An approach to modulate degradation and mesenchymal stem cell behavior in poly(ethylene glycol) networks.

abstract：:Thermoresponsive polymers with lower critical solution temperatures (LCSTs) are of significant interest for a wide range of applications from sensors to drug delivery vehicles. However, the most widely investigated LCST polymers have nondegradable backbones, limiting their applications in vivo or in the environment. D...

journal_title：Biomacromolecules

authors： Rabiee Kenaree A,Sirianni QEA,Classen K,Gillies ER

更新日期：2020-09-14 00:00:00

abstract：:meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate (TMP) is a photosensitizer that can be used in photodynamic therapy (PDT) to induce cell death through generation of reactive oxygen species in targeted tumor cells. However, TMP is highly hydrophilic, and therefore, its ability to accumulate intracellularly is li...

journal_title：Biomacromolecules

authors： Abdelghany SM,Schmid D,Deacon J,Jaworski J,Fay F,McLaughlin KM,Gormley JA,Burrows JF,Longley DB,Donnelly RF,Scott CJ

更新日期：2013-02-11 00:00:00

abstract：:Targeted delivery of antigens to immune cells using micro/nanocarriers may serve as a therapeutic application for vaccination. However, synthetic carriers have potential drawbacks including cytotoxicity, low encapsulation efficiency of antigen, and lack of a morphological design, which limit the translation of the del...

journal_title：Biomacromolecules

authors： Nishiguchi A,Shima F,Singh S,Akashi M,Moeller M

更新日期：2020-06-08 00:00:00

abstract：:The production of large quantities of artificial spider silk fibers that match the mechanical properties of the native material has turned out to be challenging. Recent advancements in the field make biomimetic spinning approaches an attractive way forward since they allow the spider silk proteins to assemble into the...

journal_title：Biomacromolecules

authors： Gonska N,López PA,Lozano-Picazo P,Thorpe M,Guinea GV,Johansson J,Barth A,Pérez-Rigueiro J,Rising A

更新日期：2020-06-08 00:00:00

abstract：:Reversible addition-fragmentation chain transfer (RAFT) radical polymerization, mediated by 4-cyanopentanoic acid dithiobenzoate and 4,4'-azobis(4-cyanovaleric acid) (V-501) in water at 70 degrees C, of biocompatible 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) yields a macro-chain transfer agent (CTA) that was em...

journal_title：Biomacromolecules

authors： Yu B,Lowe AB,Ishihara K

更新日期：2009-04-13 00:00:00

abstract：:Thymic epithelial cells (TECs) are the main regulators of T lymphocyte development and selection, requiring a three-dimensional (3D) environment to properly perform these biological functions. The aim of this work was to develop a 3D culture substrate that allows the survival and proliferation of TECs. Thus, electrosp...

journal_title：Biomacromolecules

authors： Silva CS,Pinto RD,Amorim S,Pires RA,Correia-Neves M,Reis RL,Alves NL,Martins A,Neves NM

更新日期：2020-12-14 00:00:00

abstract：:Strategies to prevent the uptake of modified low density lipoproteins (LDLs) by immune cells, a major trigger of inflammation and atherogenesis, are challenged by complex interfacial factors governing LDL receptor-mediated uptake. We examine a new approach based on a family of "nanoblockers", which are designed to exa...

journal_title：Biomacromolecules

authors： Chnari E,Nikitczuk JS,Wang J,Uhrich KE,Moghe PV

更新日期：2006-06-01 00:00:00

abstract：:Degradable polymers with specifically designed functionality have wide applications in biomedical fields. We reported herein the synthesis and characterization of a water-soluble and fast-degradable polycarbonate, functionalized with tertiary amine groups in the backbone. A novel cyclic carbonate monomer, namely, 6,14...

journal_title：Biomacromolecules

authors： Wang HF,Su W,Zhang C,Luo XH,Feng J

更新日期：2010-10-11 00:00:00

abstract：:Owing to their diverse functions and tunable physicochemical properties, peptides are promising alternatives to the conventional gene delivery tools that are available for plant systems. However, peptide-mediated gene delivery is limited by low transfection efficiency in plants because of the insufficient cytosolic tr...

journal_title：Biomacromolecules

authors： Miyamoto T,Tsuchiya K,Numata K

更新日期：2020-07-13 00:00:00

abstract：:A hyperbranched conjugated polyelectrolyte (HCPE) with a core-shell structure is designed and synthesized via alkyne polycyclotrimerization and click chemistry. The HCPE has an emission maximum at 565 nm with a quantum yield of 12% and a large Stokes shift of 143 nm in water. By virtue of its poly(ethylene glycol) she...

