Hydrogels for Therapeutic Delivery: Current Developments and Future Directions.

Abstract:

:Hydrogels are attractive materials for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. Recent advances in organic and polymer chemistry, bioengineering and nanotechnology have resulted in several new developments in the field of hydrogels for therapeutic delivery. In this Perspective, we present our view on the state-of-the-art in the field, thereby focusing on a number of exciting topics, including bioorthogonal cross-linking methods, multicomponent hydrogels, stimuli-responsive hydrogels, nanogels, and the release of therapeutics from 3D printed hydrogels. We also describe the challenges that should be overcome to facilitate translation from academia to the clinic and last, we share our ideas about the future of this rapidly evolving area of research.

journal_name

Biomacromolecules

journal_title

Biomacromolecules

authors

Buwalda SJ,Vermonden T,Hennink WE

doi

10.1021/acs.biomac.6b01604

subject

Has Abstract

pub_date

2017-02-13 00:00:00

pages

316-330

issue

2

eissn

1525-7797

issn

1526-4602

journal_volume

18

pub_type

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