Hydrogels for Therapeutic Delivery: Current Developments and Future Directions.

Abstract:

:Hydrogels are attractive materials for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. Recent advances in organic and polymer chemistry, bioengineering and nanotechnology have resulted in several new developments in the field of hydrogels for therapeutic delivery. In this Perspective, we present our view on the state-of-the-art in the field, thereby focusing on a number of exciting topics, including bioorthogonal cross-linking methods, multicomponent hydrogels, stimuli-responsive hydrogels, nanogels, and the release of therapeutics from 3D printed hydrogels. We also describe the challenges that should be overcome to facilitate translation from academia to the clinic and last, we share our ideas about the future of this rapidly evolving area of research.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Buwalda SJ,Vermonden T,Hennink WE

doi

10.1021/acs.biomac.6b01604

subject

Has Abstract

pub_date

2017-02-13 00:00:00

pages

316-330

issue

2

eissn

1525-7797

issn

1526-4602

journal_volume

18

pub_type

杂志文章
  • Short- and Long-Term Effects of X-ray Synchrotron Radiation on Cotton Paper.

    abstract::X-ray analytical techniques are increasingly being used to study manuscripts and works of art on paper, whether with laboratory equipment or synchrotron sources. However, it is difficult to anticipate the impact of X-ray photons on paper- and cellulose-based artifacts, particularly due to the large variety of their co...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.0c00512

    authors: Gimat A,Schöder S,Thoury M,Missori M,Paris-Lacombe S,Dupont AL

    更新日期:2020-07-13 00:00:00

  • Tethered lipid bilayers on electrolessly deposited gold for bioelectronic applications.

    abstract::This paper presents the formation of a novel biomimetic interface consisting of an electrolessly deposited gold film overlaid with a tethered bilayer lipid membrane (tBLM). Self-assembly of colloidal gold particles was used to create an electrolessly deposited gold film on a glass slide. The properties of the film wer...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm0603995

    authors: Kohli N,Hassler BL,Parthasarathy L,Richardson RJ,Ofoli RY,Worden RM,Lee I

    更新日期:2006-12-01 00:00:00

  • Biocompatibility of plasma enhanced chemical vapor deposited poly(2-hydroxyethyl methacrylate) films for biomimetic replication of the intestinal basement membrane.

    abstract::It is recognized that topographical features such as ridges and grooves can dramatically influence cell phenotype, motivating the development of substrates with precisely biomimetic topography for study of the influence on cultured cells. Intestinal basement membrane topography has been precisely replicated using plas...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm100209b

    authors: Pfluger CA,Burkey DD,Wang L,Sun B,Ziemer KS,Carrier RL

    更新日期:2010-06-14 00:00:00

  • Self-Assembled Peptide-Carbon Nitride Hydrogel as a Light-Responsive Scaffold Material.

    abstract::Peptide self-assembly is a facile route to the development of bioorganic hybrid materials that have sophisticated nanostructures toward diverse applications. Here, we report the synthesis of self-assembled peptide (Fmoc-diphenylalanine, Fmoc-FF)/graphitic carbon nitride (g-C3N4) hydrogels for light harvesting and biom...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00889

    authors: Ko JW,Choi WS,Kim J,Kuk SK,Lee SH,Park CB

    更新日期:2017-11-13 00:00:00

  • Artificial forisomes are ideal models of forisome assembly and activity that allow the development of technical devices.

    abstract::Forisomes are protein polymers found in leguminous plants that have the remarkable ability to undergo reversible "muscle-like" contractions in the presence of divalent cations and in extreme pH environments. To gain insight into the molecular basis of forisome structure and assembly, we used confocal laser scanning mi...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm3008499

    authors: Groscurth S,Müller B,Schwan S,Menzel M,Diekstall F,Senft M,Kendall A,Kommor BA,Neumann U,Kalischuk M,Kawchuk LM,Krzyzanek V,Heilmann A,Stubbs G,Twyman RM,Prüfer D,Noll GA

    更新日期:2012-10-08 00:00:00

  • Rapid cellular internalization of multifunctional star polymers prepared by atom transfer radical polymerization.

    abstract::Poly(ethylene glycol) (PEG) star polymers containing GRGDS (Gly-Arg-Gly-Asp-Ser) peptide sequences on the star periphery were synthesized by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) methyl ether methacrylate (PEGMA), GRGDS modified poly(ethylene glycol) acrylate (GRGDS-PEG-Acryl), fluoresce...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm1006272

    authors: Cho HY,Gao H,Srinivasan A,Hong J,Bencherif SA,Siegwart DJ,Paik HJ,Hollinger JO,Matyjaszewski K

