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Design and synthesis of water-soluble glycopolymers bearing breast tumor marker and enhanced lipophilicity for solid-phase assays.

Abstract：

:Water-soluble T-antigen containing glycopolymers [Gal beta(1,3)-GalNAc alpha) having a high degree of lipophilicity were synthesized from poly[N-(acryloxy)succinimide] (6-10) by amidation with an amine-ending T-antigen derivative (3) and various amines of increasing alkyl chain length (ammonia and methyl-, ethyl-, and propylamine). The enhanced lipophilicity was demonstrated by a solid-phase microtiter plate assay (ELISA) with mouse monoclonal antibody FAA-J11 (IgG3) and by a core 2-beta(1,6)-N-acetylglucoaminyltransferase using tritium-(3H-) labeled UDP-GlcNAc substrate. The new materials were thus useful in solid-phase high-throughput screening for drug discovery.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Baek MG,Roy R

doi

10.1021/bm005593k

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

768-70

issue

4

eissn

1525-7797

issn

1526-4602

journal_volume

1

pub_type

杂志文章

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