High internal phase emulsion templating with self-emulsifying and thermoresponsive chitosan-graft-PNIPAM-graft-oligoproline.

Abstract:

:High internal phase emulsion (HIPE)-templating is an attractive method of producing high porosity polymer foams with tailored pore structure, pore size and porosity. However, this method typically requires the use of large amounts of surfactants to stabilize the immiscible liquid phases, and polymerizable monomers/cross-linker in the continuous minority phase to solidify the HIPE, which may not be desirable in many applications. We show that polyHIPEs with a porosity of 73% can be formed solely using a copolymer of chitosan-graft-PNIPAM-graft-oligoproline (CSN-PRO), which acts simultaneously as emulsifier and thermoresponsive gelator, and forms upon removal of the liquid templating phases, the bulk structure of the resulting polyHIPE. With only a small amount of surfactant (1%v/v in the aqueous phase), and varying the polymer concentration and internal phase volume ratio, different polyHIPEs with porosities of up to 99%, surface areas in excess of 300 m(2)/g and controlled pore interconnectivity can be formed. The poly(CSN-PRO)HIPEs are also shown to be thermoresponsive and remained intact when immersed into water above 34 °C but dissolve below their LCST, which is useful for applications such as drug delivery and tissue engineering scaffolds.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Oh BH,Bismarck A,Chan-Park MB

doi

10.1021/bm500172u

subject

Has Abstract

pub_date

2014-05-12 00:00:00

pages

1777-87

issue

5

eissn

1525-7797

issn

1526-4602

journal_volume

15

pub_type

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