Abstract:
:Poloxamer thermoresponsive gels are widely explored in controlled drug delivery. Nevertheless, these gels possess inadequate mechanical properties, poor bioadhesiveness, and high permeability to water. To overcome these issues, we blended mucoadhesive hyaluronic acid (HA) with poloxamer analogs. This study aimed to investigate the features affecting the microscopic properties of the gels, which determine their macroscopic properties and capability to control/sustain protein release. Results showed that HA hampers water-poloxamer interactions, thus, strongly influencing physicochemical properties of poloxamer gels. This leads to gels with improved mechanical properties in which the diffusion kinetics of macromolecular active molecules are drastically slowed down. Poloxamer-HA gels can sustain the delivery of proteins, such as insulin, and may allow the modulation of its release kinetics by modifying HA content within the gels in the administration sites in which the active molecule release mechanism is mainly governed by its diffusion.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Mayol L,Biondi M,Quaglia F,Fusco S,Borzacchiello A,Ambrosio L,La Rotonda MIdoi
10.1021/bm1008958subject
Has Abstractpub_date
2011-01-10 00:00:00pages
28-33issue
1eissn
1525-7797issn
1526-4602journal_volume
12pub_type
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