Nanoparticles Presenting Potent TLR7/8 Agonists Enhance Anti-PD-L1 Immunotherapy in Cancer Treatment.

abstract：:Regenerated silk fibroin (RSF) fibers were obtained by extruding a concentrated aqueous silk fibroin solution into an ammonium sulfate coagulation bath. A custom-made simplified industrial-type wet-spinning device with continuous mechanical postdraw was used. The effect of dope concentration, coagulation bath, extrusi...

journal_title：Biomacromolecules

authors： Yan J,Zhou G,Knight DP,Shao Z,Chen X

更新日期：2010-01-11 00:00:00

abstract：:In this work, we report on an ATP-responsive low-molecular-weight polyethylenimine (LMW-PEI)-based supramolecular assembly. It formed via host-guest interaction between PEI (MW = 1.8 kDa)-α-cyclodextrin (α-CD) conjugates and PEI1.8k-phenylboronic acid (PBA) conjugates. The host-guest interaction between PEI1.8k-α-CD a...

journal_title：Biomacromolecules

authors： Jiang C,Qi Z,Jia H,Huang Y,Wang Y,Zhang W,Wu Z,Yang H,Liu J

更新日期：2019-01-14 00:00:00

abstract：:On the basis of their versatile structure and chemistry as well as tunable mechanical properties, polymer brushes are well-suited as supports for enzyme immobilization. However, a robust surface design is hindered by an inadequate understanding of the impact on activity from the coupling motif and enzyme distribution ...

journal_title：Biomacromolecules

authors： Lane SM,Kuang Z,Yom J,Arifuzzaman S,Genzer J,Farmer B,Naik R,Vaia RA

更新日期：2011-05-09 00:00:00

abstract：:We synthesized extremely deformable red blood cell-like microgel particles and loaded them with bovine hemoglobin (Hb) to potentiate oxygen transport. With similar shape and size as red blood cells (RBCs), the particles were fabricated using the PRINT (particle replication in nonwetting templates) technique. Low cross...

journal_title：Biomacromolecules

authors： Chen K,Merkel TJ,Pandya A,Napier ME,Luft JC,Daniel W,Sheiko S,DeSimone JM

更新日期：2012-09-10 00:00:00

abstract：:Poly(dimethyl siloxane) (PDMS) is extensively used for biomedical applications due to its low cost, ease of fabrication, high durability and flexibility, oxygen permeability, and self-healing properties. PDMS, however, has some significant drawbacks. PDMS endures unacceptably high levels of nonspecific protein fouling...

journal_title：Biomacromolecules

authors： Keefe AJ,Brault ND,Jiang S

更新日期：2012-05-14 00:00:00

abstract：:The synthesis of quaternary ammonium (QA)-functionalized silica nanoparticles with and without nitric oxide (NO) release capabilities is described. Glycidyltrialkylammonium chlorides of varied alkyl chain lengths (i.e., methyl, butyl, octyl, and dodecyl) were tethered to the surface of amine-containing silica nanopart...

journal_title：Biomacromolecules

authors： Carpenter AW,Worley BV,Slomberg DL,Schoenfisch MH

更新日期：2012-10-08 00:00:00

abstract：:A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic estrogen hormone used as contraceptive, from water was tested. The yarns were prepared by spinning a deep eutec...

journal_title：Biomacromolecules

authors： Orelma H,Virtanen T,Spoljaric S,Lehmonen J,Seppälä J,Rojas OJ,Harlin A

更新日期：2018-02-12 00:00:00

abstract：:This work demonstrates a versatile and environmentally friendly route for the development of new orthogonal monomers that can be used for postfunctionalizable polymer networks. A monomer containing both vinyl ether (VE) and cyclic disulfide moieties was synthesized via enzyme catalysis under benign reaction conditions...

journal_title：Biomacromolecules

authors： Brännström S,Johansson M,Malmström E

更新日期：2019-03-11 00:00:00

abstract：:A comprehensive understanding of the mechanism by which type I collagen (Col) interacts with hydroxyapatite nanoparticles (Hap NPs) in aqueous solutions is a pivotal step for guiding the design of biologically relevant nanocomposites with controlled hierarchical structure. In this paper we use a variety of Hap NPs dif...

journal_title：Biomacromolecules

authors： Colaço E,Brouri D,Aissaoui N,Cornette P,Dupres V,Domingos RF,Lambert JF,Maisonhaute E,Kirat KE,Landoulsi J

更新日期：2019-12-09 00:00:00

abstract：:Starches from WT, lam, and r pea mutants differing in amylopectin/amylose contents (70, 90, and 28% amylopectin, respectively) were used in kinetic studies of pancreatic α-amylase action at 37 °C and for investigations of their supramolecular structure and physicochemical properties during heating. For WT and lam star...

