Abstract：
:High internal phase emulsion (HIPE)-templating is an attractive method of producing high porosity polymer foams with tailored pore structure, pore size and porosity. However, this method typically requires the use of large amounts of surfactants to stabilize the immiscible liquid phases, and polymerizable monomers/cross-linker in the continuous minority phase to solidify the HIPE, which may not be desirable in many applications. We show that polyHIPEs with a porosity of 73% can be formed solely using a copolymer of chitosan-graft-PNIPAM-graft-oligoproline (CSN-PRO), which acts simultaneously as emulsifier and thermoresponsive gelator, and forms upon removal of the liquid templating phases, the bulk structure of the resulting polyHIPE. With only a small amount of surfactant (1%v/v in the aqueous phase), and varying the polymer concentration and internal phase volume ratio, different polyHIPEs with porosities of up to 99%, surface areas in excess of 300 m(2)/g and controlled pore interconnectivity can be formed. The poly(CSN-PRO)HIPEs are also shown to be thermoresponsive and remained intact when immersed into water above 34 °C but dissolve below their LCST, which is useful for applications such as drug delivery and tissue engineering scaffolds.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Oh BH,Bismarck A,Chan-Park MBdoi
10.1021/bm500172usubject
Has Abstractpub_date
2014-05-12 00:00:00pages
1777-87issue
5eissn
1525-7797issn
1526-4602journal_volume
15pub_type
杂志文章abstract：:Glycosidases have long been used for the synthesis of glycosides by transglycosylation reactions. Especially glycosidases from hyperthermophilic bacteria are useful for reactions under extreme reaction conditions, e.g., in the presence of organic solvents. We herein report the facile enzymatic synthesis and purificati...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b01647
更新日期：2020-02-10 00:00:00
abstract：:In situ polymerizable hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. In the present paper a novel polysaccharidic matrix based on calcium alginate (Ca(II)-Alg) hydrogel and dextran methacrylate derivative (Dex-MA), showing potential applicability in the field of pharm...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm800252c
更新日期：2008-07-01 00:00:00
abstract：:Phase separation mechanisms and kinetics were studied using small-angle light scattering in a gelatin/maltodextrin system where phase separation could be studied in both liquid and gelled states. Nucleation and growth or spinodal decomposition occurred, depending on the quench depth. The transition between the two mec...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm025501m
更新日期：2002-07-01 00:00:00
abstract：:Glycogen is mainly found as the principal storage form of glucose in cells. Many bacteria are able to synthesize large amounts of glycogen under unfavorable life conditions. By combining infrared spectroscopy, single molecule force spectroscopy (SMFS) and immuno-staining technique, we evidenced that planktonic P. flu...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm300497c
更新日期：2012-07-09 00:00:00
abstract：:Generation of bioenergy, new functional polymers, or chemicals and biomaterials from hemicelluloses are important uses for biomass. In this paper, a novel functional biopolymer with carbon-carbon double bond and carboxyl groups was prepared by a homogeneous esterification of xylan-rich hemicelluloses (XH) with maleic ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm1010118
更新日期：2010-12-13 00:00:00
abstract：:l-Proline is the only, out of 20 essential, amino acid that contains a cyclized substituted α-amino group (is formally an imino acid), which restricts its conformational shape. The synthesis of well-defined homo- and copolymers of l-proline has been plagued either by the low purity of the monomer or the inability of m...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm200495n
更新日期：2011-06-13 00:00:00
abstract：:Electrically conductive hydrogel composites consisting of oligo(polyethylene glycol) fumarate (OPF) and polypyrrole (PPy) were developed for applications in nerve regeneration. OPF-PPy scaffolds were synthesized using three different anions: naphthalene-2-sulfonic acid sodium salt (NSA), dodecylbenzenesulfonic acid so...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm100526a
更新日期：2010-11-08 00:00:00
abstract：:Water-soluble conjugated polymers (WCPs) composed of a hydrophobic polythiophene main chain with hydrophilic tertiary amine side-chains can directly self-assemble into sphere-like nano-objects in an aqueous solution due to phase separation between the hydrophilic and hydrophobic segments of the polymeric structure. Du...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.0c01336
更新日期：2020-12-14 00:00:00
abstract：:Photoinitiated polymerization remains a robust method for fabrication of hydrogels, as these reactions allow facile spatial and temporal control of gelation and high compatibility for encapsulation of cells and biologics. The chain-growth reaction of macromolecular monomers, such as acrylated PEG and hyaluronan, is co...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm300671s
更新日期：2012-08-13 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm901147k
更新日期：2010-03-08 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm030073l
更新日期：2004-03-01 00:00:00
abstract：:In this contribution, a hydrophobically modified polysaccharide derivative is synthesized in an eco-friendly solvent water by conjugation of benzylamine with the backbone of the biopolymer. Owing to the presence of aromatic moieties, the resulting water-soluble polysaccharide derivative self-assembles spontaneously an...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.5b00638
更新日期：2015-08-10 00:00:00
abstract：:Antibacterial nanodevices could bring coatings of plastic materials and wound dressings a big step forward if the release of the antibacterial agents could be triggered by the presence of the bacteria themselves. Here, we show that novel hyaluronic acid (HA)-based nanocapsules containing the antimicrobial agent polyhe...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm302003m
更新日期：2013-04-08 00:00:00
