Hydrogels for Therapeutic Delivery: Current Developments and Future Directions.


:Hydrogels are attractive materials for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. Recent advances in organic and polymer chemistry, bioengineering and nanotechnology have resulted in several new developments in the field of hydrogels for therapeutic delivery. In this Perspective, we present our view on the state-of-the-art in the field, thereby focusing on a number of exciting topics, including bioorthogonal cross-linking methods, multicomponent hydrogels, stimuli-responsive hydrogels, nanogels, and the release of therapeutics from 3D printed hydrogels. We also describe the challenges that should be overcome to facilitate translation from academia to the clinic and last, we share our ideas about the future of this rapidly evolving area of research.






Buwalda SJ,Vermonden T,Hennink WE




Has Abstract


2017-02-13 00:00:00












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    abstract::A new family of cationic dendron-bearing lipids (CDLs) with poly(amidoamine) dendrons of first to third generation (named as A1, A2, and A3, respectively) was synthesized through a synthesis approach that permits facile variation of chemical structures. All CDLs could effectively bind small interfering RNA (siRNA) to ...


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    authors: Zhang Y,Chen J,Xiao C,Li M,Tian H,Chen X

    更新日期:2013-12-09 00:00:00

  • Conformational study of silk-like peptides containing the calcium-binding sequence from calbindin D9k using 13C CP/MAS NMR spectroscopy.

    abstract::The calcium-binding sites of calbindin D(9k) have a helix-loop-helix motif. In this study, the helix motifs were replaced by several Ala-Gly repeating regions designed on the basis of the primary sequences of several silk fibroins. The synthesized peptides were treated with several organic solvents to modify the secon...


    pub_type: 杂志文章


    authors: Asakura T,Hamada M,Nakazawa Y,Ha SW,Knight DP

    更新日期:2006-02-01 00:00:00

  • Advanced Cellulose Fibers for Efficient Immobilization of Enzymes.

    abstract::Biocatalytic pulp fibers were prepared using surface functionalization of bleached kraft pulp with amino groups (F) and further immobilization of a cross-linked glucose oxidase (G*) from Aspergillus niger. The cross-linked enzymes (G*) were characterized using X-ray spectroscopy, Fourier transform infrared spectroscop...


    pub_type: 杂志文章


    authors: Vega Erramuspe IB,Fazeli E,Näreoja T,Trygg J,Hänninen P,Heinze T,Fardim P

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  • Synthesis of chitosan-stabilized gold nanoparticles in the absence/presence of tripolyphosphate.

    abstract::Gold nanoparticles were prepared by reducing gold salt with a polysaccharide, chitosan, in the absence/presence of tripolyphosphate (TPP). Here, chitosan acted as a reducing/stabilizing agent. The obtained gold nanoparticles were characterized with UV--vis spectroscopy and transmission electron microscopy. The results...


    pub_type: 杂志文章


    authors: Huang H,Yang X

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  • Monolithic silica rods grafted with thermoresponsive anionic polymer brushes for high-speed separation of basic biomolecules and peptides.

    abstract::Thermoresponsive anionic copolymer brushes, poly(N-isopropylacrylamide-co-acrylic acid-co-tert-butylacrylamide) [P(IPAAm-co-AAc-co-tBAAm)], were grafted onto a monolithic silica rod column through surface-initiated atom-transfer radical polymerization (ATRP) to prepare an effective thermoresponsive anionic chromatogra...


    pub_type: 杂志文章


    authors: Nagase K,Kobayashi J,Kikuchi A,Akiyama Y,Kanazawa H,Okano T

    更新日期:2014-04-14 00:00:00

  • Synthesis and characterization of glycopolymer-polypeptide triblock copolymers.

    abstract::Glycopolymer-polypeptide triblock copolymers of the structure, poly(l-alanine)-b-poly(2-acryloyloxyethyl-lactoside)-b-poly(l-alanine) (AGA), have been synthesized by sequential atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP). Controlled free radical polymerization of 2-O-acryloyl-oxye...


    pub_type: 杂志文章


    authors: Dong CM,Sun XL,Faucher KM,Apkarian RP,Chaikof EL

    更新日期:2004-01-01 00:00:00

  • Temperature-Controlled Orientation of Proteins on Temperature-Responsive Grafted Polymer Brushes: Poly(butyl methacrylate) vs Poly(butyl acrylate): Morphology, Wetting, and Protein Adsorption.

    abstract::Poly( n-butyl methacrylate) (PBMA) or poly( n-butyl acrylate) (PBA)-grafted brush coatings attached to glass were successfully prepared using atom-transfer radical polymerization "from the surface". The thicknesses and composition of the PBMA and PBA coatings were examined using ellipsometry and time-of-flight seconda...


    pub_type: 杂志文章


    authors: Awsiuk K,Stetsyshyn Y,Raczkowska J,Lishchynskyi O,Dąbczyński P,Kostruba A,Ohar H,Shymborska Y,Nastyshyn S,Budkowski A

    更新日期:2019-06-10 00:00:00

  • Self-Standing Nanocellulose Janus-Type Films with Aldehyde and Carboxyl Functionalities.

