Multiple targeted drugs carrying biodegradable membrane barrier: anti-adhesion, hemostasis, and anti-infection.

abstract：:The intermolecular distributions of amide groups within two commercial LMA pectins was studied after removal of the methyl esters followed by fractionation of the different populations by anion exchange chromatography. The populations obtained had almost equal degrees of amidation while the values of the degree of blo...

journal_title：Biomacromolecules

authors： Guillotin SE,Mey N,Ananta E,Boulenguer P,Schols HA,Voragen AG

更新日期：2006-06-01 00:00:00

abstract：:Water soluble polymer anticancer conjugates can improve the pharmacokinetics of covalently bound drugs by limiting cellular uptake to the endocytic route, thus prolonging plasma circulation time and consequently facilitating tumor targeting by the enhanced permeability and retention (EPR) effect. Many of the first gen...

journal_title：Biomacromolecules

authors： Andersson L,Davies J,Duncan R,Ferruti P,Ford J,Kneller S,Mendichi R,Pasut G,Schiavon O,Summerford C,Tirk A,Veronese FM,Vincenzi V,Wu G

更新日期：2005-03-01 00:00:00

abstract：:Spidroins, the major silk proteins making up the spider's dragline silk, originate in two distinct tissue layers (A and B) in the spider's major ampullate gland. Formation of the complex thread from spidroins occurs in the lumen of the duct connected to the gland. Using pH-sensitive microelectrode probes, we showed th...

journal_title：Biomacromolecules

authors： Dicko C,Vollrath F,Kenney JM

更新日期：2004-05-01 00:00:00

abstract：:Biomaterials conceived for vectorization of bioactives are currently considered for biomedical, biological, and environmental applications. We have produced a pH-sensitive biomaterial composed of natural source alginate and chitosan polysaccharides for application as a drug delivery system via oral administration. The...

journal_title：Biomacromolecules

authors： Mathews PD,Fernandes Patta ACM,Gonçalves JV,Gama GDS,Garcia ITS,Mertins O

更新日期：2018-02-12 00:00:00

abstract：:The formation of a microvasculature is regulated in large part by cell-cell interactions. Ephrins and their Eph receptors mediate cell adhesion, repulsion, and migration, all critical processes in angiogenesis. (1) Here we use a covalently immobilized ephrinA1, conjugated to poly(ethylene glycol), to induce vessel for...

journal_title：Biomacromolecules

authors： Saik JE,Gould DJ,Keswani AH,Dickinson ME,West JL

更新日期：2011-07-11 00:00:00

abstract：:The synergistic interaction between xanthan and glucomannan in solution and in the gel phase has been studied by circular dichroism spectroscopy and differential scanning calorimetry. The study in solution of the polysaccharidic mixture indicates a preferred stoichiometry of the interaction corresponding to a weight f...

journal_title：Biomacromolecules

authors： Paradossi G,Chiessi E,Barbiroli A,Fessas D

更新日期：2002-05-01 00:00:00

abstract：:Although composed simply of glucose polymers, the starch granule is a complex, semicrystalline structure. Much of this complexity arises from the fact that the two primary enzymes of synthesis-starch synthase and starch-branching enzyme-exist as multiple isoforms. Each form has distinct properties and plays a unique r...

journal_title：Biomacromolecules

authors： Smith AM

更新日期：2001-07-01 00:00:00

abstract：:Macromolecular dynamics in biological systems, which play a crucial role for biomolecular function and activity at ambient temperature, depend strongly on moisture content. Yet, a generally accepted quantitative model of hydration-dependent phenomena based on local relaxation and diffusive dynamics of both polymer and...

journal_title：Biomacromolecules

authors： Chen P,Terenzi C,Furó I,Berglund LA,Wohlert J

更新日期：2018-07-09 00:00:00

abstract：:Oligopeptide hydrogels are emerging as useful matrices for cell culture with commercial products on the market, but L-oligopeptides are labile to proteases. An obvious solution is to create D-oligopeptide hydrogels, which lack enzymatic recognition. However, D-oligopeptide matrices do not support cell growth as well a...

journal_title：Biomacromolecules

authors： Hyland LL,Twomey JD,Vogel S,Hsieh AH,Yu YB

更新日期：2013-02-11 00:00:00

abstract：:In situ polymerizable hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. In the present paper a novel polysaccharidic matrix based on calcium alginate (Ca(II)-Alg) hydrogel and dextran methacrylate derivative (Dex-MA), showing potential applicability in the field of pharm...