abstract：:The development of sustainable materials by employing natural and nontoxic resources has been attracting much attention over the previous years. In this work, we discuss for the first time the chemical combination between resorcinol diglycidyl ether (RDGE), an aromatic biobased thermosetting monomer, and polyhydroxybu...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.0c00876
更新日期：2020-08-10 00:00:00
abstract：:PEO-PPO-PEO triblock copolymers have opposing effects on lipid membrane integrity: they can behave either as membrane sealants or as membrane permeabilizers. To gain insights into their biomembrane activities, the fundamental interactions between a series of PEO-based polymers and phospholipid vesicles were investigat...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm300847x
更新日期：2012-09-10 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章,评审
doi：10.1021/acs.biomac.7b00764
更新日期：2017-11-13 00:00:00
abstract：:Nanofibrous materials containing the antitumor drug doxorubicin hydrochloride (DOX) were easily prepared using a one-step method by electrospinning of DOX/poly(L-lactide-co-D,L-lactide) (coPLA) and DOX/quaternized chitosan (QCh)/coPLA solutions. The pristine and DOX-containing mats were characterized by ATR-FTIR and X...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm100285n
更新日期：2010-06-14 00:00:00
abstract：:A new method to form colloidally stable oligosaccharide-grafted synthetic polymer particles has been developed. The oligosaccharides, of weight-average degree of polymerization approximately 38, were obtained by enzymatic debranching of amylopectin. Through the use of a cerium(IV)-based redox initiation process, oligo...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm061119o
更新日期：2007-06-01 00:00:00
abstract：:The SEC-MALS-QELS (size-exclusion chromatography equipped with multiangle light scattering and quasi-elastic light scattering detectors) method using lithium chloride/N,N-dimethylacetamide (LiCl/DMAc) and LiCl/1,3-dimethyl-2-imidazolidinone (LiCl/DMI) as mobile phases was applied to cellulose and cellulose tricarbanil...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm049386m
更新日期：2005-05-01 00:00:00
abstract：:Images of high methoxyl orange pectin deposited from solution and high methoxyl sugar acid gels (HMSAG) were obtained by atomic force microscopy (AFM) in the tapping mode. For the first time, images of pectin deposited from water revealed that the transition from pectin networks to individual molecules or aggregates t...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0607729
更新日期：2007-02-01 00:00:00
abstract：:Assembly of (bio)polymers into long-range anisotropic nanostructured gels and aerogels is of great interest in advanced material engineering since it enables directional tuning of properties, such as diffusivity, light, heat, and sound propagation, cell proliferation, and mechanical properties. Here we present an appr...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.8b01278
更新日期：2018-11-12 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm0612236
更新日期：2007-06-01 00:00:00
abstract：:Bone fractures constitute a major cause of morbidity and mortality especially in the elderly. Complications associated with osteoporosis drugs and the age of the patient slow bone turnover and render such fractures difficult to heal. Increasing the speed of fracture repair by administration of a fracture-targeted bone...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.5b00777
更新日期：2015-10-12 00:00:00
abstract：:The objective of this study is to investigate the influence of point mutations on the structural stability of coiled coil fragments of the human hair intermediate filament by molecular dynamics simulations and free energy calculations. Mutations in the helix termination motif of human hair keratin gene hHb6 seem to be...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm049788u
更新日期：2004-11-01 00:00:00
abstract：:Superparamagnetic iron oxide nanoparticles are widely used as nanoprobes for magnetic resonance imaging (MRI). Water-soluble iron oxide nanoparticles were synthesized by coating iron oxide nanoparticles with a hydrophilic, biocompatible, biodegradable poly(amino acid) derivative, poly(2-hydroxyethyl aspartamide) graft...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm100560m
更新日期：2010-11-08 00:00:00
abstract：:A cellulose-chitin hybrid polysaccharide having alternatingly beta(1-->4)-linked D-glucose (Glc) and N-acetyl-d-glucosamine (GlcNAc) was synthesized via two modes of enzymatic polymerization. First, a sugar oxazoline monomer of Glcbeta(1-->4)GlcNAc (1) was designed as a transition-state analogue substrate (TSAS) monom...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm060094q
更新日期：2006-05-01 00:00:00
abstract：:Genome-editing technologies hold tremendous potential for treating genetic diseases. However, the efficient and safe delivery of genome-editing elements to the location of interest, and the achievement of specific targeted gene correction without off-target side effect remains a big challenge. In this Perspective, we ...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.9b00783
更新日期：2019-09-09 00:00:00
abstract：:A new series of cationic, thermo-sensitive, and biodegradable poly(L-lactide)-poly(2-ethyl-2-oxazoline)-poly(L-lactide) (PLLA-PEOz-PLLA) triblock copolymers were synthesized by ring-opening polymerization. With increasing molecular weight and crystallinity of hydrophobic PLLA blocks, the critical micellization concent...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/bm034190s
更新日期：2003-11-01 00:00:00
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journal_title：Biomacromolecules
pub_type： 杂志文章,评审
doi：10.1021/bm801103c
更新日期：2009-01-12 00:00:00
abstract：:Polypeptide-based formulations that undergo liquid to hydrogel transitions upon change in temperature have become desirable targets since they can be mixed with cells or injected into tissues as liquids, and subsequently transform into rigid scaffolds or depots. Such materials have been challenging to prepare using sy...
journal_title：Biomacromolecules
pub_type： 杂志文章
doi：10.1021/acs.biomac.5b00124
更新日期：2015-04-13 00:00:00