    更新日期:2010-09-13 00:00:00

  • Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold.

    abstract::Peptide ligation is an indispensable step in the chemical synthesis of target peptides and proteins that are difficult to synthesize at once by a solid-phase synthesis. The ligation reaction is generally conducted with two peptide fragments at a high aqueous concentration to increase the reaction rate; however, this o...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.8b01655

    authors: Hayashi G,Yanase M,Nakatsuka Y,Okamoto A

    更新日期:2019-03-11 00:00:00

  • PLGA:poloxamer and PLGA:poloxamine blend nanoparticles: new carriers for gene delivery.

    abstract::The main objective of the present work was the development of new nanoparticulate carrier systems for the delivery of plasmid DNA. These new carriers consist of a blend matrix formed by a poly(lactic-co-glycolic acid) (PLGA) copolymer and polyoxyethylene derivatives. More specifically, we have prepared nanostructures ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm049577p

    authors: Csaba N,Caamaño P,Sánchez A,Domínguez F,Alonso MJ

    更新日期:2005-01-01 00:00:00

  • Material properties and cytocompatibility of injectable MMP degradable poly(lactide ethylene oxide fumarate) hydrogel as a carrier for marrow stromal cells.

    abstract::Injectable in situ crosslinkable biomaterials seeded with multipotent progenitor cells and coupled with minimally invasive arthroscopic techniques are an attractive alternative for treating irregularly shaped osteochondral defects. An in situ crosslinkable poly(lactide-co-ethylene oxide-co-fumarate) (PLEOF) macromer h...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm060671a

    authors: He X,Jabbari E

    更新日期:2007-03-01 00:00:00

  • Self-Assembly of Mesoscopic Peptide Surfactant Fibrils Investigated by STORM Super-Resolution Fluorescence Microscopy.

    abstract::Super-resolution fluorescence microscopy, specifically stochastic reconstruction microscopy (STORM), and atomic force microscopy (AFM) were used to image the self-assembly processes of the peptide surfactant I3K. The peptide surfactants self-assembled into giant helical fibrils with diameters between 5 and 10 nm with ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b00465

    authors: Cox H,Georgiades P,Xu H,Waigh TA,Lu JR

    更新日期:2017-11-13 00:00:00

  • Photoluminescence Control of Cellulose via Surface Functionalization Using Oxidative Polymerization.

    abstract::Control of the photoluminescence properties of cellulose is conducted by introduction of conducting polymers including fluorene (F) and 3-hexylthiophene (3HT) on cellulose surface through FeCl3 oxidative polymerization. The UV-vis absorption peak of cellulose grafted with the 3-hexylthiophene and fluorene copolymer wa...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.7b01067

    authors: Phung Hai TA,Sugimoto R

    更新日期:2017-12-11 00:00:00

  • Polymersome encapsulated hemoglobin: a novel type of oxygen carrier.

    abstract::Bovine hemoglobin (Hb) was encapsulated inside polymer vesicles (polymersomes) to form polymersome encapsulated Hb (PEH) dispersions. PEH particles are 100% surface PEGylated with longer PEG chains and possess thicker hydrophobic membranes as compared to conventional liposomes. Polymersomes were self-assembled from po...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm0501454

    authors: Arifin DR,Palmer AF

    更新日期:2005-07-01 00:00:00

  • Nanogel formation consisting of DNA and poly(amido amine) dendrimer studied by static light scattering and atomic force microscopy.

    abstract::Binding of a poly(amido amine) dendrimer with salmon testes DNA in an aqueous solution of 0.01 M NaCl at pH 6.5 has been investigated. It was shown from the physicochemical experiments of static light scattering and ultra-violet and circular dichroism spectroscopy that at a 0.2 mixing ratio of dendrimer/DNA (number ra...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm034239u

    authors: Mitra A,Imae T

    更新日期:2004-01-01 00:00:00

  • Diffusion of 1-ethyl-3-methyl-imidazolium acetate in glucose, cellobiose, and cellulose solutions.

    abstract::Solutions of glucose, cellobiose and microcrystalline cellulose in the ionic liquid 1-ethyl-3-methyl-imidazolium ([C2mim][OAc]) have been examined using pulsed-field gradient (1)H NMR. Diffusion coefficients of the cation and anion across the temperature range 20-70 °C have been determined for a range of concentration...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm401652c

    authors: Ries ME,Radhi A,Keating AS,Parker O,Budtova T

    更新日期:2014-02-10 00:00:00

  • Joining Two Natural Motifs: Catechol-Containing Poly(phosphoester)s.

