Abstract:
:Hydrogels are attractive materials for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. Recent advances in organic and polymer chemistry, bioengineering and nanotechnology have resulted in several new developments in the field of hydrogels for therapeutic delivery. In this Perspective, we present our view on the state-of-the-art in the field, thereby focusing on a number of exciting topics, including bioorthogonal cross-linking methods, multicomponent hydrogels, stimuli-responsive hydrogels, nanogels, and the release of therapeutics from 3D printed hydrogels. We also describe the challenges that should be overcome to facilitate translation from academia to the clinic and last, we share our ideas about the future of this rapidly evolving area of research.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Buwalda SJ,Vermonden T,Hennink WEdoi
10.1021/acs.biomac.6b01604subject
Has Abstractpub_date
2017-02-13 00:00:00pages
316-330issue
2eissn
1525-7797issn
1526-4602journal_volume
18pub_type
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