Kinetics and structure during self-assembly of oppositely charged proteins in aqueous solution.

abstract：:Selectively spooling single plasmid DNA (pDNA), as a giant polyelectrolyte, into a nanosized toroidal structure or folding it into a rod-like structure has been accomplished by polyion complexation with block catiomers to form polymeric micelles in varying NaCl concentrations. The interactive potency between the pDNA ...

journal_title：Biomacromolecules

authors： Li Y,Osada K,Chen Q,Tockary TA,Dirisala A,Takeda KM,Uchida S,Nagata K,Itaka K,Kataoka K

更新日期：2015-09-14 00:00:00

abstract：:Water-soluble T-antigen containing glycopolymers [Gal beta(1,3)-GalNAc alpha) having a high degree of lipophilicity were synthesized from poly[N-(acryloxy)succinimide] (6-10) by amidation with an amine-ending T-antigen derivative (3) and various amines of increasing alkyl chain length (ammonia and methyl-, ethyl-, and...

journal_title：Biomacromolecules

authors： Baek MG,Roy R

更新日期：2000-01-01 00:00:00

abstract：:pH-dependent release from monoolein (MO) cubic phase was obtained by taking advantage of complex coacervation between hydrophobically modified alginate (HmAL) and hydrophobically modified silk fibroin (HmSF) in the water channels. The degree of coacervation was investigated at pH 3.0 by a light scattering method and t...

journal_title：Biomacromolecules

authors： Kwon TK,Kim JC

更新日期：2011-02-14 00:00:00

abstract：:There is a lack of hydrogel materials whose properties can be tuned at the point of use. Biological hydrogels, such as collagen, gelate at physiological temperatures; however, they are not always ideal as scaffolds because of their low mechanical strength. Their mechanics can be improved through cross-linking and chem...

journal_title：Biomacromolecules

authors： Barnes AL,Genever PG,Rimmer S,Coles MC

更新日期：2016-03-14 00:00:00

abstract：:Nanocoating of individual mammalian cells with polymer layers has been of increasing interest in biotechnology and biomedical engineering applications. Electrostatic layer-by-layer (LbL) deposition of polyelectrolytes on negatively charged cell surfaces has been utilized for cell nanocoatings using synthetic or natura...

journal_title：Biomacromolecules

authors： Hasturk O,Sahoo JK,Kaplan DL

更新日期：2020-07-13 00:00:00

abstract：:On-line size-exclusion chromatography monitoring of potato phosphorylase catalyzed amylose synthesis--starting from alpha-D-glucose-1-P and maltohexaose--revealed rather monodisperse amylose populations. In the presence of lipids, amylose-lipid complexes spontaneously formed and precipitated. They were recovered by ce...

journal_title：Biomacromolecules

authors： Gelders GG,Goesaert H,Delcour JA

更新日期：2005-09-01 00:00:00

abstract：:It is well-known that 3D in vitro cell cultures provide a much better model than 2D cell cultures for understanding the in vivo microenvironment of cells. However, significant technical challenges in handling and analyzing 3D cell cultures remain, which currently limits their widespread application. Herein, we demonst...

journal_title：Biomacromolecules

authors： Simon KA,Warren NJ,Mosadegh B,Mohammady MR,Whitesides GM,Armes SP

更新日期：2015-12-14 00:00:00

abstract：:We studied methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-dimethylaminoethyl methacrylate) (mPEG-b-PCL-b-PDMAEMA) nanoparticles as the codelivery vector of hydrophobic drug and pDNA by employing dynamic light scattering (DLS), ζ potential, transmission electron microscopy (TEM), gel retardation assay, a...

journal_title：Biomacromolecules

authors： Yue X,Qiao Y,Qiao N,Guo S,Xing J,Deng L,Xu J,Dong A

更新日期：2010-09-13 00:00:00

abstract：:We have investigated the thermodynamic and dynamic behavior of multistranded β-lactoglobulin protein fibrils in water, by combining static, dynamic, and depolarized dynamic light scattering (SLS, DLS, DDLS), small angle neutron scattering (SANS), rheology, and cryogenic transmission electron microscopy (cryo-TEM). We ...

journal_title：Biomacromolecules

authors： Bolisetty S,Harnau L,Jung JM,Mezzenga R

更新日期：2012-10-08 00:00:00

abstract：:This study describes the formulation and physicochemical characterization of poly(acrylic acid) (PAA) organogels, designed as bioactive implants for improved treatment of infectious diseases of the oral cavity. Organogels were formulated containing a range of concentrations of PAA (3-10% w/w) and metronidazole (2 or 5...