    abstract::Numerous catechol-containing polymers, including biodegradable polymers, are currently heavily discussed for modern biomaterials. However, there is no report combining poly(phosphoester)s (PPEs) with catechols. Adhesive PPEs have been prepared via acyclic diene metathesis polymerization. A novel acetal-protected catec...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.6b01613

    authors: Becker G,Ackermann LM,Schechtel E,Klapper M,Tremel W,Wurm FR

    更新日期:2017-03-13 00:00:00

  • Suppressing surface reconstruction of superhydrophobic PDMS using a superhydrophilic zwitterionic polymer.

    abstract::Poly(dimethyl siloxane) (PDMS) is extensively used for biomedical applications due to its low cost, ease of fabrication, high durability and flexibility, oxygen permeability, and self-healing properties. PDMS, however, has some significant drawbacks. PDMS endures unacceptably high levels of nonspecific protein fouling...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm300399s

    authors: Keefe AJ,Brault ND,Jiang S

    更新日期:2012-05-14 00:00:00

  • Enzymatic Synthesis of 2-(β-Galactosyl)-ethyl Methacrylate by β-Galactosidase from Pyrococcus woesei and Application for Glycopolymer Synthesis and Lectin Studies.

    abstract::Glycosidases have long been used for the synthesis of glycosides by transglycosylation reactions. Especially glycosidases from hyperthermophilic bacteria are useful for reactions under extreme reaction conditions, e.g., in the presence of organic solvents. We herein report the facile enzymatic synthesis and purificati...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b01647

    authors: Hoffmann M,Gau E,Braun S,Pich A,Elling L

    更新日期:2020-02-10 00:00:00

  • Nanoparticles Presenting Potent TLR7/8 Agonists Enhance Anti-PD-L1 Immunotherapy in Cancer Treatment.

    abstract::Cancer immunotherapy can be augmented with toll-like receptor agonist (TLRa) adjuvants, which interact with immune cells to elicit potent immune activation. Despite their potential, use of many TLRa compounds has been limited clinically due to their extreme potency and lack of pharmacokinetic control, causing systemic...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.0c00812

    authors: Smith AAA,Gale EC,Roth GA,Maikawa CL,Correa S,Yu AC,Appel EA

    更新日期:2020-09-14 00:00:00

  • Sulfated glycosaminoglycans exploit the conformational plasticity of bone morphogenetic protein-2 (BMP-2) and alter the interaction profile with its receptor.

    abstract::Sulfated glycosaminoglycans (GAGs) can direct cellular processes by interacting with proteins of the extracellular matrix (ECM). In this study we characterize the interaction profiles of chemically sulfated hyaluronan (HA) and chondroitin sulfate (CS) derivatives with bone morphogenetic protein-2 (BMP-2) and investiga...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm5006855

    authors: Hintze V,Samsonov SA,Anselmi M,Moeller S,Becher J,Schnabelrauch M,Scharnweber D,Pisabarro MT

    更新日期:2014-08-11 00:00:00

  • Compression molding and tensile properties of thermoplastic potato starch materials.

    abstract::The mechanical and melt flow properties of two thermoplastic potato starch materials with different amylose contents were evaluated. The materials were prepared by mixing starch, glycerol, and water, mainly in the weight proportions of 10:3:4.5. Compression molding was used to produce sheets/films with a thickness in ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm050804c

    authors: Thunwall M,Boldizar A,Rigdahl M

    更新日期:2006-03-01 00:00:00

  • Poly(ε-caprolactone) nanofibers with a self-induced nanohybrid shish-kebab structure mimicking collagen fibrils.

    abstract::A three-dimensional structure consisting of poly(ε-caprolactone) (PCL) nanofibers covered by periodically spaced PCL crystal lamellae, a self-induced nanohybrid shish-kebab (SINSK) structure, was created using electrospinning followed by a self-induced crystallization. The resulting structure that resembles the nanoto...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm400928b

    authors: Wang X,Salick MR,Wang X,Cordie T,Han W,Peng Y,Li Q,Turng LS

    更新日期:2013-10-14 00:00:00

  • Glycol chitosan/heparin immobilized iron oxide nanoparticles with a tumor-targeting characteristic for magnetic resonance imaging.

    abstract::We described the preparation of the glycol chitosan/heparin immobilized iron oxide nanoparticles (composite NPs) as a magnetic resonance imaging agent with a tumor-targeting characteristic. The iron oxide nanoseeds used clinically as a magnetic resonance imaging agent were immobilized into the glycol chitosan/heparin ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm200413a

    authors: Yuk SH,Oh KS,Cho SH,Lee BS,Kim SY,Kwak BK,Kim K,Kwon IC

    更新日期:2011-06-13 00:00:00

  • Giant bent-core mesogens in the thread forming process of marine mussels.