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    pub_type: 杂志文章


    authors: Nypelö T,Amer H,Konnerth J,Potthast A,Rosenau T

    更新日期:2018-03-12 00:00:00

  • A Polymer Therapeutic Having Universal Heparin Reversal Activity: Molecular Design and Functional Mechanism.

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    pub_type: 杂志文章


    authors: Kalathottukaren MT,Abbina S,Yu K,Shenoi RA,Creagh AL,Haynes C,Kizhakkedathu JN

    更新日期:2017-10-09 00:00:00

  • Controlling the Self-Assembly Behavior of Aqueous Chitin Nanocrystal Suspensions.

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    pub_type: 杂志文章


    authors: Narkevicius A,Steiner LM,Parker RM,Ogawa Y,Frka-Petesic B,Vignolini S

    更新日期:2019-07-08 00:00:00

  • Enzymatic Synthesis of 2-(β-Galactosyl)-ethyl Methacrylate by β-Galactosidase from Pyrococcus woesei and Application for Glycopolymer Synthesis and Lectin Studies.

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    pub_type: 杂志文章


    authors: Hoffmann M,Gau E,Braun S,Pich A,Elling L

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  • Carbohydrate/monomer complexes in aqueous polymerizations: methylated-beta-cyclodextrin mediated aqueous polymerization of hydrophobic methacrylic monomers.

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    pub_type: 杂志文章


    authors: Madison PH,Long TE

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  • Formation of α-helical nanofibers by mixing β-structured and α-helical coiled coil peptides.

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    pub_type: 杂志文章


    authors: Brandenburg E,Berlepsch HV,Leiterer J,Emmerling F,Koksch B

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  • Unraveling the Correlations between Conformation, Lubrication, and Chemical Stability of Bottlebrush Polymers at Interfaces.

    abstract::In the present study, we monitored the conformation and chemical stability of a hydrophilic bottlebrush (BB) polymer in pure water and buffered saline solutions. We correlated these parameters to lubricating and wear protecting properties. Using the surface forces apparatus (SFA), we show that the BB polymer partially...


    pub_type: 杂志文章


    authors: Faivre J,Shrestha BR,Xie G,Delair T,David L,Matyjaszewski K,Banquy X

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  • Synthesis and properties of degradable poly(urethane urea)s to be used for ligament reconstructions.

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    authors: Gisselfält K,Edberg B,Flodin P

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  • Mild and selective oxidation of cellulose fibers in the presence of N-hydroxyphthalimide.

    abstract::The oxidation reaction of regenerated cellulose fibers mediated by N-hydroxyphthalimide (NHPI) and various cocatalysts at room temperature for different time intervals and various amounts of low concentration sodium hypochlorite solution has been investigated to produce oxidized cellulose (OC), a biocompatible and bio...


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    authors: Coseri S,Nistor G,Fras L,Strnad S,Harabagiu V,Simionescu BC

    更新日期:2009-08-10 00:00:00

  • New amphiphilic poly(2-ethyl-2-oxazoline)/ poly(L-lactide) triblock copolymers.

    abstract::A new series of cationic, thermo-sensitive, and biodegradable poly(L-lactide)-poly(2-ethyl-2-oxazoline)-poly(L-lactide) (PLLA-PEOz-PLLA) triblock copolymers were synthesized by ring-opening polymerization. With increasing molecular weight and crystallinity of hydrophobic PLLA blocks, the critical micellization concent...


    pub_type: 杂志文章


    authors: Wang CH,Hsiue GH

    更新日期:2003-11-01 00:00:00

  • Readily controllable step-growth polymerization method for poly(lactic acid) copolymers having a high glass transition temperature.

    abstract::Poly(lactic acid) (PLA) copolymers having a significantly higher glass transition temperature (T(g)) than that of high molar mass PLA homopolymers (typically 60 +/- 5 degrees C) were prepared. Lactic acid was copolymerized with 1,4:3,6-dianhydro-D-glucitol (isosorbide, ISB) and succinic acid (SA-2), 1,2,3,4-butanetetr...


    pub_type: 杂志文章


    authors: Inkinen S,Stolt M,Södergård A

    更新日期:2010-05-10 00:00:00

  • Cellulosic graft copolymer: poly(methyl methacrylate) with cellulose side chains.

    abstract::A cellulose macromonomer, N-(15-methacryloyloxypentadecanoyl)-tri-O-acetyl-beta-cellulosylamine (CTA-C15-MA (2); M(2)) with number averaged degree of polymerization (DP(n)) = 13), was copolymerized with methyl methacrylate (MMA; M(1)) to give cellulosic copolymer with CTA side chains, PMMA-g-(CTA-C15) (3-A). An absolu...


    pub_type: 杂志文章


    authors: Enomoto-Rogers Y,Kamitakahara H,Takano T,Nakatsubo F

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  • Enzymatic Degradation of Bombyx mori Silk Materials: A Review.

    abstract::As a biomaterial, silk presents unique features with a combination of excellent mechanical properties, biocompatibility, and biodegradability. The biodegradability aspects of silk biomaterials, especially with options to control the rate from short (days) to long (years) time frames in vivo, make this protein-based bi...