journal_title：Biomacromolecules

authors： Jones DS,Muldoon BC,Woolfson AD,Andrews GP,Sanderson FD

更新日期：2008-02-01 00:00:00

abstract：:For efficient reversal of multidrug resistance (MDR) in chemotherapy for breast cancer, multifunctional self-assembled nanoparticles (MSN) based on a new amphiphilic copolymer consisting of bioreducible poly[bis(2-hydroxylethyl)-disulfide-diacrylate-β-tetraethylenepentamine] and polycaprolactone (PBD-PCL) were constru...

journal_title：Biomacromolecules

authors： Yin Q,Shen J,Zhang Z,Yu H,Chen L,Gu W,Li Y

更新日期：2013-07-08 00:00:00

abstract：:Electrospinning for the formation of nanoscale diameter fibers has been explored for high-performance filters and biomaterial scaffolds for vascular grafts or wound dressings. Fibers with nanoscale diameters provide benefits due to high surface area. In the present study we explore electrospinning for protein-based bi...

journal_title：Biomacromolecules

authors： Jin HJ,Fridrikh SV,Rutledge GC,Kaplan DL

更新日期：2002-11-01 00:00:00

abstract：:Chitin nanocrystal aqueous dispersions were prepared by acid hydrolysis of crude chitin from crab shells. The resulting dispersions were studied with small deformation oscillatory experiments and polarized optical microscopy under different conditions of nanocrystal concentration, ionic strength, pH, and temperature. ...

journal_title：Biomacromolecules

authors： Tzoumaki MV,Moschakis T,Biliaderis CG

更新日期：2010-01-11 00:00:00

abstract：:Electrically conducting polymeric membranes were prepared by incorporating multiwalled carbon nanotubes (MWCNTs) into bacterial cellulose pellicles produced by Gluconacetobacter xylinum. The MWCNTs were dispersed in a surfactant (cationic cetyl trimethylammonium bromide) solution, and cellulose pellicles were dipped i...

journal_title：Biomacromolecules

authors： Yoon SH,Jin HJ,Kook MC,Pyun YR

更新日期：2006-04-01 00:00:00

abstract：:Degradation of fibrillar collagen is critical for tissue maintenance. Yet, understanding collagen catabolism has been challenging partly due to a lack of atomistic picture for its load-dependent conformational dynamics, as both mechanical load and local unfolding of collagen affect its cleavage by matrix metalloprotei...

journal_title：Biomacromolecules

authors： Teng X,Hwang W

更新日期：2014-08-11 00:00:00

abstract：:Tissue engineering approaches need biomaterials with suitable properties to provide an appropriate environment for cell attachment and growth. The performance of these biomaterials can be greatly enhanced through the incorporation of bioactive agents. For this reason, we developed chitosan films with cell-attachment a...

journal_title：Biomacromolecules

authors： Abarrategi A,Civantos A,Ramos V,Sanz Casado JV,López-Lacomba JL

更新日期：2008-02-01 00:00:00

abstract：:A subtle but highly pertinent factor in the self-assembly of hierarchical nanostructures is the kinetic landscape. Self-assembly of a hierarchical multicomponent system requires the intricate balance of noncovalent interactions on a similar energy scale that can result in several self-assembly processes occurring at d...

journal_title：Biomacromolecules

authors： Ang J,Jung BT,Dong H,Xu T

更新日期：2017-03-13 00:00:00

abstract：:Developing green and nontoxic biomaterials, derived from renewable sources and processable through 3D bioprinting technologies, is an emerging challenge of sustainable tissue engineering. Here, pectin from citrus peels was cross-linked for the first time with (3-glycidyloxypropyl)trimethoxysilane (GPTMS) through a one...

journal_title：Biomacromolecules

authors： Lapomarda A,De Acutis A,Chiesa I,Fortunato GM,Montemurro F,De Maria C,Mattioli Belmonte M,Gottardi R,Vozzi G

更新日期：2020-02-10 00:00:00

abstract：:A variety of natural polymers and proteins are considered to be 3D cell culture structures able to mimic the extracellular matrix (ECM) to promote bone tissue regeneration. Pectin, a natural polysaccharide extracted from the plant cell walls and having a chemical structure similar to alginate, provides interesting pro...

journal_title：Biomacromolecules

authors： Munarin F,Guerreiro SG,Grellier MA,Tanzi MC,Barbosa MA,Petrini P,Granja PL

更新日期：2011-03-14 00:00:00

abstract：:In the present contribution, two-dimensional ATR-FTIR spectroscopy was used to study the diffusion of water in poly(epsilon-caprolactone) (PCL). In the spectral region of the nu(OH) stretching vibration of water, four absorption bands (3635, 3560, 3411, and 3220 cm(-1)) can be identified. The higher wavenumber band pa...