    abstract::In marine mussels (Mytilus), byssal threads are made in minutes from prefabricated smectic polymer liquid crystals by a process resembling reaction injection molding. The mesogens in these arrays are known to be natural block copolymers with rodlike collagen cores. Using atomic force microscopy, it was shown that thes...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm049899t

    authors: Hassenkam T,Gutsmann T,Hansma P,Sagert J,Waite JH

    更新日期:2004-07-01 00:00:00

  • Silk Fibroin-Sophorolipid Gelation: Deciphering the Underlying Mechanism.

    abstract::Silk fibroin (SF) protein, produced by silkworm Bombyx mori, is a promising biomaterial, while sophorolipid (SL) is an amphiphilic functional biosurfactant synthesized by nonpathogenic yeast Candida bombicola. SL is a mixture of two forms, acidic (ASL) and lactonic (LSL), which when added to SF results in accelerated ...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.6b01069

    authors: Dubey P,Kumar S,Aswal VK,Ravindranathan S,Rajamohanan PR,Prabhune A,Nisal A

    更新日期:2016-10-10 00:00:00

  • Formation of a lamellar compound by reaction of acrylic acid crystallosolvated in highly crystalline beta-chitin.

    abstract::A lamellar compound resulted from reaction of acrylic acid inside crystalline beta-chitin and the structure was investigated. Beta-chitin acts like a layered crystal, having stacked molecular sheets composed of parallel chains bound in one direction by intermolecular amide hydrogen bonding. Small guest molecules can b...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm060643s

    authors: Saito Y,Tomotake Y,Shida S

    更新日期:2007-04-01 00:00:00

  • Fast Degradable Polycaprolactone for Drug Delivery.

    abstract::Polycaprolactone (PCL) was reported a long time ago; however, its biomedical applications has not been extensively investigated in comparison with poly(lactide- co-glycolide) (PLGA) due to its too slow degradation profile. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer (PCL-OX) as a...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.8b00266

    authors: Chang SH,Lee HJ,Park S,Kim Y,Jeong B

    更新日期:2018-06-11 00:00:00

  • Ultrasensitive Detection of MicroRNA in Tumor Cells and Tissues via Continuous Assembly of DNA Probe.

    abstract::Nucleic acids have been engineered to participate in a wide variety of tasks. Among them, the enzyme-free amplification modes, enzyme-free DNA circuits (EFDCs), and hybridization chain reactions (HCRs) have been widely applied in a series of studies of bioanalysis. We demonstrated here an ultrasensitive hairpin probe-...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.5b00959

    authors: Liao Y,Fu Y,Wu Y,Huang R,Zhou X,Xing D

    更新日期:2015-11-09 00:00:00

  • New gelatin-based hydrogels via enzymatic networking.

    abstract::New types of hydrogels have been obtained starting from high bloom purified gelatin A, alone or in mixtures with hyaluronan and with a hyaluronan derivative bearing primary amino groups, by transglutaminase-catalyzed cross-linking. The reticulation process, carried out adopting two different temperature protocols, and...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm025657m

    authors: Crescenzi V,Francescangeli A,Taglienti A

    更新日期:2002-11-01 00:00:00

  • Nanomaterials Derived from Fungal Sources-Is It the New Hype?

    abstract::Greener alternatives to synthetic polymers are constantly being investigated and sought after. Chitin is a natural polysaccharide that gives structural support to crustacean shells, insect exoskeletons, and fungal cell walls. Like cellulose, chitin resides in nanosized structural elements that can be isolated as nanof...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/acs.biomac.9b01141

    authors: Nawawi WMFBW,Jones M,Murphy RJ,Lee KY,Kontturi E,Bismarck A

    更新日期:2020-01-13 00:00:00

  • Effects of temperature and pressure on the aggregation properties of an engineered elastin model polypeptide in aqueous solution.

    abstract::The pressure and temperature dependence of the cloud point transition of an aqueous solution of an elastin-like polypeptide (MGLDGSMG(VPGIG)40VPLE), prepared by bacterial expression of the corresponding artificial gene, was measured. A temperature-pressure diagram was constructed over a wide range of conditions. The (...

    journal_title:Biomacromolecules

    pub_type: 杂志文章

    doi:10.1021/bm005606u

    authors: Tamura T,Yamaoka T,Kunugi S,Panitch A,Tirrell DA

    更新日期:2000-01-01 00:00:00