journal_title：Biomacromolecules

authors： Pu KY,Shi J,Cai L,Li K,Liu B

更新日期：2011-08-08 00:00:00

abstract：:The polymerization of N-isopropylacrylamide (NIPAAm) with ionizable monomers results in pH-responsive lower critical solution temperature (LCST) polymer which works in an ionization-dependent manner. However, gradual ionization of the comonomer occurs at a broad pH range due to the electrostatic field generated by the...

journal_title：Biomacromolecules

authors： Muttaqien SE,Nomoto T,Takemoto H,Matsui M,Tomoda K,Nishiyama N

更新日期：2019-04-08 00:00:00

abstract：:The formation of calcite prism architecture in the prismatic layer of the mollusk shell involves the participation of a number of different proteins. One protein family, Asprich, has been identified as a participant in amorphous calcium carbonate stabilization and calcite architecture in the prismatic layer of the mol...

journal_title：Biomacromolecules

authors： Ndao M,Keene E,Amos FF,Rewari G,Ponce CB,Estroff L,Evans JS

更新日期：2010-10-11 00:00:00

abstract：:Structures of three pectic arabinogalactans, one from Vernonia kotschyana (Vk2a) and two from Cochlospermum tinctorium (Ct50A1 and Ct50A2), and their complement fixation and induction of B cell proliferation in vitro were compared. The polysaccharide Vk2a expressed potent biological activity in both assays compared wi...

journal_title：Biomacromolecules

authors： Nergard CS,Kiyohara H,Reynolds JC,Thomas-Oates JE,Matsumoto T,Yamada H,Patel T,Petersen D,Michaelsen TE,Diallo D,Paulsen BS

更新日期：2006-01-01 00:00:00

abstract：:The importance of the stabilization of the quaternary structure of multimeric enzymes has been illustrated using a model reaction with great industrial relevance: the enzymatic synthesis of ampicillin from 6-amino penicillanic acid (6APA) and phenylglycine methyl ester (PGM) catalyzed by the tetrameric enzyme alpha-am...

journal_title：Biomacromolecules

authors： Fernández-Lafuente R,Hernández-Jústiz O,Mateo C,Terreni M,Fernández-Lorente G,Moreno MA,Alonso J,García-López JL,Guisan JM

更新日期：2001-04-01 00:00:00

abstract：:The drying dynamics of protein coatings is of importance for many applications. The main focus of research so far was to investigate macroscopic properties of protein coatings, leaving drying dynamics virtually unexplored. A unique combination of techniques is used to monitor drying of a coating containing the protein...

journal_title：Biomacromolecules

authors： Bouman J,de Vries R,Venema P,Belton P,Baukh V,Huinink HP,van der Linden E

更新日期：2015-01-12 00:00:00

abstract：:In the present contribution, two-dimensional ATR-FTIR spectroscopy was used to study the diffusion of water in poly(epsilon-caprolactone) (PCL). In the spectral region of the nu(OH) stretching vibration of water, four absorption bands (3635, 3560, 3411, and 3220 cm(-1)) can be identified. The higher wavenumber band pa...

journal_title：Biomacromolecules

authors： Peng Y,Wu P,Siesler HW

更新日期：2003-07-01 00:00:00

abstract：:Tissue regeneration involves versatile types of cells. The accumulation and disorganized behaviors of undesired cells impair the natural healing process, leading to uncontrolled immune response, restenosis, and/or fibrosis. Cell-selective surfaces and interfaces can have specific and positive effects on desired types ...

journal_title：Biomacromolecules

authors： Zhang H,Zheng X,Ahmed W,Yao Y,Bai J,Chen Y,Gao C

更新日期：2018-06-11 00:00:00

abstract：:Poly(epsilon-caprolactone)/polylactide blend (PCL/PLA) is an interesting biomaterial because PCL and PLA present good complementarity in their physical properties and biodegradability. However, the thermodynamic incompatibility between two component polymers restricts further applications of their blend. In this work,...

journal_title：Biomacromolecules

authors： Wu D,Zhang Y,Zhang M,Yu W

更新日期：2009-02-09 00:00:00

abstract：:A challenge in the development of multifunctional drug delivery systems is to establish a reasonable and effective synthetic route for multifunctional polymer preparation. Herein, we propose a unique protocol to prepare multifunctional micelles by a cross-assembly process using three different functional polyurethanes...

journal_title：Biomacromolecules

authors： Pan Z,Ren Y,Song N,Song Y,Li J,He X,Luo F,Tan H,Fu Q

更新日期：2016-06-13 00:00:00

abstract：:The antiproliferative activity of alkylated heparin, in which the terminal end of heparin is derivatized with an alkyl group (butyl, octyl, lauryl, stearyl), was examined using vascular smooth muscle cells. The proliferation of cells, which were growth-arrested prior to addition of heparin, was inhibited in proportion...