journal_title：Biomacromolecules

authors： Matricardi P,Pontoriero M,Coviello T,Casadei MA,Alhaique F

更新日期：2008-07-01 00:00:00

abstract：:We investigated the rheological properties and the penetration of differently sized carboxylated nanoparticles in pig pulmonary mucus, on different distance and time scales. Nanoparticles were either mechanically mixed into the mucus samples or deposited as an aerosol, the latter resembling a more physiologically rele...

journal_title：Biomacromolecules

authors： Murgia X,Pawelzyk P,Schaefer UF,Wagner C,Willenbacher N,Lehr CM

更新日期：2016-04-11 00:00:00

abstract：:Transparent and bendable regenerated cellulose films prepared from aqueous alkali (NaOH or LiOH)/urea (AU) solutions exhibit high oxygen barrier properties, which are superior to those of conventional cellophane, poly(vinylidene chloride), and poly(vinyl alcohol). Series of AU cellulose films are prepared from differe...

journal_title：Biomacromolecules

authors： Yang Q,Fukuzumi H,Saito T,Isogai A,Zhang L

更新日期：2011-07-11 00:00:00

abstract：:Super-resolution fluorescence microscopy, specifically stochastic reconstruction microscopy (STORM), and atomic force microscopy (AFM) were used to image the self-assembly processes of the peptide surfactant I3K. The peptide surfactants self-assembled into giant helical fibrils with diameters between 5 and 10 nm with ...

journal_title：Biomacromolecules

authors： Cox H,Georgiades P,Xu H,Waigh TA,Lu JR

更新日期：2017-11-13 00:00:00

abstract：:Poloxamer thermoresponsive gels are widely explored in controlled drug delivery. Nevertheless, these gels possess inadequate mechanical properties, poor bioadhesiveness, and high permeability to water. To overcome these issues, we blended mucoadhesive hyaluronic acid (HA) with poloxamer analogs. This study aimed to in...

journal_title：Biomacromolecules

authors： Mayol L,Biondi M,Quaglia F,Fusco S,Borzacchiello A,Ambrosio L,La Rotonda MI

更新日期：2011-01-10 00:00:00

abstract：:The development of sustainable materials by employing natural and nontoxic resources has been attracting much attention over the previous years. In this work, we discuss for the first time the chemical combination between resorcinol diglycidyl ether (RDGE), an aromatic biobased thermosetting monomer, and polyhydroxybu...

journal_title：Biomacromolecules

authors： Cantarutti C,Dinu R,Mija A

更新日期：2020-08-10 00:00:00

abstract：:Consensus motifs for sequences of both crystallizable and amorphous blocks in silks and natural structural analogues of silks vary widely. To design novel silklike polypeptides, an important question is therefore how the nature of either the crystallizable or the amorphous block affects the self-assembly and resulting...

journal_title：Biomacromolecules

authors： Willems L,van Westerveld L,Roberts S,Weitzhandler I,Calcines Cruz C,Hernandez-Garcia A,Chilkoti A,Mastrobattista E,van der Oost J,de Vries R

更新日期：2019-10-14 00:00:00

abstract：:Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy their entire life, there is currently a great desire to formulate antibodies for bolus injection ...

journal_title：Biomacromolecules

authors： Gong Y,Soleymani Abyaneh H,Drossis N,Niederquell A,Kuentz M,Leroux JC,de Haan HW,Gauthier MA

更新日期：2019-09-09 00:00:00

abstract：:Polymer therapeutics, including polymeric drugs and polymer-protein conjugates, are clinically established as first-generation nanomedicines. Knowing that the coiled-coil peptide motif is fundamentally important in the regulation of many cellular and pathological processes, the aim of these studies was to examine the ...

journal_title：Biomacromolecules

authors： Deacon SP,Apostolovic B,Carbajo RJ,Schott AK,Beck K,Vicent MJ,Pineda-Lucena A,Klok HA,Duncan R

更新日期：2011-01-10 00:00:00

abstract：:Enzyme-responsive polypeptide vesicles have attracted considerable attention for precision theranostics because of their biocompatibility, biodegradability, and unique secondary conformation transition triggered by the catalytic actions of enzymes. These promising potentials of polypeptide vesicles could be limited in...

journal_title：Biomacromolecules

authors： Duan W,Ji S,Guan Y,Mu X,Fang S,Lu Y,Zhou X,Sun J,Li Z

更新日期：2020-12-14 00:00:00

abstract：:F-actins are semi-flexible polyelectrolytes and can be assembled into a large polymer-actin complex with polymorphism through electrostatic interaction with polycations. This study investigates the structural phase behavior and the growth of polymer-actin complexes in terms of its longitudinal and lateral sizes in var...