journal_title：Biomacromolecules

authors： Tahir R,Ellis PR,Bogracheva TY,Meares-Taylor C,Butterworth PJ

更新日期：2011-01-10 00:00:00

abstract：:In this work, we have analyzed the structural, topographical, and surface dilatational characteristics of pure beta-lactoglobulin adsorbed films and the effect of the self-assembly of monoglycerides (monopalmitin or monoolein) in beta-lactoglobulin films at the air-water interface. Measurements were performed in a sin...

journal_title：Biomacromolecules

authors： Rodríguez Patino JM,Fernandez MC,Rodríguez Niño MR,Sanchez CC

更新日期：2006-09-01 00:00:00

abstract：:Type I collagen is explored heavily for use in biomaterials, but the role of other extracellular matrix components in regulating collagen organization is gaining attention. We show that as the ratio of type III to type I collagen increases, fibril diameter decreases. A mixture of the two collagen types results in a mo...

journal_title：Biomacromolecules

authors： Stuart K,Panitch A

更新日期：2009-01-12 00:00:00

abstract：:To develop a safe, effective, and biocompatible gene delivery vector, a series of hydrophobic amino acid grafted chitosan (AGC) derivatives were synthesized by carbodiimide mediated coupling reaction. Chemical characterization of AGC polymers was performed by NMR and elemental analysis. AGC polymers demonstrated excel...

journal_title：Biomacromolecules

authors： Layek B,Singh J

更新日期：2013-02-11 00:00:00

abstract：:This paper introduces a chitosan microneedle patch for efficient and sustained transdermal delivery of hydrophilic macromolecules. Chitosan microneedles have sufficient mechanical strength to be inserted in vitro into porcine skin at approximately 250 μm in depth and in vivo into rat skin at approximately 200 μm in de...

journal_title：Biomacromolecules

authors： Chen MC,Ling MH,Lai KY,Pramudityo E

更新日期：2012-12-10 00:00:00

abstract：:We report the facile preparation of gels from the hydrothermal treatment of suspensions of cellulose nanocrystals (CNCs). The properties of the hydrogels have been investigated by rheology, electron microscopy, and spectroscopy with respect to variation in the temperature, time, and CNC concentration used in preparati...

journal_title：Biomacromolecules

authors： Lewis L,Derakhshandeh M,Hatzikiriakos SG,Hamad WY,MacLachlan MJ

更新日期：2016-08-08 00:00:00

abstract：:This paper describes the synthesis and cytotoxicity of poly(anhydride esters) that are composed of several salicylate derivatives, including halogenated salicylates, aminosalicylates, salicylsalicylic acid, and thiolsalicylic acid. The incorporation of these nonsteroidal antiinflammatory drugs (NSAIDs) into a biodegra...

journal_title：Biomacromolecules

authors： Schmeltzer RC,Schmalenberg KE,Uhrich KE

更新日期：2005-01-01 00:00:00

abstract：:Synthesis of novel zwitterionic block copolypeptides, poly(N-isopropylacrylamide)-block-poly(L-glutamic acid-co-L-lysine) [PNiPAM(n)(PLG(x)-co-PLLys(y))m , where n is the number-average degree of polymerization (DP(n)) of PNiPAM block, x and y are the mole fraction of glutamic acid and lysine residues, respectively, a...

journal_title：Biomacromolecules

authors： Li J,Wang T,Wu D,Zhang X,Yan J,Du S,Guo Y,Wang J,Zhang A

更新日期：2008-10-01 00:00:00

abstract：:(1,3)(1,4)-β-D-Glucan (mixed-linkage glucan or MLG), a characteristic hemicellulose in primary cell walls of grasses, was investigated to determine both its role in cell walls and its interaction with cellulose and other cell wall polysaccharides in vitro. Binding isotherms showed that MLG adsorption onto microcrystal...

journal_title：Biomacromolecules

authors： Kiemle SN,Zhang X,Esker AR,Toriz G,Gatenholm P,Cosgrove DJ

更新日期：2014-05-12 00:00:00

abstract：:Hydrogels with pH-sensitive poly(acrylic acid) (PAAc) chains and biodegradable acryloyl-poly(-caprolactone)-2-hydroxylethyl methacrylate (AC-PCL-HEMA) chains were designed and synthesized. The morphology of hydrogel was observed by scanning electron microscopy. The degradation of the hydrogel in the presence of Pseudo...

journal_title：Biomacromolecules

authors： Wu DQ,Sun YX,Xu XD,Cheng SX,Zhang XZ,Zhuo RX

更新日期：2008-04-01 00:00:00

abstract：:A successful strategy for the immobilization of rennet from Mucor miehei has been developed. The strategy is based on the immobilization of the enzyme, via their sugar chains at high ionic strength on aminated supports having primary amino groups with a very low pK value. The rennet was covalently immobilized via suga...