journal_title：Biomacromolecules

authors： Peng Y,Wu P,Siesler HW

更新日期：2003-07-01 00:00:00

abstract：:The average pore size of hydrated dextran microspheres is derived from rheological and protein release data. The microspheres were prepared by cross-linking an aqueous solution of methacrylated dextran emulsified in a continuous poly(ethylene glycol) phase. The rheological data were obtained using a novel micromanipul...

journal_title：Biomacromolecules

authors： Stenekes RJ,De Smedt SC,Demeester J,Sun G,Zhang Z,Hennink WE

更新日期：2000-01-01 00:00:00

abstract：:The effect of solution pH during layer-by-layer assembly of polyelectrolyte multilayer (PEM) coatings on properties relevant to orthopedic implant success was investigated. Bone morphogenetic protein 2 (BMP-2), a potent osteoconductive growth factor, was adsorbed onto the surface of anodized titanium, and PEM coatings...

journal_title：Biomacromolecules

authors： Salvi C,Lyu X,Peterson AM

更新日期：2016-06-13 00:00:00

abstract：:In a previous study, we have reported chemical synthesis of novel aliphatic poly(butylene succinate-co-cyclic carbonate) P(BS-co-CC)s bearing various functionalizable carbonate building blocks, and this work will continue to present our new studies on their enzymatic degradation and in vitro cell biocompatibility assa...

journal_title：Biomacromolecules

authors： Yang J,Tian W,Li Q,Li Y,Cao A

更新日期：2004-11-01 00:00:00

abstract：:Hyperbranched poly(amino ester)s containing tertiary amines in the core and primary, secondary, and tertiary amines in the periphery, respectively, were evaluated for DNA delivery in vitro. The same core structure facilitated the investigation on the effects of the terminal amine type on the properties of hyperbranche...

journal_title：Biomacromolecules

authors： Wu D,Liu Y,Jiang X,He C,Goh SH,Leong KW

更新日期：2006-06-01 00:00:00

abstract：:The leading cause of death in the United States is cardiovascular disease. The majority of these cases result from heart failure post-myocardial infarction (MI). We present data providing evidence for use of acetalated dextran (AcDex) microparticles as a delivery vehicle for therapeutics to the heart post-MI. We harne...

journal_title：Biomacromolecules

authors： Suarez S,Grover GN,Braden RL,Christman KL,Almutairi A

更新日期：2013-11-11 00:00:00

abstract：:In biomedicine, PEGylation is one of the most successful strategies to modify the physicochemical and biological properties of peptides, proteins, and other biomacromolecules. Because of the polydisperse nature of regular PEGs and limited PEGylation strategies, it is challenging to quantitatively fine-tune and accurat...

journal_title：Biomacromolecules

authors： Wang X,Li Y,Wu T,Yang Z,Zheng X,Chen S,Zhou X,Jiang ZX

更新日期：2020-02-10 00:00:00

abstract：:The introduction of polymers into a chiral nematic cellulose nanocrystal (CNC) matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials. In this study, we explored the incorporation of hydroxypropyl cellulose (HPC) into a CNC film prepared by slow eva...

journal_title：Biomacromolecules

authors： Walters CM,Boott CE,Nguyen TD,Hamad WY,MacLachlan MJ

更新日期：2020-03-09 00:00:00

abstract：:The hierarchical self-assembly of cellulose nanocrystals (CNCs) is an important phenomenon occurring naturally in plant cell walls. Utilization of this assembly for advanced applications requires a fundamental theoretical understanding of interactions between the CNCs, which is still incomplete. Hence, in this work, w...

journal_title：Biomacromolecules

authors： Garg M,Linares M,Zozoulenko I

更新日期：2020-08-10 00:00:00

abstract：:Given the significance of hydrogels as cell-instructive materials, it is important to understand how differences in their chemical and physical properties are able to direct cell fate. For example, it remains unclear how different hydrogel cross-linking chemistries and gelation mechanisms influence cell behavior. Here...

journal_title：Biomacromolecules

authors： Loebel C,Szczesny SE,Cosgrove BD,Alini M,Zenobi-Wong M,Mauck RL,Eglin D

更新日期：2017-03-13 00:00:00

abstract：:Hydrophilic copolymers with high refractive index and bactericide properties based on quaternary ammonium salts monomers and methacrylates bearing benzothiazole moieties have been developed for application as foldable intraocular lenses. Composition of the systems was adjusted to get materials with optimized flexibili...

journal_title：Biomacromolecules

authors： Parra F,Vázquez B,Benito L,Barcenilla J,San Román J

更新日期：2009-11-09 00:00:00