journal_title：Biomacromolecules

authors： Kwon HJ,Kakugo A,Shikinaka K,Osada Y,Gong JP

更新日期：2005-11-01 00:00:00

abstract：:Silk fibroin hydrogels with tunable properties could be obtained from aqueous fibroin solutions (4.2 w/v %) in a short period of time. This was achieved by the addition of ethylene glycol diglycidyl ether (EGDE) into the reaction solution. Introduction of EGDE cross-links between the fibroin molecules decreases the mo...

journal_title：Biomacromolecules

authors： Karakutuk I,Ak F,Okay O

更新日期：2012-04-09 00:00:00

abstract：:Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) hyaluronic acid (HA) hydrogels offers a potential therapeutic biomaterial for nucleus pulposus (NP...

journal_title：Biomacromolecules

authors： Isa IL,Srivastava A,Tiernan D,Owens P,Rooney P,Dockery P,Pandit A

更新日期：2015-06-08 00:00:00

abstract：:Supramolecular nanogel, a physically cross-linked nanosize hydrogel, spontaneously self-assembles in aqueous solution via secondary interactions and is thus of great interest in nanomedicine as a drug carrier. We developed a versatile method for supramolecular nanogel self-assembled by electrostatic interaction betwee...

journal_title：Biomacromolecules

authors： Kim K,Bae B,Kang YJ,Nam JM,Kang S,Ryu JH

更新日期：2013-10-14 00:00:00

abstract：:Photoinitiated polymerization remains a robust method for fabrication of hydrogels, as these reactions allow facile spatial and temporal control of gelation and high compatibility for encapsulation of cells and biologics. The chain-growth reaction of macromolecular monomers, such as acrylated PEG and hyaluronan, is co...

journal_title：Biomacromolecules

authors： McCall JD,Anseth KS

更新日期：2012-08-13 00:00:00

abstract：:New pH-responsive polymersomes for active anticancer oligonucleotide delivery were prepared from triblock copolymers. The delivery systems were formed by two terminal hydrophilic blocks, PEG and polyglycerolmethacrylate (poly-GMA), and a central weakly basic block, polyimidazole-hexyl methacrylate (poly-ImHeMA), which...

journal_title：Biomacromolecules

authors： Gallon E,Matini T,Sasso L,Mantovani G,Armiñan de Benito A,Sanchis J,Caliceti P,Alexander C,Vicent MJ,Salmaso S

更新日期：2015-07-13 00:00:00

abstract：:We describe the synthesis of hydrophilic poly(poly(ethylene glycol) methyl ether methacrylate) (PmPEGMA) and hydrophobic poly(methyl methacrylate) (PMMA) caspofungin conjugates by a post-polymerization modification of copolymers containing 10 mol % pentafluorophenyl methacrylate (PFPMA), which were obtained via revers...

journal_title：Biomacromolecules

authors： Alex J,González K,Kindel T,Bellstedt P,Weber C,Heinekamp T,Orasch T,Guerrero-Sanchez C,Schubert US,Brakhage AA

更新日期：2020-06-08 00:00:00

abstract：:Hydrogels are attracting increasing attention due to their potential use in various fields. However, most of the existing hydrogels have limitations in either dissipating mechanical energy or maintaining high stretchability under deformation, thus do not possess high mechanical properties. Herein, poly(vinyl alcohol) ...

journal_title：Biomacromolecules

authors： Chen W,Li N,Ma Y,Minus ML,Benson K,Lu X,Wang X,Ling X,Zhu H

更新日期：2019-12-09 00:00:00

abstract：:Small-angle X-ray scattering (SAXS) experiments with in situ dehydration have been performed on small bundles of flax fibers. Analysis indicated that the structure of the cellulose microfibrils is consistent with a cross section of approximately 10 x 50 A2. The microfibril misalignment was Gaussian with a full width a...

journal_title：Biomacromolecules

authors： Astley OM,Donald AM

更新日期：2001-10-01 00:00:00

abstract：:Cancer immunotherapy can be augmented with toll-like receptor agonist (TLRa) adjuvants, which interact with immune cells to elicit potent immune activation. Despite their potential, use of many TLRa compounds has been limited clinically due to their extreme potency and lack of pharmacokinetic control, causing systemic...

journal_title：Biomacromolecules

authors： Smith AAA,Gale EC,Roth GA,Maikawa CL,Correa S,Yu AC,Appel EA

更新日期：2020-09-14 00:00:00

abstract：:Biofilm formation, in which bacteria are embedded within an extracellular matrix, is the default form of microbial life in most natural and engineered habitats. In this work, atomistic molecular dynamics simulations were employed to examine the self-assembly of the polysaccharide Granulan to provide insight into the m...

journal_title：Biomacromolecules

authors： Seviour T,Malde AK,Kjelleberg S,Yuan Z,Mark AE

更新日期：2012-06-11 00:00:00