journal_title：Biomacromolecules

authors： Pessela BC,Torres R,Fuentes M,Mateo C,Fernandez-Lafuente R,Guisán JM

更新日期：2004-09-01 00:00:00

abstract：:The leading cause of death in the United States is cardiovascular disease. The majority of these cases result from heart failure post-myocardial infarction (MI). We present data providing evidence for use of acetalated dextran (AcDex) microparticles as a delivery vehicle for therapeutics to the heart post-MI. We harne...

journal_title：Biomacromolecules

authors： Suarez S,Grover GN,Braden RL,Christman KL,Almutairi A

更新日期：2013-11-11 00:00:00

abstract：:The first step in the conventional approach to self-assembled biomaterials is to develop well-defined nanostructures in vitro, which is followed by disruption of the preformed nanostructures at the inside of the cell to achieve bioactivity. Here, we propose an inverse strategy to develop in-cell gain-of-function self-...

journal_title：Biomacromolecules

authors： Waqas M,Jeong WJ,Lee YJ,Kim DH,Ryou C,Lim YB

更新日期：2017-03-13 00:00:00

abstract：:Materials with fungi-bioinspired surface have been designed to host ergosterol-binding polyene antibiotics and to release them via a competitive mechanism only when fungi are present in the medium. Silicone rubber (SR) surfaces were endowed with selective loading and fungi-triggered release of polyene antifungal agent...

journal_title：Biomacromolecules

authors： Segura T,Puga AM,Burillo G,Llovo J,Brackman G,Coenye T,Concheiro A,Alvarez-Lorenzo C

更新日期：2014-05-12 00:00:00

abstract：:The manufacture of biodegradable materials from agricultural sources is a real challenge, because of environmental concerns and the need to make full use of resources. Cottonseed is an important protein source that could be used in nonfood applications, as a substitute for synthetic polymers. For the first time, the v...

journal_title：Biomacromolecules

authors： Grevellec J,Marquié C,Ferry L,Crespy A,Vialettes V

更新日期：2001-01-01 00:00:00

abstract：:The bioconjugation of proteins and peptides with synthetic polymers is a promising method for tailoring the chemical, biological, and physical properties of both the polymeric and protein-based components. Here, we describe macromolecular assemblies of polyethylene glycol-coiled-coil alternating multiblock polymers gu...

journal_title：Biomacromolecules

authors： Sahin E,Kiick KL

更新日期：2009-10-12 00:00:00

abstract：:Bionanocomposite materials, combining the properties of biopolymers and nanostructured materials, are attracting interest of the wider scientific community due to their potential application in design of implants, drug delivery systems, and tissue design platforms. Herein, we report on the use of maleimide-coated silv...

journal_title：Biomacromolecules

authors： García-Astrain C,Chen C,Burón M,Palomares T,Eceiza A,Fruk L,Corcuera MÁ,Gabilondo N

更新日期：2015-04-13 00:00:00

abstract：:Although micelles are commonly used for drug delivery purposes, their long-term fate is often unknown due to photobleaching of the fluorescent labels or the use of toxic materials. Here, we present a metal-free, nontoxic, nonbleaching, fluorescent micelle that can address these shortcomings. A simple, yet versatile, p...

journal_title：Biomacromolecules

authors： Zaquen N,Lu H,Chang T,Mamdooh R,Lutsen L,Vanderzande D,Stenzel M,Junkers T

更新日期：2016-12-12 00:00:00

abstract：:Self-assembly in aqueous solution of two oppositely charged globular proteins, hen egg white lysozyme (LYS) and bovine calcium-depleted α-lactalbumin (apo α-LA), was investigated at pH 7.5. The aggregation rate of equimolar mixtures of the two proteins was determined using static and dynamic light scattering as a func...

journal_title：Biomacromolecules

authors： Salvatore D,Croguennec T,Bouhallab S,Forge V,Nicolai T

更新日期：2011-05-09 00:00:00

abstract：:Polycaprolactone (PCL) was reported a long time ago; however, its biomedical applications has not been extensively investigated in comparison with poly(lactide- co-glycolide) (PLGA) due to its too slow degradation profile. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer (PCL-OX) as a...

journal_title：Biomacromolecules

authors： Chang SH,Lee HJ,Park S,Kim Y,Jeong B

更新日期：2018-06-11 00:00:00

abstract：:Peptide RATEA16 spontaneously self-assembled into higher-order nanofiber hydrogels with extremely high water content (>99.5% (wt/vol)) under physiological condition. The hydrogels could undergo pH-reversible transitions from viscous solution to elastic hydrogel and to precipitate. The supramolecular self-assembly and ...

journal_title：Biomacromolecules

authors： Zhao Y,Yokoi H,Tanaka M,Kinoshita T,Tan T

更新日期：2008-06-01 00:00:00