K,Doerfert M,Winter T,Mishra A,Ma H,Liang H

更新日期：2020-06-08 00:00:00

abstract：:We examine the protein distribution within an electrospun polymer nanofiber using polyvinyl alcohol and bovine serum albumin as a model system. We hypothesize that the location of the protein within the nanofiber can be controlled by carefully selecting the pH and the applied polarity of the electric field as the pH a...

journal_title：Biomacromolecules

authors： Tang C,Ozcam AE,Stout B,Khan SA

更新日期：2012-05-14 00:00:00

abstract：:Self-cross-linking polyelectrolytes are used to strengthen the surface of calcium alginate beads for cell encapsulation. Poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride), containing 30 mol % 2-aminoethyl methacrylate, and poly(sodium methacrylate), containing 30 mol % 2-(methacryloyloxy)ethyl acetoacetate, w...

journal_title：Biomacromolecules

authors： Mazumder MA,Shen F,Burke NA,Potter MA,Stöver HD

更新日期：2008-09-01 00:00:00

abstract：:Hollow poly(6-O-acryloyl-alpha-D-galactopyranose) (PAGP) nanospheres were prepared in a facile manner using the RAFT (reversible addition fragmentation chain transfer) process. Initially, an amphiphilic block copolymer, poly(lactide)-block-poly(6-O-acryloyl-alpha-D-galactopyranose) (PLA-b-PAGP), was synthesized using ...

journal_title：Biomacromolecules

authors： Ting SR,Gregory AM,Stenzel MH

更新日期：2009-02-09 00:00:00

abstract：:The gold standard for implant metals is titanium, and coatings such as collagen-I, RGD-peptide, chondroitin sulfate, and calcium phosphate have been used to modify its biocompatibility. We investigated how titanium coated with pectins, adaptable bioactive plant polysaccharides with anti-inflammatory effects, supports ...

journal_title：Biomacromolecules

authors： Kokkonen H,Cassinelli C,Verhoef R,Morra M,Schols HA,Tuukkanen J

更新日期：2008-09-01 00:00:00