Abstract:
:Biomimetic nanocomposites and scaffolds hold the key to a wide range of biomedical applications. Here we show, for the first time, a facile scheme of cofibrillizing pathogenic and functional amyloid fibrils via gold nanoparticles (AuNPs) and their applications against amyloidogenesis. This scheme was realized by β-sheet stacking between human islet amyloid polypeptide (IAPP) and the β-lactoglobulin "corona" of the AuNPs, as revealed by transmission electron microscopy, 3D atomic force microscopy, circular dichroism spectroscopy, and molecular dynamics simulations. The biomimetic AuNPs eliminated IAPP toxicity, enabled X-ray destruction of IAPP amyloids, and allowed dark-field imaging of pathogenic amyloids and their immunogenic response by human T cells. In addition to providing a viable new nanotechnology against amyloidogenesis, this study has implications for understanding the in vivo cross-talk between amyloid proteins of different pathologies.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Javed I,Sun Y,Adamcik J,Wang B,Kakinen A,Pilkington EH,Ding F,Mezzenga R,Davis TP,Ke PCdoi
10.1021/acs.biomac.7b01359subject
Has Abstractpub_date
2017-12-11 00:00:00pages
4316-4322issue
12eissn
1525-7797issn
1526-4602journal_volume
18pub_type
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