    pub_type: 杂志文章


    authors: Guo C,Li C,Kaplan DL

    更新日期:2020-05-11 00:00:00

  • Altering peptide fibrillization by polymer conjugation.

    abstract::A strategy is presented that exploits the ability of synthetic polymers of different nature to disturb the strong self-assembly capabilities of amyloid based β-sheet forming peptides. Following a convergent approach, the peptides of interest were synthesized via solid-phase peptide synthesis (SPPS) and the polymers vi...


    pub_type: 杂志文章


    authors: Dehn S,Castelletto V,Hamley IW,Perrier S

    更新日期:2012-09-10 00:00:00

  • Conformational preferences of the O-antigen polysaccharides of Escherichia coli O5ac and O5ab using NMR spectroscopy and molecular modeling.

    abstract::Escherichia coli serogroup O5 comprises two different subgroups (O5ab and O5ac), which are indiscernible from the point of view of standard immunological serotyping. The structural similarities between the O-antigen polysaccharides (PSs) of these two strains are remarkable, with the only difference being the glycosidi...


    pub_type: 杂志文章


    authors: Sarkar A,Fontana C,Imberty A,Pérez S,Widmalm G

    更新日期:2013-07-08 00:00:00

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    abstract::Six methyl celluloses (MCs), one with a degree of substitution (DS) of 1.32 and five with DS between 1.83 and 1.88, were thoroughly investigated. Monomer composition and methyl distribution in the polymer chain were analyzed after total or partial random hydrolysis and appropriate derivatization with gas chromatograph...


    pub_type: 杂志文章


    authors: Adden R,Melander C,Brinkmalm G,Gorton L,Mischnick P

    更新日期:2006-05-01 00:00:00

  • Nanostructured biocomposite scaffolds based on collagen coelectrospun with nanohydroxyapatite.

    abstract::Nanofibrous biocomposite scaffolds of type I collagen and nanohydroxyapatite (nanoHA) of varying compositions (wt %) were prepared by electrostatic cospinning. The scaffolds were characterized for structure and morphology by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), atomic fo...


    pub_type: 杂志文章


    authors: Thomas V,Dean DR,Jose MV,Mathew B,Chowdhury S,Vohra YK

    更新日期:2007-02-01 00:00:00

  • Candida antarctica lipase B chemically immobilized on epoxy-activated micro- and nanobeads: catalysts for polyester synthesis.

    abstract::Candida antarctica Lipase B (CALB) was covalently immobilized onto epoxy-activated macroporous poly(methyl methacrylate) Amberzyme beads (235 microm particle size, 220 A pore size) and nanoparticles (nanoPSG, diameter 68 nm) with a poly(glycidyl methacrylate) outer region. Amberzyme beads allowed CALB loading up to 0....


    pub_type: 杂志文章


    authors: Chen B,Hu J,Miller EM,Xie W,Cai M,Gross RA

    更新日期:2008-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Sakai S,Kamei H,Mori T,Hotta T,Ohi H,Nakahata M,Taya M

    更新日期:2018-02-12 00:00:00

  • Endothelial Cell Migration on Poly(ε-caprolactone) Nanofibers Coated with a Nanohybrid Shish-Kebab Structure Mimicking Collagen Fibrils.

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    pub_type: 杂志文章


    authors: Guo X,Wang X,Li X,Jiang YC,Han S,Ma L,Guo H,Wang Z,Li Q

    更新日期:2020-03-09 00:00:00

  • Construction of Injectable Double-Network Hydrogels for Cell Delivery.

    abstract::Herein we present a unique method of using dynamic cross-links, which are dynamic covalent bonding and ionic interaction, for the construction of injectable double-network (DN) hydrogels, with the objective of cell delivery for cartilage repair. Glycol chitosan and dibenzaldhyde capped poly(ethylene oxide) formed the ...


    pub_type: 杂志文章


    authors: Yan Y,Li M,Yang D,Wang Q,Liang F,Qu X,Qiu D,Yang Z

    更新日期:2017-07-10 00:00:00

  • Redox-responsive alginate nanogels with enhanced anticancer cytotoxicity.

    abstract::Although doxorubicin (Dox) has been widely used in the treatment of different types of cancer, its insufficient cellular uptake and intracellular release is still a limitation. Herein, we report an easy process for the preparation of redox-sensitive nanogels that were shown to be highly efficient in the intracellular ...


    pub_type: 杂志文章


    authors: Maciel D,Figueira P,Xiao S,Hu D,Shi X,Rodrigues J,Tomás H,Li Y

    更新日期:2013-09-09 00:00:00

  • Self-association of mucin.

    abstract::Aggregation phenomena in aqueous solutions of purified human tracheobronchial mucin have been studied by rheological methods, steady-state fluorescence, quasielastic light scattering, and spin probe techniques. At temperatures below 30 degrees C and concentrations above 15 mg/mL and in the absence of chaotropic agents...


    pub_type: 杂志文章


    authors: Bromberg LE,Barr DP

    更新日期:2000-10-01 00:00:00