journal_title：Biomacromolecules

authors： Gohda M,Magoshi T,Kato S,Noguchi T,Yasuda S,Nonogi H,Matsuda T

更新日期：2001-01-01 00:00:00

abstract：:Light-harvesting antenna core (LH1-RC) complexes isolated from Rhodoseudomonas palustris were self-assembled on a gold electrode modified with self-assembled monolayers (SAMs) of the alkanethiols NH2(CH2)nSH, n = 2, 6, 8, 11; HOOC(CH2)7SH; and CH3(CH2)7SH, respectively. Adsorption of the LH1-RC complexes on the SAMs d...

journal_title：Biomacromolecules

authors： Kondo M,Nakamura Y,Fujii K,Nagata M,Suemori Y,Dewa T,Iida K,Gardiner AT,Cogdell RJ,Nango M

更新日期：2007-08-01 00:00:00

abstract：:Saccharide-functionalized shell cross-linked (SCK) polymer micelles designed as polyvalent nanoscaffolds for selective interactions with receptors on Gram negative bacteria were constructed from mixed micelles composed of poly(acrylic acid-b-methyl acrylate) and mannosylated poly(acrylic acid-b-methyl acrylate). The m...

journal_title：Biomacromolecules

authors： Joralemon MJ,Murthy KS,Remsen EE,Becker ML,Wooley KL

更新日期：2004-05-01 00:00:00

abstract：:This study investigated the impact of the protein adsorption mechanism(s) on the efficiency of thermally controlled cell adhesion and release from poly(N-isopropyl acrylamide) brushes. Large format polymer gradients were used to screen for grafting densities and substrate chemistries that alter both cell adhesion at 3...

journal_title：Biomacromolecules

authors： Choi S,Choi BC,Xue C,Leckband D

更新日期：2013-01-14 00:00:00

abstract：:Coniferyl alcohol was polymerized in pectin solution in order to mimic the lignification that is the final step of biosynthesis of plant cell wall. Dehydrogenated polymers (DHP = coniferyl alcohol polymers = synthetic lignin) interact with pectin to form hydrophobic clusters as monitored by pyrene fluorescence spectro...

journal_title：Biomacromolecules

authors： Lairez D,Cathala B,Monties B,Bedos-Belval F,Duran H,Gorrichon L

更新日期：2005-03-01 00:00:00

abstract：:Polycaprolactone (PCL) was reported a long time ago; however, its biomedical applications has not been extensively investigated in comparison with poly(lactide- co-glycolide) (PLGA) due to its too slow degradation profile. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer (PCL-OX) as a...

journal_title：Biomacromolecules

authors： Chang SH,Lee HJ,Park S,Kim Y,Jeong B

更新日期：2018-06-11 00:00:00

abstract：:Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow tumorigenic behaviors to be observed and manipulated, we cultured related MCF10 breast cell lines on fibers composed of the Drosophila protein Ultrabithorax (Ubx). These...

journal_title：Biomacromolecules

authors： Hsiao HC,Santos A,Howell DW,Patterson JL,Fuchs-Young RS,Bondos SE

更新日期：2016-11-14 00:00:00

abstract：:The controlled delivery of growth factors is a very challenging task because many different issues have to be addressed to develop the best suited system. A wide range of approaches have been employed for the controlled delivery of growth factors by hydrogels. Direct loading, electrostatic interaction, covalent bindin...

journal_title：Biomacromolecules

authors： Silva AK,Richard C,Bessodes M,Scherman D,Merten OW

更新日期：2009-01-12 00:00:00

abstract：:Photosensitive supramolecular micelles, a combination of intermolecular hydrogen bonds between complementary adenine (A) and uracil (U) groups and a blend of two types of supramolecular polymers, can stably self-assemble into structurally stable, spherical micelles in aqueous solution before and after photoirradiation...

journal_title：Biomacromolecules

authors： Abebe Alemayehu Y,Tewabe Gebeyehu B,Cheng CC

更新日期：2019-12-09 00:00:00

abstract：:We have constructed a tandem gene expression cassette containing three Ralstonia eutropha poly[(R)-3-hydroxybutyrate] (PHB) synthesis genes under the control of the Pichia pastoris glyceraldehyde-3-phosphate promoter and the green fluorescent protein (Gfp) under the control of the P. pastoris alcohol oxidase promoter....

journal_title：Biomacromolecules

authors： Vijayasankaran N,Carlson R,Srienc F

更新日期：2005-03-01 00:00:00

abstract：:Solid films of deoxyribonucleic acid (DNA) containing a hydrated ionic liquid, choline dihydrogen phosphate (CDP), were prepared by a solvent-casting method. Thermal properties, aggregation structure, thermal molecular motion, and tensile properties of CDP-containing DNA films were examined by thermogravimetry (TG), w...

journal_title：Biomacromolecules

authors： Morimitsu Y,Matsuno H,Ohta N,Sekiguchi H,Takahara A,Tanaka K

更新日期：2020-02-10 00:00:00